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General Information
Symbol
Dmel\Egfrunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0066102
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
EGFRnull
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Egfrunspecified mutant cells are nearly always located at the rear of the cluster during border cell dorsal migration in mosaic border cell clusters consisting of both wild-type and mutant cells.

    In Egfrunspecified mutant somatic clones in the 3rd instar eye disc, photoreceptors R2-R5 fail to undergo or differentiation. Within Egfrunspecified mutant somatic clones there is a failure of G1 arrest in the furrow: all cells except R8s re-enter the cell cycle. However, none of these cells progress past G2.

    Mutant females produce eggs with either narrowed and fused dorsal appendages or no appendages at all. Embryos produced from mutant females mated to wild-type males show cuticle patterning defects; expanded and fused ventral denticles.

    Collapsed CNS axon phenotype with frequent breaks in the longitudinal connectives. Midline glial cells are displaced ventrally at stage 12. By stage 16 midline glial cells are no longer evident, having degenerated.

    Dominantly suppresses the ability of Src42ASu(phl)1-1 to suppress the lethality of phl1/Y flies.

    Embryos form a ball of dorsal hypoderm with the external organs extruded anteriorly. Ventral cuticle is absent or strongly reduced. Abnormalities are first visible in the extended germ band stage. Pole cell transplantation experiments suggest there is no maternal effect.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhancer of
    Statement
    Reference

    Egfr[+]/Egfrunspecified is an enhancer of lethal phenotype of Raf12

    Egfr[+]/Egfrunspecified is an enhancer of visible phenotype of ksr::torΔNksr.hs.sev

    NOT Enhancer of
    Statement
    Reference

    Egfr[+]/Egfrunspecified is a non-enhancer of visible phenotype of Ras85DV12.sev

    NOT Suppressor of
    Statement
    Reference

    Egfr[+]/Egfrunspecified is a non-suppressor of visible phenotype of Ras85DV12.sev

    Phenotype Manifest In
    Enhancer of
    Statement
    Reference

    Egfr[+]/Egfrunspecified is an enhancer of axon & mechanosensory neuron & adult head phenotype of Scer\GAL4sca-537.4, htlDN.UAS.cMb

    Egfrunspecified is an enhancer of axon & ocellus sensory structure | conditional ts phenotype of Nrgl10

    Egfrunspecified is an enhancer of axon & mechanosensory neuron & adult head | conditional ts phenotype of Nrgl10

    Egfr[+]/Egfrunspecified is an enhancer of eye phenotype of ksr::torΔNksr.hs.sev

    Egfrunspecified is an enhancer of wing vein | ectopic phenotype of rlSem

    NOT Enhancer of
    Statement
    Reference

    Egfr[+]/Egfrunspecified is a non-enhancer of eye phenotype of Ras85DV12.sev

    Suppressor of
    Statement
    Reference

    Egfr[+]/Egfrunspecified is a suppressor of axon & ocellus sensory structure phenotype of Scer\GAL4sca-537.4, htlDN.UAS.cMb

    Egfr[+]/Egfrunspecified is a suppressor of phenotype of Src42ASu(Raf)1-1

    NOT Suppressor of
    Statement
    Reference

    Egfr[+]/Egfrunspecified is a non-suppressor of eye phenotype of Ras85DV12.sev

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Egfrunspecified Pvrunspecified double mutant cells are generally located at the rear of the cluster during border cell posterior migration in mosaic border cell clusters consisting of both wild-type and mutant cells.

    Within Egfrunspecified mutant clones in the eye disc in a BacA\p35GMR.PH background, caspase activation is seen posterior to column 5, relative to the morphogenetic furrow. There is no increase in caspase activation outside of these clones.

    The proportion of eyaScer\UAS.cHa; Scer\GAL4dpp.PH flies with blistered wings (76%) is decreased by heterozygosity for Egfrunspecified to 14%, while the proprotion with only mild wing defects is increased from 24% to 86%. (All data from experiments with a single, 'strong' P{UAS-eya.H} insertion; n=approximately 300 in each case).

    The addition of Egfrunspecified to EgfrDN.Scer\UAS.cBa animals (when driven by Scer\GAL4unspecified) causes a suppression of the Ocellar pioneer (OP) axon phenotypes and an enhancement of the bristle mechanosensory (BM) phenotypes.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    Comments
    Comments

    The ectopic veination and mild blistering seen in the wings of Pstu\aarAScer\UAS.cGa; Scer\GAL4Bx-MS1096 flies is partially suprressed by heterozygosity for spiunspecified or Egfrunspecified.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (4)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (19)