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General Information
Symbol
Dmel\vg83b27-R
Species
D. melanogaster
Name
FlyBase ID
FBal0082055
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
vg83b27R
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Mutation has the original vg83b27 deletion and a second deletion similar in size and location to that of vgnw.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous clones are rarely recovered in the wing blade region of the wing disc.

Mature mutant wing discs lack the wing primordium.

The dorsal/ventral compartment boundary is only slightly disturbed in vgnull/vg83b27-R wing discs.

Homozygous clones induced in the second larval instar cause a dramatic reorganisation of cell fate in the distal wing, including the induction of epithelial folds that are reminiscent of the hinge.

Of the indirect flight muscles in vg83b27-R mutants, the dorsal medial muscles are severely reduced and the dorso-ventral muscles (lateral oblique dorsal muscles and tergosternal muscles) are minimal or completely missing (10/10 examined).

Homozygous clones in the wing disc are infrequent and round, suggesting that they sort out from surrounding wild-type cells.

Mutants exhibit a severely reduced hinge and sometimes lack both the blade and the hinge and display wing to notum transformations.

vgWR2 produces an extreme vg phenotype in combination with vg83b27-R; all adult structures derived from the wing discs, including the notum, are deleted.

Clones induced in the wing disc are readily recovered in the notum but not in the wing disc. At most two- or three-cell clones can be found in the developing wing pouch.

Wing structures eliminated, retaining only a small amount of wing hinge.

Display erect postscutellar bristles and extreme wing phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
NOT Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Other
Additional Comments
Genetic Interactions
Statement
Reference

Homozygous vg83b27-R clones that are also expressing ykiScer\UAS.cHa under the control of Scer\GAL4tub.PU are readily recovered in the wing blade region of the wing disc.

When tkvQ253D.Scer\UAS.cNc is driven by Scer\GAL4Act5C.PP in a vg83b27-R background, complete suppression of the proliferation phenotype is seen.

Expression of SerScer\UAS.cSa does not cause ectopic wing margin formation, but mediated coexpression with vgScer\UAS.cKa leads to significant induction of an ectopic wing margin. Scer\GAL4dpp.blk1-mediated expression of wgScer\UAS.cGa or wgl-12.Scer\UAS fails to rescue loss of wing tissue.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Not rescued by
Comments

Scer\GAL4dpp.blk1-mediated expression of vgScer\UAS.cKa rescues the wing margin. Expression does not cause ectopic wing margin formation.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Lost complementation ability of vg83b27.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (28)