Allele Dmel\tgo³

General Information
Symbol	Dmel\tgo³	Species	D. melanogaster
Name		FlyBase ID	FBal0082186
Feature type	allele	Associated gene	Dmel\tgo

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Sonnenfeld et al., 1997)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3R:4,843,671..4,843,672 comment=G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation. (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental pr_change=W578@\|tgo-PA reported_pr_change=W578@ (Sonnenfeld et al., 2005)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: W578@. (Sonnenfeld et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Sonnenfeld et al., 1997) neuroanatomy defective (Sonnenfeld et al., 2005)
Phenotype Manifest In
	dorsal branch primordium (Sonnenfeld et al., 2005) dorsal trunk primordium (Sonnenfeld et al., 2005) ganglionic branch primordium (Sonnenfeld et al., 2005) presumptive embryonic/larval tracheal system (Sonnenfeld et al., 2005) transverse connective primordium (Sonnenfeld et al., 2005)
Detailed Description
	Statement Reference In tgo³ homozygous embryos branching of the terminal cells is absent and no connections develop between each side of the tracheal dorsal trunk so the dorsal trunk does not form a continuous tubular structure. In addition, the transverse connectives misroute resulting in an absence of dorsal branches. There is also an absence of ganglionic branches in the ventral nerve cord in tgo³ homozygous embryos. (Sonnenfeld et al., 2005)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference Dominant enhancer of the Df(3R)ss-D114.4/+ weak antenna to tarsus transformation phenotype. (Emmons et al., 1999)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	tgo⁵ (Emmons et al., 1999) tgo⁶ (Emmons et al., 1999) tgo⁷ (Emmons et al., 1999)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	tgo³
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Sonnenfeld et al., 2005, Dev. Genes Evol. 215(5): 221--229 Analysis of the transcriptional activation domain of the Drosophila tango bHLH-PAS transcription factor. [FBrf0188583] Emmons et al., 1999, Development 126(17): 3937--3945 The spineless-aristapedia and tango bHLH-PAS proteins interact to control antennal and tarsal development in Drosophila. [FBrf0109662] Sonnenfeld et al., 1997, Development 124(22): 4571--4582 The Drosophila tango gene encodes a bHLH-PAS protein that is orthologous to mammalian Arnt and controls CNS midline and tracheal development. [FBrf0099730]

Allele Dmel\tgo3

Allele Dmel\tgo³