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General Information
Symbol
Dmel\tgo1
Species
D. melanogaster
Name
FlyBase ID
FBal0082188
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

T9018093R

Amino acid change:

Y530term | tgo-PA; Y530term | tgo-PB

Reported amino acid change:

Y530term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Termination codon at amino acid 532 that deletes a Pro-rich region, the PRD repeat and a Gln-rich region.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

During stage 9 of oogenesis, 80-90% of border cell clusters with tgo1-mutant cells migrate faster than the corresponding anterior follicle cells, reaching the nurse cell and oocyte border prematurely. In contrast, the predominant phenotype observed during stage 10 is a delay in migration.

Intermediate allele. Homozygous clones have no effect in the proximal antennal segments (segments 1 and 2). However, they transform the distal part of antennal segment 3, the basal cylinder and the arista to a well-segmented tarsus that usually has a partially formed claw. The proximal part of antennal segment 3 is unaffected. Homozygous clones in the leg can show weak pattern deletions. Defects include shortening of tarsal segments and a partial fusion of tarsal segments 4 and 5. Clones in the proximal part of the leg have no effect. Homozygous clones in the maxillary palps result in weak deletions in the palp. Homozygous clones in the wing hinge region cause the wing to be held out away from the body. Homozygous clones have an intermediate effect on bristle size compared to tgo5 clones.

Reduction in the number of midline glia to 1 per segment. The number of VUM neurons and MNB progeny are reduced to 60% of wild type and do not migrate into the ventral regions of the VNC. Flies exhibit severe defects in tracheal tubule formation. Some embryos show a mild defect in axon morphology.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Statement
Reference

tgo1/tgo[+] is an enhancer of trachea phenotype of jing[+]/jing01094, trh1

tgo1/tgo[+] is an enhancer of commissure phenotype of jing01094

tgo1/tgo[+] is an enhancer of trachea phenotype of jing01094, trh1/trh[+]

Other
Additional Comments
Genetic Interactions
Statement
Reference

In almost 40% tgo1, jing01094 double homozygotes fused commissures are seen. 2/3 of tgo1, jing01094, sim2 triple heterozygotes exhibit a 'collapsed axon' phenotype, about 10% have fused commissures. The midline cells are also displaced dorsally and ventrally in these embryos. jing01094, tgo1 double heterozygous embryos display a loss of about 1/5 of their trachea. When trh1 is also added, 69% of embryos display a loss of about half of their trachea.

Dominant enhancer of the Df(3R)ss-D114.4/+ weak antenna to tarsus transformation phenotype.

sim2 tgo1 double mutants display a severe collapsed CNS. trh8 tgo1 double mutants completely lack tracheal staining.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)