Allele Dmel\stich1^S143702

General Information
Symbol	Dmel\stich1^S143702	Species	D. melanogaster
Name		FlyBase ID	FBal0082209
Feature type	allele	Associated gene	Dmel\stich1

Allele class
Mutagen	Delta2-3, P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	Delta2-3 (Deak et al., 1997) P-element activity (Deak et al., 1997, Salzberg et al., 1997, Szeged Stock Center, 1998-, Prokopenko et al., 2000, Dubruille et al., 2002)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AF175945 AF175946 AF175947 AF175948

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{lacW} insertion in the jumu gene associated with a deficiency which removes both Rfx and jumu coding regions. (Dubruille et al., 2002) Flanking sequence recovered from either side of the P{lacW} insertion in stich1^S143702 are located at least 28kb apart on the genomic sequence. This suggests that there may be 2 different P{lacW} elements that map 28kb apart in the "l(3)S143702" line, or the P{lacW}stich1^S143702 insertion may be associated with a 28kb deletion. One set of flanking sequence indicates that the P{lacW} element is inserted approximately 90bp upstream of the 5' end of the GM05287 cDNA. The other set of flanking sequence maps within the first intron of jumu, suggesting that both GM05287 and jumu may be affected in the "l(3)S143702" line. (Prokopenko et al., 2000)
Caused by insertion	P{lacW}stich1^S143702 (Szeged Stock Center, 1998-, Dubruille et al., 2002, Prokopenko et al., 2000, Deak et al., 1997)
Caused by aberration	Df(3R)S143702 (Dubruille et al., 2002)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Szeged Stock Center, 1998-, Deak et al., 1997, Salzberg et al., 1997)
Phenotype Manifest In
	neuron \| embryonic stage (Salzberg et al., 1997)
Detailed Description
	Statement Reference Early lethal. (Deak et al., 1997) Embryos exhibit loss of neurons in v and v' clusters and a change in morphology of the remaining neurons. (Salzberg et al., 1997)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	stich1^EP359 (Prokopenko et al., 2000)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	P{lacW} element can be reverted. Complements: jumu^06142a. Complements: l(3)j8B6^j8B6. (Prokopenko et al., 2000) In reversion analysis, P{lacW}stich1^S143702 does not excise to restore viability to the chromosome. (Salzberg et al., 1997)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	1437/2 (Salzberg et al., 1997) 1437/02 (Deak et al., 1997) l(3)S143702 (Prokopenko et al., 2000) stich1^S143702
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Dubruille et al., 2002, Development 129(23): 5487--5498 Drosophila Regulatory factor X is necessary for ciliated sensory neuron differentiation. [FBrf0151940] Prokopenko et al., 2000, Genetics 156(4): 1691--1715 Mutations affecting the development of the peripheral nervous system in Drosophila: A molecular screen for novel proteins. [FBrf0131381] Deak et al., 1997, Genetics 147(4): 1697--1722 P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: correlation of physical and cytogenetic maps in chromosomal region 86E-87F. [FBrf0099762] Salzberg et al., 1997, Genetics 147(4): 1723--1741 P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: Mutations affecting embryonic PNS development. [FBrf0099763]
Abstract	Salzberg et al., 1994, A. Dros. Res. Conf. 35: 13 Mutations affecting the development of the peripheral nervous system reveal novel aspects of neuronal development. [FBrf0067717]
Stock list	Szeged Stock Center, 1998-, Szeged Stock Center P-element collection. (Computer file) Szeged Stock Center P-element collection. (Computer file) [FBrf0111308]

Allele Dmel\stich1S143702

Allele Dmel\stich1^S143702