Open Close
General Information
Symbol
Dmel\pntunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0082324
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference
    Mosaic dorsal tracheal branches lack a terminal cell in 26% of cases. In 80% of the cases where the terminal cell is missing, a homozygous mutant cell is located in the stalk position nearest the tip.
    When homozygous pnt cardioblast clones are made in the embryo, a small proportion of clones exhibit more cardioblasts than expected, suggesting a slight increase in the proliferative capability of cardioblast precursors.
    Mutant embryos show a clear fusion of commissures and frequent disruption of longitudinal connectives. Midline glial cells are either reduce in number or fail to properly migrate in between anterior and posterior commissures. General embryonic morphology is relatively normal, though the PNS shows a slight reduction in sensory neurons and defects in the trajectories of motoneurons.
    Fas2-positive nerve bundles are seen to cross the midline in mutant embryos, in contrast to wild-type.
    The axon bundles of the anterior commissures are not organised into three sub-regions in homozygous embryos, in contrast to wild-type. One or two discrete axon bundles can be seen within the commissure. The commissural axons leave the longitudinal tracts at apparently random, irregular positions along the dorso-ventral axis of the connective.
    pntunspecified mutant embryos have narrow denticle bands. The central nervous system is broad and less dense than wild-type. The head skeleton has fused ventral arms.
    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhancer of
    Statement
    Reference
    pntunspecified/pnt[+] is an enhancer of lethal phenotype of Raf12
    pntunspecified/pnt[+] is an enhancer of visible phenotype of ksr::torΔNksr.hs.sev
    Suppressor of
    Statement
    Reference
    pntunspecified/pnt[+] is a suppressor of visible phenotype of Ras85DV12.sev
    Phenotype Manifest In
    Enhanced by
    Statement
    Reference
    Enhancer of
    Statement
    Reference
    Suppressor of
    Statement
    Reference
    pntunspecified/pnt[+] is a suppressor of eye phenotype of Ras85DV12.sev
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    foiunspecified pntunspecified or surunspecified pntunspecified double mutant embryos show a slightly enhanced fused commissure phenotype compared to the phenotypes of the single mutants. The number of midline glial cells is reduced in the double mutant embryos. Commissures fail to develop in most neuromeres of Hemunspecified pntunspecified double mutant embryos.
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    pntunspecified
    Name Synonyms
    Secondary FlyBase IDs
      References (8)