FB2025_01 , released February 20, 2025
Allele: Dmel\pnrD4.UAS
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General Information
Symbol
Dmel\pnrD4.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0082344
Feature type
allele
Associated gene
Dmel\pnr
Associated Insertion(s)
Carried in Construct
P{UAS-pnr.D4}
Also Known As
UAS-pnrD4
Key Links
Transgenic product class
missense_variant
(Haenlin et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Haenlin et al., 1997)
Mutagen
in vitro construct
(Haenlin et al., 1997)
Progenitor genotype
Carried in construct
P{UAS-pnr.D4}
Cytology
Description

pnrD4 is expressed under the control of UASt regulatory sequences.

(Haenlin et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
pnr
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of pnrD4.UAS under the control of Scer\GAL4He.PZ or Scer\GAL4lz-gal4 leads to an increase in larval crystal cell numbers when compared to controls.

      (Chatterjee et al., 2019)

      Expression of pnrD4.Scer\UAS under the control of Scer\GAL4ey.PH results in a small or no eye phenotype.

      (Singh et al., 2005)

      Expression of pnrD4.Scer\UAS under the control of Scer\GAL4ey.PH results in a dramatic reduction in the size of the eye disc and a complete loss of the eye.

      (Maurel-Zaffran and Treisman, 2000)

      Overexpression of pnrD4.Scer\UAS using Scer\GAL4pnr-MD237 leads to an excess of dorsocentral bristles and reduced viability.

      (Haenlin et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Scer\GAL4ey.PH, pnrD4.UAS has visible phenotype, enhanceable by L2/L[+]

      (Singh et al., 2005)

      Scer\GAL4bi-omb-Gal4, pnrD4.UAS has visible phenotype, enhanceable by L2/L[+]

      (Singh et al., 2005)
      Other
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Scer\GAL4ey.PH, pnrD4.UAS has eye phenotype, enhanceable by L2/L[+]

      (Singh et al., 2005)

      Scer\GAL4bi-omb-Gal4, pnrD4.UAS has eye phenotype, enhanceable by L2/L[+]

      (Singh et al., 2005)
      Suppressed by
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Only 41% of L2/+ animals expressing pnrD4.Scer\UAS under the control of Scer\GAL4ey.PH eclose, and these animals have greatly reduced heads with no eyes, but normal antennae.

      (Singh et al., 2005)

      Flies expressing both pnrD4.Scer\UAS and Dl::NΔECN.Scer\UAS under the control of Scer\GAL4ey.PH show restored photoreceptor differentiation in the eye disc.

      (Maurel-Zaffran and Treisman, 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pnrD4.Scer\UAS
      pnrD4.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (9)