Allele Dmel\numb^SW

General Information
Symbol	Dmel\numb^SW	Species	D. melanogaster
Name		FlyBase ID	FBal0082383
Feature type	allele	Associated gene	Dmel\numb

Allele class	hypomorphic allele - genetic evidence
Mutagen	Delta2-3
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Wang et al., 1997)
Mutagen	Delta2-3 (Wang et al., 1997)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	numb¹ (Wang et al., 1997)
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	viable (Wang et al., 1997) visible (Wang et al., 1997)
Phenotype Manifest In
	sensory neuron (Wang et al., 1997) socket (Wang et al., 1997) trichogen cell (Wang et al., 1997)
Detailed Description
	Statement Reference 100% of heterozygous flies show rhythmic locomotor activity, with a period of 24.4 +/- 0.0 hours. 88% of homozygous flies show rhythmic locomotor activity, with a period of 24.9 +/- 0.2 hours. 92% of numb^nuts/numb^SW flies show rhythmic locomotor activity, with a period of 24.7 +/- 0.1 hours. 93% of numb¹/numb^SW flies show rhythmic locomotor activity, with a period of 24.6 +/- 0.1 hours. 94% of numb²/numb^SW flies show rhythmic locomotor activity, with a period of 24.3 +/- 0.1 hours. 79% of numb³/numb^SW flies show rhythmic locomotor activity, with a period of 24.6 +/- 0.1 hours. (Stempfl et al., 2002) Both macrochaetae and microchaetae exhibit abnormal external sensory structures. Homozygotes exhibit a weak double-socket phenotype, bristles are produced at the expense of a hair. The severity of the phenotype varies with the genotype. Adult sensory organs also show transformation of the neuron into a sheath. (Wang et al., 1997)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference numb^SW has visible phenotype, enhanceable by H^B21 (Wang et al., 1997) numb^SW has visible phenotype, enhanceable by H^B55 (Wang et al., 1997) numb^SW has visible phenotype, enhanceable by H^D9 (Wang et al., 1997) numb^SW has visible phenotype, enhanceable by H^DEB1 (Wang et al., 1997)
Suppressed by
Statement Reference numb^SW has visible phenotype, suppressible by Su(H)⁸ (Wang et al., 1997)
Phenotype Manifest In
Enhanced by
Statement Reference numb^SW has trichogen cell phenotype, enhanceable by H^B21 (Wang et al., 1997) numb^SW has trichogen cell phenotype, enhanceable by H^B55 (Wang et al., 1997) numb^SW has trichogen cell phenotype, enhanceable by H^D9 (Wang et al., 1997) numb^SW has trichogen cell phenotype, enhanceable by H^DEB1 (Wang et al., 1997)
Suppressed by
Statement Reference numb^SW has trichogen cell phenotype, suppressible by Su(H)⁸ (Wang et al., 1997)
Additional Comments
Genetic Interactions
Statement Reference Su(H)⁸ mutation dominantly suppresses the double socket phenotype, but not the double sheath phenotype, of numb^SW/numb² mutants. Su(H)⁸ does not suppress the phenotype of numb^SW homozygotes. Removing one copy of H greatly enhances the double socket phenotype of homozygotes. (Wang et al., 1997)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	numb^SW
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Stempfl et al., 2002, Genetics 160(2): 571--593 Identification of circadian-clock-regulated enhancers and genes of Drosophila melanogaster by transposon mobilization and luciferase reporting of cyclical gene expression. [FBrf0144900] Nagel et al., 2000, Mech. Dev. 94(1-2): 3--12 Su(H)-independent activity of Hairless during mechano-sensory organ formation in Drosophila. [FBrf0128585] Wang et al., 1997, Development 124(22): 4435--4446 Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless. [FBrf0099728]
Review	Stanewsky, 2003, J. Neurobiol. 54(1): 111--147 Genetic analysis of the circadian system in Drosophila melanogaster and mammals. [FBrf0155881]

Allele Dmel\numbSW

Allele Dmel\numb^SW