Allele Dmel\bon^S048706

General Information
Symbol	Dmel\bon^S048706	Species	D. melanogaster
Name		FlyBase ID	FBal0083058
Feature type	allele	Associated gene	Dmel\bon
Also Known As	bon⁴⁸⁷

Allele class
Mutagen	Delta2-3, P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	Delta2-3 (Deak et al., 1997) P-element activity (Salzberg et al., 1997, Szeged Stock Center, 1998-)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{lacW} insertion in the middle of intron 1. (Beckstead et al., 2001)
Caused by insertion	P{lacW}bon^S048706 (Salzberg et al., 1997, Szeged Stock Center, 1998-, Deak et al., 1997, Beckstead et al., 2001)
Cytology
Phenotypic Data
Phenotypic Class
	body color defective (with bon^S024108) (Beckstead et al., 2001) lethal \| pharate adult stage \| recessive (Salzberg et al., 1997, Deak et al., 1997) lethal \| recessive (Szeged Stock Center, 1998-, Beckstead et al., 2001) suppressor of variegation, with Dp(1;f)γ878 (Beckstead et al., 2005) suppressor of variegation \| dominant, with P{SUPor-P}25-4-3 (Beckstead et al., 2005)
Phenotype Manifest In
	abdominal sternite bristle (with bon^S024108) (Beckstead et al., 2001) abdominal tergite & macrochaeta (with bon^S024108) (Beckstead et al., 2001) embryonic/larval salivary gland (with bon^21B) (Beckstead et al., 2001) eye \| P-stage (with bon^21B) (Beckstead et al., 2001) head \| P-stage (with bon^21B) (Beckstead et al., 2001) neuron \| embryonic stage (Salzberg et al., 1997) pupal abdomen & cuticle (with bon^S024108) (Beckstead et al., 2001) wing (with bon^S024108) (Beckstead et al., 2001) wing \| P-stage (with bon^21B) (Beckstead et al., 2001) wing margin bristle (with bon^S024108) (Beckstead et al., 2001)
Detailed Description
	Statement Reference bon^S048706/+ suppresses the variegation of the y gene in the P{SUPor-P}25-4-3 insertion. (Beckstead et al., 2005) Most bon^S048706/bon^21B pupae have an almost complete lack of pigmentation. They initiate but fail to complete development of the legs, wings, head, eyes and cuticle. Salivary glands are still present 4 days post-pupariation (they normally undergo apoptosis at 12 hours post-pupariation) and are similar in size to third instar salivary glands. bon^S024108/bon^S048706 pharate adults show defects in cuticle and bristle development; the abdominal cuticle is immature and the tergite and sternal bristles are severely reduced or absent. The anterior wing margin bristles are almost completely missing. There is a dramatic reduction in pigmentation of the wing cuticle. (Beckstead et al., 2001) Embryos exhibit two extra neurons located anteriorly to each dorsal cluster and one or two very large and round cells darkly stained with the MAb 22C10 are found posterior to the v' cluster. (Salzberg et al., 1997)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference bon^S048706/bon[+] is an enhancer of visible phenotype of Ret^GMR.PR (Read et al., 2005) bon^S048706/bon[+] is an enhancer of visible phenotype of Ret^MEN2A.GMR (Read et al., 2005) bon^S048706/bon[+] is an enhancer of visible phenotype of Ret^MEN2B.GMR (Read et al., 2005)
Suppressor of
Statement Reference bon^S048706/bon[+] is a suppressor \| partially of lethal \| recessive \| partially phenotype of ftz-f1^ex17 (Beckstead et al., 2001) bon^S048706/bon[+] is a suppressor \| partially of lethal phenotype of ftz-f1^ex17/Df(3L)Cat (Beckstead et al., 2001) bon^S048706/bon[+] is a suppressor of visible \| dominant phenotype of Egfr^E1 (Read et al., 2005)
Phenotype Manifest In
Enhancer of
Statement Reference bon^S048706/bon[+] is an enhancer of eye phenotype of Ret^GMR.PR (Read et al., 2005) bon^S048706/bon[+] is an enhancer of eye phenotype of Ret^MEN2A.GMR (Read et al., 2005) bon^S048706/bon[+] is an enhancer of eye phenotype of Ret^MEN2B.GMR (Read et al., 2005)
Suppressor of
Statement Reference bon^S048706/bon[+] is a suppressor of eye phenotype of Egfr^E1 (Read et al., 2005)
Additional Comments
Genetic Interactions
Statement Reference 87% of ftz-f1^ex17/Df(3L)Cat animals are rescued to the pharate adult stage by one copy of bon^S048706. The number of homozygous ftz-f1^ex17 adult escapers is increased by one copy of bon^S048706 (72%). (Beckstead et al., 2001)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	bon^21B (Beckstead et al., 2001)
Partially rescued by	bon^S024108/bon^S048706 is partially rescued by bon^{Hsp83.T:Zzzz\FLAG} (Beckstead et al., 2001)
Comments
Stocks ( 1 )
Bloomington	4543 y¹ w^67c23; P{lacW}bon^S048706/TM3, Sb¹ Ser¹
Notes on Origin
Discoverer

Comments
	Allelic series: Df(3R)H-B79 > bon^21B > bon^S048706 > bon^S024108 = bon^S024912. (Beckstead et al., 2001) Δ2-3 induced reversion demonstrates the insertion is responsible for the lethal phenotype. (Salzberg et al., 1997)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	487/6 (Salzberg et al., 1997) 0487/06 (Deak et al., 1997) bon⁴⁸⁷ (Beckstead et al., 2005, Beckstead et al., 2001) bon^S048706 l(3)S048706 (Bloomington Drosophila Stock Center, 1998.6.3)
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	Beckstead et al., 2005, Genetics 169(2): 783--794 Bonus, a Drosophila TIF1 homolog, is a chromatin-associated protein that acts as a modifier of position-effect variegation. [FBrf0188491] Read et al., 2005, Genetics 171(3): 1057--1081 A Drosophila model of multiple endocrine neoplasia type 2. [FBrf0190765] Beckstead et al., 2001, Mol. Cell 7(4): 753--765 Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit FTZ-F1-dependent transcription. [FBrf0135890] Deak et al., 1997, Genetics 147(4): 1697--1722 P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: correlation of physical and cytogenetic maps in chromosomal region 86E-87F. [FBrf0099762] Salzberg et al., 1997, Genetics 147(4): 1723--1741 P-element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: Mutations affecting embryonic PNS development. [FBrf0099763]
Personal communication to FlyBase	Bloomington Drosophila Stock Center, 1998.6.3, bonpotpmeltaaytrn. bonpotpmeltaaytrn. [FBrf0102826]
Stock list	Szeged Stock Center, 1998-, Szeged Stock Center P-element collection. (Computer file) Szeged Stock Center P-element collection. (Computer file) [FBrf0111308]

Allele Dmel\bonS048706

Allele Dmel\bon^S048706