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General Information
Symbol
Dmel\bonS024108
Species
D. melanogaster
Name
FlyBase ID
FBal0083060
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
bon241
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{lacW} insertion in the 5' end of exon 1.

P{lacW} insertion in the 5' UTR, 686bp upstream of the bon AUG codon.

Insertion components
P{lacW}bonS024108
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous males die as first instar larvae, while homozygous females survive at least to the second larval instar stage. bonS024108/+ suppresses the variegation of the y gene in the P{SUPor-P}25-4-3 insertion.

34% of homozygotes survive to the pharate adult stage. bonS024108/bonS048706 pharate adults show defects in cuticle and bristle development; the abdominal cuticle is immature and the tergite and sternal bristles are severely reduced or absent. The anterior wing margin bristles are almost completely missing. There is a dramatic reduction in pigmentation of the wing cuticle.

Embryos exhibit two extra neurons located anteriorly to each dorsal cluster and one or two very large and round cells darkly stained with the MAb 22C10 are found posterior to the v' cluster.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement
Reference
Suppressor of
Statement
Reference

bonS024108/bon[+] is a suppressor | partially of lethal phenotype of ftz-f1ex17/Df(3L)Cat

Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The lethality of bonS024108 homozygous males is not rescued if they are also carrying Sxlf1; no Sxlf1/Y ; bonS024108/bonS024108 male animals survive beyond the first larval instar.

70% of ftz-f1ex17/Df(3L)Cat animals are rescued to the pharate adult stage by one copy bonS024108. The number of homozygous ftz-f1ex17 adult escapers is increased by one copy of bonS024108 (60%).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Partially rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Δ2-3 induced reversion demonstrates the insertion is responsible for the lethal phenotype.

External Crossreferences and Linkouts ( 3 )
Crossreferences
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)