Allele Dmel\Moe^{hs.T:Avic\GFP}

General Information
Symbol	Dmel\Moe^{hs.T:Avic\GFP}	Species	D. melanogaster
Name		FlyBase ID	FBal0083341
Feature type	allele	Associated gene	Dmel\Moe

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Edwards et al., 1997) in vitro construct - regulatory fusion (Edwards et al., 1997)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: The C-terminal portion of Moe (lacking the N-terminal moesin head domain) tagged at the amino terminal end with T:Avic\GFP is expressed under the control of an Hsp70 promoter. (Edwards et al., 1997)
Carried in construct	P{hs-GFP-Moe} (Fei et al., 2002, Schneider et al., 2006, Guild et al., 2002, Royou et al., 2004, Chang and Ready, 2000, Roegiers et al., 2001, Hummel et al., 2000, Edwards et al., 1997, Brand, 1999, Fox et al., 2005, Fox and Peifer, 2007, Riggs et al., 2007, Vilmos et al., 2009, Martin et al., 2009)
Tagged with	T:Avic\GFP (Brand, 1999, Kiehart et al., 1999, Hummel et al., 2000, Roegiers et al., 2001, Chang and Ready, 2000, Guild et al., 2002, Royou et al., 2004, Huisken et al., 2004, Edwards et al., 1997)
Cytology
Phenotypic Data
Phenotypic Class
	fertile (Edwards et al., 1997)
Phenotype Manifest In

Detailed Description
	Statement Reference Flies carrying Moe^{hs.T:Avic\GFP} remain fertile even when maintained on a daily heat shock regimen for multiple generations. After approximately 20 minutes at 37^oC, flies carrying Moe^{hs.T:Avic\GFP} become paralysed, in contrast to their non-transgenic siblings, although they recover quickly. (Edwards et al., 1997)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Moe^{hs.T:Avic\GFP} Moe^hs.T:GFP
Name Synonym
Secondary FlyBase IDs

References ( 18 )
Research paper	Martin et al., 2009, Nature 457(7228): 495--499 Pulsed contractions of an actin-myosin network drive apical constriction. [FBrf0206985] Vilmos et al., 2009, Europ. J. Cell Biol. 88(10): 609--619 Live imaging reveals that the Drosophila actin-binding ERM protein, moesin, co-localizes with the mitotic spindle. [FBrf0208602] Fox and Peifer, 2007, Development 134(3): 567--578 Abelson kinase (Abl) and RhoGEF2 regulate actin organization during cell constriction in Drosophila. [FBrf0195363] Riggs et al., 2007, Mol. Biol. Cell 18(9): 3313--3322 The concentration of Nuf, a Rab11 effector, at the microtubule-organizing center is cell cycle-regulated, dynein-dependent, and coincides with furrow formation. [FBrf0200966] Wada et al., 2007, Dev. Biol. 301(2): 340--349 Specialized extraembryonic cells connect embryonic and extraembryonic epidermis in response to Dpp during dorsal closure in Drosophila. [FBrf0193483] Schneider et al., 2006, J. Cell Biol. 174(3): 349--358 Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development. [FBrf0194369] Fox et al., 2005, Development 132(21): 4819--4831 Rho1 regulates Drosophila adherens junctions independently of p120ctn. [FBrf0190288] Huisken et al., 2004, Science 305(5686): 1007--1009 Optical sectioning deep inside live embryos by selective plane illumination microscopy. [FBrf0180675] Royou et al., 2004, Mol. Biol. Cell 15(2): 838--850 Reassessing the Role and Dynamics of Nonmuscle Myosin II during Furrow Formation in Early Drosophila Embryos. [FBrf0167867] Chihara et al., 2003, Development 130(7): 1419--1428 Rac promotes epithelial cell rearrangement during tracheal tubulogenesis in Drosophila. [FBrf0155702] Fei et al., 2002, J. Cell Sci. 115(19): 3797--3806 The growth of Drosophila bristles and laterals is not restricted to the tip or base. [FBrf0152120] Guild et al., 2002, J. Cell Sci. 115(3): 641--653 Actin filament turnover removes bundles from Drosophila bristle cells. [FBrf0144954] Roegiers et al., 2001, Nat. Cell Biol. 3(1): 58--67 Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage. [FBrf0132424] Chang and Ready, 2000, Science 290(5498): 1978--1980 Rescue of photoreceptor degeneration in rhodopsin-null Drosophila mutants by activated Rac1. [FBrf0132447] Hummel et al., 2000, Genes Dev. 14(7): 863--873 The Drosophila HEM-2/NAP1 homolog KETTE controls axonal pathfinding and cytoskeletal organization. [FBrf0127130] Brand, 1999, Methods Cell Biol. 58: 165--181 GFP as a cell and developmental marker in the Drosophila nervous system. [FBrf0105780] Edwards et al., 1997, Dev. Biol. 191(1): 103--117 GFP-Moesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila. [FBrf0099197]
Abstract	Kiehart et al., 1999, A. Dros. Res. Conf. 40: 30 Forces for dorsal closure are both parallel and perpendicular to the morphogenic movements of the lateral epidermis. [FBrf0106757]

Allele Dmel\Moehs.T:Avic\GFP

Allele Dmel\Moe^{hs.T:Avic\GFP}