Allele Dmel\Cam⁵

General Information
Symbol	Dmel\Cam⁵	Species	D. melanogaster
Name		FlyBase ID	FBal0083598
Feature type	allele	Associated gene	Dmel\Cam

Map ( GBrowse )
Allele class	hypomorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Harrisingh et al., 2007)
Mutagen	ethyl methanesulfonate (Nelson et al., 1997)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2R:8,152,375..8,152,375 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental pr_change=P44L\|Cam-PB,P44L\|Cam-PA reported_pr_change=P43L na_change=C8152375T (Nelson et al., 1997)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: P43L. Alters a residue present in the linker region between sites 1 and 2. (Nelson et al., 1997)
Cytology
Phenotypic Data
Phenotypic Class
	auditory perception defective \| adult stage (Senthilan et al., 2012) auditory perception defective \| adult stage (with Camⁿ³³⁹) (Senthilan et al., 2012) behavior defective (Nelson et al., 1997) lethal \| recessive (Nelson et al., 1997)
Phenotype Manifest In
	mesothoracic tergum (Nelson et al., 1997) wing vein \| ectopic (Nelson et al., 1997)
Detailed Description
	Statement Reference Sound-evoked compound action potentials in the antennal nerve are not significantly different from wild type in Cam[5]/Cam[n339] flies. However, nonlinear mechanical amplification is significantly increased compared to wild type. (Senthilan et al., 2012) Cam⁵ heterozygotes exhibit little effect on the average period of free-running. (Harrisingh et al., 2007) Some hemizygotes reared separately from wild-type siblings survive to the adult stage. These mutants are ill coordinated and weak and do not live long as adults. Mutants perform very poorly in vortex, flight and climb tests. Transheterozygous combinations with other Cam mutations produces an incompletely penetrant ectopic wing vein phenotype and either lateral or bilateral cuticular 'scabs' on the notum. (Nelson et al., 1997)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference Cam[+]/Cam⁵ is an enhancer of circadian rhythm defective phenotype of Mmmm\PV^{Scer\UAS.T:Hsap\MYC}, Scer\GAL4^P2.4.Pdf (Harrisingh et al., 2007)
Other
Statement Reference Cam⁵, l(2)C43^C43 has lethal phenotype (Nelson et al., 1997, Nelson et al., 1997)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference In combination with l(2)C43^C43 mutants exhibit completely penetrant lethality. (Nelson et al., 1997)
Xenogenetic Interactions
Statement Reference A heterozygous Cam⁵ background in flies expressing Mmmm\PV^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^P2.4.Pdf can result in lengthening of the free-running period, compared to controls, after 5 weeks in constant darkness. (Harrisingh et al., 2007)
Complementation & Rescue Data
Partially complements	Cam^3c1 (Nelson et al., 1997) Cam^4c1 (Nelson et al., 1997) Cam^6c4 (Nelson et al., 1997) Cam⁷ (Nelson et al., 1997) Cam^8t (Nelson et al., 1997)
Fails to complement	Cam^8t (Nelson et al., 1997) Camⁿ³³⁹ (Nelson et al., 1997)
Comments
Stocks ( 1 )
Bloomington	6814 Cam⁵ L²/CyO, amos^Roi-1 bw¹
Notes on Origin
Discoverer

Comments
	Allelic series of the relative strength of the lethal mutations: Cam^8t > Cam⁷ > Cam^6c4 > Cam⁵ > Cam^4c1 > Cam^3c1. (Nelson et al., 1997)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Cam⁵ (Harrisingh et al., 2007, Senthilan et al., 2012)
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Senthilan et al., 2012, Cell 150(5): 1042--1054 Drosophila auditory organ genes and genetic hearing defects. [FBrf0219321] Harrisingh et al., 2007, J. Neurosci. 27(46): 12489--12499 Intracellular Ca[2+] Regulates Free-Running Circadian Clock Oscillation In Vivo. [FBrf0204998] Nelson et al., 1997, Genetics 147(4): 1783--1798 Calmodulin point mutations affect Drosophila development and behavior. [FBrf0099767]

Allele Dmel\Cam5

Allele Dmel\Cam⁵