FlyBase Allele Report: Dmel\Cam[5]

General Information

Symbol

Dmel\Cam⁵

Species

D. melanogaster

Name

FlyBase ID

FBal0083598

Feature type

allele

Associated gene

Dmel\Cam

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Harrisingh et al., 2007)

Mutagen

ethyl methanesulfonate

(Nelson et al., 1997)

Progenitor genotype

Cytology

Description

Amino acid replacement: P43L. Alters a residue present in the linker region between sites 1 and 2.

(Nelson et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:12,264,870..12,264,870 [+]

Nucleotide change:

C12264870T

Amino acid change:

Reported amino acid change:

P43L

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Nelson et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal auditory perception | adult stage

(Senthilan et al., 2012)

abnormal auditory perception | adult stage (with Camⁿ³³⁹)

(Senthilan et al., 2012)

abnormal behavior

(Nelson et al., 1997)

lethal | recessive

(Nelson et al., 1997)

Phenotype Manifest In

mesonotum

(Nelson et al., 1997)

wing vein | ectopic

(Nelson et al., 1997)

Detailed Description

Statement

Reference

Sound-evoked compound action potentials in the antennal nerve are not significantly different from wild type in Cam⁵/Camⁿ³³⁹ flies. However, nonlinear mechanical amplification is significantly increased compared to wild type.

(Senthilan et al., 2012)

Cam⁵ heterozygotes exhibit little effect on the average period of free-running.

(Harrisingh et al., 2007)

Some hemizygotes reared separately from wild-type siblings survive to the adult stage. These mutants are ill coordinated and weak and do not live long as adults. Mutants perform very poorly in vortex, flight and climb tests. Transheterozygous combinations with other Cam mutations produces an incompletely penetrant ectopic wing vein phenotype and either lateral or bilateral cuticular 'scabs' on the notum.

(Nelson et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Cam[+]/Cam⁵ is an enhancer of abnormal circadian rhythm phenotype of Mmmm\PV^UAS.Tag:MYC, Scer\GAL4^P2.4.Pdf

(Harrisingh et al., 2007)

Other

Statement

Reference

Cam⁵, l(2)C43^C43 has lethal phenotype

(Nelson et al., 1997)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

In combination with l(2)C43^C43 mutants exhibit completely penetrant lethality.

(Nelson et al., 1997)

Xenogenetic Interactions

Statement

Reference

A heterozygous Cam⁵ background in flies expressing Mmmm\PV^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^P2.4.Pdf can result in lengthening of the free-running period, compared to controls, after 5 weeks in constant darkness.

(Harrisingh et al., 2007)

Complementation and Rescue Data

Partially complements

Cam^3c1

(Nelson et al., 1997)

Cam^4c1

(Nelson et al., 1997)

Cam^6c4

(Nelson et al., 1997)

Cam⁷

(Nelson et al., 1997)

Cam^8t