FB2025_01 , released February 20, 2025
Allele: Dmel\Cam352
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General Information
Symbol
Dmel\Cam352
Species
D. melanogaster
Name
FlyBase ID
FBal0083601
Feature type
allele
Associated gene
Dmel\Cam
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - genetic evidence

    (Scott et al., 1997)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Excision of a P-element, removing approximately 4.5kb DNA in the Cam promoter region.

    (Scott et al., 1997)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The slow Ca[2[+]]-activated K[+] current found in photoreceptors is absent in Cam352 mutants.

        (Abou Tayoun et al., 2011)

        Light response in ommatidia dissociated from Camn339/Cam352 transheterozygotes display calcium-independent deactivation defects. Single photon absorption produces long trains of quantum bumps. These defects are not rescued when the flies are reared on a vitamin-A deficient diet.

        (Liu et al., 2008)

        Mutant larvae are sluggish and show 100% pupal lethality. The amount of backward movement seen in Cam352/Camn339 larvae is increased by high light intensity.

        (Wang et al., 2003)

        Camn339/Cam352 animals do not eclose from the pupal case. Camn339/Cam352 photoreceptors have dramatic defects in deactivation kinetics, displaying greatly prolonged deactivation times. Similar deactivation kinetics are seen at different concentrations of extracellular calcium ions, in contrast to wild-type. A single photon produces a train of quantum bumps in Cam352/Camn339 double mutant photoreceptors, in contrast to wild-type.

        (Scott et al., 1997)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        trp9; Cam352/Camn339 double mutant photoreceptors do not have transient light responses.

        (Scott et al., 1997)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Cam352/Camn339 is rescued by Camhs.PDH

        (Scott et al., 1997)
        Comments

        The Camn339/Cam352 photoreceptor deactivation time phenotype can be partially rescued by Camhs.PDH, the degree of rescue depending on the number of heat shocks given.

        (Scott et al., 1997)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Cam352
        cam352
        (Liu et al., 2008, Satoh et al., 2008, Alloway and Dolph, 1999)
        Name Synonyms
        Secondary FlyBase IDs
          References (6)