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General Information
Symbol
Dmel\RhoGEF24.4
Species
D. melanogaster
Name
FlyBase ID
FBal0085929
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C17031888T

Amino acid change:

R264term | RhoGEF2-PD; R264term | RhoGEF2-PE; R264term | RhoGEF2-PF; R264term | RhoGEF2-PG; R264term | RhoGEF2-PH

Reported amino acid change:

R264term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: R264term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Late embryos from RhoGEF24.4 heterozygous mothers display a wild-type cuticle pattern, as compared to controls.

RhoGEF24.4/RhoGEF24.1 animals show 98% embryonic viability, 97% first larval instar viability and 0% adult viability.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

RhoGEF24.4 is a suppressor of visible phenotype of Rho1GMR.PH

Phenotype Manifest In
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference

RhoGEF24.4 is a suppressor of eye phenotype of Rho1GMR.PH

Additional Comments
Genetic Interactions
Statement
Reference

RhoGEF24.4 heterozygosity strongly enhances the ventral cuticle defects displayed by late embryos from tslΔ homozygous mothers, leading to fully penetrant absence of ventral cuticle.

Dominantly suppresses the Rho1GMR.PH rough eye phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

Isolated as a dominant suppressor of the Rho1GMR.PH rough eye phenotype.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (4)