RhoGEF2PX6/cta5 RhoGEF24.1 animals show 8% adult viability. The frequency of wing defects in these animals is 92% (compared to 70% in RhoGEF2PX6/RhoGEF24.1 adults). RhoGEF2PX10/cta5 RhoGEF24.1 animals show 28% adult viability. The frequency of wing defects in these animals is 35% (compared to 4% in RhoGEF2PX10/RhoGEF24.1 adults). 6% of fog4/+ ; RhoGEF24.1/+ animals have wing defects.
RhoGEF24.1 shows a moderate interaction (25-49% of double heterozygotes have at least one malformed leg) with the following mutations: Rho112-6. br1 fails to show a significant genetic interaction (assayed in terms of a malformed leg phenotype) with RhoGEF24.1. RhoGEF24.1 shows a moderate interaction (25-49% of double heterozygotes have at least one malformed wing) with the following mutations: Rho1E3.10. Sbsbd-201/Sbsbd-1 shows a weak interaction (5-24% of double mutants have at least one malformed leg) with the following mutations: RhoGEF24.1/+.
27% of RhoGEF24.1/zipEbr double heterozygotes have a malformed leg phenotype, which shows variable expressivity. In less severe cases, there is a dent in the femur or tibia. Flies with malformed legs often also show wing defects. Weak phenotypes include a broadening of the wing blade and folding back of the distal portion of the wing blade. In the most severe cases, wings are greatly reduced in size.
Dominantly suppresses the Rho1GMR.PH rough eye phenotype. The transient depression in the dorsal head region seen in embryos carrying foghkb.PB in a wild-type background is not seen in embryos carrying foghkb.PB which are derived from homozygous RhoGEF24.1 female germline clones.