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General Information
Symbol
Dmel\vigEP812
Species
D. melanogaster
Name
FlyBase ID
FBal0086272
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion within the vig coding region, which results in a severe reduction in the level of vig protein relative to wild type.

P{EP} insertion within the vig putative coding region.

P{EP} insertion at position 72346 of DS00929.

The P{EP}vigEP812 insertion maps within the vig coding region, which results in a severe reduction in the level of vig protein relative to wild type (see FBrf0208478). The insertion also maps within the intron between the first and second exons common to vas and solo (since vig lies within this intron). The insertion also appears to affect vas function, since it is female sterile in combination with vas3 (see FBrf0111326). It is not known whether or not solo function is affected by the insertion ( date:2015.04.14 ).

Insertion components
P{EP}vigEP812
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

vigEP812 dominantly suppresses PEV, as assayed using the y PEV reporter lines P{SUPor-P}B079 or P{SUPor-P}J448.

Expression of P{EP}vigEP812 under the control of Scer\GAL4fkh.PH produces a weakly penetrant 'lumpy lumen' phenotype in the embryonic salivary gland (it is not known whether this is due to an effect on vig or vas (or both)).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: a P{EP} insertion line that modifies the pnrMD237/+ phenotype when expressed using Scer\GAL4pnr-MD237.

The P{EP}vigEP812 insertion results in a reduction in expression of vig protein, but it may also affect vas (as the vig gene is within an intron of vas). The modification of position effect variegation (PEV) seen in P{EP}vigEP812/+ flies appears to be due to the reduced levels of vig protein and not due to an effect on vas, since a mutation that only affects vas does not modify PEV.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (10)