FB2025_02 , released April 17, 2025
Allele: Dmel\trxunspecified
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General Information
Symbol
Dmel\trxunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0086282
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Type I neuroblasts in homozygous clones in larval brains retain their functional identity (as assayed by expression of cell fate markers). However, mutant type II neuroblasts in the homozygous clones adopt a type I neuroblast identity and directly generate ganglion mother cells.

    Many germ cells are able to coalesce along with gonadal mesoderm to form a gonad; however, some germ cells are excluded from this gonad, presumably due to the reduction in number of somatic gonadal precursors (SGPs). These 'lost' germ cells remain in an area ventral and posterior to the gonad until after coalescence.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    NOT Enhanced by
    Statement
    Reference

    trxunspecified has phenotype, non-enhanceable by lolalk02512/lolal[+]

    trxunspecified has phenotype, non-enhanceable by Iswiunspecified/Iswi[+]

    trxunspecified has phenotype, non-enhanceable by AsxR11

    Suppressed by
    NOT suppressed by
    Statement
    Reference

    trxunspecified has phenotype, non-suppressible by lolalk02512/lolal[+]

    trxunspecified has phenotype, non-suppressible by Iswiunspecified/Iswi[+]

    NOT Enhancer of
    Statement
    Reference
    Suppressor of
    NOT Suppressor of
    Statement
    Reference

    trx[+]/trxunspecified is a non-suppressor of phenotype of lolalk02512

    Other
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    trxunspecified suppresses the supernumerary type II neuroblast phenotype seen in ermunspecified type II neuroblast clones in the larval brain, and the number of GMCs and neurons is significantly increased in the double mutant clone.

    trxunspecified suppresses the supernumerary type II neuroblast phenotype seen in bratunspecified type II neuroblast clones in the larval brain, and the number of GMCs and neurons is significantly increased in the double mutant clone.

    trxunspecified pros17 double mutant type II neuroblast clones form supernumerary type I neuroblasts.

    Expression of btdScer\UAS.T:Ivir\HA1 using a Scer\GAL4 driver in trxunspecified type II neuroblast clones in the larval brain restores the ability of the type II neuroblasts to generate intermediate neural progenitors.

    The wing defects caused by simultaneous expression of two copies of escdsRNA.Scer\UAS and escldsRNA.Scer\UAS under the control of Scer\GAL4Bx-MS1096 are completely suppressed by trxunspecified/+.

    trxunspecified does not enhance the eye tumour phenotype of flies expressing DlScer\UAS.cDa under the control of Scer\GAL4ey.PH and also carrying the P{GSV1}lolaGS88A8 insertion (which results in the lolaGS88A8 and psqGS88A8 alleles being expressed under the control of Scer\GAL4ey.PH).

    The addition of heterozygous, trxunspecified to lolalk02512/+ animals shows enhancement or suppression.

    The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by trxunspecified.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    Comments
    Comments

    17 mutants are isolated.

    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    trxunspecified
    Name Synonyms
    Secondary FlyBase IDs
      References (11)