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General Information
Symbol
Dmel\trxunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0086282
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Type I neuroblasts in homozygous clones in larval brains retain their functional identity (as assayed by expression of cell fate markers). However, mutant type II neuroblasts in the homozygous clones adopt a type I neuroblast identity and directly generate ganglion mother cells.

Many germ cells are able to coalesce along with gonadal mesoderm to form a gonad; however, some germ cells are excluded from this gonad, presumably due to the reduction in number of somatic gonadal precursors (SGPs). These 'lost' germ cells remain in an area ventral and posterior to the gonad until after coalescence.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Statement
Reference

trxunspecified has phenotype, non-enhanceable by lolalk02512/lolal[+]

trxunspecified has phenotype, non-enhanceable by Iswiunspecified/Iswi[+]

trxunspecified has phenotype, non-enhanceable by AsxR11

Suppressed by
NOT suppressed by
Statement
Reference

trxunspecified has phenotype, non-suppressible by lolalk02512/lolal[+]

trxunspecified has phenotype, non-suppressible by Iswiunspecified/Iswi[+]

NOT Enhancer of
Statement
Reference
Suppressor of
NOT Suppressor of
Statement
Reference

trx[+]/trxunspecified is a non-suppressor of phenotype of lolalk02512

Other
Additional Comments
Genetic Interactions
Statement
Reference

trxunspecified suppresses the supernumerary type II neuroblast phenotype seen in ermunspecified type II neuroblast clones in the larval brain, and the number of GMCs and neurons is significantly increased in the double mutant clone.

trxunspecified suppresses the supernumerary type II neuroblast phenotype seen in bratunspecified type II neuroblast clones in the larval brain, and the number of GMCs and neurons is significantly increased in the double mutant clone.

trxunspecified pros17 double mutant type II neuroblast clones form supernumerary type I neuroblasts.

Expression of btdScer\UAS.T:Ivir\HA1 using a Scer\GAL4 driver in trxunspecified type II neuroblast clones in the larval brain restores the ability of the type II neuroblasts to generate intermediate neural progenitors.

The wing defects caused by simultaneous expression of two copies of escdsRNA.Scer\UAS and escldsRNA.Scer\UAS under the control of Scer\GAL4Bx-MS1096 are completely suppressed by trxunspecified/+.

trxunspecified does not enhance the eye tumour phenotype of flies expressing DlScer\UAS.cDa under the control of Scer\GAL4ey.PH and also carrying the P{GSV1}lolaGS88A8 insertion (which results in the lolaGS88A8 and psqGS88A8 alleles being expressed under the control of Scer\GAL4ey.PH).

The addition of heterozygous, trxunspecified to lolalk02512/+ animals shows enhancement or suppression.

The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by trxunspecified.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

17 mutants are isolated.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
trxunspecified
Name Synonyms
Secondary FlyBase IDs
    References (10)