Allele Dmel\sty²⁵⁴

General Information
Symbol	Dmel\sty²⁵⁴	Species	D. melanogaster
Name		FlyBase ID	FBal0086312
Feature type	allele	Associated gene	Dmel\sty
Also Known As	spry²⁵⁴

Allele class	loss of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Kramer et al., 1999)
Mutagen	ethyl methanesulfonate (Hacohen et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Nucleotides 2237 to 2243 are replaced by TA, causing a frameshift that adds 134 new residues. (Kramer et al., 1995)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| pharate adult stage \| recessive (Kramer et al., 1999) lethal \| pupal stage \| recessive (Kramer et al., 1995) visible \| recessive (Kramer et al., 1999)
Phenotype Manifest In
	chordotonal organ (Kramer et al., 1999) cone cell (Kramer et al., 1999) embryonic/larval dorsal branch (Kramer et al., 1995) embryonic/larval ganglionic branch (Kramer et al., 1995) eye (Kramer et al., 1999) mystery cell (Kramer et al., 1999) ommatidium (Kramer et al., 1999)
Detailed Description
	Statement Reference Escapers of lethality show a disorganized eye phenotype. Majority of ommatidia have extra R7 cells, generated by transformation of cone cells. Some of the extra photoreceptors resemble outer (R1-R6) photoreceptor neurons. Mystery cells assume R3/R4 fates. In heterozygous condition, 1-7% of ommatidia show an extra R7 cell or an occasional gain or loss of an outer photoreceptor cell. In embryos, 37% of hemisegments show an extra chordotonal organ in the lateral cluster. In clones in the eye the ommatidial phenotype changes abruptly at the boundary, indicating that the mutant phenotype is cell autonomous. There is no absolute requirement for sty⁺ in any of the photoreceptor neurons, and sty⁺ can function non-autonomously to prevent cone cells from differentiating as R7 photoreceptor neurons. The requirement for sty⁺ function is mainly cell autonomous in the cells that differentiate as extra R7 cells. (Kramer et al., 1999) Pupal lethal when hemizygous. The number of tracheal branches emanating from the dorsal and ganglionic branches is higher than normal in homozygous embryos. (Kramer et al., 1995)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT Enhanced by
Statement Reference sty²⁵⁴ has phenotype, non-enhanceable by sev¹⁴ (Kramer et al., 1999)
Suppressed by
Statement Reference sty²⁵⁴ has photoreceptor cell R7 phenotype, suppressible by sina² (Kramer et al., 1999)
Other
Statement Reference aos²⁵⁷, sty²⁵⁴ has photoreceptor cell phenotype (Kramer et al., 1999, Kramer et al., 1999)
Additional Comments
Genetic Interactions
Statement Reference No R7 cells form in sty²⁵⁴, sina² double mutant ommatidia. Massive neuronal differentiation occurs in sty²⁵⁴, argos²⁵⁷ double mutants. (Kramer et al., 1999)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Selected as: Dominant suppressor of the rough eye phenotype caused by ectopic expression of svp in photoreceptors R2 and R5. (Kramer et al., 1995)
Comments
	Amorph or strong hypomorph. (Kramer et al., 1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	spry²⁵⁴ (Kramer et al., 1999, Hacohen et al., 1998) sty²⁵⁴
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Kramer et al., 1999, Development 126(11): 2515--2525 Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila. [FBrf0108521] Hacohen et al., 1998, Cell 92(2): 253--263 sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. [FBrf0100567] Kramer et al., 1995, Development 121(5): 1361--1372 Cell fate control in the Drosophila retina by the orphan receptor seven-up: its role in the decisions mediated by the ras signaling pathway. [FBrf0078827]

Allele Dmel\sty254

Allele Dmel\sty²⁵⁴