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General Information
Symbol
Dmel\sty226
Species
D. melanogaster
Name
FlyBase ID
FBal0086313
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
spry226
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: C2055T.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Escapers of lethality show a disorganized eye phenotype. Majority of ommatidia have extra R7 cells, generated by transformation of cone cells. Some of the extra photoreceptors resemble outer (R1-R6) photoreceptor neurons. Mystery cells assume R3/R4 fates. In heterozygous condition, 1-7% of ommatidia show an extra R7 cell or an occasional gain or loss of an outer photoreceptor cell.

Pupal lethal when hemizygous. The number of tracheal branches emanating from the dorsal and ganglionic branches is higher than normal in homozygous embryos.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

sty[+]/sty226 is an enhancer of visible phenotype of Scer\GAL4Tub.PU, cswN308D.UASp

Suppressor of
Phenotype Manifest In
Enhanced by
Statement
Reference

sty226 has photoreceptor cell R7 | ectopic phenotype, enhanceable by Gap1[+]/RasGAP1B2

sty226 has photoreceptor cell R7 | ectopic phenotype, enhanceable by aopyan-1/aop[+]

Enhancer of
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Presence of sty226/+ suppresses pupal lethality in Scer\GAL4how-24B>SmndsRNA.C.Scer\UAS.WIZ flies and partially suppresses pupal lethality in Scer\GAL4how-24B>SmndsRNA.N.Scer\UAS.WIZ flies.

The presence of a sty226 background significantly enhances ectopic wing vein formation found in cswY279C.Scer\UAS (Scer\GAL4tub) mutants.

A sty226 background enhances the cswY279C.Scer\UAS (Scer\GAL4tub) rough eye phenotype, with the number of R7 in each ommatidium increasing.

The addition of sty226/+ enhances the eye cell polarity phenotype seen in fz19/fz20 animals. Heterozygotes suppress the ommatidial polarity defects seen in Ras64BV14.Act5C.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Selected as: Dominant suppressor of the rough eye phenotype caused by ectopic expression of svp in photoreceptors R2 and R5.

Comments
Comments

Amorph or strong hypomorph.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (11)