FlyBase Allele Report: Dmel\sty[226]

General Information

Symbol

Dmel\sty²²⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0086313

Feature type

allele

Associated gene

Dmel\sty

Associated Insertion(s)

Carried in Construct

Also Known As

spry²²⁶

Key Links

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Kramer et al., 1999)

Mutagen

ethyl methanesulfonate

(Hacohen et al., 1998)

Progenitor genotype

Cytology

Description

Nucleotide substitution: C2055T.

(Kramer et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of P-stage | recessive

(Kramer et al., 1999)

lethal - all die before end of pupal stage | recessive

(Kramer et al., 1995)

some die during pharate adult stage | recessive

(Kramer et al., 1999)

some die during pupal stage | recessive

(Kramer et al., 1995)

visible | recessive

(Kramer et al., 1999)

Phenotype Manifest In

cone cell

(Kramer et al., 1999)

embryonic/larval dorsal tracheal branch

(Kramer et al., 1995)

embryonic/larval ganglionic tracheal branch

(Kramer et al., 1995)

eye

(Kramer et al., 1999)

mystery cell

(Kramer et al., 1999)

ommatidium

(Kramer et al., 1999)

Detailed Description

Statement

Reference

Escapers of lethality show a disorganized eye phenotype. Majority of ommatidia have extra R7 cells, generated by transformation of cone cells. Some of the extra photoreceptors resemble outer (R1-R6) photoreceptor neurons. Mystery cells assume R3/R4 fates. In heterozygous condition, 1-7% of ommatidia show an extra R7 cell or an occasional gain or loss of an outer photoreceptor cell.

(Kramer et al., 1999)

Pupal lethal when hemizygous. The number of tracheal branches emanating from the dorsal and ganglionic branches is higher than normal in homozygous embryos.

(Kramer et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

sty[+]/sty²²⁶ is an enhancer of visible phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

sty²²⁶ is an enhancer of abnormal cell polarity phenotype of fz²⁰/fz¹⁹

(Strutt and Strutt, 2003)

Suppressor of

Statement

Reference

sty[+]/sty²²⁶ is a suppressor of some die during P-stage phenotype of Scer\GAL4^how-24B, Smn^{RNAi.C.UAS.WIZ}

(Sen et al., 2011)

sty[+]/sty²²⁶ is a suppressor | partially of majority die during P-stage phenotype of Scer\GAL4^how-24B, Smn^{RNAi.N.UAS.WIZ}

(Sen et al., 2011)

sty²²⁶ is a suppressor of visible phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

sty²²⁶ is a suppressor of abnormal cell polarity phenotype of Ras64B^V14.Act5C

(Strutt and Strutt, 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

sty²²⁶ has photoreceptor cell R7 | ectopic phenotype, enhanceable by Gap1[+]/RasGAP1^B2

(Kramer et al., 1999)

sty²²⁶ has photoreceptor cell R7 | ectopic phenotype, enhanceable by aop^yan-1/aop[+]

(Kramer et al., 1999)

Enhancer of

Statement

Reference

sty²²⁶/Scer\GAL4^Tub.PU is an enhancer of wing vein phenotype of Scer\GAL4^Tub.PU, csw^Y279C.UASp

(Oishi et al., 2009)

sty²²⁶/Scer\GAL4^Tub.PU is an enhancer of eye phenotype of Scer\GAL4^Tub.PU, csw^Y279C.UASp

(Oishi et al., 2009)

sty²²⁶/Scer\GAL4^Tub.PU is an enhancer of ommatidium phenotype of Scer\GAL4^Tub.PU, csw^Y279C.UASp

(Oishi et al., 2009)

sty²²⁶/Scer\GAL4^Tub.PU is an enhancer of photoreceptor cell R7 | ectopic phenotype of Scer\GAL4^Tub.PU, csw^Y279C.UASp

(Oishi et al., 2009)

sty[+]/sty²²⁶ is an enhancer of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

sty²²⁶ is an enhancer of ommatidium phenotype of fz²⁰/fz¹⁹

(Strutt and Strutt, 2003)

Suppressor of

Statement

Reference

sty²²⁶ is a suppressor of eye phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

sty²²⁶ is a suppressor of ommatidium phenotype of Ras64B^V14.Act5C

(Strutt and Strutt, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Presence of sty²²⁶/+ suppresses pupal lethality in Scer\GAL4^how-24B>Smn^{dsRNA.C.Scer\UAS.WIZ} flies and partially suppresses pupal lethality in Scer\GAL4^how-24B>Smn^{dsRNA.N.Scer\UAS.WIZ} flies.

(Sen et al., 2011)

The presence of a sty²²⁶ background significantly enhances ectopic wing vein formation found in csw^{Y279C.Scer\UAS} (Scer\GAL4^tub) mutants.

A sty²²⁶ background enhances the csw^{Y279C.Scer\UAS} (Scer\GAL4^tub) rough eye phenotype, with the number of R7 in each ommatidium increasing.

(Oishi et al., 2009)

The addition of sty²²⁶/+ enhances the eye cell polarity phenotype seen in fz¹⁹/fz²⁰ animals. Heterozygotes suppress the ommatidial polarity defects seen in Ras64B^V14.Act5C.

(Strutt and Strutt, 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6383

w^*; sty²²⁶ hry¹ e^* ca¹/TM6B, Tb¹

Notes on Origin

Discoverer

Selected as: Dominant suppressor of the rough eye phenotype caused by ectopic expression of svp in photoreceptors R2 and R5.

(Kramer et al., 1995)

Comments

Amorph or strong hypomorph.

(Kramer et al., 1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Sty²²⁶

(Oishi et al., 2009)

spry²²⁶

(Kramer et al., 1999, Hacohen et al., 1998)

sty²²⁶

(Caviglia and Luschnig, 2013, Fregoso Lomas et al., 2013, Sen et al., 2011, Lachance et al., 2009, Oishi et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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