Allele Dmel\sty²²⁶

General Information
Symbol	Dmel\sty²²⁶	Species	D. melanogaster
Name		FlyBase ID	FBal0086313
Feature type	allele	Associated gene	Dmel\sty
Also Known As	spry²²⁶

Allele class	loss of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Kramer et al., 1999)
Mutagen	ethyl methanesulfonate (Hacohen et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Nucleotide substitution: C2055T. (Kramer et al., 1995)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| pharate adult stage \| recessive (Kramer et al., 1999) lethal \| pupal stage \| recessive (Kramer et al., 1995) visible \| recessive (Kramer et al., 1999)
Phenotype Manifest In
	cone cell (Kramer et al., 1999) embryonic/larval dorsal branch (Kramer et al., 1995) embryonic/larval ganglionic branch (Kramer et al., 1995) eye (Kramer et al., 1999) mystery cell (Kramer et al., 1999) ommatidium (Kramer et al., 1999)
Detailed Description
	Statement Reference Escapers of lethality show a disorganized eye phenotype. Majority of ommatidia have extra R7 cells, generated by transformation of cone cells. Some of the extra photoreceptors resemble outer (R1-R6) photoreceptor neurons. Mystery cells assume R3/R4 fates. In heterozygous condition, 1-7% of ommatidia show an extra R7 cell or an occasional gain or loss of an outer photoreceptor cell. (Kramer et al., 1999) Pupal lethal when hemizygous. The number of tracheal branches emanating from the dorsal and ganglionic branches is higher than normal in homozygous embryos. (Kramer et al., 1995)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference sty[+]/sty²²⁶ is an enhancer of visible phenotype of Scer\GAL4^tub.PU, csw^{N308D.Scer\UAS.P\T} (Oishi et al., 2006) sty²²⁶ is an enhancer of cell polarity defective phenotype of fz²⁰/fz¹⁹ (Strutt and Strutt, 2003)
Suppressor of
Statement Reference sty²²⁶ is a suppressor of cell polarity defective phenotype of Ras64B^V14.Act5C (Strutt and Strutt, 2003) sty²²⁶ is a suppressor of visible phenotype of H^Scer\UAS.cMa/H^Scer\UAS.cMa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mueller et al., 2005)
Phenotype Manifest In
Enhanced by
Statement Reference sty²²⁶ has photoreceptor cell R7 \| ectopic phenotype, enhanceable by aop^yan-1/aop[+] (Kramer et al., 1999) sty²²⁶ has photoreceptor cell R7 \| ectopic phenotype, enhanceable by Gap1[+]/RasGAP1^B2 (Kramer et al., 1999)
Enhancer of
Statement Reference sty[+]/sty²²⁶ is an enhancer of wing vein \| ectopic phenotype of Scer\GAL4^tub.PU, csw^{N308D.Scer\UAS.P\T} (Oishi et al., 2006) sty²²⁶/Scer\GAL4^tub.PU is an enhancer of eye phenotype of Scer\GAL4^tub.PU, csw^{Y279C.Scer\UAS.P\T} (Oishi et al., 2009) sty²²⁶/Scer\GAL4^tub.PU is an enhancer of ommatidium phenotype of Scer\GAL4^tub.PU, csw^{Y279C.Scer\UAS.P\T} (Oishi et al., 2009) sty²²⁶/Scer\GAL4^tub.PU is an enhancer of photoreceptor cell R7 \| ectopic phenotype of Scer\GAL4^tub.PU, csw^{Y279C.Scer\UAS.P\T} (Oishi et al., 2009) sty²²⁶/Scer\GAL4^tub.PU is an enhancer of wing vein phenotype of Scer\GAL4^tub.PU, csw^{Y279C.Scer\UAS.P\T} (Oishi et al., 2009) sty²²⁶ is an enhancer of ommatidium phenotype of fz²⁰/fz¹⁹ (Strutt and Strutt, 2003)
Suppressor of
Statement Reference sty²²⁶ is a suppressor of eye phenotype of H^Scer\UAS.cMa/H^Scer\UAS.cMa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mueller et al., 2005) sty²²⁶ is a suppressor of ommatidium phenotype of Ras64B^V14.Act5C (Strutt and Strutt, 2003)
Additional Comments
Genetic Interactions
Statement Reference The presence of a sty[226] background significantly enhances ectopic wing vein formation found in csw[Y279C.Scer\UAS] (Scer\GAL4[tub]) mutants. A sty[226] background enhances the csw[Y279C.Scer\UAS] (Scer\GAL4[tub]) rough eye phenotype, with the number of R7 in each ommatidium increasing. (Oishi et al., 2009) The addition of sty²²⁶/+ enhances the eye cell polarity phenotype seen in fz¹⁹/fz²⁰ animals. Heterozygotes suppress the ommatidial polarity defects seen in Ras64B^V14.Act5C. (Strutt and Strutt, 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	6383 w^; sty²²⁶ h¹ e^ ca¹/TM6B, Tb¹
Notes on Origin
Discoverer
	Selected as: Dominant suppressor of the rough eye phenotype caused by ectopic expression of svp in photoreceptors R2 and R5. (Kramer et al., 1995)
Comments
	Amorph or strong hypomorph. (Kramer et al., 1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	spry²²⁶ (Kramer et al., 1999, Hacohen et al., 1998) sty²²⁶ (Lachance et al., 2009, Oishi et al., 2006) Sty²²⁶ (Oishi et al., 2009)
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Lachance et al., 2009, Development 136(17): 2893--2902 Graded Egfr activity patterns the Drosophila eggshell independently of autocrine feedback. [FBrf0208553] Oishi et al., 2009, Hum. Mol. Genet. 18(1): 193--201 Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development. [FBrf0207302] Oishi et al., 2006, Hum. Mol. Genet. 15(4): 543--553 Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations. [FBrf0190828] Mueller et al., 2005, Genetics 171(3): 1137--1152 Genetic modifier screens on hairless gain-of function phenotypes reveal genes involved in cell differentiation, cell growth and apoptosis in Drosophila melanogaster. [FBrf0190751] Strutt and Strutt, 2003, Curr. Biol. 13(16): 1451--1457 EGF signaling and ommatidial rotation in the Drosophila eye. [FBrf0162001] Kramer et al., 1999, Development 126(11): 2515--2525 Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila. [FBrf0108521] Hacohen et al., 1998, Cell 92(2): 253--263 sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. [FBrf0100567] Kramer et al., 1995, Development 121(5): 1361--1372 Cell fate control in the Drosophila retina by the orphan receptor seven-up: its role in the decisions mediated by the ras signaling pathway. [FBrf0078827]

Allele Dmel\sty226

Allele Dmel\sty²²⁶