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General Information
Symbol
Dmel\styΔ5
Species
D. melanogaster
Name
FlyBase ID
FBal0086316
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
spryΔ5, styD5
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Imprecise excision of the P{lacW} element present in the P{lacW}s2683 insertion, removing the 5' exon common to all splice forms of sty.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
styΔ5/+ does not cause significant cardiac enlargement or reduced fractional shortening in adult hearts.
Eggs derived from egg chambers containing complete homozygous follicle cell clones have an expanded dorsal midline region, with the dorsal appendages being further apart than normal. In addition, most of the appendages are mildly shorter in length or thicker in width than normal, some have branched tips, and rarely, a small pseudo-appendage is seen at the base of one of the appendages.
Eggs derived from females with mosaic styΔ5 egg chambers occasionally have multiple, ectopic dorsal appendages. More commonly, the eggs have thinner dorsal appendages that are located more laterally than normal.
styΔ5 larva show extra terminal cells in their tracheal systems, when compared to wild-type larva.
styΔ5 homozygous clones in the dorsal air sac primordium are found at the tip of the primordium at a significantly lower frequency than wild-type clones.
Homozygotes have a variable number of outer photoreceptor neurons per ommatidium; some ommatidia have more and some have fewer than the normal number of outer photoreceptor neurons, and although the average number is 6.01 per ommatidium in the mutant (almost the same as wild type), the standard deviation is large (1.05).
When mutant somatic clones are made in the border cells no effect is seen.
Homozygous eggs are not recovered from females containing homozygous germ line clones, suggesting a requirement for sty function in the germline.
Escapers of lethality show a disorganized eye phenotype. Majority of ommatidia have extra R7 cells, generated by transformation of cone cells. Some of the extra photoreceptors resemble outer (R1-R6) photoreceptor neurons. Mystery cells assume R3/R4 fates. In heterozygous condition, 1-7% of ommatidia show an extra R7 cell or an occasional gain or loss of an outer photoreceptor cell. In embryos, 26% of hemisegments show an extra chordotonal organ in the lateral cluster. Midline glial cells are increased in number.
When clones are induced in the ovary, or specifically in the follicle cells, a range of phenotypes occurs, depending on the size of the clone. Eggs may be dorsalized, dorsal appendages may be misplaced or enlarged, and, rarely, dorsal appendages may be duplicated or split.
Pupal lethal when hemizygous. 30-120% more tracheal branches than normal bud from the dorsal, lateral trunk anterior, lateral trunk posterior, ganglionic and visceral branches. These additional branches arise from the stalks of the primary branches, close to the positions where secondary and terminal branches normally bud. The total number of tracheal cells is not increased in these embryos. In homozygous clones in which only the tracheal tip cell GB1 is sty-, there is always an ectopic branch in the neighbouring sty+ stalk cell, GB2. These ectopic branches usually turn away from the ventral nerve cord, and growth of the normal branch from the sty- GB1 cell may be slowed. In contrast, in clones in which a subset of stalk cells (GB2-7) are sty- and GB1 is sty+, the ganglionic branch generally appears normal, with no ectopic branches. In clones in which the tracheal tip cell DB1 is sty-, nearby sty+ cells form ectopic branches.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
sty[+]/styΔ5 is an enhancer of visible phenotype of Chmp1GD11219, Scer\GAL4Bx-MS1096
styΔ5 is an enhancer of visible | dominant phenotype of KrIf-1
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
NOT suppressed by
Statement
Reference
styΔ5 has phenotype, non-suppressible by aosGMR.PS
Enhancer of
Statement
Reference
styΔ5 is an enhancer of ommatidium phenotype of fz20/fz19
styΔ5 is an enhancer of eye phenotype of KrIf-1
styΔ5 is an enhancer of ommatidium phenotype of KrIf-1
Suppressor of
Statement
Reference
sty[+]/styΔ5 is a suppressor of eye phenotype of rauf04153/Df(2L)rauΔ
styΔ5 is a suppressor of ommatidium phenotype of Ras64BV14.Act5C
styΔ5 is a suppressor of eye phenotype of Pp2B-14Dact.GMR
styΔ5 is a suppressor of phenotype of aosGMR.PS
NOT Suppressor of
Statement
Reference
sty[+]/styΔ5 is a non-suppressor of outer photoreceptor cell phenotype of cswCS.hs.2sev
Other
Additional Comments
Genetic Interactions
Statement
Reference
styΔ5/+ rescues the reduced fractional shortening phenotype but not the cardiac enlargement of flies expressing Pp2B-14Dact.Scer\UAS.T:Avic\GFP-EYFP under the control of Scer\GAL4tin.CΔ4.
styΔ5/+ suppresses the rough eye of Df(2L)rauΔ adults and the 'R7 cell loss' phenotype seen in Df(2L)rauΔ eye discs.
The loss of photoreceptor cells seen in homozygous mopT612 clones in the eye disc is rescued if the clones are also homozygous for styΔ5.
argosΔ7 styΔ5 Minute clones in the eye disc form large, disorganised clusters in the morphogenetic furrow compared to the clusters formed in wild-type eye discs.
Flies that express one copy of csw::Src64Bhs.2sev in developing eyes with a styΔ5/+ background show an enhancement of the extra R7 photoreceptor cell phenotype seen when csw::Src64Bhs.2sev is expressed in a wild-type background. A higher proportion of the csw::Src64Bhs.2sev/+; styΔ5/+ flies show 3, 4, 5,or 6 R7 photoreceptor cells per ommatidium.
The addition of styΔ5/+ enhances the eye cell polarity phenotype seen in fz19/fz20 animals. Heterozygotes suppress the ommatidial polarity defects seen in Ras64BV14.Act5C.
Weakly suppresses the eye phenotype produced by activated arm constructs. (either armS44Y.GMR or armS56F.GMR).
Eyes mutant for both styΔ5 and carrying argosGMR.PS have a normal-size eye and an extra-R7 phenotype similar to that of styΔ5 alone.
Xenogenetic Interactions
Statement
Reference
The ectopic wing vein phenotype seen when Hsap\ATN1N917.65Q.Scer\UAS is expressed under the control of Scer\GAL4GMR.PF is enhanced in styΔ5 heterozygotes.
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments
Amorph or strong hypomorph.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
References (26)