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General Information
Symbol
Dmel\ph-pP1
Species
D. melanogaster
Name
FlyBase ID
FBal0086381
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
phP1
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Insertion of a 1.2kb P-element into the untranslated leader sequence at 109bp (coordinate according to the cDNA clone map described in FBrf0054014). The P-element is transcribed in the same orientation as ph-p. Sequences between 829bp and 2560bp of the P-element are deleted, with the filler sequence TAGCTACAAA inserted at the breakpoint.
Insertion of 1.2 kb P-element into the 5' transcribed non-translated region.
Insertion components
P{}ph-pP1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Mutation represses transcription of P-element-induced alleles at the y locus. The duplication and triplication of the P-element at the y locus enhanced the repression effect of the ph-pP1 mutation.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
ph-pP1, y+sA8 has body color defective phenotype, suppressible | partially by Su(y)P22P22/Su(y)P22[+]
ph-pP1, y+sA8 has body color defective phenotype, suppressible | partially by Su(y)P31[+]/Su(y)P31P31
ph-pP1, y+s has body color defective | recessive phenotype, suppressible by sneP1/sn[+]
ph-pP1, y+s has body color defective | recessive phenotype, suppressible by Su(y)P22P22/Su(y)P22[+]
ph-pP1, y+s has body color defective | recessive phenotype, suppressible by Su(y)P31[+]/Su(y)P31P31
ph-pP1, y+s22 has body color defective phenotype, suppressible | partially by sneP1/sn[+]
ph-pP1, y+s22 has body color defective phenotype, suppressible | partially by Su(y)P22P22/Su(y)P22[+]
ph-pP1, y+s22 has body color defective phenotype, suppressible | partially by Su(y)P31[+]/Su(y)P31P31
ph-pP1, y2s14 has body color defective phenotype, suppressible by Su(y)P22P22/Su(y)P22[+]
ph-pP1, y2s14 has body color defective phenotype, suppressible by Su(y)P31[+]/Su(y)P31P31
ph-pP1, y+sA22 has body color defective phenotype, suppressible | partially by Su(y)P22P22/Su(y)P22[+]
ph-pP1, y+sA22 has body color defective phenotype, suppressible | partially by Su(y)P31[+]/Su(y)P31P31
NOT suppressed by
Statement
Reference
ph-pP1, y2s7 has body color defective phenotype, non-suppressible by sneP1
ph-pP1, y2s26 has body color defective phenotype, non-suppressible by sneP1
ph-pP1, y2s11 has body color defective phenotype, non-suppressible by sneP1
ph-pP1, y2s25 has body color defective phenotype, non-suppressible by sneP1
ph-pP1, y2s14 has body color defective phenotype, non-suppressible by sn+P11
ph-pP1, y2s14 has body color defective phenotype, non-suppressible by sn+P12
Enhancer of
Statement
Reference
ph-pP1 is an enhancer of visible | homeotic phenotype of Trf2P1
ph-pP1 is an enhancer of body color defective phenotype of y2s2
ph-pP1 is an enhancer of eye color defective phenotype of wΔP
Other
Phenotype Manifest In
Enhancer of
Statement
Reference
ph-pP1 is an enhancer of tarsal segment | ectopic phenotype of Trf2P1
ph-pP1 is an enhancer of arista phenotype of Trf2P1
ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y2s14
ph-pP1 is an enhancer of leg sensillum phenotype of y2s14
ph-pP1 is an enhancer of wing sensillum phenotype of y2s14
ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y2s14
ph-pP1 is an enhancer of wing phenotype of y+s
ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y+s
ph-pP1 is an enhancer of leg sensillum phenotype of y+s
ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y+s
ph-pP1 is an enhancer of wing phenotype of y2s26
ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y2s26
ph-pP1 is an enhancer of leg sensillum phenotype of y2s26
ph-pP1 is an enhancer of wing sensillum phenotype of y2s26
ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y2s26
ph-pP1 is an enhancer of wing phenotype of y2s10-2
ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y2s10-2
ph-pP1 is an enhancer of leg sensillum phenotype of y2s10-2
ph-pP1 is an enhancer of wing sensillum phenotype of y2s10-2
ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y2s10-2
ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y2s7
ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y2s16
ph-pP1 is an enhancer of leg sensillum phenotype of y2s16
ph-pP1 is an enhancer of wing sensillum phenotype of y2s16
ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y2s16
ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y2s11
ph-pP1 is an enhancer of leg sensillum phenotype of y2s11
ph-pP1 is an enhancer of wing sensillum phenotype of y2s11
ph-pP1 is an enhancer of leg sensillum phenotype of y2s7
ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y2s11
ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y2s2
ph-pP1 is an enhancer of leg sensillum phenotype of y2s2
ph-pP1 is an enhancer of wing sensillum phenotype of y2s2
ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y2s2
ph-pP1 is an enhancer of wing sensillum phenotype of y2s7
ph-pP1 is an enhancer of wing phenotype of y+sA12
ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y+sA12
ph-pP1 is an enhancer of leg sensillum phenotype of y+sA12
ph-pP1 is an enhancer of wing sensillum phenotype of y+sA12
ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y+sA12
ph-pP1 is an enhancer of wing phenotype of y+s32
ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y+s32
ph-pP1 is an enhancer of leg sensillum phenotype of y+s32
ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y2s7
ph-pP1 is an enhancer of pigment cell phenotype of wΔP
ph-pP1 is an enhancer of wing phenotype of y+s22
ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y+s22
ph-pP1 is an enhancer of leg sensillum phenotype of y+s22
ph-pP1 is an enhancer of wing sensillum phenotype of y+s22
ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y+s22
ph-pP1 is an enhancer of wing phenotype of y2s25
ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y2s25
ph-pP1 is an enhancer of leg sensillum phenotype of y2s25
ph-pP1 is an enhancer of wing sensillum phenotype of y2s25
ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y2s25
ph-pP1 is an enhancer of wing phenotype of y+sA11
ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y+sA11
ph-pP1 is an enhancer of leg sensillum phenotype of y+sA11
ph-pP1 is an enhancer of wing sensillum phenotype of y+sA11
ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y+sA11
ph-pP1 is an enhancer of macrochaeta phenotype of yΔP.tBa
ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y2s42
ph-pP1 is an enhancer of leg sensillum phenotype of y2s42
ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y76d28
ph-pP1 is an enhancer of adult cuticle phenotype of yds62
ph-pP1 is an enhancer of wing phenotype of yds62
ph-pP1 is an enhancer of adult cuticle phenotype of y2s11
ph-pP1 is an enhancer of adult cuticle phenotype of y2s7
ph-pP1 is an enhancer of adult cuticle phenotype of y76d28
ph-pP1 is an enhancer of wing sensillum phenotype of y76d28
NOT Enhancer of
Statement
Reference
ph-pP1 is a non-enhancer of phenotype of y+s27
ph-pP1 is a non-enhancer of phenotype of sneP1
ph-pP1 is a non-enhancer of phenotype of ytBa
ph-pP1 is a non-enhancer of phenotype of snwP14
ph-pP1 is a non-enhancer of phenotype of sne
ph-pP1 is a non-enhancer of phenotype of snw
ph-pP1 is a non-enhancer of phenotype of snwP13
ph-pP1 is a non-enhancer of phenotype of y2s34
ph-pP1 is a non-enhancer of phenotype of y+ews2
ph-pP1 is a non-enhancer of phenotype of y+ls4
ph-pP1 is a non-enhancer of phenotype of y2
ph-pP1 is a non-enhancer of phenotype of y+ews1
Other
Statement
Reference
ph-pP1, y+s7 has adult thorax & macrochaeta phenotype
ph-pP1, y2s7 has adult thorax & macrochaeta phenotype
ph-pP1, y2s14 has adult thorax & macrochaeta phenotype
ph-pP1, y2s11 has adult thorax & macrochaeta phenotype
ph-pP1, y2s20 has adult thorax & macrochaeta phenotype
ph-pP1, y2sA3 has adult thorax & macrochaeta phenotype
ph-pP1, yds62 has adult thorax & macrochaeta phenotype
ph-pP1, y+s8 has adult thorax & macrochaeta phenotype
Additional Comments
Genetic Interactions
Statement
Reference
The viability of ph-pP1 Trf2P1 double mutants is strongly decreased. Mortality is seen at the late embryonic stage (approximately 50%) and larval and pupal stages (approximately 30%). Approximately 10% of double hemizygous males and 1% of double homozygous females survive to adulthood. The adults die in 5 to 10 days after eclosion. The double homozygous females are completely sterile and the double hemizygous males have decreased fertility. Approximately 30% of the adults have an extreme transformation of arista to tarsus. The adults have shortened bodies. Approximately 10% of ph-pP1 Trf2P1 double mutant embryos have defects in central nervous system development, and approximately 20% of the mutant embryos have defects in the ventral and lateral clusters of the embryonic peripheral nervous system. Defects in segment organisation are seen in approximately 15% of the embryos. The karyosome often appears more diffuse than normal in ph-pP1 Trf2P1 double mutant oocytes. ph-pP1 Trf2P1 double mutant ovaries contain few mature oocytes and have abnormally shaped egg chambers. The ovarioles often contain several follicles that have not separated from the germarium. Many egg chambers contain more than the normal number of 16 nuclei, representing joint cysts packaged inside a monolayer of follicle cells. ph-pP1 Trf2P1 double mutant males have thinner testes than wild-type males. No abnormalities are seen in young primary spermatocytes, but at later stages, many primary spermatocytes show differentiation defects; the chromosome bivalents look more diffuse during metaphase, and aberrant spindles are seen. A significant number of cysts in the mutant testis contain abnormal mature spermatocytes that are probably necrotic.
Lethal during the middle and late embryonic stages in combination with e(y)1P1. This phenotype is rescued by e(y)1+tSa.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments
Mutation encodes a chimeric P-element-ph-p protein, consisting of the DNA binding domain of the P-element and theph-pPh protein lacking 12 amino-terminal amino acids.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (7)