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General Information
Symbol
Dmel\ph-pP1
Species
D. melanogaster
Name
FlyBase ID
FBal0086381
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
phP1
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of a 1.2kb P-element into the untranslated leader sequence at 109bp (coordinate according to the cDNA clone map described in FBrf0054014). The P-element is transcribed in the same orientation as ph-p. Sequences between 829bp and 2560bp of the P-element are deleted, with the filler sequence TAGCTACAAA inserted at the breakpoint.

Insertion of 1.2 kb P-element into the 5' transcribed non-translated region.

Insertion components
P{}ph-pP1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutation represses transcription of P-element-induced alleles at the y locus. The duplication and triplication of the P-element at the y locus enhanced the repression effect of the ph-pP1 mutation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

ph-pP1, y+sA8 has abnormal body color phenotype, suppressible | partially by Su(y)P22P22/Su(y)P22[+]

ph-pP1, y+sA8 has abnormal body color phenotype, suppressible | partially by Su(y)P31[+]/Su(y)P31P31

ph-pP1, y+s has abnormal body color | recessive phenotype, suppressible by sneP1/sn[+]

ph-pP1, y+s has abnormal body color | recessive phenotype, suppressible by Su(y)P22P22/Su(y)P22[+]

ph-pP1, y+s has abnormal body color | recessive phenotype, suppressible by Su(y)P31[+]/Su(y)P31P31

ph-pP1, y+s22 has abnormal body color phenotype, suppressible | partially by sneP1/sn[+]

ph-pP1, y+s22 has abnormal body color phenotype, suppressible | partially by Su(y)P22P22/Su(y)P22[+]

ph-pP1, y+s22 has abnormal body color phenotype, suppressible | partially by Su(y)P31[+]/Su(y)P31P31

ph-pP1, y2s14 has abnormal body color phenotype, suppressible by Su(y)P22P22/Su(y)P22[+]

ph-pP1, y2s14 has abnormal body color phenotype, suppressible by Su(y)P31[+]/Su(y)P31P31

ph-pP1, y+sA22 has abnormal body color phenotype, suppressible | partially by Su(y)P22P22/Su(y)P22[+]

ph-pP1, y+sA22 has abnormal body color phenotype, suppressible | partially by Su(y)P31[+]/Su(y)P31P31

NOT suppressed by
Statement
Reference

ph-pP1, y2s7 has abnormal body color phenotype, non-suppressible by sneP1

ph-pP1, y2s26 has abnormal body color phenotype, non-suppressible by sneP1

ph-pP1, y2s11 has abnormal body color phenotype, non-suppressible by sneP1

ph-pP1, y2s25 has abnormal body color phenotype, non-suppressible by sneP1

ph-pP1, y2s14 has abnormal body color phenotype, non-suppressible by sn+P11

ph-pP1, y2s14 has abnormal body color phenotype, non-suppressible by sn+P12

Enhancer of
Statement
Reference

ph-pP1 is an enhancer of visible | homeotic phenotype of Trf2P1

ph-pP1 is an enhancer of abnormal body color phenotype of y2s26

ph-pP1 is an enhancer of abnormal body color phenotype of y2s16

ph-pP1 is an enhancer of abnormal body color phenotype of y2s2

ph-pP1 is an enhancer of abnormal body color phenotype of y+s32

ph-pP1 is an enhancer of abnormal eye color phenotype of wΔP

ph-pP1 is an enhancer of abnormal body color phenotype of y+s22

ph-pP1 is an enhancer of abnormal body color phenotype of y2s25

ph-pP1 is an enhancer of abnormal body color phenotype of y2s42

ph-pP1 is an enhancer of abnormal body color phenotype of yds62

ph-pP1 is an enhancer of abnormal body color phenotype of y2s20

ph-pP1 is an enhancer of abnormal body color phenotype of y2sA3

Other
Phenotype Manifest In
Enhancer of
Statement
Reference

ph-pP1 is an enhancer of tarsal segment | ectopic phenotype of Trf2P1

ph-pP1 is an enhancer of arista phenotype of Trf2P1

ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y2s14

ph-pP1 is an enhancer of leg sensillum phenotype of y2s14

ph-pP1 is an enhancer of wing sensillum phenotype of y2s14

ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y2s14

ph-pP1 is an enhancer of wing phenotype of y+s

ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y+s

ph-pP1 is an enhancer of leg sensillum phenotype of y+s

ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y+s

ph-pP1 is an enhancer of wing phenotype of y2s26

ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y2s26

ph-pP1 is an enhancer of leg sensillum phenotype of y2s26

ph-pP1 is an enhancer of wing sensillum phenotype of y2s26

ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y2s26

ph-pP1 is an enhancer of wing phenotype of y2s10-2

ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y2s10-2

ph-pP1 is an enhancer of leg sensillum phenotype of y2s10-2

ph-pP1 is an enhancer of wing sensillum phenotype of y2s10-2

ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y2s10-2

ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y2s7

ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y2s16

ph-pP1 is an enhancer of leg sensillum phenotype of y2s16

ph-pP1 is an enhancer of wing sensillum phenotype of y2s16

ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y2s16

ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y2s11

ph-pP1 is an enhancer of leg sensillum phenotype of y2s11

ph-pP1 is an enhancer of wing sensillum phenotype of y2s11

ph-pP1 is an enhancer of leg sensillum phenotype of y2s7

ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y2s11

ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y2s2

ph-pP1 is an enhancer of leg sensillum phenotype of y2s2

ph-pP1 is an enhancer of wing sensillum phenotype of y2s2

ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y2s2

ph-pP1 is an enhancer of wing sensillum phenotype of y2s7

ph-pP1 is an enhancer of wing phenotype of y+sA12

ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y+sA12

ph-pP1 is an enhancer of leg sensillum phenotype of y+sA12

ph-pP1 is an enhancer of wing sensillum phenotype of y+sA12

ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y+sA12

ph-pP1 is an enhancer of wing phenotype of y+s32

ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y+s32

ph-pP1 is an enhancer of leg sensillum phenotype of y+s32

ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y2s7

ph-pP1 is an enhancer of pigment cell phenotype of wΔP

ph-pP1 is an enhancer of wing phenotype of y+s22

ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y+s22

ph-pP1 is an enhancer of leg sensillum phenotype of y+s22

ph-pP1 is an enhancer of wing sensillum phenotype of y+s22

ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y+s22

ph-pP1 is an enhancer of wing phenotype of y2s25

ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y2s25

ph-pP1 is an enhancer of leg sensillum phenotype of y2s25

ph-pP1 is an enhancer of wing sensillum phenotype of y2s25

ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y2s25

ph-pP1 is an enhancer of wing phenotype of y+sA11

ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y+sA11

ph-pP1 is an enhancer of leg sensillum phenotype of y+sA11

ph-pP1 is an enhancer of wing sensillum phenotype of y+sA11

ph-pP1 is an enhancer of adult abdomen & macrochaeta phenotype of y+sA11

ph-pP1 is an enhancer of macrochaeta phenotype of yΔP.tBa

ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y2s42

ph-pP1 is an enhancer of leg sensillum phenotype of y2s42

ph-pP1 is an enhancer of adult thorax & macrochaeta phenotype of y76d28

ph-pP1 is an enhancer of adult cuticle phenotype of yds62

ph-pP1 is an enhancer of wing phenotype of yds62

ph-pP1 is an enhancer of adult cuticle phenotype of y2s11

ph-pP1 is an enhancer of adult cuticle phenotype of y2s7

ph-pP1 is an enhancer of adult cuticle phenotype of y76d28

ph-pP1 is an enhancer of wing sensillum phenotype of y76d28

NOT Enhancer of
Statement
Reference

ph-pP1 is a non-enhancer of phenotype of y+s27

ph-pP1 is a non-enhancer of phenotype of sneP1

ph-pP1 is a non-enhancer of phenotype of ytBa

ph-pP1 is a non-enhancer of phenotype of snwP14

ph-pP1 is a non-enhancer of phenotype of sne

ph-pP1 is a non-enhancer of phenotype of snw

ph-pP1 is a non-enhancer of phenotype of snwP13

ph-pP1 is a non-enhancer of phenotype of y2s34

ph-pP1 is a non-enhancer of phenotype of y+ews2

ph-pP1 is a non-enhancer of phenotype of y+ls4

ph-pP1 is a non-enhancer of phenotype of y2

ph-pP1 is a non-enhancer of phenotype of y+ews1

Other
Statement
Reference

ph-pP1, y+s7 has adult thorax & macrochaeta phenotype

ph-pP1, y2s7 has adult thorax & macrochaeta phenotype

ph-pP1, y2s14 has adult thorax & macrochaeta phenotype

ph-pP1, y2s11 has adult thorax & macrochaeta phenotype

ph-pP1, y2s20 has adult thorax & macrochaeta phenotype

ph-pP1, y2sA3 has adult thorax & macrochaeta phenotype

ph-pP1, yds62 has adult thorax & macrochaeta phenotype

ph-pP1, y+s8 has adult thorax & macrochaeta phenotype

Additional Comments
Genetic Interactions
Statement
Reference

The viability of ph-pP1 Trf2P1 double mutants is strongly decreased. Mortality is seen at the late embryonic stage (approximately 50%) and larval and pupal stages (approximately 30%). Approximately 10% of double hemizygous males and 1% of double homozygous females survive to adulthood. The adults die in 5 to 10 days after eclosion. The double homozygous females are completely sterile and the double hemizygous males have decreased fertility. Approximately 30% of the adults have an extreme transformation of arista to tarsus. The adults have shortened bodies.

Approximately 10% of ph-pP1 Trf2P1 double mutant embryos have defects in central nervous system development, and approximately 20% of the mutant embryos have defects in the ventral and lateral clusters of the embryonic peripheral nervous system. Defects in segment organisation are seen in approximately 15% of the embryos.

The karyosome often appears more diffuse than normal in ph-pP1 Trf2P1 double mutant oocytes. ph-pP1 Trf2P1 double mutant ovaries contain few mature oocytes and have abnormally shaped egg chambers. The ovarioles often contain several follicles that have not separated from the germarium. Many egg chambers contain more than the normal number of 16 nuclei, representing joint cysts packaged inside a monolayer of follicle cells.

ph-pP1 Trf2P1 double mutant males have thinner testes than wild-type males. No abnormalities are seen in young primary spermatocytes, but at later stages, many primary spermatocytes show differentiation defects; the chromosome bivalents look more diffuse during metaphase, and aberrant spindles are seen. A significant number of cysts in the mutant testis contain abnormal mature spermatocytes that are probably necrotic.

Lethal during the middle and late embryonic stages in combination with e(y)1P1. This phenotype is rescued by e(y)1+tSa.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Mutation encodes a chimeric P-element-ph-p protein, consisting of the DNA binding domain of the P-element and theph-pPh protein lacking 12 amino-terminal amino acids.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (7)