|Feature type||allele||Associated gene||Dmel\ph-p|
|Also Known As||phP1|
|Map ( GBrowse )||
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Insertion of a 1.2kb P-element into the untranslated leader sequence at 109bp (coordinate according to the cDNA clone map described in FBrf0054014). The P-element is transcribed in the same orientation as ph-p. Sequences between 829bp and 2560bp of the P-element are deleted, with the filler sequence TAGCTACAAA inserted at the breakpoint.
|Caused by insertion|
|Phenotype Manifest In|
ph-pP1, y+s22 has body color defective phenotype, suppressible | partially by Su(y)P22P22/Su(y)P22[+]
ph-pP1, y+s22 has body color defective phenotype, suppressible | partially by Su(y)P31[+]/Su(y)P31P31
ph-pP1, y+sA8 has body color defective phenotype, suppressible | partially by Su(y)P22P22/Su(y)P22[+]
ph-pP1, y+sA8 has body color defective phenotype, suppressible | partially by Su(y)P31[+]/Su(y)P31P31
ph-pP1, y+sA22 has body color defective phenotype, suppressible | partially by Su(y)P22P22/Su(y)P22[+]
|NOT suppressed by|
|Phenotype Manifest In|
|NOT Enhancer of|
Trf2P1, ph-pP1 has presumptive embryonic/larval central nervous system phenotype
Trf2P1, ph-pP1 has presumptive embryonic/larval peripheral nervous system phenotype
The viability of ph-p[P1] Trf2[P1] double mutants is strongly decreased. Mortality is seen at the late embryonic stage (approximately 50%) and larval and pupal stages (approximately 30%). Approximately 10% of double hemizygous males and 1% of double homozygous females survive to adulthood. The adults die in 5 to 10 days after eclosion. The double homozygous females are completely sterile and the double hemizygous males have decreased fertility. Approximately 30% of the adults have an extreme transformation of arista to tarsus. The adults have shortened bodies. Approximately 10% of ph-p[P1] Trf2[P1] double mutant embryos have defects in central nervous system development, and approximately 20% of the mutant embryos have defects in the ventral and lateral clusters of the embryonic peripheral nervous system. Defects in segment organisation are seen in approximately 15% of the embryos. The karyosome often appears more diffuse than normal in ph-p[P1] Trf2[P1] double mutant oocytes. ph-p[P1] Trf2[P1] double mutant ovaries contain few mature oocytes and have abnormally shaped egg chambers. The ovarioles often contain several follicles that have not separated from the germarium. Many egg chambers contain more than the normal number of 16 nuclei, representing joint cysts packaged inside a monolayer of follicle cells. ph-p[P1] Trf2[P1] double mutant males have thinner testes than wild-type males. No abnormalities are seen in young primary spermatocytes, but at later stages, many primary spermatocytes show differentiation defects; the chromosome bivalents look more diffuse during metaphase, and aberrant spindles are seen. A significant number of cysts in the mutant testis contain abnormal mature spermatocytes that are probably necrotic.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 3 )|
|Secondary FlyBase IDs|
|References ( 7 )|