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General Information
Symbol
Dmel\communspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0086680
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Medial longitudinal tracts often cross the midline in mutant embryos (one or two segments in 9% of embryos).

    No axons cross the midline in mutant embryos and as a result no commissures are formed. 97% of ganglionic branches stall or turn to migrate dorsally and posteriorly prematurely, before reaching the midline.

    No commissures are seen in homozygous embryos.

    Almost no axons cross the midline in communspecified mutant embryos.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhanced by
    Statement
    Reference

    communspecified has neuroanatomy defective phenotype, enhanceable by sli2/sli[+]

    Enhancer of
    Phenotype Manifest In
    Enhanced by
    Statement
    Reference

    communspecified has longitudinal connective phenotype, enhanceable by sli2/sli[+]

    NOT Enhancer of
    Statement
    Reference
    NOT Suppressor of
    Statement
    Reference
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The midline crossing defects of axons seen in Scer\GAL4eg-Mz360-driven fraΔC.Scer\UAS.T:Ivir\HA-expressing embryos are enhanced in a heterozygous communspecified/+ genetic background.

    The longitudinal tract midline crossing phenotype seen in communspecified mutants is significantly enhanced by sli2/+, both in terms of the numbers of segments and the number of embryos affected.

    The addition of communspecified to robounspecified embryos does not affect the number of commissure crossing the midline. The addition of communspecified to sliunspecified mutants has no effect on the sliunspecified phenotype.

    Some axons can cross the midline in communspecified kusunspecified double mutant embryos, but in most neuromeres the comm mutant phenotype is epistatic to the kus mutant phenotype. However, if commissural axons have crossed the midline, then this neuromere shows a kus mutant phenotype. Commissures are formed in communspecified sliunspecified double mutant embryos but in an irregular pattern.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    communspecified
    Name Synonyms
    Secondary FlyBase IDs
      References (7)