FB2025_01 , released February 20, 2025
Allele: Dmel\Sin3Aunspecified
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General Information
Symbol
Dmel\Sin3Aunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0086750
Feature type
allele
Associated gene
Dmel\Sin3A
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Neufeld et al., 1998, Pennetta and Pauli, 1998)
X ray
(Neufeld et al., 1998)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The average number of crystal cells per embryo is reduced in homozygous stage 13-14 embryos compared to wild type.

      (Milchanowski et al., 2004)

      Homozygous clones in the eye do not survive to adulthood, but produce scars across the eye. These scars contain large vacuoles, have ommatidia with missing photoreceptors and show disruptions in the pigment lattice.

      (Neufeld et al., 1998)

      Some homozygous embryos show brief contractions, although most fail to hatch. Those that free themselves from the egg shell show only sporadic movements and quickly die as first instar larvae. Does not dominantly enhance position effect variegation of w caused by In(1)wm4h.

      (Pennetta and Pauli, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Sin3Aunspecified is an enhancer of phenotype of sinaGMR.PN

      (Neufeld et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: Dominant modifier of the sinaGMR.PN eye phenotype.

      (Neufeld et al., 1998)
      Comments
      Comments

      "ethyl methanesulfonate" was stated as tentative. "X ray" was stated as tentative.

      (Neufeld et al., 1998)

      Complements: Amph26.

      (Zelhof et al., 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Sin3Aunspecified
      Name Synonyms
      Secondary FlyBase IDs
        References (4)