FlyBase Allele Report: Dmel\Sin3A[k07401]

General Information

Symbol

Dmel\Sin3A^k07401

Species

D. melanogaster

Name

FlyBase ID

FBal0086751

Feature type

allele

Associated gene

Dmel\Sin3A

Associated Insertion(s)

P{lacW}Sin3A^k07401

Carried in Construct

Also Known As

l(2)7401

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Neufeld et al., 1998)

Progenitor genotype

Associated Insertion(s)

P{lacW}Sin3A^k07401

Cytology

Description

P{lacW} insertion within the 5' intron.

(Tsai et al., 1999)

P{lacW} insertion within an intron.

(Neufeld et al., 1998)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates multiple endocrine neoplasia type 2B

modeled by Ret^MEN2B.GMR

(Read et al., 2005)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Sin3A^k07401 is an enhancer of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

Other

Statement

Reference

EcR^E261st, Sin3A^k07401 has lethal phenotype

(Tsai et al., 1999)

EcR^E261st, Sin3A^k07401 has visible phenotype

(Tsai et al., 1999)

Phenotype Manifest In

Enhancer of

Statement

Reference

Sin3A^k07401 is an enhancer of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

Other

Statement

Reference

EcR^E261st, Sin3A^k07401 has wing phenotype

(Tsai et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Genetic interaction between EcR^E261st and Sin3A^k07401 reported in FBrf0111507 is not evident when EcR^C300Y is combined with Sin3A⁰⁸²⁶⁹, suggesting that the original observed interaction could be due to background effects.

(Bodai, 2000.12.22)

Only 14% of EcR^E261st/Sin3A^k07401 flies derived from a cross of Sin3A^k07401 females to EcR^E261st males survive (significantly lower than the expected 33.3%). Escapers show delayed development and wing defects; the wings are held horizontally at a 45-90^o angle from the body axis. None of the EcR^E261st/Sin3A^k07401 progeny of a cross of EcR^E261st females to Sin3A^k07401 males survive to adulthood.

(Tsai et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Sin3A^unspecified

(Neufeld et al., 1998)

Sin3A⁰⁸²⁶⁹

(BDGP Project Members, 1994-1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Sin3A^k07401

dSin3A^K07401

(Tsai et al., 1999)

l(2)7401

(Neufeld et al., 1998, Pennetta and Pauli, 1998)

sin3^l(2)7401

(Rebay et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

Open Close