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General Information
Symbol
Dmel\Med15
Species
D. melanogaster
Name
FlyBase ID
FBal0086802
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C31614699T

Amino acid change:

A705V | Med-PA; A631V | Med-PB; A705V | Med-PC

Reported amino acid change:

A679V

Comment:

One of two amino acid changes reported in Med15 mutant.

point mutation
Nucleotide change:

C31614804A

Amino acid change:

T740K | Med-PA; T666K | Med-PB; T740K | Med-PC

Reported amino acid change:

T714K

Comment:

Site of nucleic acid difference in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: A679V. Amino acid replacement: T714K.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous adults do not have any obvious phenotypic abnormalities. Med11/Med15 flies have a large medial cleft in the notum. Legs show shortening of the femur and tibia and loss of the fourth and fifth tarsal segments. Med13/Med15 flies lack the posterior crossvein and have a large discontinuity in wing vein L4. Embryos derived from homozygous females mated to wild-type males die with a partially ventralised phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

Med15 has lethal | maternal effect phenotype, suppressible by Smurf15C/lack[+]

Med15 has lethal | maternal effect phenotype, suppressible by Smurf11R/lack[+]

Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Enhancer of
Statement
Reference

Med[+]/Med15 is an enhancer of phenotype of dpphr4

Suppressor of
Statement
Reference

Med[+]/Med15 is a suppressor | partially of denticle phenotype of sogY506

Other
Additional Comments
Genetic Interactions
Statement
Reference

The progeny from Med15/+ mothers and dpphr4/+ fathers present embryo ventralization in most cases and exhibit near lethality, as compared to controls; the progeny from Med15/+ mothers and either dpphr27/+, dpphr56/+ or dppe87/+ fathers exhibit lethality, as compared to controls.

Animals derived from homozygous Med15 females mated to dpphr4/+ males show strong lethality (less than 5% of the expected number survive).

Med15/+ partially suppresses the cuticle phenotype of sogY506 hemizygous embryos. The embryos have partially restored denticles, a normal body shape and misplaced, misshapen Filzkorper.

The severe loss of climbing ability in a negative geotaxis assay which is seen in Scgδ840 mutants is suppressed if the flies are also carrying Med15/+.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (10)