mutant flies carrying two copies of CtBPNAD.T:Zzzz\FLAG
show notched wings, while no phenotype is observed when these transgenes are present in a wild-type background or if only one copy of CtBPNAD.T:Zzzz\FLAG
heterozygous and CtBP03463
homozygous pharates display extra dorsal thoracic mechanosensory bristles (additional bristles attached to sockets) and, less frequently, double bristles (two bristles housed in the same socket structure) and bald cuticle (complete loss of both bristles and their associated sockets). Only a subset of bristles are affected.
homozygous wing discs contain two, instead of the normal one, sens
-positive posterior dorsocentral SOP cells.
Single cell class IV dendrite arborisation (da) neuron clones that are homozygous for CtBP03463
do not show defects in the establishment or maintenance of dendritic tiling.
2.7% of CtBP03463
heterozygotes show an extra macrochaete phenotype on the dorsal thorax.
The average number of crystal cells per embryo is reduced (to 13.3) in homozygous stage 13-14 embryos compared to wild type (36 +/- 2.2 cells on average).
When dissected from the pupal case homozygotes exhibit duplicated and ectopic bristles on the notum and scutellum. Loss of maternal CtBP
does not result in a neurogenic phenotype. Larval cuticles generated from germline mosaics exhibit a severely disrupted pattern: segmentation defects resulting in pair-wise fusions and large holes in the ventral cuticle.
Germline clones produce eggs with patterning defects: embryos exhibit ventral holes and segment fusion.