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General Information
Symbol
Dmel\CtBP03463
Species
D. melanogaster
Name
FlyBase ID
FBal0086957
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dCtBP03463, P1590, CtBPP1590
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
The P{PZ} insertion is 7353bp upstream of the putative ATG start codon.
P{PZ} insertion maps within the 5' untranslated intron, intron is located 37bp downstream of the 5' end of the largest CtBP cDNA.
P{PZ} insertion maps within the CtBP transcription unit.
Insertion components
P{PZ}CtBP03463
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
scutellum & macrochaeta | maternal effect
scutum & macrochaeta | maternal effect
Detailed Description
Statement
Reference
Heterozygous CtBP03463 mutant flies carrying two copies of CtBPNAD.T:Zzzz\FLAG show notched wings, while no phenotype is observed when these transgenes are present in a wild-type background or if only one copy of CtBPNAD.T:Zzzz\FLAG is present.
CtBP03463/CtBP87De-10 heterozygous and CtBP03463 homozygous pharates display extra dorsal thoracic mechanosensory bristles (additional bristles attached to sockets) and, less frequently, double bristles (two bristles housed in the same socket structure) and bald cuticle (complete loss of both bristles and their associated sockets). Only a subset of bristles are affected. CtBP03463 homozygous wing discs contain two, instead of the normal one, sens-positive posterior dorsocentral SOP cells.
Single cell class IV dendrite arborisation (da) neuron clones that are homozygous for CtBP03463 do not show defects in the establishment or maintenance of dendritic tiling.
2.7% of CtBP03463 heterozygotes show an extra macrochaete phenotype on the dorsal thorax.
The average number of crystal cells per embryo is reduced (to 13.3) in homozygous stage 13-14 embryos compared to wild type (36 +/- 2.2 cells on average).
CtBP03463/CtBP87De-10 pharate adults show bristle shaft defects and shaft loss.
When dissected from the pupal case homozygotes exhibit duplicated and ectopic bristles on the notum and scutellum. Loss of maternal CtBP does not result in a neurogenic phenotype. Larval cuticles generated from germline mosaics exhibit a severely disrupted pattern: segmentation defects resulting in pair-wise fusions and large holes in the ventral cuticle.
Germline clones produce eggs with patterning defects: embryos exhibit ventral holes and segment fusion.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
CtBP[+]/CtBP03463 is an enhancer of visible phenotype of upd1GMR.PB
CtBP03463 is an enhancer of visible phenotype of upd1GMR.PB
NOT Enhancer of
Statement
Reference
CtBP[+]/CtBP03463 is a non-enhancer of visible phenotype of upd11
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
CtBP[+]/CtBP03463 is a non-suppressor of visible phenotype of upd11
Phenotype Manifest In
Enhancer of
Statement
Reference
NOT Enhancer of
Statement
Reference
CtBP[+]/CtBP03463 is a non-enhancer of retina phenotype of Hsap\HTT128Q.1-336.UAS, Scer\GAL4GMR.PU
CtBP[+]/CtBP03463 is a non-enhancer of eye phenotype of upd11
Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference
CtBP[+]/CtBP03463 is a non-suppressor of eye phenotype of upd11
Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Sir205327a does not show a dominant synthetic lethal interaction with CtBP03463.
The partial lethality due to runScer\UAS.cLa; Scer\GAL4nos.PG (3% viable) is partially suppressed by maternal heterozygosity for CtBP03463 (rescues to 15% viable).
The pair-rule phenotype of h26/h30 embryos is suppressed by one maternal copy of CtBP03463. The enhancement of the pair-rule phenotype of h26/h30 embryos caused by one maternal copy of groE47 is reversed when one copy of CtBP03463 is also present maternally.
Embryos derived from mothers transheterozygous for RpII140wimp and CtBP03463 die and cuticle preparations of the embryos show segmentation defects ranging from pair-wise fusion of adjacent denticle belts to more widespread denticle fusions.
Xenogenetic Interactions
Statement
Reference
One copy of CtBP03463 does not enhance the retinal phenotype seen when Hsap\HTT128Q.1-336.Scer\UAS is expressed under the control of Scer\GAL4GMR.PU. One copy of CtBP03463 enhances the retinal phenotype seen when Hsap\ATXN182Q.Scer\UAS is expressed under the control of Scer\GAL4GMR.PU.
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
A. Spradling.
Comments
Comments
Mobilisation of the P{PZ} element demonstrates the insertion is responsible for the mutant phenotype.
Complements: l(3)j2C3j2C3. Complements: l(3)neo391. Complements: l(3)neo401.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (10)
References (38)