Allele Dmel\MRG15^j6A3

General Information
Symbol	Dmel\MRG15^j6A3	Species	D. melanogaster
Name		FlyBase ID	FBal0086983
Feature type	allele	Associated gene	Dmel\MRG15
Also Known As	l(3)j6A3

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	P-element activity (BDGP Project Members, 1994-1999)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 3R:11,103,522..11,103,522 (BDGP Project Members, 1994-1999, Spradling et al., 1999, Zraly et al., 2002, Qi et al., 2006, Joyce et al., 2011)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Insertion in the second exon, 174 nucleotides downstream of the ATG codon. (Qi et al., 2006)
Caused by insertion	P{lacW}MRG15^j6A3 (BDGP Project Members, 1994-1999, Spradling et al., 1999, Zraly et al., 2002, Qi et al., 2006, Joyce et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Spradling et al., 1999, Zraly et al., 2002, BDGP Project Members, 1994-1999) suppressor of variegation \| dominant, with T(1;4)w^m258-21 (Qi et al., 2006)
Phenotype Manifest In

Detailed Description
	Statement Reference MRG15[j6A3] mutant germline cells exhibit a complete absence of His2Av, both phosphorylated and unphosphorylated, throughout oogenesis. (Joyce et al., 2011)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Other
Statement Reference MRG15^j6A3, Pc[+]/Pc¹¹ has visible \| dominant phenotype (Qi et al., 2006) MRG15^j6A3, Psc[+]/Psc¹ has visible \| dominant phenotype (Qi et al., 2006)
Phenotype Manifest In
Other
Statement Reference MRG15^j6A3, Pc[+]/Pc¹¹ has mesothoracic leg & sex comb \| ectopic phenotype (Qi et al., 2006) MRG15^j6A3, Pc[+]/Pc¹¹ has metathoracic leg & sex comb \| ectopic phenotype (Qi et al., 2006) MRG15^j6A3, Psc[+]/Psc¹ has mesothoracic leg & sex comb \| ectopic phenotype (Qi et al., 2006) MRG15^j6A3, Psc[+]/Psc¹ has metathoracic leg & sex comb \| ectopic phenotype (Qi et al., 2006)
Additional Comments
Genetic Interactions
Statement Reference MRG15^j6A3 Pc¹¹ double heterozygous males have ectopic sex combs on the second and third legs (85% and 54% of flies respectively). Psc¹/+ ; MRG15^j6A3/+ double heterozygous males have ectopic sex combs on the second and third legs (38% and 11% of flies respectively). MRG15^j6A3 does not show an ectopic sex comb phenotype in either the second or third legs in double heterozygous combination with esc¹. (Qi et al., 2006)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	10290 y¹ w¹¹¹⁸; P{lacW}MRG15^j6A3/TM3, Sb¹
Kyoto	111041 y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}82B P{lacW}MRG15^j6A3/TM6B, P{Car20y}TPN1, Tb¹
Notes on Origin
Discoverer
	Separable from: a second site lethal mutation on the same chromosome. (Qi et al., 2006)
Comments
	Complements: Hsc70-4⁰³⁵⁵⁰. Complements: Hsc70-4^j1C1. (BDGP Project Members, 1994-1999)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	dMRG15^j6A3 (Qi et al., 2006) dMRG15^P (Qi et al., 2006) l(3)j6A3 (Zraly et al., 2002, Spradling et al., 1999) l(3)j6A3^j6A3 (BDGP Project Members, 1994-1999, ) MRG15^j6A3 (Cook et al., 2009.2.28, Joyce et al., 2011) MRG15^P{lacW}PJ6A3 (Pai et al., 2004)
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Joyce et al., 2011, J. Cell Biol. 195(3): 359--367 Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair. [FBrf0216489] Qi et al., 2006, Genetics 174(1): 241--251 Drosophila Reptin and other TIP60 complex components promote generation of silent chromatin. [FBrf0193464] Pai et al., 2004, Mol. Cell 16(5): 737--748 The Centrosomal Protein CP190 Is a Component of the gypsy Chromatin Insulator. [FBrf0180528] Zraly et al., 2002, Genetics 160(3): 1051--1065 Genetic and molecular analysis of region 88E9; 88F2 in Drosophila melanogaster, including the ear gene related to human factors involved in lineage-specific leukemias. [FBrf0147056] Spradling et al., 1999, Genetics 153(1): 135--177 The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489]
Supplementary material	Kusch et al., 2004, Science 306(5704): Supporting online material for; Acetylation by Tip60 Is Required for Selective Histone Variant Exchange at DNA Lesions. [FBrf0185743]
Personal communication to FlyBase	Cook et al., 2009.2.28, Isolation and characterization of Df(3R)BSC741. Isolation and characterization of Df(3R)BSC741. [FBrf0207396] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]

Allele Dmel\MRG15j6A3

Allele Dmel\MRG15^j6A3