Allele Dmel\Kr-h1^k05905

General Information
Symbol	Dmel\Kr-h1^k05905	Species	D. melanogaster
Name		FlyBase ID	FBal0087047
Feature type	allele	Associated gene	Dmel\Kr-h1
Also Known As	Kr-h⁶

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	P-element activity (BDGP Project Members, 1994-1999, Roch et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site 2L:6,083,084..6,083,084 (BDGP Project Members, 1994-1999, Beck et al., 2004, Pecasse et al., 2000, Roch et al., 1998)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference The P{lacW} insertion is at the 5' end of exon 1 of the Kr-h1α transcript. This allele also contains 6kb deletion 5' to exon 1, removing that exon and most of the first intron. (Beck et al., 2004) Insertion of P{lacW} into the first exon of the more extensive Kr-h1 transcript. (Pecasse et al., 2000)
Caused by insertion	P{lacW}Kr-h1^k05905 (BDGP Project Members, 1994-1999, Beck et al., 2004, Pecasse et al., 2000, Roch et al., 1998)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| larval stage \| recessive (Beck et al., 2004) lethal \| prepupal stage (with Kr-h1^7.1) (Beck et al., 2004) lethal \| prepupal stage (with Kr-h1^7id) (Beck et al., 2004) lethal \| prepupal stage (with Kr-h1^k04411) (Beck et al., 2004) lethal \| recessive (Pecasse et al., 2000, Roch et al., 1998) partially lethal - majority die \| dominant (Beck et al., 2004)
Phenotype Manifest In
	eye \| pharate adult stage (Pecasse et al., 2000) imaginal disc (Roch et al., 1998)
Detailed Description
	Statement Reference 18% of homozygotes die during embryogenesis while the rest die during the first larval instar. Kr-h1^k05905/Kr-h1^7.1, Kr-h1^k05905/Kr-h1^7id and Kr-h1^k05905,Kr-h1^k04411 animals die as prepupae. (Beck et al., 2004) The vast majority of homozygous animals show a lethal phenotype before head sac eversion. Mutant animals that have undergone head eversion die with the legs and wings apparent and translucent but with hypertrophied eye structures. In most cases necroses appear at one third body length and increase with time. (Pecasse et al., 2000) Lethality occurs during third instar larval or pupal stages. Mutants exhibit visible disc abnormalities. Heterozygotes are lethal over a Minute chromosome. (Roch et al., 1998)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	Kr-h1¹ (Pecasse et al., 2000) Kr-h1¹⁰⁶⁴² (BDGP Project Members, 1994-1999) Kr-h1^k04411 (Pecasse et al., 2000) Kr-h1^k05917 (BDGP Project Members, 1994-1999) Kr-h1^k06134 (Pecasse et al., 2000) Kr-h1^k12409a (Pecasse et al., 2000) Kr-h1^k12409b (Pecasse et al., 2000) Kr-h1^k16802 (Pecasse et al., 2000)
Comments
Stocks ( 1 )
Kyoto	102426 y¹ w^67c23 ; P{lacW}Kr-h1^k05905 / CyO
Notes on Origin
Discoverer	I. Kiss.

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	59/5 (Roch et al., 1998) Kr-h1^k05905 Kr-h⁶ (Beck et al., 2004, Pecasse et al., 2000) l(2)59/5 l(2)10642^k05905 Pow^k05905 (BDGP Project Members, 1994-1999, )
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Beck et al., 2004, Dev. Biol. 268(1): 64--75 Kruppel-homolog is essential for the coordination of regulatory gene hierarchies in early Drosophila development. [FBrf0174527] Pecasse et al., 2000, Dev. Biol. 221(1): 53--67 Kruppel-homolog, a stage-specific modulator of the prepupal ecdysone response, is essential for Drosophila metamorphosis. [FBrf0127270] Roch et al., 1998, Mol. Gen. Genet. 257(2): 103--112 Screening of larval/pupal P-element induced lethals on the second chromosome in Drosophila melanogaster: clonal analysis and morphology of imaginal discs. [FBrf0100624]
Personal communication to FlyBase	Beaton, 1999.12.12, Alleles of the lines in the P-element paper. Alleles of the lines in the P-element paper. [FBrf0125032] BDGP Project Members, 1994-1999, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. (Computer file) [FBrf0067338]

Allele Dmel\Kr-h1k05905

Allele Dmel\Kr-h1^k05905