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General Information
Symbol
Dmel\beat-Iatric-1
Species
D. melanogaster
Name
FlyBase ID
FBal0088571
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
No mutation in the coding region.
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Motoneuron development is not affected by beat-Iatric-1. Cells of the Bolwig's organs (BOs) form in homozygous embryos, but the morphology of the larval visual system (LVS) is severely disrupted and increased numbers of photoreceptor cells are apparent from the earliest stages of LVS development. Extra photoreceptor cells are seen both in the normal location of the BO clusters and dispersed between the two clusters. Embryos sometimes contain three BO's and, rarely, four BO clusters are seen. Migration of the BOs appears relatively normal in some embryos, but in others it is disrupted and the BO does not achieve its proper location even though head involution appears normal, or the BO is elongated. Larval visual system development occurs normally in 93% of beat-Iatric-1 embryos expressing beat-IaScer\UAS.cFa under the control of Scer\GAL4bi-omb-Gal4. However, a large number of these embryos fail to develop.
In a subset of embryos three distinct Bolwig's organs are seen.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
The defects in development of the LVS seen in both beat-Iatric-1 and Fas2e76 single mutants are partly suppressed in Fas2e76; beat-Iatric-1 double mutants; the LVS develops normally in the majority of double mutant embryos and the defects seen are relatively minor.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments
Mutants have Bolwig organ defects. Motoneurons are unaffected. The Bolwig organ defect is rescued by expression of beat-IaScer\UAS.cFa directed to the Bolwig organs or optic lobes. Fails to complement beat-Iaunspecified when the Bolwig organ phenotype is assessed.
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)