FlyBase Allele Report: Dmel\ds[UAO71]

Expression of ds^{ΔECD.Scer\UAS} under the control of Scer\GAL4^hh.PU in a ds^UAO71 mutant background produces wing disc tissue overgrowth, particularly in the hinge region.

(Degoutin et al., 2013)

ds^UAO71/ds⁰⁵¹⁴² mutant wings display abnormal morphology. The region between wing veins L4 and L5 of ds^UAO71/ds⁰⁵¹⁴² mutant wings retains wild-type hair polarity, but has primarily anterior-posterior ridges.

(Hogan et al., 2011)

ds^UAO71/ds^38k flies have abnormally shaped wings, but wing area is not much altered compared to controls. The flies have a planar polarity phenotype in the wing.

Flies expressing ds^{Act5C.T:Avic\GFP-EGFP} in a ds^UAO71/ds^38k background show a reduction in wing area compared to wild type.

Flies expressing ds^{SAx3.Act5C.T:Avic\GFP-EGFP} in a ds^UAO71/ds^38k background show a reduction in wing area compared to wild type.

(Brittle et al., 2010)

ds^38k/ds^UAO71 wings show a planar cell polarity phenotype; reverse orientation and swirling of wing hairs is seen in the proximal region of the wing with high penetrance.

ds^38k/ds^UAO71 animals show defects in the directional preferences of growing microtubules in mutant wing cells compared to wild type; growing microtubules fail to converge along the proximodistal axis as strongly as in wild type. The distally biased asymmetry of microtubule growth that is seen in the wild-type is substantially weakened in the mutant at the anterior crossvein and at the L3-1 location (position of the most proximal dorsal campaniform sensillum on vein L3) at 24 hours after puparium formation (APF). In addition, plus end-proximal microtubules are more abundant at the L3-3 location (position of the most distal dorsal campaniform sensillum on vein L3) in the mutants at 24 hours APF (microtubule polarity is symmetrical at this position in wild-type flies at this stage).

(Harumoto et al., 2010)

ds^UAO71 mutants exhibit largely depolarized denticle belts.

(Repiso et al., 2010)

ds^UAO71 larvae show mild wing disc overgrowth.

(Matakatsu and Blair, 2006)

Postmitotic orientation is randomized in ds^36D/ds^UAO71 clones in the wing disc.

(Baena-Lopez et al., 2005)

The orientation of cell division is randomized in ds^36D/ds^UAO71 mitotic clones in wing discs. Therefore, in contrast to wild-type postmitotic cells, ds^36D/ds^UAO71 postmitotic cells do not show any preferential orientation. Mitotic recombination clones in ds^36D/ds^UAO71 mutant wings show a rounded shape, instead of the elongated shape seen in wild-type clones. At the adult stage, ds^36D/ds^UAO71 wings are shorter, rounder and wider than wild type. Likewise, ds^36D/ds^UAO71 mitotic clones in eye discs show a defective shape and preferential orientations of cell divisions are lost. Resulting adult eyes are rounder than wild type. ds^36D/ds^UAO71 flies also have shorter, wider legs than wild-type flies.

(Baena-Lopez et al., 2005)

Occasionally in ds^38k/ds^UAO71 escapers, the wing is replaced by a winglet and, posterior to it, a lateral protuberance that looks like an scutum and scutellum. The winglet is composed of proximal anterior structures arranged in a mirror-image duplication. The smallest examples of these winglets consist of a mirror image duplication of anterior hinge structures - the tegula and humeral sclerite. Larger examples also have a rudimentary wing blade consisting of a mirror image duplication of anterior structures - the costa and anterior wing margin.

(Rodriguez, 2004)

ds^38k/ds^UAO71 flies have disorganised ommatidial polarity; no obvious equator is present. Flies expressing ds^{Scer\UAS.P\T.cSa} under the control of Scer\GAL4^αTub84B.PL in a ds^38k/ds^UAO71 background have a normal overall pattern of polarisation in the eye; an equator can easily be discerned. 97.6% of ommatidia are correctly constructed and rotated in these animals. Expression of ds^{Scer\UAS.P\T.cSa} under the control of Scer\GAL4^fj-VG1 in a ds^38k/ds^UAO71 background results in eyes with disorganised ommatidial polarity.

(Simon, 2004)

Planar polarity is disrupted in ds^UAO71 eyes; dorsal and ventral ommatidia are intermixed and no obvious equatorial line can be drawn.

Homozygous clones in the eye can non-autonomously affect the planar polarity of wild-type ommatidia on the equatorial side of the clone. Polarity is also affected within the clone.

(Fanto et al., 2003)

In the abdomen of ds^UAO71 mutant flies, the anterior parts of the anterior compartments are fairly normal, but much of the rest of the anterior and posterior compartments is affected by whorls. In addition, hair orientation in the back half of the P compartments, both dorsal and ventral, is reversed In the tergites, ds^UAO71 somatic clones are characterized by whorling hairs within the clone. In the anterior compartments clones cause some swirly repolarization of the hairs in front of the clone, but not behind. In the posterior compartments clones induce clear reversal of hairs behind the clone without affecting the front. Those clones situated at the compartment boundary reorient hairs outside the clone, both anterior to the clone and posterior to it. Hairs within the clone are more whorly than with fj expressing clones.

(Casal et al., 2002)

The wings of ds^33k/ds^UAO71 animals have a trichome swirling pattern that is distinct from that due to fz¹⁵/fz²⁵. In ds^33k/ds^UAO71 wings, trichomes form on cell edges. The dorsal-ventral polarity of ommatidia in ds^38k/ds^UAO71 flies is partially randomised. Defects in anterior-posterior ommatidial polarity or randomised rotation are not seen.

(Strutt and Strutt, 2002)

About 40% of ommatidia in homozygous mutant clones show reversed polarity. When homozygous mutant clones are made specifically in the equatorial R3/R4 precursor, almost all (87%) of the consequent ommatidia are in the wild-type polarity. When clones are made specifically in the polar R3/R4 precursor, about half (43%) of the consequent ommatidia are in the reverse polarity. The mutant photoreceptor precursor eventually becomes an R3 photoreceptor 68% of the time (50% in wild-type). The eyes of homozygous mutant or ds^UAO71/ds^38k escapers have eyes with ommatidia that randomly adopt either dorsal or ventral polarity. Homozygous ds^UAO71 mutant clones also display ommatidial polarity defects, both within the clone and in neighbouring wild-type tissue along the equatorial border of the clone.

(Yang et al., 2002)

Homozygous clones in the wing have a tissue polarity phenotype. Rare homozygous adult flies have shortened wings with misplaced and severely eroded crossveins, a short fat body and severely distorted legs. ds^33k/ds^UAO71 flies have reduced viability, with only approximately half the expected number of adults emerging. Most of the adults that emerge quickly get stuck in the food and die. These flies also have a severely distorted body shape. ds^33k/ds^UAO71 flies have a wing tissue polarity phenotype similar to that of ds^UAO71 homozygotes and hemizygotes. There is a region at the anterior margin with a swirl of partially reversed polarity hairs. In the anterior/central proximal part of the wing blade there are regions of completely reversed polarity (hairs pointing proximally). These regions are separated from regions of relatively normal polarity by a region of swirling. The polarity disruptions are more severe on the ventral surface of the wing than the dorsal surface. Prehairs initiate in the vicinity of the distal vertex of the wing cells (as in wild-type) in wing regions of ds^33k/ds^UAO71 flies that do not show substantial polarity alterations. In most regions with abnormal polarity, prehairs initiate at an alternative location along the cell periphery. In the regions with reversed polarity, prehairs initiate at the proximal-most vertex, while in regions where hair polarity is close to random and in the regions at the centre of swirls, prehairs initiate in the central regions of the cells. Approximately half the wings of ds^UAO71/ds¹ flies have a very weak tissue polarity phenotype, consisting of a couple of multiple hair cells and/or a small region of polarity disruption in the proximal part of the wing.

(Adler et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^αTub84B.PL, ds^UAO71, ft¹⁵, ft^UAS.cMa has abnormal planar polarity | cell non-autonomous | somatic clone phenotype, enhanceable | somatic clone by fj^UAS.cZa/Scer\GAL4^αTub84B.PL

(Brittle et al., 2010)

ds^UAO71 has abnormal planar polarity phenotype, enhanceable by ft¹⁵

(Repiso et al., 2010)

ds¹/ds^UAO71 has abnormal planar polarity phenotype, enhanceable by fj^d1/fj^d1

(Strutt et al., 2004)

NOT Enhanced by

Statement

Reference

ds^UAO71 has abnormal planar polarity phenotype, non-enhanceable by Scer\GAL4^ptc-559.1/fz^UAS.cZa

(Repiso et al., 2010)

Suppressed by

Statement

Reference

ds^UAO71, ft⁸/ft^G-rv has increased size | larval stage phenotype, suppressible by dachs^GC13

(Matakatsu and Fehon, 2024)

ds^UAO71, ft⁸/ft^G-rv has increased size | larval stage phenotype, suppressible | partially by app^12-3/app^12-3

(Matakatsu and Fehon, 2024)

ds^UAO71, ft⁸/ft^G-rv has increased size | larval stage phenotype, suppressible | partially by Dlish^Y003/Dlish^Y003

(Matakatsu and Fehon, 2024)

Scer\GAL4^hh.PU, ds^ΔECD.UAS, ds^UAO71 has increased cell number phenotype, suppressible | partially by wap^RNAi.UAS.cUa/Scer\GAL4^hh.PU

(Degoutin et al., 2013)

ds^38k/ds^UAO71 has increased size | adult stage phenotype, suppressible by dachs¹/dachs^GC13

(Brittle et al., 2012)

ds^38k/ds^UAO71 has abnormal planar polarity | adult stage phenotype, suppressible | partially by dachs¹/dachs^GC13

(Brittle et al., 2012)

Scer\GAL4^αTub84B.PL, ds^UAO71, ds^ecto.UAS, ft¹⁵ has abnormal planar polarity | somatic clone | cell non-autonomous phenotype, suppressible | somatic clone by fj^UAS.cZa/Scer\GAL4^αTub84B.PL

(Brittle et al., 2010)

ds^UAO71 has visible | recessive phenotype, suppressible by fz^I.hs

(Adler et al., 1998)

Enhancer of

Statement

Reference

ds^UAO71/ds^UAO71 is an enhancer of increased size | larval stage phenotype of ft⁸/ft^G-rv

(Matakatsu and Fehon, 2024)

ds^UAO71/ds[+] is an enhancer of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

ds^UAO71 is an enhancer of abnormal planar polarity phenotype of ft¹²/ft¹⁵

(Repiso et al., 2010)

ds^UAO71 is an enhancer of abnormal size | third instar larval stage phenotype of ft⁸/ft^G-rv

(Matakatsu and Blair, 2006)

ds¹/ds^UAO71 is an enhancer of abnormal planar polarity phenotype of fj^d1

(Strutt et al., 2004)

NOT Enhancer of

Statement

Reference

ds^UAO71/ds^YAC41 is a non-enhancer of visible | adult stage phenotype of in^IH56

(Wang et al., 2017)

ds^UAO71/ds^YAC41 is a non-enhancer of abnormal planar polarity | adult stage phenotype of in^IH56

(Wang et al., 2017)

ds^38k/ds^UAO71 is a non-enhancer of abnormal planar polarity | adult stage phenotype of dachs¹/dachs^GC13

(Brittle et al., 2012)

Suppressor of

Statement

Reference

ds^UAO71 is a suppressor of abnormal cell polarity | somatic clone phenotype of ft^G-rv

(Yang et al., 2002)

NOT Suppressor of

Statement

Reference

ds^38k/ds^UAO71 is a non-suppressor of abnormal planar polarity | adult stage phenotype of dachs¹/dachs^GC13

(Brittle et al., 2012)

Other

Statement

Reference

ds::Hsap\DCHS1^CrDCHS1:V5, ds^UAO71 has visible | adult stage phenotype

(Tripathi and Irvine, 2024)

ds::Hsap\DCHS1^CrDCHS1:V5, ds^UAO71 has abnormal planar polarity | adult stage phenotype

(Tripathi and Irvine, 2024)

ds::Hsap\DCHS1^CrDCHS1:V5, ds^UAO71 has abnormal size | adult stage phenotype

(Tripathi and Irvine, 2024)

Scer\GAL4^αTub84B.PL, ds^UAO71, ds^ecto.UAS, ft¹⁵ has abnormal planar polarity | somatic clone | cell non-autonomous phenotype

(Brittle et al., 2010)

Scer\GAL4^αTub84B.PL, ds^UAO71, ft¹⁵, ft^UAS.cMa has abnormal planar polarity | somatic clone | cell non-autonomous phenotype

(Brittle et al., 2010)

ds^UAO71/Df(2L)ED94, lft^TG2 has lethal phenotype

(Mao et al., 2009)

ds^38k/ds^UAO71, fj^N7/fj^d1 has abnormal planar polarity phenotype

(Simon, 2004)

ds¹/ds^UAO71, fj^d1 has abnormal planar polarity phenotype

(Strutt et al., 2004)

ds^UAO71, fj^N7 has abnormal cell polarity | somatic clone phenotype

(Yang et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^αTub84B.PL, ds^UAO71, ft¹⁵, ft^UAS.cMa has trichome & tergite | cell non-autonomous | somatic clone phenotype, enhanceable | somatic clone by fj^UAS.cZa/Scer\GAL4^αTub84B.PL

(Brittle et al., 2010)

ds^UAO71 has ventral denticle belt phenotype, enhanceable by ft¹⁵

(Repiso et al., 2010)

ds^UAO71 has denticle row 5 phenotype, enhanceable by ft¹⁵

(Repiso et al., 2010)

ds^UAO71 has denticle row 6 phenotype, enhanceable by ft¹⁵

(Repiso et al., 2010)

ds¹/ds^UAO71 has wing phenotype, enhanceable by fj^d1/fj^d1

(Strutt et al., 2004)

Suppressed by

Statement

Reference

ds^UAO71, ft⁸/ft^G-rv has wing disc phenotype, suppressible by dachs^GC13

(Matakatsu and Fehon, 2024)

ds^UAO71, ft⁸/ft^G-rv has wing disc phenotype, suppressible | partially by app^12-3/app^12-3

(Matakatsu and Fehon, 2024)

ds^UAO71, ft⁸/ft^G-rv has wing disc phenotype, suppressible | partially by Dlish^Y003/Dlish^Y003

(Matakatsu and Fehon, 2024)

Scer\GAL4^hh.PU, ds^ΔECD.UAS, ds^UAO71 has wing disc phenotype, suppressible | partially by wap^RNAi.UAS.cUa/Scer\GAL4^hh.PU

(Degoutin et al., 2013)

ds^38k/ds^UAO71 has wing hair phenotype, suppressible | partially by dachs¹/dachs^GC13

(Brittle et al., 2012)

ds^38k/ds^UAO71 has wing phenotype, suppressible | partially by dachs¹/dachs^GC13

(Brittle et al., 2012)

ds^38k/ds^UAO71 has ommatidium | adult stage phenotype, suppressible | partially by dachs¹/dachs^GC13

(Brittle et al., 2012)

Scer\GAL4^αTub84B.PL, ds^UAO71, ds^ecto.UAS, ft¹⁵ has trichome & tergite | cell non-autonomous | somatic clone phenotype, suppressible | somatic clone by fj^UAS.cZa/Scer\GAL4^αTub84B.PL

(Brittle et al., 2010)

ds^UAO71 has photoreceptor cell R3 | somatic clone phenotype, suppressible by fj^N7

(Yang et al., 2002)

ds^UAO71 has photoreceptor cell R4 | ectopic | somatic clone phenotype, suppressible by fj^N7

(Yang et al., 2002)

ds^UAO71 has wing phenotype, suppressible by fz^I.hs

(Adler et al., 1998)

ds^UAO71 has wing hair phenotype, suppressible by fz^I.hs

(Adler et al., 1998)

Enhancer of

Statement

Reference

ds^UAO71/ds^UAO71 is an enhancer of wing disc phenotype of ft⁸/ft^G-rv

(Matakatsu and Fehon, 2024)

ds^UAO71/ds[+] is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

ds^UAO71 is an enhancer of ventral denticle belt phenotype of ft¹²/ft¹⁵

(Repiso et al., 2010)

ds^UAO71 is an enhancer of denticle row 5 phenotype of ft¹²/ft¹⁵

(Repiso et al., 2010)

ds^UAO71 is an enhancer of denticle row 6 phenotype of ft¹²/ft¹⁵

(Repiso et al., 2010)

ds^UAO71 is an enhancer of wing disc phenotype of ft⁸/ft^G-rv

(Matakatsu and Blair, 2006)

ds¹/ds^UAO71 is an enhancer of wing phenotype of fj^d1

(Strutt et al., 2004)

ds^UAO71/ds[+] is an enhancer of crossvein phenotype of fj^{t14.Tag:Golgi(hGALNT3)}

(Strutt et al., 2004)

ds^UAO71/ds[+] is an enhancer of wing phenotype of fj^{t14.Tag:Golgi(hGALNT3)}

(Strutt et al., 2004)

ds^UAO71 is an enhancer of phenotype of fz^unspecified

(Adler et al., 1998)

NOT Enhancer of

Statement

Reference

ds^UAO71/ds^YAC41 is a non-enhancer of abdominal sternite bristle phenotype of in^IH56

(Wang et al., 2017)

ds^38k/ds^UAO71 is a non-enhancer of wing hair phenotype of dachs¹/dachs^GC13

(Brittle et al., 2012)

ds^38k/ds^UAO71 is a non-enhancer of wing | proximal phenotype of dachs¹/dachs^GC13

(Brittle et al., 2012)

ds^UAO71/ds[+] is a non-enhancer of wing hair phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

ds^UAO71 is a non-enhancer of interommatidial bristle | somatic clone phenotype of ft⁴²²

(Willecke et al., 2006)

ds^UAO71 is a non-enhancer of pigment cell | somatic clone phenotype of ft⁴²²

(Willecke et al., 2006)

ds^UAO71 is a non-enhancer of eye | somatic clone phenotype of ft⁴²²

(Willecke et al., 2006)

Suppressor of

Statement

Reference

ds^UAO71 is a suppressor | partially of wing disc phenotype of Scer\GAL4^hh-Gal4, ft^{ΔICD.UAS.Tag:HA}

(Matakatsu and Blair, 2012)

ds^UAO71 is a suppressor of ommatidium | somatic clone phenotype of ft^G-rv

(Yang et al., 2002)

ds^UAO71 is a suppressor of photoreceptor cell R3 | somatic clone phenotype of ft^G-rv

(Yang et al., 2002)

ds^UAO71 is a suppressor of photoreceptor cell R4 | ectopic | somatic clone phenotype of ft^G-rv

(Yang et al., 2002)

NOT Suppressor of

Statement

Reference

ds^38k/ds^UAO71 is a non-suppressor of wing hair phenotype of dachs¹/dachs^GC13

(Brittle et al., 2012)

ds^38k/ds^UAO71 is a non-suppressor of wing | proximal phenotype of dachs¹/dachs^GC13

(Brittle et al., 2012)

ds^UAO71/ds[+] is a non-suppressor of wing hair phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Weber et al., 2012)

Other

Statement

Reference

ds::Hsap\DCHS1^CrDCHS1:V5, ds^UAO71 has wing phenotype

(Tripathi and Irvine, 2024)

ds::Hsap\DCHS1^CrDCHS1:V5, ds^UAO71 has leg phenotype

(Tripathi and Irvine, 2024)

ds::Hsap\DCHS1^CrDCHS1:V5, ds^UAO71 has posterior crossvein phenotype

(Tripathi and Irvine, 2024)

ds::Hsap\DCHS1^CrDCHS1:V5, ds^UAO71 has crossvein phenotype

(Tripathi and Irvine, 2024)

ds::Hsap\DCHS1^CrDCHS1:V5, ds^UAO71 has adult hindgut phenotype

(Tripathi and Irvine, 2024)

ds::Hsap\DCHS1^CrDCHS1:V5, ds^UAO71 has segment of leg | decreased number phenotype

(Tripathi and Irvine, 2024)

Scer\GAL4^αTub84B.PL, ds^UAO71, ds^ecto.UAS, ft¹⁵ has trichome & tergite | somatic clone | cell non-autonomous phenotype

(Brittle et al., 2010)

Scer\GAL4^αTub84B.PL, ds^UAO71, ft¹⁵, ft^UAS.cMa has trichome & tergite | somatic clone | cell non-autonomous phenotype

(Brittle et al., 2010)

ds^38k/ds^UAO71, fj^N7/fj^d1 has wing blade phenotype

(Simon, 2004)

ds¹/ds^UAO71, fj^d1 has ommatidium phenotype

(Strutt et al., 2004)

ds¹/ds^UAO71, fj^d1 has wing hair phenotype

(Strutt et al., 2004)

ds¹/ds^UAO71, fj^d1 has posterior crossvein phenotype

(Strutt et al., 2004)

ds^UAO71, fj^N7 has ommatidium | somatic clone phenotype

(Yang et al., 2002)

ds^UAO71, fj^N7 has photoreceptor cell R3 | somatic clone phenotype

(Yang et al., 2002)

ds^UAO71, fj^N7 has photoreceptor cell R4 | ectopic | somatic clone phenotype

(Yang et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

in^IH56;ds^YAC41/ds^UAO71 double mutant adults display hair polarity defects in abdominal bristles that are similarly severe as in in^IH56 single mutants.

(Wang et al., 2017)

Expression of wap^VDRC.cUa substantially suppresses the wing disc morphological defects seen when ds^{ΔECD.Scer\UAS} is expressed under the control of Scer\GAL4^hh.PU in a ds^UAO71 mutant background.

(Degoutin et al., 2013)

The overgrowth of the wing disc caused by expression of ft^{ΔICD.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^hh-Gal4 is partially suppressed in a ds^UAO71 background.

(Matakatsu and Blair, 2012)

ds^UAO71/+ enhances the ommatidial rotation defects induced by the overexpression of dgo^Scer\UAS.cFa under the control of Scer\GAL4^hs.2sev.

(Weber et al., 2012)

ds^UAO71 ft¹⁵ double mutant clones in the dorsal adult abdomen where the clones are also expressing ds^{ecto.Scer\UAS} under the control of Scer\GAL4^αTub84B.PL strongly repolarise hairs behind the clone, reversing their polarity (100% of clones repolarise with a maximum range of up to seven cells). This repolarisation is largely suppressed by co-expression of fj^Scer\UAS.cZa within the clone (48% of clones show some repolarisation with a range of one to three cells).

ds^UAO71 ft¹⁵ double mutant clones in the dorsal adult abdomen where the clones are also expressing ft^Scer\UAS.cMa under the control of Scer\GAL4^αTub84B.PL cause repolarisation in front of the clones, so that hairs point away from the clone (64% of clones repolarise with a maximum range of seven cells). Co-expression of fj^Scer\UAS.cZa within these clones strengthens the repolarisation (95% of clones repolarise with a maximum range of seven cells).

Adding fj^p1/fj^d1 has little effect on the wing area of ds^UAO71/ds^38k flies.

Adding fj^p1/fj^d1 dramatically reduces the wing area of flies expressing ds^{Act5C.T:Avic\GFP-EGFP} in a ds^UAO71/ds^38k background.

Adding fj^p1/fj^d1 has no effect on the wing area of flies expressing ds^{SAx3.Act5C.T:Avic\GFP-EGFP} in a ds^UAO71/ds^38k background.

Adding fj^p1/fj^d1 has no effect on the wing area of flies expressing ds^{SDx3.Act5C.T:Avic\GFP-EGFP} in a ds^UAO71/ds^38k background.

(Brittle et al., 2010)

ds^UAO71 ft¹⁵ double mutants exhibit largely depolarized denticle belts (with rows 5 and 6 more disturbed than in ds^UAO71 mutants). In addition to the orientation defects, the rows partially lose their distinctive characteristics.

Expression of fz^Scer\UAS.cZa in ds^UAO71 larvae under the control of Scer\GAL4^ptc-559.1 does not affect denticle belt polarity.

(Repiso et al., 2010)

ds^UAO71, ft^G-rv/ft⁸ double mutant larvae show an enhancement of the wing disc overgrowth phenotype of ft^G-rv/ft⁸ single mutants.

(Matakatsu and Blair, 2006)

ds^UAO71 mutants do not significantly enhance the extra ommatidial cell phenotype of ft⁴²² mutants.

(Willecke et al., 2006)

ds^38k fj^N7/ds^UAO71 fj^d1 flies have disorganised ommatidial polarity; no obvious equator is present. Flies expressing both fj^Scer\UAS.cZa and ds^{Scer\UAS.P\T.cSa} under the control of Scer\GAL4^αTub84B.PL in a ds^38k fj^N7/ds^UAO71 fj^d1 background have a disorganised ommatidial polarity; no obvious equator is present. Flies expressing ds^{Scer\UAS.P\T.cSa} under the control of Scer\GAL4^αTub84B.PL in a ds^38k fj^N7/ds^UAO71 fj^d1 background have a disorganised ommatidial polarity; no obvious equator is present. Flies expressing fj^Scer\UAS.cZa under the control of Scer\GAL4^αTub84B.PL in a ds^38k fj^N7/ds^UAO71 fj^d1 background have a disorganised ommatidial polarity; no obvious equator is present. Flies expressing ds^{Scer\UAS.P\T.cSa} under the control of Scer\GAL4^fj-VG1 in a ds^UAO71 fj^VG1/ds^38k fj^N7 background have a disorganised ommatidial polarity; the eye contains a clearly perceptible equator in which most of the nearby ommatidia are reversed in polarity and thus point away from the equator. Flies expressing both fj^Scer\UAS.cZa and ds^{Scer\UAS.P\T.cSa} under the control of Scer\GAL4^αTub84B.PL in a ds^38k fj^N7/ds^UAO71 fj^d1 background have normal polarity throughout the wing blade with the exception of a small region along the anterior proximal margin of the wing, where a small swirl is often present. Flies expressing ds^{Scer\UAS.P\T.cSa} under the control of Scer\GAL4^αTub84B.PL in a ds^38k fj^N7/ds^UAO71 fj^d1 background have normal polarity throughout the wing blade with the exception of a small region along the anterior proximal margin of the wing, where a small swirl is often present.

(Simon, 2004)

Unlike either single mutant, 'fj^d1 ds¹/fj^d1 ds^UAO71' flies completely lack a posterior crossvein and have defects in wing hair polarity. 16% of ommatidia in these double mutants are inverted compared to less than 1% in either single mutant. The number of ommatidial inversions in ds¹/ds^UAO71 flies is also enhanced by fj^unspecified/+. Reduction in the distance between anterior and posterior cross-veins in fj^{t14.T:Hsap\GALNT3} flies is enhanced by ds^UAO71/+.

(Strutt et al., 2004)

When ft^G-rv/ds^UAO71 homozygous mutant clones are made specifically in the equatorial R3/R4 precursor, most (64%) of the consequent ommatidia are in the reverse polarity. When clones are made specifically in the polar R3/R4 precursor, almost all (97.5%) of the consequent ommatidia are in the wild-type polarity. The mutant photoreceptor precursor eventually becomes an R4 photoreceptor 80% of the time (50% in wild-type). When ds^UAO71 homozygous mutant clones are made specifically in the equatorial R3/R4 precursors of fj^N7 mutant flies, almost all (92%) of the consequent ommatidia are in the wild-type polarity. When clones are made specifically in the polar R3/R4 precursor, most (73%) of the consequent ommatidia are in the reverse polarity. The mutant photoreceptor precursor eventually becomes an R3 photoreceptor 85% of the time (50% in wild-type). When fj^N7 homozygous mutant clones are made in the R3/R4 precursors of ds^UAO71 mutant flies, The mutant photoreceptor precursor eventually becomes an R3 photoreceptor half of the time (50% in wild-type). When fj^N7 homozygous mutant clones are made in the R3/R4 precursors of ds^UAO71 mutant flies, The mutant photoreceptor precursor eventually becomes an R3 photoreceptor half of the time (50% in wild-type).

(Yang et al., 2002)

The distinctive ds polarity phenotype of ds^33k/ds^UAO71 flies (regions of reversed polarity on the wing) is suppressed by expression of fz^I.hs 24 hours after white prepupa formation using a 1 hour heat shock. The appendage shape abnormalities and wing vein placement abnormalities are not suppressed. The domineering nonautonomy of fz¹ clones is enhanced by ds^UAO71/ds^33k.

(Adler et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

ds¹

(Adler et al., 1998)

ds^33k

(Adler et al., 1998)

Partially rescued by

ds^38k/ds^UAO71 is partially rescued by ds^Act5C.EGFP

(Brittle et al., 2010)

Comments

The planar polarity defects seen in the wings of ds^UAO71/ds^38k animals are almost completely rescued by ds^{Act5C.T:Avic\GFP-EGFP}.

(Brittle et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

41784

w^*; ds^UAO71 P{neoFRT}40A/T(2;3)SM6a-TM6B, Tb¹

Notes on Origin

Discoverer

Separable from: TBCD¹

(Okumura et al., 2015)

The DL1 olfactory projection neuron (PN) defects observed on the ds^UAO71 chromosome are caused by a second-site mutation, TBCD¹ : a ds rescue construct is unable to rescue the construct, the PN phenotypes and ds mutation can be genetically segregated using meiotic recombination, and another strong ds mutant does not show any defects in PN morphology.

(Okumura et al., 2015)

Comments

Analysis of ds^33k/ds^UAO71 clones shows that ds displays domineering cell nonautonomy.

(Adler et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

ds⁰⁷¹

(Vrabioiu and Struhl, 2015)

ds^UA

(Rodrigues-Campos and Thompson, 2014)

ds^UAO71

(Matakatsu and Fehon, 2024, Ayukawa et al., 2022, Wang et al., 2017, Kahsai et al., 2016, Okumura et al., 2015, Degoutin et al., 2013, Krzemien et al., 2012, Matakatsu and Blair, 2012, Harumoto et al., 2010, Repiso et al., 2010, Mao et al., 2006, Matakatsu and Blair, 2006, Willecke et al., 2006, Fanto et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (45)

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