Allele Dmel\cora⁶

General Information
Symbol	Dmel\cora⁶	Species	D. melanogaster
Name		FlyBase ID	FBal0089376
Feature type	allele	Associated gene	Dmel\cora
Also Known As	cor⁶

Map ( GBrowse )
Allele class	antimorphic allele - genetic evidence, hypomorphic allele - genetic evidence
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	antimorphic allele - genetic evidence (Lamb et al., 1998) hypomorphic allele - genetic evidence (Ward et al., 1998)
Mutagen	ethyl methanesulfonate (Lamb et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2R:15,123,136..15,123,136 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental pr_change=L39Q\|cora-PA,L39Q\|cora-PB,L39Q\|cora-PD,L39Q\|co ra-PC reported_pr_change=L39Q na_change=T15123136A (Fehon et al., 1994)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: L39Q. (Ward et al., 2001) Amino acid replacement: L39Q. L39Q falls in the conserved amino-terminal region. (Ward et al., 1998)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Lamb et al., 1998)
Phenotype Manifest In
	embryonic/first instar larval cuticle (Lamb et al., 1998) embryonic/first instar larval cuticle \| dorsal (Lamb et al., 1998) embryonic/larval salivary gland \| embryonic stage (Lamb et al., 1998)
Detailed Description
	Statement Reference Homozygous embryos have a highly penetrant anterior open phenotype. Hemizygous embryos have a dorsal hole phenotype. The remains of the salivary glands are present as necrotic material. No adult escapers are produced. (Lamb et al., 1998)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference cora⁶ is a suppressor of visible \| dominant phenotype of Egfr^E1 (Lamb et al., 1998)
Phenotype Manifest In
Suppressor of
Statement Reference cora⁶ is a suppressor of eye phenotype of Egfr^E1 (Lamb et al., 1998)
Additional Comments
Genetic Interactions
Statement Reference Dominantly suppresses the rough eye phenotype of Egfr^E1/+ heterozygotes; the eye is smaller than wild type with some roughening. (Lamb et al., 1998)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	cora¹ (Lamb et al., 1998) cora² (Lamb et al., 1998) cora¹⁵ (Lamb et al., 1998)
Partially rescued by	cora⁶ is partially rescued by cora^1.Ubi-p63E (Lamb et al., 1998)
Not rescued by	cora⁶ is not rescued by cora^{1-383.Scer\UAS.T:Hsap\MYC}/Scer\GAL4^T80 (Ward et al., 2001)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	cor⁶ (Ward et al., 2001, Lamb et al., 1998, Ward et al., 1998) cora⁶
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Ward et al., 2001, Genetics 159(1): 219--228 The Protein 4.1, Ezrin, Radixin, Moesin (FERM) Domain of Drosophila Coracle, a Cytoplasmic Component of the Septate Junction, Provides Functions Essential for Embryonic Development and Imaginal Cell Proliferation. [FBrf0138412] Lamb et al., 1998, Mol. Biol. Cell 9(12): 3505--3519 Drosophila coracle, a member of the protein 4.1 superfamily, has essential structural functions in the septate junctions and developmental functions in embryonic and adult epithelial cells. [FBrf0105869] Ward et al., 1998, J. Cell Biol. 140(6): 1463--1473 A conserved functional domain of Drosophila coracle is required for localization at the septate junction and has membrane-organizing activity. [FBrf0102020] Fehon et al., 1994, Development 120(3): 545--557 A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene. [FBrf0073060]

Allele Dmel\cora6

Allele Dmel\cora⁶