Allele Dmel\Dsp1^EP355

General Information
Symbol	Dmel\Dsp1^EP355	Species	D. melanogaster
Name		FlyBase ID	FBal0089430
Feature type	allele	Associated gene	Dmel\Dsp1

Map ( GBrowse )	Untitled Document
Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (Rorth et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References transposable element insertion site X:16,227,667..16,227,667 (Rorth et al., 1998, Zhu et al., 2005, Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001, Cao et al., 2008)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference The P{EP} element is inserted within the 5' UTR. (Kraut et al., 2001)
Caused by insertion	P{EP}Dsp1^EP355 (Rorth et al., 1998, Zhu et al., 2005, Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001, Cao et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective \| larval stage, with Scer\GAL4^elav-C155 (Kraut et al., 2001) visible, with Scer\GAL4^ap-md544 (Pena-Rangel et al., 2002) visible, with Scer\GAL4^GMR.PF (Mueller et al., 2005)
Phenotype Manifest In
	adult thorax \| dorsal, with Scer\GAL4^ap-md544 (Pena-Rangel et al., 2002) anterior fascicle & synapse, with Scer\GAL4^elav-C155 (Kraut et al., 2001) eye, with Scer\GAL4^GMR.PF (Mueller et al., 2005) intersegmental nerve, with Scer\GAL4^elav-C155 (Kraut et al., 2001) scutellum, with Scer\GAL4^ap-md544 (Pena-Rangel et al., 2002) wing, with Scer\GAL4^ap-md544 (Pena-Rangel et al., 2002)
Detailed Description
	Statement Reference Expression using Scer\GAL4[ey.PU] does not induce a rough eye phenotype. (Cao et al., 2008) Mutant flies show a higher bacterial clearance activity than do control flies after injection with E.coli. Mutant flies show a lower survival rate after infection with E.coli than do control flies. (Kim et al., 2007) Expression of Dsp1^EP355 under the control of Scer\GAL4^GMR.PF results in a weak rough eye phenotype. (Mueller et al., 2005) Flies expressing Dsp1^EP355 under the control of Scer\GAL4^ap-md544 have a strong thoracic cleft and a deformed scutellum and wings. (Pena-Rangel et al., 2002) Mutant larvae expressing Dsp1^EP355 under the control of Scer\GAL4^elav-C155 have ISN neuron pathfinding defects. Mutant larvae expressing Dsp1^EP355 under the control of Scer\GAL4^elav-C155 have reduced or abnormal synapses. (Kraut et al., 2001)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference Dsp1^EP355, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Rac1^N17.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Dsp1^EP355/Scer\GAL4^pnr-MD237 is an enhancer of visible phenotype of pnr^MD237 (Pena-Rangel et al., 2002)
NOT Enhancer of
Statement Reference Dsp1^EP355, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Cdc42^L89.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Dsp1^EP355, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, btl::Egfr^{Scer\UAS.T:λ\cI-DD} (Zhu et al., 2005)
Suppressor of
Statement Reference Dsp1^EP355, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a suppressor of visible phenotype of H^Scer\UAS.cMa/H^Scer\UAS.cMa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mueller et al., 2005) Dsp1^EP355, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, btl^{Scer\UAS.T:λ\cI-DD}, stumps^{Scer\UAS.T:Zzzz\FLAG} (Zhu et al., 2005)
NOT Suppressor of
Statement Reference Dsp1^EP355, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Cdc42^L89.Scer\UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Zhu et al., 2005) Dsp1^EP355, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, btl::Egfr^{Scer\UAS.T:λ\cI-DD} (Zhu et al., 2005)
Other
Statement Reference Dsp1^EP355, Hsap\MAPT^Scer\UAS.cWa, Scer\GAL4^ey.PU has lethal phenotype (Cao et al., 2008)
Phenotype Manifest In
Enhancer of
Statement Reference Dsp1^EP355, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\HTT^{Q93.ex1p.Scer\UAS}, Scer\GAL4^GMR.PU (Cao et al., 2008) Dsp1^EP355/Scer\GAL4^ey.PU is an enhancer of eye phenotype of Hsap\APP^Aβ42.GMR (Cao et al., 2008) Dsp1^EP355/Scer\GAL4^pnr-MD237 is an enhancer of adult thorax phenotype of pnr^MD237 (Pena-Rangel et al., 2002)
NOT Enhancer of
Statement Reference Dsp1^EP355, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, btl::Egfr^{Scer\UAS.T:λ\cI-DD} (Zhu et al., 2005)
Suppressor of
Statement Reference Dsp1^EP355, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of H^Scer\UAS.cMa/H^Scer\UAS.cMa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mueller et al., 2005) Dsp1^EP355, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, btl^{Scer\UAS.T:λ\cI-DD}, stumps^{Scer\UAS.T:Zzzz\FLAG} (Zhu et al., 2005)
NOT Suppressor of
Statement Reference Dsp1^EP355, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF, btl::Egfr^{Scer\UAS.T:λ\cI-DD} (Zhu et al., 2005)
Other
Statement Reference Dsp1^EP355, Scer\GAL4^pnr-MD237, pnr^MD237/pnr[+] has scutellum phenotype (Pena-Rangel et al., 2002) Dsp1^EP355, Scer\GAL4^pnr-MD237, pnr^MD237 has scutellum phenotype (Pena-Rangel et al., 2002)
Additional Comments
Genetic Interactions
Statement Reference The lower survival rate seen in Dsp1[EP355] mutant flies after infection with E.coli is suppressed if the flies are also heterozygous for Rel[E20]. (Kim et al., 2007) pnr^MD237/+ adults expressing Dsp1^EP355 under the control of Scer\GAL4^pnr-MD237 have a strong thoracic and scutellar cleft. (Pena-Rangel et al., 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	17270 w¹¹¹⁸ P{EP}Dsp1^EP355
Notes on Origin
Discoverer
	Selected as: a P{EP} insertion line that modifies the pnr^MD237/+ phenotype when expressed using Scer\GAL4^pnr-MD237. (Pena-Rangel et al., 2002)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	bss^EP355 Dsp1^EP355 (Ji et al., 2012, Kim et al., 2007) unnamed (Rorth et al., 1998)
Name Synonym
Secondary FlyBase IDs

References ( 10 )
Research paper	Ji et al., 2012, G3 (Bethesda) 2(12): 1651--1660 In Vivo Regulation of E2F1 by Polycomb Group Genes in Drosophila. [FBrf0220353] Cao et al., 2008, Genetics 178(3): 1457--1471 Identification of novel genes that modify phenotypes induced by Alzheimer's beta-amyloid overexpression in Drosophila. [FBrf0205107] Kim et al., 2007, PLoS Biol. 5(9): e238 Down-regulation of NF-kappa B target genes by the AP-1 and STAT complex during the innate immune response in Drosophila. [FBrf0201134] Mueller et al., 2005, Genetics 171(3): 1137--1152 Genetic modifier screens on hairless gain-of function phenotypes reveal genes involved in cell differentiation, cell growth and apoptosis in Drosophila melanogaster. [FBrf0190751] Zhu et al., 2005, Genetics 170(2): 767--777 A screen for genes that influence fibroblast growth factor signal transduction in Drosophila. [FBrf0187664] Pena-Rangel et al., 2002, Genetics 160(3): 1035--1050 A misexpression study examining dorsal thorax formation in Drosophila melanogaster. [FBrf0147055] Kraut et al., 2001, Curr. Biol. 11(6): 417--430 A gain-of-function screen for genes controlling motor axon guidance and synaptogenesis in Drosophila. [FBrf0135708] Rorth et al., 1998, Development 125(6): 1049--1057 Systematic gain-of-function genetics in Drosophila. [FBrf0101995]
Supplementary material	Kraut et al., 2001, Curr. Biol. 11(6): A gain-of-function screen for genes controlling motor axon guidance and synaptogenesis in Drosophila. [FBrf0135968]
Personal communication to FlyBase	Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177]

Allele Dmel\Dsp1EP355

Allele Dmel\Dsp1^EP355