Allele Dmel\Ras85D^unspecified

General Information
Symbol	Dmel\Ras85D^unspecified	Species	D. melanogaster
Name		FlyBase ID	FBal0089554
Feature type	allele	Associated gene	Dmel\Ras85D

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Therrien et al., 2000)
Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference Ras85D[+]/Ras85D^unspecified is an enhancer of lethal phenotype of phl¹² (Therrien et al., 2000) Ras85D[+]/Ras85D^unspecified is an enhancer of visible phenotype of ksr::tor^{ΔNksr.hs.sev} (Therrien et al., 2000)
Suppressor of
Statement Reference phl[+], phl¹², Ras85D[+], Ras85D^unspecified is a suppressor \| partially of small body \| pupal stage phenotype of Nf1^E2 (Walker et al., 2006)
NOT Suppressor of
Statement Reference Dsor1[+], Ras85D[+], Ras85D^unspecified, Dsor1^S-1221 is a non-suppressor of small body \| pupal stage phenotype of Nf1^E2 (Walker et al., 2006) Ras64B^unspecified, Ras85D[+], Ras85D^unspecified is a non-suppressor of small body \| pupal stage phenotype of Nf1^E2 (Walker et al., 2006) Ras85D[+]/Ras85D^unspecified is a non-suppressor of small body \| pupal stage phenotype of Nf1^E2 (Walker et al., 2006)
Phenotype Manifest In
Suppressed by
Statement Reference Ras85D^unspecified has phenotype, suppressible by aop^S2382 (Rebay and Rubin, 1995)
Enhancer of
Statement Reference Ras85D[+]/Ras85D^unspecified is an enhancer of eye phenotype of ksr::tor^{ΔNksr.hs.sev} (Therrien et al., 2000) Ras85D^unspecified is an enhancer of phenotype of PTP-ER^hs.sev (Karim and Rubin, 1999)
NOT Enhancer of
Statement Reference Ras85D^unspecified is a non-enhancer of phenotype of Hsap\RALA^G23V.GMR (Sawamoto et al., 1999)
Suppressor of
Statement Reference Ras85D[+]/Ras85D^unspecified is a suppressor of photoreceptor cell R8 \| supernumerary phenotype of ed^4.12 (Rawlins et al., 2003) Ras85D[+]/Ras85D^unspecified is a suppressor of wing vein \| ectopic phenotype of Egfr^E1 (Li and Li, 2003)
NOT Suppressor of
Statement Reference Ras85D^unspecified is a non-suppressor of phenotype of Hsap\RALA^G23V.GMR (Sawamoto et al., 1999)
Additional Comments
Genetic Interactions
Statement Reference The ed^4.12 R8 cell twinning phenotype is strongly suppressed by Ras85D^unspecified/+. (Rawlins et al., 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Ras85D^unspecified
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	Walker et al., 2006, Genes Dev. 20(23): 3311--3323 Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons. [FBrf0193208] Li and Li, 2003, Genetics 164(1): 247--258 Drosophila gain-of-function mutant RTK Torso triggers ectopic Dpp and STAT signaling. [FBrf0158996] Rawlins et al., 2003, Development 130(16): 3715--3724 Echinoid limits R8 photoreceptor specification by inhibiting inappropriate EGF receptor signalling within R8 equivalence groups. [FBrf0160869] Therrien et al., 2000, Genetics 156(3): 1231--1242 A genetic screen for modifiers of a kinase suppressor of ras-dependent rough eye phenotype in Drosophila. [FBrf0131405] Karim and Rubin, 1999, Mol. Cell 3(6): 741--750 PTP-ER, a novel tyrosine phosphatase, functions downstream of Ras1 to downregulate MAP kinase during Drosophila eye development. [FBrf0108829] Sawamoto et al., 1999, Oncogene 18(11): 1967--1974 Ectopic expression of constitutively activated Ral GTPase inhibits cell shape changes during Drosophila eye development. [FBrf0108270] Rebay and Rubin, 1995, Cell 81(6): 857--866 Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway. [FBrf0082515]

Allele Dmel\Ras85Dunspecified

Allele Dmel\Ras85D^unspecified