The addition of Hsap\APP695-Swedish.Scer\UAS, Hsap\APP695SPA4CT.Scer\UAS.T:Hsap\MYC, Hsap\APLP2::Hsap\APPScer\UAS.T:Hsap\MYC, or Hsap\APP695.T.Scer\UAS (when driven by Scer\GAL4Appl.G1a) to Klc8ex94/+ animals causes the organelle jamming phenotype to be seen in this animals, thus enhancing the phenotype. The addition of Hsap\APP695ΔCT.Scer\UAS.T:Hsap\MYC has no effect on this phenotype.
KlcGEN rescues homozygous and Klc8ex94/Klc59A animals to adulthood. KlcUbi-p63E.T:Hsap\MYC rescues Klc8ex94/Klc59A animals to adulthood. KlcUbi-p63E.T:Hsap\MYC allows homozygotes to survive to the late third larval instar stage, although these animals never enter the wandering stage that occurs before pupariation. Klc8ex94/Klc59A larvae flip their posterior end off the surface of the food during crawling. This phenotype is rescued by KlcGEN and KlcUbi-p63E.T:Hsap\MYC.