Allele Dmel\Fs(2)1¹

General Information
Symbol	Dmel\Fs(2)1¹	Species	D. melanogaster
Name		FlyBase ID	FBal0089706
Feature type	allele	Associated gene	Dmel\Fs(2)1
Also Known As	Fs(2)1

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Szabad et al., 1987, Szabad et al., 1989)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology	Polytene chromosomes normal. (Szabad et al., 1987)
Phenotypic Data
Phenotypic Class
	female sterile (Irish and Gelbart, 1987) female sterile \| dominant (Szabad et al., 1989) female sterile germline-dependent \| dominant (Szabad et al., 1987) viable (Szabad et al., 1987)
Phenotype Manifest In
	chorion (Szabad et al., 1987) dorsal appendage (Szabad et al., 1987, Szabad et al., 1989) egg (Szabad et al., 1987, Szabad et al., 1989) nurse cell (Szabad et al., 1987)
Detailed Description
	Statement Reference Heterozygous females deposit few, mostly flaccid eggs that do not have dorsal chorionic appendages. (Szabad et al., 1989) Germ line-dependent female sterile. (Irish and Gelbart, 1987) The dominant female sterile phenotype of Fs(2)1¹ is fully penetrant and expressive. Fs(2)1¹ has no affect on the rate of development or on male fertility. Heterozygous females produce 0-4 eggs per day, which usually collapse after deposition. The dorsal appendages are missing, and the anterior part of the egg is often not covered with chorion. Egg primordia develop normally up to stages 8-10, but then pyknosis of the nurse cell nuclei is seen, chorion defects develop and 90-95% of the egg primordia are resorbed. Heterozygous ovaries transplanted into wild-type hosts show the mutant phenotype, while wild-type ovaries transplanted into heterozygous females develop normally, indicating that the Fs(2)1¹ phenotype is ovary autonomous. (Szabad et al., 1987)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Germ line clonal analysis indicates that Fs(2)1¹ is germ line-dependent. (Szabad et al., 1987)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Fs(2)1 (Szabad et al., 1989, Szabad et al., 1987) Fs(2)1¹
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Szabad et al., 1989, Genetics 122: 823--835 Isolation and characterization of dominant female sterile mutations of Drosophila melanogaster. [FBrf0049937] Irish and Gelbart, 1987, Genes Dev. 1: 868--879 The decapentaplegic gene is required for dorsal-ventral patterning of the Drosophila embryo. [FBrf0046290] Szabad et al., 1987, Acta biol. hung. 38: 257--266 Characterization of Fs(2)1, a germ-line dependent dominant female sterile mutation of Drosophila. [FBrf0045529]

Allele Dmel\Fs(2)11

Allele Dmel\Fs(2)1¹