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General Information
Symbol
Dmel\Rho1J3.8
Species
D. melanogaster
Name
FlyBase ID
FBal0090395
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
RhoAJ3.8
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    point mutation
    Nucleotide change:

    C16106010T

    Reported nucleotide change:

    C?T

    Amino acid change:

    Q180term | Rho1-PA; Q180term | Rho1-PB; Q180term | Rho1-PC; Q180term | Rho1-PD; Q180term | Rho1-PF; Q180term | Rho1-PG

    Reported amino acid change:

    Q180term

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Amino acid replacement: Q180term.

    Nucleotide substitution: C?T.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhancer of
    Statement
    Reference

    Rho1J3.8/Rho1[+] is an enhancer of visible phenotype of br1

    Suppressor of
    Statement
    Reference

    Rho1J3.8/Rho1[+] is a suppressor of lethal | embryonic stage | partially | recessive phenotype of peb308

    Rho1J3.8/Rho1[+] is a suppressor of visible | heat sensitive phenotype of peb1

    Other
    Statement
    Reference

    Rho1J3.8/Rho1[+], Sb1 has visible | dominant phenotype

    Rho1J3.8/Rho1[+], Sb70 has visible | dominant phenotype

    Rho1J3.8/Rho1[+], Rok2 has visible | dominant phenotype

    Rho1J3.8/Rho1[+], br1 has visible | cold sensitive phenotype

    Rho1J3.8/Rho1[+], Rok1 has visible | dominant phenotype

    Rho1J3.8, br1 has visible | cold sensitive phenotype

    E(zip)12-5[+]/E(zip)12-512-5, Rho1J3.8 has visible phenotype

    E(zip)18-5[+]/E(zip)18-518-5, Rho1J3.8 has visible phenotype

    E(zip)31-631-6/E(zip)31-6[+], Rho1J3.8 has visible phenotype

    Rho1J3.8, RhoGEF204291/RhoGEF2[+] has visible phenotype

    Rho1J3.8, RhoGEF21.1/RhoGEF2[+] has visible phenotype

    Rho1J3.8, RhoGEF211-3/RhoGEF2[+] has visible phenotype

    Rho1J3.8, RhoGEF24.1/RhoGEF2[+] has visible phenotype

    Rho1J3.8, Sb[+]/Sb1 has visible phenotype

    Rho1J3.8, Sb[+]/Sb70 has visible phenotype

    Rho1J3.8, rok[+]/Rok1 has visible phenotype

    Rho1J3.8, rok[+]/Rok2 has visible phenotype

    Mcr1, Rho1J3.8/Rho1[+] has visible | dominant phenotype

    E(br)121Ebr121/E(br)121[+], Rho1J3.8 has visible phenotype

    E(br)155[+]/Mcr1, Rho1J3.8 has visible phenotype

    E(br)420[+]/E(br)420Ebr420, Rho1J3.8 has visible phenotype

    E(br)444[+]/E(br)444Ebr444, Rho1J3.8 has visible phenotype

    E(br)65Ebr65/E(br)65[+], Rho1J3.8 has visible phenotype

    Phenotype Manifest In
    Enhancer of
    Statement
    Reference

    Rho1J3.8/Rho1[+] is an enhancer of leg phenotype of br1

    Suppressor of
    Statement
    Reference

    Rho1J3.8/Rho1[+] is a suppressor of eye | heat sensitive phenotype of peb1

    Other
    Statement
    Reference

    Rho1J3.8/Rho1[+], Sb1 has leg phenotype

    Rho1J3.8/Rho1[+], SbSpi has leg phenotype

    Rho1J3.8/Rho1[+], Sb70 has leg phenotype

    Rho1J3.8/Rho1[+], Sb70 has wing phenotype

    Rho1J3.8/Rho1[+], Rok2 has leg phenotype

    Rho1J3.8/Rho1[+], RhoGEF24.1 has leg phenotype

    Rho1J3.8/Rho1[+], Sb63b has leg phenotype

    Rho1J3.8/Rho1[+], Sb63b has wing phenotype

    Rho1J3.8/Rho1[+], br1 has leg | cold sensitive phenotype

    Rho1J3.8/Rho1[+], Rok1 has leg phenotype

    Rho1J3.8/Rho1[+], RhoGEF211-3 has leg phenotype

    Rho1J3.8/Rho1[+], RhoGEF21.1 has leg phenotype

    Rho1J3.8/Rho1[+], zip33-1 has leg phenotype

    Rho1J3.8, br1 has leg | cold sensitive phenotype

    E(br)65Ebr65, Rho1J3.8/Rho1[+] has leg phenotype

    Mcr1, Rho1J3.8/Rho1[+] has leg phenotype

    Rho1J3.8/Rho1[+], SbEbr623 has leg phenotype

    Rho1J3.8, zip[+]/zipEbr has leg phenotype

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Rho1J3.8 shows a strong interaction (at least 50% of double heterozygotes have at least one malformed leg) with the following mutations: RhoGEF211-3, E(zip)12-512-5, E(zip)18-518-5, E(zip)31-631-6, zip33-1, Sb63b and Sb70. Rho1J3.8 shows a moderate interaction (25-49% of double heterozygotes have at least one malformed leg) with the following mutations: Df(3R)sbd105. Rho1J3.8 shows a weak interaction (5-24% of double heterozygotes have at least one malformed leg) with the following mutations: Sb1, SbSpi. Rho1J3.8 shows no interaction with sqhunspecified (assayed in terms of a malformed leg phenotype). Rho1J3.8 shows a strong interaction (at least 50% of double heterozygotes have at least one malformed wing) with the following mutations: Sb63b, Sb70, RhoGEF211-3 and E(zip)12-512-5. Rho1J3.8 shows a moderate interaction (25-49% of double heterozygotes have at least one malformed wing) with the following mutations: E(zip)18-518-5 and E(zip)31-631-6. Sbsbd-201/Sbsbd-1 shows a strong interaction (at least 50% of double mutants have at least one malformed leg) with the following mutations: Rho1J3.8/+.

    Dominantly enhances the frequency of br1 mutant animals with malformed legs. The fraction of flies showing a malformed leg phenotype in at least one leg, for Rho1J3.8 in double heterozygous combination with one of the following alleles is - SbEbr20 : 16%, SbEbr48 : 15%, SbEbr228 : 3%, SbEbr448 : 15%, SbEbr536 : 19%, SbEbr623 : 21%, bsEbr292 : 7%, E(br)24Ebr24 : 11%, E(br)65Ebr65 : 28%, E(br)155Ebr155 : 57%, E(br)165Ebr165 : 15%, E(br)333Ebr333 : 1%, E(br)72Ebr72 : 16%, E(br)121Ebr121 : 37%, E(br)160Ebr160 : 7%, E(br)187Ebr187 : 1%, E(br)420Ebr420 : 21% and E(br)444Ebr444 : 29%.

    100% of Rho1J3.8/zipEbr double heterozygotes have a malformed leg phenotype. 19% of Rho1J3.8/Df(2R)Jp1 double heterozygotes show a malformed phenotype.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (4)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (5)