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General Information
Symbol
Dmel\fz2UAS.cCa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Cadigan
FlyBase ID
FBal0090424
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-DFz2, UAS-Fz2, UASDfz2
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

A 2.2kb fragment of the fz2 coding region is expressed under the control of UAS regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

When fz2Scer\UAS.cCa is driven by Scer\GAL4C96 mutant wings have notched wings and ectopic bristles near the wing margin.

Expression of fz2Scer\UAS.cCa under the control of Scer\GAL4hs.PB using four days of pulsed heat shock treatment consistently produces more follicle cells that accumulate between egg chambers. These extra follicle cells form long stalks with multiple rows of cells instead of one row in the wild type.

When fz2Scer\UAS.cCa is driven by Scer\GAL4C57 synaptic boutons lack Subsynaptic reticulum, active zones and mitochondria.

Expression of fz2Scer\UAS.cCa under the control of Scer\GAL4da.G32 results in a mild ectopic wg phenotype in the dorsal epidermis of the embryo, consisting of expanded 4o cells at the expense of 3o cells (in wild-type embryos each parasegment contains 4 types of cells in the dorsal epidermis; the 1o, 2o and 3o cells in the anterior half of the parasegment and the 4o cells in the posterior half of the parasegment).

Overexpression of fz2Scer\UAS.cCa under the control of Scer\GAL4Bx-MS1096 results in ectopic margin bristles in the wing.

Uniform expression of fz2Scer\UAS.cCa in the wing pouch by Scer\GAL469B leads to wings with ectopic bristles.

Ubiquitous overexpression of fz2Scer\UAS.cCa under the control of Scer\GAL4e22c does not alter epidermal patterning in a wild-type background.

Animals expressing fz2Scer\UAS.cCa under the control of Scer\GAL4h-1J3 usually die as pupae at 29oC. At lower temperatures, some escapers are seen. These adults have ectopic bristles on the wing blades. Ectopic bristles in the anterior compartment are almost always of the slender or chemosensory type, although an occasional stout bristle is also seen. Ectopic bristles in the posterior compartment are similar to the noninnervated bristles seen at the posterior margin. This "hairy wing" phenotype is also seen in flies expressing fz2Scer\UAS.cCa under the control of Scer\GAL469B or Scer\GAL471B.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
NOT Suppressor of
Statement
Reference
Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Smooth cuticle formation in wgl-17/wgl-17 embryos is not restored by fz2Scer\UAS.cCa; Scer\GAL4prd.RG1.

Coexpression of wgl-12.Scer\UAS and fz2Scer\UAS.cCa under the control of Scer\GAL430A results in a diminution of axillary sclerite 3 in the wing hinge.

The notching and loss of margin bristles seen in arr2 clones in the wing is not suppressed if fz2Scer\UAS.cCa is expressed in these flies under the control of Scer\GAL4Bx-MS1096.

The ectopic bristles produced by expression of fz2Scer\UAS.cCa under the control of Scer\GAL469B are strikingly reduced in fz2Scer\UAS.cCa, dally06464/Scer\GAL469B, dally06464 flies.

Overexpression of fz2Scer\UAS.cCa under the control of Scer\GAL4e22c in a wgl-17/+ background results in cuticle patterning defects in 60% of embryos; ectopic denticles appear in the domain of cells that normally secrete naked cuticle.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments

Rescues the embryonic cuticle phenotype of double mutants of fz21 or fz23 with Df(3L)fz2.

The RP2/sib lineage defects seen in fz2 deficient Df(3L)N2-27 embryos are partially rescued by fz2Scer\UAS.cCa expressed under the control of Scer\GAL4arm.PS.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
fz2Scer\UAS.cCa
fz2UAS.cCa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Cadigan
Secondary FlyBase IDs
    References (13)