FlyBase Allele Report: Dmel\Tig[x]

General Information

Symbol

Dmel\Tig^x

Species

D. melanogaster

Name

FlyBase ID

FBal0090523

Feature type

allele

Associated gene

Dmel\Tig

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Bunch et al., 1998)

Mutagen

Delta2-3 transposase

(Bunch et al., 1998)

Progenitor genotype

P{lacW}Fic^k07502b

(Bunch et al., 1998)

P{lacW}k09239

(Bunch et al., 1998)

Caused by aberration

Df(2L)Tig^x

Cytology

Description

Excision of DNA between the two P{lacW} elements present on the progenitor chromosome, removing the Tig gene. The breakpoints of the deletion do not extend more than 1kb beyond the original P{lacW} insertions.

(Bunch et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Stevens and Jacobs, 2002)

lethal (with Df(2L)BSC296)

(Kahsai et al., 2016)

lethal - all die before end of pupal stage | recessive

(Bunch et al., 1998)

partially lethal - majority die (with Tig^A1)

(Bunch et al., 1998)

some die during pupal stage | recessive

(Bunch et al., 1998)

Phenotype Manifest In

abdominal 2 segment border muscle cell

(Bunch et al., 1998)

abdominal 3 segment border muscle cell

(Bunch et al., 1998)

abdominal 4 segment border muscle cell

(Bunch et al., 1998)

abdominal 5 segment border muscle cell

(Bunch et al., 1998)

abdominal 6 segment border muscle cell

(Bunch et al., 1998)

abdominal 7 segment border muscle cell

(Bunch et al., 1998)

adult abdomen

(Bunch et al., 1998)

air bubble

(Bunch et al., 1998)

fascicle

(Stevens and Jacobs, 2002)

larval somatic muscle cell

(Bunch et al., 1998)

muscle cell of abdominal 2 lateral oblique muscle 1

(Bunch et al., 1998)

muscle cell of abdominal 2 ventral longitudinal muscle 3

(Bunch et al., 1998)

muscle cell of abdominal 2 ventral longitudinal muscle 4

(Bunch et al., 1998)

muscle cell of abdominal 3 lateral oblique muscle 1

(Bunch et al., 1998)

muscle cell of abdominal 3 ventral longitudinal muscle 3

(Bunch et al., 1998)

muscle cell of abdominal 3 ventral longitudinal muscle 4

(Bunch et al., 1998)

muscle cell of abdominal 4 lateral oblique muscle 1

(Bunch et al., 1998)

muscle cell of abdominal 4 ventral longitudinal muscle 3

(Bunch et al., 1998)

muscle cell of abdominal 4 ventral longitudinal muscle 4

(Bunch et al., 1998)

muscle cell of abdominal 5 lateral oblique muscle 1

(Bunch et al., 1998)

muscle cell of abdominal 5 ventral longitudinal muscle 3

(Bunch et al., 1998)

muscle cell of abdominal 5 ventral longitudinal muscle 4

(Bunch et al., 1998)

muscle cell of abdominal 6 lateral oblique muscle 1

(Bunch et al., 1998)

muscle cell of abdominal 6 ventral longitudinal muscle 3

(Bunch et al., 1998)

muscle cell of abdominal 6 ventral longitudinal muscle 4

(Bunch et al., 1998)

muscle cell of abdominal 7 lateral oblique muscle 1

(Bunch et al., 1998)

muscle cell of abdominal 7 ventral longitudinal muscle 3

(Bunch et al., 1998)

muscle cell of abdominal 7 ventral longitudinal muscle 4

(Bunch et al., 1998)

pupa

(Bunch et al., 1998)

wing

(Bunch et al., 1998)

Detailed Description

Statement

Reference

Embryos homozygous for Tig^x have a subtle Fas2 fascicle phenotype in which axon tracts are wavy, and no midline axon guidance errors are seen. Fas2 labelling of the most lateral axon tract is interrupted between segments.

(Stevens and Jacobs, 2002)

99% of homozygotes do not survive to adulthood. Most of the lethality is in the pupal phase. Adult escapers appear relatively normal, although they have elongated, misshapen abdomens. 7-8% of the escapers have wing defects, which include notched wings, deformed anterior margins, smaller and rounder wings than normal, and wavy posterior regions of the wing. Homozygous pupae are 16% longer than wild-type pupae. Pupation, defined by the appearance of a gas bubble in the abdomen, occurs, but dispersion of the bubble and head eversion fail to occur in about half the pupae. Muscle contraction waves that pass from the posterior to the anterior are much slower in homozygous first and third instar larvae than in wild-type larvae. Homozygous larvae have severe muscle defects. Muscles 6 and 7 appear stringy and are not anchored to other muscles or the epidermis. Often these muscles are missing or unrecognisable. Sites where muscles 3, 4, 5, 8 and 16 normally come together are rarely recognisable, and muscles 5 and 8 are usually missing. Large gaps are seen between muscles 9 and 10.

(Bunch et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Tig^x/Tig[+] is a non-enhancer of visible | dominant phenotype of sog^EP7

(Araujo et al., 2003)

Tig^x/Tig[+] is a non-enhancer of visible | dominant phenotype of sog^EP11

(Araujo et al., 2003)

NOT Suppressor of

Statement

Reference

Tig^x/Tig[+] is a non-suppressor of visible | dominant phenotype of sog^EP11

(Araujo et al., 2003)

Tig^x/Tig[+] is a non-suppressor of visible | dominant phenotype of sog^EP7

(Araujo et al., 2003)

Other

Statement

Reference

pgant3[+]/Pgant3^c01318, Tig^x has visible | dominant | cold sensitive phenotype

(Zhang et al., 2008)

Tig^x, sli^unspecified has abnormal neuroanatomy phenotype

(Stevens and Jacobs, 2002)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Tig^x/Tig[+] is a non-enhancer of heart primordium phenotype of sli²

(MacMullin and Jacobs, 2006)

Tig^x/Tig[+] is a non-enhancer of wing vein phenotype of sog^EP7

(Araujo et al., 2003)

Tig^x/Tig[+] is a non-enhancer of wing vein phenotype of sog^EP11

(Araujo et al., 2003)

NOT Suppressor of

Statement

Reference

Tig^x/Tig[+] is a non-suppressor of wing vein phenotype of sog^EP11

(Araujo et al., 2003)

Tig^x/Tig[+] is a non-suppressor of wing vein phenotype of sog^EP7

(Araujo et al., 2003)

Other

Statement

Reference

pgant3[+]/Pgant3^c01318, Tig^x has wing blade | cold sensitive phenotype

(Zhang et al., 2008)

Tig^x, sli^unspecified has fascicle phenotype

(Stevens and Jacobs, 2002)

Tig^x, rhea¹ has muscle attachment site phenotype

(Martin-Bermudo and Brown, 2000)

Additional Comments

Genetic Interactions

Statement

Reference

8% of pgant3^c01318/Tig^x double heterozygotes show wing blistering at 18[o]C.

(Zhang et al., 2008)

Tig^x/+, sli²/+ embryos do not show defects in heart formation.

(MacMullin and Jacobs, 2006)

Tig^x has a semidominant interaction with sli^unspecified, Fas2 labelling of fascicles between segments is reduced and midline guidance defects are observed in one in three segments.

(Stevens and Jacobs, 2002)

Tig^x ; rhea¹ double mutant embryos have a severe muscle detachment phenotype compared to either single mutant.

(Martin-Bermudo and Brown, 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Tig^A1

(Bunch et al., 1998)

Tig^O2

(Bunch et al., 1998)

Rescued by

Tig^A1/Tig^x is rescued by Tig^UAS.cBa/Scer\GAL4^c363

(Bunch et al., 1998)

Partially rescued by

Tig^A1/Tig^x is partially rescued by Tig^UAS.cBa/Scer\GAL4^elav-C155

(Bunch et al., 1998)

Tig^A1/Tig^x is partially rescued by Tig^LGA.UAS/Scer\GAL4^c363

(Bunch et al., 1998)

Tig^A1/Tig^x is partially rescued by Scer\GAL4^elav-C155/Tig^LGA.UAS

(Bunch et al., 1998)

Tig^O2/Tig^x is partially rescued by Tig^UAS.cBa/Scer\GAL4^c363

(Bunch et al., 1998)

Tig^O2/Tig^x is partially rescued by Tig^UAS.cBa/Scer\GAL4^elav-C155

(Bunch et al., 1998)

Tig^O2/Tig^x is partially rescued by Tig^LGA.UAS/Scer\GAL4^c363

(Bunch et al., 1998)

Tig^O2/Tig^x is partially rescued by Scer\GAL4^elav-C155/Tig^LGA.UAS

(Bunch et al., 1998)

Tig^x is partially rescued by Tig^UAS.cBa/Scer\GAL4^185Y

(Bunch et al., 1998)

Tig^x is partially rescued by Tig^UAS.cBa/Scer\GAL4^elav-C155

(Bunch et al., 1998)

Tig^x is partially rescued by Tig^UAS.cBa/Scer\GAL4^c363

(Bunch et al., 1998)

Tig^x is partially rescued by Tig^LGA.UAS/Scer\GAL4^185Y

(Bunch et al., 1998)

Tig^x is partially rescued by Scer\GAL4^elav-C155/Tig^LGA.UAS

(Bunch et al., 1998)

Tig^x is partially rescued by Tig^LGA.UAS/Scer\GAL4^c363

(Bunch et al., 1998)

Comments

The lethality of homozygotes is rescued by Tig^Scer\UAS.cBa expressed under the control of Scer\GAL4^c363, Scer\GAL4^185Y or Scer\GAL4^elav-C155. The time required for muscle contraction waves to pass from the posterior to the anterior of the larvae is rescued to wild-type by Tig^Scer\UAS.cBa expressed under the control of Scer\GAL4^unspecified. Bodywall muscle defects are rescued to wild-type by Tig^Scer\UAS.cBa expressed under the control of Scer\GAL4^c363. Adult abdominal and wing defects are rescued by Tig^Scer\UAS.cBa expressed under the control of Scer\GAL4^unspecified. The lethality of homozygotes is partially rescued by Tig^LGA.Scer\UAS expressed under the control of Scer\GAL4^c363, Scer\GAL4^185Y or Scer\GAL4^elav-C155. A small amount of rescue of muscle defects is seen in homozygotes expressing Tig^LGA.Scer\UAS under the control of Scer\GAL4^c363. Some rescue of the time required for muscle contraction waves to pass from the posterior to the anterior of the larvae is seen in homozygotes expressing Tig^LGA.Scer\UAS under the control of Scer\GAL4^unspecified.

(Bunch et al., 1998)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8796

w^*; Tig^x/CyO, P{lacZ.w⁺}276

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Tig^X

(Green et al., 2016, Zhang et al., 2008)

Tig^x

(Luedke et al., 2024)

tig^X

(Vanderploeg et al., 2012, MacMullin and Jacobs, 2006, Stevens and Jacobs, 2002, Martin-Bermudo and Brown, 2000, Siechen and Chiba, 2000)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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