|Feature type||allele||Associated gene||Dmel\Med|
|Map ( GBrowse )|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: G609S.
|Phenotype Manifest In|
When neutral marked clones are induced in the ovary, the proportion of germaria carrying marked somatic stem cells 3 weeks after clone induction is around 70% of that seen one week after clone induction. However, for Med26 homozygous clones, the equivalent figure is only 4%. Significantly fewer Med26 homozygous clones are seen in the ovarian follicle cells than neutral control clones, and those clones that are present contain about 50% the number of cells as their wild-type twin-spot clones. The proportion of cells in these clones in S-phase (labelled with BrdU) is also less than in control clones.
Clones of male Med26 homozygous germline stem cells are still present in only 2% of testes one week after clone induction and none are present two weeks after clone induction. This is in contrast to wild-type control clones, which are present in 82% of testes one week after clone induction and 64% two weeks after clone induction.
Encapsulation defects of 16-cell cysts are seen in ovaries containing homozygous follicle cell clones.
Homozygous clones in the eye are only seen at the margins of the eye, most commonly at the posterior margin, and result in loss of eye tissue.
Clonal analysis in the germarium reveals that mutant stem cells are lost more rapidly than wild type, though there is no effect on the formation of 16 cell cysts or their subsequent development. Stem cell half life is 0.38 weeks (wild type being 4.6 weeks). Stem cell division rate relative to control is 0.39. Cysts contain the normal 16 cells, including and oocyte.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Fails to complement|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 1 )|
|Secondary FlyBase IDs|
|References ( 6 )|