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General Information
Symbol
Dmel\Med13
Species
D. melanogaster
Name
FlyBase ID
FBal0090597
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Medea13
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C31612110T

Reported nucleotide change:

C814T

Amino acid change:

R66term | Med-PA; R66term | Med-PB; R66term | Med-PC

Reported amino acid change:

?66term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: ?66term.

Nucleotide position refers to cDNAs 29 and O513.

Nucleotide substitution: C814T.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
 

Med13 suppresses the heart tube dysfunction component of muscular dystrophy in Scgδ840 flies, as well as muscle dysfunction.

Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Eggs laid by females containing large homozygous follicle cell clones lack dorsoventral eggshell polarity. The region surrounding the micropyle is reduced in size and lacks follicle cell imprints.

Med13 mutant clones display defects in dorsal cluster neurons but do not exhibit remodeling defects in γ mushroom body neurons.

Lethal in trans with Med12, Med11, Med14, Med16, Med18 or Df(3R)E40. Med13/Med15 flies lack the posterior crossvein and have a large discontinuity in wing vein L4. Females containing homozygous Med13 germ line clones mated to Med14/+ males produce eggs of two phenotypic classes: 48% have a partially ventralised phenotype (presumptive zygotic genotype Med13/+) characterised by the presence of dorsal hairs, internalisation of filzkorper and elimination of dorsolaterally derived structures of the head. The second class of embryos (presumptive zygotic genotype Med13/Med14) do not differentiate any dorsal structures, but instead differentiate ventral denticle bands around the entire embryonic circumference. These embryos do not differentiate amnioserosa.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Suppressor of
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference

Med13/Med[+] is an enhancer of phenotype of dpphr4

Suppressor of
Statement
Reference

Med13/Med[+] is a suppressor of adult heart phenotype of Scgδ840

Other
Additional Comments
Genetic Interactions
Statement
Reference

The severe loss of climbing ability in a negative geotaxis assay which is seen in Scgδ840 mutants is suppressed if the flies are also carrying Med13/+.

The dilated heart tube seen in Scgδ840 adults (detected as increased end-systolic and end-diastolic diameters as measured by optical coherence tomography) is rescued if the flies are carrying Med13/+.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (13)