FlyBase Allele Report: Hsap\ATXN3[tr.Q78.UAS.Tag:HA]

General Information

Symbol

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

Species

H. sapiens

Name

FlyBase ID

FBal0090630

Feature type

allele

Associated gene

Hsap\ATXN3

Associated Insertion(s)

Carried in Construct

P{UAS-hATXN3.tr-Q78}

Also Known As

UAS-MJDtr-Q78, UAS-SCA3trQ78, UAS-SCA3tr-Q78, UAS-MJDtrQ78, UAS-MJD-78Q, MJDtr-Q78, SCA3trQ78, UAS-MJDtr-78Q, UAS-MJDtr-Q78(S), SCA3tr-Q78

Key Links

Transgenic product class

inframe_deletion

(Warrick et al., 1998)

trinucleotide_repeat_expansion

(Warrick et al., 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Warrick et al., 1998)

trinucleotide_repeat_expansion

(Warrick et al., 1998)

Mutagen

in vitro construct

(Warrick et al., 1998)

Progenitor genotype

Carried in construct

P{UAS-hATXN3.tr-Q78}

Cytology

Description

A truncated form of Hsap\ATXN3, consisting of an expanded length glutamine tract (78 repeats) flanked upstream by 12 amino acids and downstream by the carboxy terminal 43 amino acids of Hsap\ATXN3, is expressed under the control of UASt regulatory sequences. The Hsap\ATXN3 protein is tagged at the N-terminal end with Tag:HA.

(Warrick et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\ATXN3

Tagged with

Tag:HA

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Machado-Joseph disease

CEA

(Prange et al., 2024, Swinter et al., 2023, Chakravorty et al., 2022, Cho et al., 2022, Chen et al., 2021, Ghosh et al., 2021, Kim et al., 2021, Nan et al., 2021, Oba et al., 2021, Tandon and Sarkar, 2021, Xie et al., 2021, Chakraborty et al., 2020, Han et al., 2020, Lohr et al., 2020, Park et al., 2020, Bason et al., 2019, Chen et al., 2019, Raj and Sarkar, 2019, Xu et al., 2019, Sowa et al., 2018, Uechi et al., 2018, Chung et al., 2017, Raj and Sarkar, 2017, Frost et al., 2016, Babcock and Ganetzky, 2015, Lazarev et al., 2015, Tsou et al., 2015, Vinatier et al., 2015, Liman et al., 2014, Singh et al., 2014, Arribat et al., 2013, Cushman-Nick et al., 2013, Yi et al., 2013, Lee et al., 2011, Rana et al., 2010, Bilen and Bonini, 2007, Ryoo et al., 2007, Senoo-Matsuda et al., 2005, Bonini, 1999, Warrick et al., 1999)

CEC

(Sun et al., 2023, Snijder et al., 2016)

model of neurodegenerative disease

CEA

(Burr et al., 2014, Tsou et al., 2013, Mallik and Lakhotia, 2009, Lam et al., 2008, Wong et al., 2008, Bilen et al., 2006, Huen and Chan, 2005, Kretzschmar et al., 2005, Lee et al., 2004, Gunawardena et al., 2003, Kanuka et al., 2003, Bonini, 2002, Chan et al., 2000, Warrick et al., 1998)

model of autosomal dominant cerebellar ataxia

CEA

(Jia et al., 2013, Jung and Bonini, 2007, Ghosh and Feany, 2004, Perez et al., 1998)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Machado-Joseph disease

is ameliorated by Rac1^UAS.cLa

(Lee et al., 2011)

is exacerbated by Rac1^V12.UAS

(Lee et al., 2011)

is ameliorated by Pak^{UAS.Tag:Myr(Src64B)}

(Lee et al., 2011)

is exacerbated by CG7130^GD2776

(Tsou et al., 2015)

is ameliorated by Hsap\ATXN3^{W87A.UAS.Tag:polyHis}

(Tsou et al., 2015)

is exacerbated by Atg7^GD11671

(Tsou et al., 2015)

is exacerbated by Atg8a^HMS01328

(Tsou et al., 2015)

is exacerbated by CG5001^KK108978

(Tsou et al., 2015)

is exacerbated by Atg12^JF02704

(Tsou et al., 2015)

is exacerbated by CG7220^KK109208

(Tsou et al., 2015)

is ameliorated by Ube4B^JF02691

(Tsou et al., 2015)

is exacerbated by DnaJ-1^HMS00688

(Tsou et al., 2015)

is ameliorated by DnaJ-1^UAS.cKa

(Tsou et al., 2015)

is ameliorated by Hsap\ATXN3^{HNHH.UAS.Tag:polyHis}

(Tsou et al., 2015)

is ameliorated by eff^HM05268

(Tsou et al., 2015)

is ameliorated by Hsc70-3^HMS00397

(Tsou et al., 2015)

is ameliorated by Hsap\ATXN3^{Scer\UAS.WT.T:Zzzz\His6}

(Tsou et al., 2015)

is ameliorated by Hsc70-4^JF03136

(Johnson et al., 2020, Tsou et al., 2015)

is exacerbated by sip3^GD3145

(Tsou et al., 2015)

is exacerbated by STUB1^HMS00986

(Tsou et al., 2015)

is ameliorated by park^HMS01651

(Tsou et al., 2015)

is exacerbated by ref(2)P^KK105338

(Tsou et al., 2015)

is ameliorated by Hsap\ATXN3^{UAS.Tag:polyHis}

(Tsou et al., 2015)

is exacerbated by Hsc70-4^K71S.UAS

(Warrick et al., 1999)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Vinatier et al., 2015, Cushman-Nick et al., 2013, Warrick et al., 1999)

is exacerbated by Debcl^RNAi.UAS

(Senoo-Matsuda et al., 2005)

is exacerbated by Buffy^UAS.cQa

(Senoo-Matsuda et al., 2005)

is ameliorated by Debcl^UAS.Tag:HA

(Senoo-Matsuda et al., 2005)

is ameliorated by CG8209^B3-Sa

(Bilen and Bonini, 2007)

is ameliorated by emb^E2-1A

(Bilen and Bonini, 2007)

is ameliorated by dbr^EP9

(Bilen and Bonini, 2007)

is ameliorated by dbr^EP456

(Bilen and Bonini, 2007)

is ameliorated by wech^JM120

(Bilen and Bonini, 2007)

is ameliorated by NFAT^EP1335

(Bilen and Bonini, 2007)

is ameliorated by Imp^EP1433

(Bilen and Bonini, 2007)

is ameliorated by DnaJ-1^EP411

(Bilen and Bonini, 2007)

is ameliorated by orb2^B8-S

(Bilen and Bonini, 2007)

is ameliorated by Usp47^E213-1A

(Bilen and Bonini, 2007)

is ameliorated by wech^EP2594

(Bilen and Bonini, 2007)

is ameliorated by CG14207^EP1348

(Bilen and Bonini, 2007)

is ameliorated by emb^E128-1A

(Bilen and Bonini, 2007)

is ameliorated by Hsp68^E407

(Bilen and Bonini, 2007)

is ameliorated by Faf2^E659

(Bilen and Bonini, 2007)

is ameliorated by wech^E546

(Bilen and Bonini, 2007)

is ameliorated by CG11700^EP1384

(Bilen and Bonini, 2007)

is ameliorated by DnaJ-1^B345.2

(Bilen and Bonini, 2007)

is ameliorated by Sin3A^B9-E

(Bilen and Bonini, 2007)

is ameliorated by wech^JM265

(Bilen and Bonini, 2007)

is ameliorated by Acox1^B227.2

(Bilen and Bonini, 2007)

is ameliorated by mrj^E1050

(Bilen and Bonini, 2007)

is ameliorated by Tpr2^EB7-1A

(Bilen and Bonini, 2007)

is ameliorated by NFAT^EP1508

(Bilen and Bonini, 2007)

is exacerbated by Cdk5^GD13840

(Liman et al., 2014)

is ameliorated by emb^EY08770

(Sowa et al., 2018)

is exacerbated by emb^JF01311

(Sowa et al., 2018)

is ameliorated by cdm^GS17666

(Sowa et al., 2018)

is NOT exacerbated by cdm^JF01428

(Sowa et al., 2018)

is exacerbated by Kap-α3^UASp.cMa

(Sowa et al., 2018)

is ameliorated by Kap-α3^JF02686

(Sowa et al., 2018)

is ameliorated by Hsap\ATXN3^{fl.Q27.UAS.Tag:MYC}

(Vinatier et al., 2015)

is ameliorated by Prp19^G3080

(Chen et al., 2021)

is exacerbated by Prp19^GD11681

(Chen et al., 2021)

is ameliorated by CrebA^UAS.cUa

(Chung et al., 2017)

is ameliorated by Rac1^UAS.cUa

(Chung et al., 2017)

is ameliorated by Cth^UAS.cSb

(Snijder et al., 2016)

is ameliorated by Hsap\DNAJB6^UAS.Tag:V5

(Bason et al., 2019)

is ameliorated by PNKP^GS21535

(Chakraborty et al., 2020)

is ameliorated by Diap1^UAS.cUa

(Raj and Sarkar, 2019, Singh et al., 2014)

is ameliorated by InR^UAS.ECFP

(Raj and Sarkar, 2019)

is ameliorated by InR^UAS.Exel

(Tandon and Sarkar, 2021, Raj and Sarkar, 2019)

is exacerbated by InR^RNAi.UAS.cUa

(Raj and Sarkar, 2019)

is exacerbated by nej^ΔBHQ.UAS

(Raj and Sarkar, 2019)

is exacerbated by nej^RNAi.UAS.cKa

(Raj and Sarkar, 2019)

is ameliorated by Atg8a^UASp.mCherry

(Chakravorty et al., 2022)

is exacerbated by Cul1^GD9650

(Chen et al., 2019)

is exacerbated by Cul1^NIG.1877R

(Chen et al., 2019)

is exacerbated by FipoQ^KK108266

(Chen et al., 2019)

is exacerbated by FipoQ^NIG.2010R

(Chen et al., 2019)

is exacerbated by Rubicon^UAS.Tag:HA

(Oba et al., 2021)

is exacerbated by Rubicon^{ΔRUN.UAS.Tag:HA}

(Oba et al., 2021)

is ameliorated by Atx2^HMS02726

(Xu et al., 2019)

is ameliorated by Atx2^{ΔPAM2.UAS.Tag:FLAG}

(Xu et al., 2019)

is ameliorated by Scer\HSP104^WT.UAS

(Cushman-Nick et al., 2013)

is ameliorated by Myc^UAS.cZa

(Singh et al., 2014)

is exacerbated by Myc^JF01762

(Singh et al., 2014)

is ameliorated by CalpA^JF03391

(Park et al., 2020)

is ameliorated by CalpA^KK104532

(Park et al., 2020)

is ameliorated by Mmus\Pja1^UAS.cGa

(Ghosh et al., 2021)

is ameliorated by Kcmf1^HMS00511

(Xie et al., 2021)

is ameliorated by Rack1^KK109073

(Xie et al., 2021)

is ameliorated by poe^HMS00739

(Xie et al., 2021)

is ameliorated by rl^UAS.Tag:FLAG

(Xie et al., 2021)

is ameliorated by Usp47^UAS.cXa

(Xie et al., 2021)

is ameliorated by Charon^KK105778

(Han et al., 2020)

is ameliorated by Dredd^HMS00063

(Han et al., 2020)

is exacerbated by Rel^{68.UAS.Tag:HA}

(Han et al., 2020)

is ameliorated by Rel^GD1199

(Han et al., 2020)

is ameliorated by casp^UAS.Tag:V5

(Han et al., 2020)

is ameliorated by ftz-f1^HMS00019

(Han et al., 2020)

is ameliorated by pros^HMJ02107

(Han et al., 2020)

is ameliorated by tup^HMC03317

(Han et al., 2020)

is ameliorated by Hsap\MYC^UAS.1

(Raj and Sarkar, 2017)

is ameliorated by Hsap\MYC^UAS.2

(Raj and Sarkar, 2017)

is ameliorated by Hsap\MYC^UAS.S

(Raj and Sarkar, 2017)

is ameliorated by Hsap\ALKBH3^UAS.cSa

(Sun et al., 2023)

is ameliorated by Usp2^GD5229

(Voßfeldt et al., 2012)

is exacerbated by CG6873^GD12062

(Voßfeldt et al., 2012)

is ameliorated by bwa^GD3476

(Voßfeldt et al., 2012)

is exacerbated by Ccs^GD9458

(Voßfeldt et al., 2012)

is exacerbated by Rab30^GD14116

(Voßfeldt et al., 2012)

is exacerbated by HisRS^GD1599

(Voßfeldt et al., 2012)

is exacerbated by Prosβ2^GD10938

(Voßfeldt et al., 2012)

is exacerbated by RpS10a^GD7556

(Voßfeldt et al., 2012)

is exacerbated by MED14^GD4081

(Voßfeldt et al., 2012)

is exacerbated by Sf3b5^GD12979

(Voßfeldt et al., 2012)

is exacerbated by Rpn9^GD6909

(Voßfeldt et al., 2012)

is exacerbated by bic^GD5037

(Voßfeldt et al., 2012)

is exacerbated by Prp8^GD6578

(Voßfeldt et al., 2012)

is exacerbated by Nelf-E^GD9903

(Voßfeldt et al., 2012)

is ameliorated by EloA^GD1290

(Voßfeldt et al., 2012)

is exacerbated by CG8086^GD12374

(Voßfeldt et al., 2012)

is exacerbated by brun^GD5423

(Voßfeldt et al., 2012)

is exacerbated by Ciz1^GD12382

(Voßfeldt et al., 2012)

is exacerbated by vnc^GD7454

(Voßfeldt et al., 2012)

is ameliorated by ppk14^GD947

(Voßfeldt et al., 2012)

is exacerbated by Uck^GD229

(Voßfeldt et al., 2012)

is exacerbated by Nrx-IV^GD2436

(Voßfeldt et al., 2012)

is exacerbated by CycJ^GD6936

(Voßfeldt et al., 2012)

is ameliorated by CG17048^GD3783

(Voßfeldt et al., 2012)

is ameliorated by Mal-A1^GD5459

(Voßfeldt et al., 2012)

is ameliorated by Polr2I^GD4234

(Voßfeldt et al., 2012)

is ameliorated by Gβ13F^GD7011

(Voßfeldt et al., 2012)

is ameliorated by aux^GD7187

(Voßfeldt et al., 2012)

is ameliorated by trbd^GD14218

(Voßfeldt et al., 2012)

is ameliorated by 5PtaseI^GD8685

(Voßfeldt et al., 2012)

is ameliorated by Hsc70-4^GD11264

(Voßfeldt et al., 2012)

is ameliorated by Hsc70-4^GD16584

(Voßfeldt et al., 2012)

is ameliorated by CG5687^GD2255

(Voßfeldt et al., 2012)

is ameliorated by CG16890^GD9226

(Voßfeldt et al., 2012)

is ameliorated by Trmt2a^GD11081

(Voßfeldt et al., 2012)

is ameliorated by Herc4^GD2240

(Voßfeldt et al., 2012)

is ameliorated by THADA^GD9074

(Voßfeldt et al., 2012)

is ameliorated by CG17919^GD17025

(Voßfeldt et al., 2012)

is ameliorated by MRG15^GD11902

(Voßfeldt et al., 2012)

is ameliorated by Hsc70-1^GD13532

(Voßfeldt et al., 2012)

is ameliorated by Prim1^GD4566

(Voßfeldt et al., 2012)

is ameliorated by Cad88C^GD2653

(Voßfeldt et al., 2012)

is ameliorated by Hrb27C^GD6964

(Voßfeldt et al., 2012)

is ameliorated by Dab^GD4886

(Voßfeldt et al., 2012)

is ameliorated by Doa^GD8588

(Voßfeldt et al., 2012)

is ameliorated by LanB1^GD13179

(Voßfeldt et al., 2012)

is exacerbated by PNKP^GD14266

(Voßfeldt et al., 2012)

is ameliorated by Droj2^GD14050

(Voßfeldt et al., 2012)

is ameliorated by roq^GD9209

(Voßfeldt et al., 2012)

is ameliorated by Isha^GD11266

(Voßfeldt et al., 2012)

is ameliorated by Stip1^GD9818

(Voßfeldt et al., 2012)

is ameliorated by Fbxo42^GD12027

(Voßfeldt et al., 2012)

is exacerbated by chm^GD1235

(Voßfeldt et al., 2012)

is exacerbated by DAAM^GD8382

(Voßfeldt et al., 2012)

is exacerbated by CG33128^GD5069

(Voßfeldt et al., 2012)

is exacerbated by timeout^GD12305

(Voßfeldt et al., 2012)

is exacerbated by Pkcδ^GD15429

(Voßfeldt et al., 2012)

is exacerbated by CG43795^GD14309

(Voßfeldt et al., 2012)

is exacerbated by Hsf^GD16368

(Voßfeldt et al., 2012)

is exacerbated by spg^GD10145

(Voßfeldt et al., 2012)

is exacerbated by CG15534^GD3127

(Voßfeldt et al., 2012)

is exacerbated by Marf^GD11094

(Voßfeldt et al., 2012)

is exacerbated by l(3)neo38^GD12076

(Voßfeldt et al., 2012)

is exacerbated by CG2887^GD9842

(Voßfeldt et al., 2012)

is exacerbated by AstA-R2^GD339

(Voßfeldt et al., 2012)

is exacerbated by VGlut2^GD3675

(Voßfeldt et al., 2012)

is exacerbated by CG15399^GD9009

(Voßfeldt et al., 2012)

is exacerbated by CG12935^GD3496

(Voßfeldt et al., 2012)

is exacerbated by Ars2^GD12300

(Voßfeldt et al., 2012)

is ameliorated by PICK1^KK109273

(McGurk and Bonini, 2012)

is ameliorated by PICK1^JF01199

(McGurk and Bonini, 2012)

is exacerbated by RhoGAP68F^KK102738

(McGurk and Bonini, 2012)

is exacerbated by fh^RNAi.UAS.cAa

(McGurk and Bonini, 2012)

is exacerbated by UQCR-C1^KK108539

(McGurk and Bonini, 2012)

is ameliorated by PICK1^ΔEP-147

(McGurk and Bonini, 2012)

is ameliorated by ppk^JF03250

(McGurk and Bonini, 2012)

is exacerbated by mAcon1^KK100999

(McGurk and Bonini, 2012)

is ameliorated by Nach^JF02566

(McGurk and Bonini, 2012)

is ameliorated by Trx2^UAS.cUa

(Umeda-Kameyama et al., 2007)

is ameliorated by dhd^UAS.cUa

(Umeda-Kameyama et al., 2007)

is ameliorated by TrxT^UAS.cUa

(Umeda-Kameyama et al., 2007)

is exacerbated by Tbp^sI10

(Hsu et al., 2014)

is exacerbated by Tbp^UAS.cHa

(Hsu et al., 2014)

is ameliorated by Hsc70-4^GLV21049

(Johnson et al., 2020)

is ameliorated by Hsc70-4^HMS00152

(Johnson et al., 2020)

model of neurodegenerative disease

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Wong et al., 2008, Huen and Chan, 2005, Bonini, 2002, Chan et al., 2000)

is exacerbated by Hsc70-4^K71S.UAS

(Huen and Chan, 2005)

is ameliorated by nej^EP1410

(Huen and Chan, 2005)

is exacerbated by Hsap\HTT^{N548.Q128.UAS}

(Lee et al., 2004)

is ameliorated by Sec61α^EP2567

(Kanuka et al., 2003)

is ameliorated by Sec61α^k04917

(Kanuka et al., 2003)

is ameliorated by DnaJ-1^UAS.Tag:FLAG

(Bonini, 2002, Chan et al., 2000)

is ameliorated by DnaJ-H^UAS.Tag:FLAG

(Chan et al., 2000)

is exacerbated by DnaJ-1^{G295D.UAS.Tag:FLAG}

(Chan et al., 2000)

is exacerbated by DnaJ-1^{ΔJ.UAS.Tag:FLAG}

(Chan et al., 2000)

is exacerbated by Khc⁹

(Gunawardena et al., 2003)

is ameliorated by Hsc70-4^UAS.cEa

(Gunawardena et al., 2003)

is exacerbated by mir-ban^Δ.as.B.UAS

(Bilen et al., 2006)

is exacerbated by mir-ban^EP3622

(Bilen et al., 2006)

is exacerbated by loqs^f00791

(Bilen et al., 2006)

is ameliorated by mir-ban^B90.1

(Bilen et al., 2006)

is ameliorated by mir-ban^D.UAS.EGFP

(Bilen et al., 2006)

is exacerbated by mir-ban^EP3208

(Bilen et al., 2006)

is ameliorated by lncRNA:Hsrω^RNAi.Sym.UAS

(Mallik and Lakhotia, 2009)

is ameliorated by Hsap\RACK1^UAS.cLa

(Lam et al., 2008)

is ameliorated by BacA\p35^UAS.cHa

(Wong et al., 2008)

is ameliorated by Hsap\ATXN3^{Scer\UAS.T:Zzzz\His6}

(Tsou et al., 2013)

is ameliorated by Hsap\ATXN3^{UAS.Tag:polyHis}

(Tsou et al., 2013)

is exacerbated by U2af50^VDRC.cUa

(Tsoi et al., 2011)

is exacerbated by U2af50^XR15

(Tsoi et al., 2011)

is exacerbated by mbl^UAS.cLa

(Li et al., 2008)

is exacerbated by Hsap\MBNL1^UAS.cGCa

(Li et al., 2008)

is ameliorated by Rpn11^DANC

(Tonoki et al., 2009)

is ameliorated by Rpn11^GS13423

(Tonoki et al., 2009)

is ameliorated by Rpn11^UAS.cTa

(Tonoki et al., 2009)

is exacerbated by Rpn11^RNAi.UAS

(Tonoki et al., 2009)

is ameliorated by Hsp60D^RNAi.Sym.UAS

(Arya et al., 2010)

model of autosomal dominant cerebellar ataxia

is exacerbated by nej^EP1179

(Jung and Bonini, 2007)

is ameliorated by nej^P

(Jung and Bonini, 2007)

is ameliorated by mus201^D1

(Jung and Bonini, 2007)

is exacerbated by CG7231^EP2510

(Ghosh and Feany, 2004)

is exacerbated by Atx2^UAS.cSa

(Lessing and Bonini, 2008, Ghosh and Feany, 2004)

is exacerbated by Hsc70-4^K71S.UAS

(Ghosh and Feany, 2004)

is ameliorated by BacA\p35^UAS.cUa

(Ghosh and Feany, 2004)

is ameliorated by Diap1^UAS.cLa

(Ghosh and Feany, 2004)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Ghosh and Feany, 2004)

is exacerbated by Atx2^EP3145

(Ghosh and Feany, 2004)

is ameliorated by DnaJ-1^UAS.cKa

(Ghosh and Feany, 2004)

is ameliorated by Hsap\MLF1^UAS.cMa

(Martin-Lanneree et al., 2006)

is ameliorated by Mlf^UAS.cFa

(Martin-Lanneree et al., 2006)

is ameliorated by Mlf^UAS.cKa

(Martin-Lanneree et al., 2006)

is ameliorated by pAbp^UAS.cSa

(Lessing and Bonini, 2008)

is ameliorated by Atx2^X1

(Lessing and Bonini, 2008)

is NOT ameliorated by Hsap\ATXN1L^UAS.Tag:FLAG

(Mizutani et al., 2005)

is exacerbated by Tg^KK101591

(Lin et al., 2015)

is exacerbated by Tg^GD10774

(Lin et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

The expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in flies results in late-onset, progressive, neurodegenerative phenotypes, with similar features to SCA3/MJD patients.

(Jia et al., 2013)

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Warrick et al., 1998)

ATXN3:p.Gln296[78]

(FlyBase curators, 2019-)

Variants Synonym(s)

ATXN3:p.Gln296[78Gln]

ATXN3, (CAG)n REPEAT EXPANSION

Associated human disease model(s)

Machado-Joseph disease (SCA3)

External database links

ClinVar: ATXN3_209995

Comments concerning this variant

Phenotypic Data

Phenotypic Class

abnormal adult locomotory behavior | progressive, with Scer\GAL4^elav-C155

(Nakamura et al., 2019)

abnormal circadian rhythm | adult stage, with Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

abnormal courtship behavior | female, with Scer\GAL4^Ddc.PL

(Kadener et al., 2006)

abnormal eye color, with Scer\GAL4^GMR.PF

(Sowa et al., 2018, Mallik and Lakhotia, 2009)

abnormal eye color | progressive, with Scer\GAL4^GMR.PU

(Uechi et al., 2018, Vinatier et al., 2015, Huen and Chan, 2005)

abnormal locomotor behavior, with Scer\GAL4^elav.PLu

(Umeda-Kameyama et al., 2007)

abnormal locomotor behavior, with Scer\GAL4^nrv2.PS

(Lin et al., 2015, Jia et al., 2013)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^elav-C155

(Li et al., 2008)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^RapGAP1-OK6

(Chakraborty et al., 2020)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^repo-M1B

(Kretzschmar et al., 2005)

abnormal locomotor behavior | chemical conditional, with Scer\GAL4^nrv2.PS

(Jia et al., 2013)

abnormal locomotor behavior | larval stage, with Scer\GAL4^179Y

(Gunawardena et al., 2003)

abnormal locomotor behavior | larval stage, with Scer\GAL4^Appl.G1a

(Gunawardena et al., 2003)

abnormal locomotor rhythm, with Scer\GAL4^tim.PE

(Kadener et al., 2006)

abnormal mating, with Scer\GAL4^tim.PE

(Kadener et al., 2006)

abnormal neuroanatomy

(Boeddrich et al., 2006)

abnormal neuroanatomy, with Scer\GAL4^elav-C155

(Khurana et al., 2010)

abnormal neuroanatomy, with Scer\GAL4^GMR.PF

(Tsoi et al., 2011)

abnormal neuroanatomy, with Scer\GAL4^GMR.PU

(Lin et al., 2015, Chan et al., 2000)

abnormal neuroanatomy, with Scer\GAL4^repo.PU

(Hegde et al., 2014)

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR.PF

(Fujikake et al., 2008)

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

abnormal neuroanatomy | adult stage, with Scer\GAL4^repo.PU

(Wang et al., 2015)

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^repo-M1B

(Kretzschmar et al., 2005)

abnormal neuroanatomy | conditional, with Scer\GAL4^ninaE.PT

(Liu et al., 2012)

abnormal neuroanatomy | heat sensitive, with Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B

(Lam et al., 2008)

abnormal neuroanatomy | larval stage, with Scer\GAL4^109(2)80

(Lee et al., 2011)

abnormal neuroanatomy | larval stage, with Scer\GAL4²²¹

(Lee et al., 2011)

abnormal neuroanatomy | larval stage, with Scer\GAL4^ppk.PG

(Lee et al., 2011)

abnormal neuroanatomy | larval stage | RU486 conditional, with Scer\GAL4^{ppk.Switch.PR}

(Lee et al., 2011)

abnormal neuroanatomy | progressive, with Scer\GAL4^GMR.long

(Jia et al., 2013)

abnormal neuroanatomy | progressive, with Scer\GAL4^GMR.PF

(Tonoki et al., 2009)

abnormal neuroanatomy | progressive, with Scer\GAL4^GMR.PU

(Chan et al., 2000)

abnormal neuroanatomy | progressive | heat sensitive, with Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B

(Wong et al., 2008)

abnormal phototaxis, with Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

abnormal phototaxis, with Scer\GAL4^GMR.PU

(Arya et al., 2010)

abnormal phototaxis | adult stage, with Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

abnormal phototaxis | adult stage | progressive, with Scer\GAL4^Appl.G1a

(Kretzschmar et al., 2005)

abnormal phototaxis | adult stage | progressive, with Scer\GAL4^repo-M1B

(Kretzschmar et al., 2005)

decreased cell number | conditional, with Scer\GAL4^ninaE.PD

(Lessing and Bonini, 2008)

decreased cell number | somatic clone, with Scer\GAL4^elav-C155

(Lessing and Bonini, 2008)

increased cell death, with Scer\GAL4^30Y

(Khurana et al., 2006)

increased cell death, with Scer\GAL4^179Y

(Gunawardena et al., 2003)

increased cell death, with Scer\GAL4^Appl.G1a

(Gunawardena et al., 2003)

increased cell death, with Scer\GAL4^GMR.PF

(Tsou et al., 2013, Bilen et al., 2006, Moreno et al., 2002)

increased cell death | adult stage, with Scer\GAL4^GMR.PF

(Sowa et al., 2018)

increased cell death | larval stage, with Scer\GAL4^Appl.G1a

(Swinter et al., 2023)

lethal, with Scer\GAL4^elav-C155

(Liman et al., 2014, Chan et al., 2000, Warrick et al., 1999, Warrick et al., 1998)

lethal, with Scer\GAL4^how-24B

(Warrick et al., 1998)

lethal | heat sensitive, with Scer\GAL4^179Y

(Gunawardena et al., 2003)

lethal | heat sensitive, with Scer\GAL4^Appl.G1a

(Gunawardena et al., 2003)

lethal - all die before end of P-stage, with Scer\GAL4^elav.PU

(Arya et al., 2010)

lethal - all die before end of P-stage, with Scer\GAL4^elav-C155

(Mallik and Lakhotia, 2009)

lethal - all die before end of P-stage, with Scer\GAL4^loco.PU

(Kretzschmar et al., 2005)

melanotic necrosis | adult stage, with Scer\GAL4^GMR.PS

(Nakamura et al., 2019)

melanotic necrosis | progressive, with Scer\GAL4^GMR.long

(Jia et al., 2013)

partially lethal - majority die, with Scer\GAL4^elav.PLu

(Fujikake et al., 2008)

short lived, with Scer\GAL4^Appl.G1a

(Kretzschmar et al., 2005)

short lived, with Scer\GAL4^da.G32

(Tonoki et al., 2009)

short lived, with Scer\GAL4^da.PU

(Lin et al., 2015)

short lived, with Scer\GAL4^elav.PU

(Kretzschmar et al., 2005)

short lived, with Scer\GAL4^elav-C155

(Sun et al., 2023, Li et al., 2008, Senoo-Matsuda et al., 2005)

short lived, with Scer\GAL4^nrv2.PS

(Jia et al., 2013)

short lived, with Scer\GAL4^repo-M1B

(Kretzschmar et al., 2005)

short lived, with Scer\GAL4^tim.PE

(Kadener et al., 2006)

short lived | chemical conditional, with Scer\GAL4^nrv2.PS

(Jia et al., 2013)

short lived | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Martin-Lanneree et al., 2006)

some die during pharate adult stage, with Scer\GAL4^elav-C155

(Mallik and Lakhotia, 2009)

some die during P-stage, with Scer\GAL4^Appl.G1a

(Kretzschmar et al., 2005)

some die during P-stage, with Scer\GAL4^elav.PU

(Arya et al., 2010, Kretzschmar et al., 2005)

some die during P-stage, with Scer\GAL4^repo-M1B

(Kretzschmar et al., 2005)

visible, with Scer\GAL4^elav-C155

(Warrick et al., 1998)

visible, with Scer\GAL4^GMR.long

(Tsou et al., 2015, Butler et al., 2012, Voßfeldt et al., 2012)

visible, with Scer\GAL4^GMR.PF

(Sowa et al., 2018, Vos et al., 2016, Kang et al., 2015, Bohm et al., 2010, Martin-Lanneree et al., 2006, Warrick et al., 2005, Bonini, 2002, Bonini, 1999, Warrick et al., 1999, Warrick et al., 1998)

visible, with Scer\GAL4^GMR.PU

(Lin et al., 2015, Hsu et al., 2014, McGurk and Bonini, 2012, Arya et al., 2010, Bilen and Bonini, 2007, Chan et al., 2000)

visible | adult stage, with Scer\GAL4^GMR.long

(Chen et al., 2012)

visible | adult stage, with Scer\GAL4^GMR.PF

(Chakraborty et al., 2020, Fujikake et al., 2008)

visible | adult stage, with Scer\GAL4^GMR.PS

(Nakamura et al., 2019)

visible | adult stage, with Scer\GAL4^GMR.PU

(Tsuboyama et al., 2020, Alexopoulou et al., 2016, Fernandez-Funez et al., 2016)

visible | adult stage, with Scer\GAL4^unspecified

(Rana et al., 2010)

visible | adult stage | progressive, with Scer\GAL4^GMR.PU

(Chen et al., 2019, Uechi et al., 2018, Vinatier et al., 2015, Huen and Chan, 2005)

visible | progressive, with Scer\GAL4^GMR.long

(Burr et al., 2014)

Phenotype Manifest In

adult brain, with Scer\GAL4^30Y

(Khurana et al., 2006, Ghosh and Feany, 2004)

adult brain, with Scer\GAL4^elav-C155

(Warrick et al., 1998)

adult brain, with Scer\GAL4^repo.PU

(Wang et al., 2015, Hegde et al., 2014)

adult brain | conditional, with Scer\GAL4^ninaE.PT

(Liu et al., 2012)

adult brain | progressive, with Scer\GAL4^repo-M1B

(Kretzschmar et al., 2005)

adult head bristle, with Scer\GAL4^GMR.PF

(Sowa et al., 2018)

anterior wing margin | somatic clone, with Scer\GAL4^elav-C155

(Lessing and Bonini, 2008)

axon | larval stage, with Scer\GAL4^Appl.G1a

(Swinter et al., 2023)

axon | larval stage | conditional, with Scer\GAL4⁴⁷⁷

(Chen et al., 2012)

dendrite | larval stage, with Scer\GAL4²²¹

(Chen et al., 2012)

dendrite | larval stage | conditional, with Scer\GAL4²²¹

(Chen et al., 2012)

dendritic tree | larval stage, with Scer\GAL4⁴⁷⁷

(Chen et al., 2012)

eye, with Scer\GAL4^elav-C155

(Warrick et al., 1999, Warrick et al., 1998)

eye, with Scer\GAL4^GMR.long

(Tsou et al., 2015, Liman et al., 2014, Jia et al., 2013, Butler et al., 2012, Voßfeldt et al., 2012)

eye, with Scer\GAL4^GMR.PF

eye, with Scer\GAL4^GMR.PS

(Nakamura et al., 2019)

eye, with Scer\GAL4^GMR.PU

(Tsuboyama et al., 2020, Fernandez-Funez et al., 2016, Lin et al., 2015, Hsu et al., 2014, McGurk and Bonini, 2012, Vos et al., 2010, Bilen and Bonini, 2007, Chan et al., 2000)

eye | adult stage, with Scer\GAL4^GMR.long

(Chen et al., 2012)

eye | adult stage, with Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

eye | adult stage, with Scer\GAL4^unspecified

(Rana et al., 2010)

eye | adult stage | progressive, with Scer\GAL4^GMR.PU

(Huen and Chan, 2005)

eye | progressive, with Scer\GAL4^GMR.long

(Burr et al., 2014)

eye | progressive, with Scer\GAL4^GMR.PF

(Tonoki et al., 2009)

eye | progressive, with Scer\GAL4^GMR.PU

(Chen et al., 2019, Uechi et al., 2018, Vinatier et al., 2015)

eye | progressive, with Scer\GAL4^ninaE.PT

(Sowa et al., 2018)

eye | progressive | heat sensitive, with Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B

(Wong et al., 2008)

eye disc, with Scer\GAL4^GMR.PF

(Fujikake et al., 2008)

eye photoreceptor cell

(Boeddrich et al., 2006)

eye photoreceptor cell, with Scer\GAL4^GMR.PF

(Bonini, 1999)

eye photoreceptor cell, with Scer\GAL4^GMR.PU

(Chan et al., 2000)

eye photoreceptor cell, with Scer\GAL4^ninaE.PT

(McGurk and Bonini, 2012)

filamentous actin, with Scer\GAL4^ppk.PG

(Lee et al., 2011)

Kenyon cell, with Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Kenyon cell, with Scer\GAL4^elav-C155

(Khurana et al., 2010)

larval dorsal multidendritic neuron ddaC | larval stage, with Scer\GAL4⁴⁷⁷

(Chen et al., 2012)

larval dorsal multidendritic neuron ddaC | larval stage | conditional, with Scer\GAL4⁴⁷⁷

(Chen et al., 2012)

larval dorsal multidendritic neuron ddaE | larval stage, with Scer\GAL4²²¹

(Chen et al., 2012)

larval dorsal multidendritic neuron ddaE | larval stage | conditional, with Scer\GAL4²²¹

(Chen et al., 2012)

larval multidendritic class I neuron | larval stage, with Scer\GAL4²²¹

(Lee et al., 2011)

larval multidendritic class IV neuron | larval stage, with Scer\GAL4^ppk.PG

(Lee et al., 2011)

larval multidendritic class IV neuron | RU486 conditional, with Scer\GAL4^{ppk.Switch.PR}

(Lee et al., 2011)

larval segmental nerve, with Scer\GAL4^Appl.G1a

(Swinter et al., 2023)

lens, with Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

LNv neuron, with Scer\GAL4^tim.PE

(Kadener et al., 2006)

lobula columnar neuron LC14 | larval stage, with Scer\GAL4^109(2)80

(Lee et al., 2011)

microtubule | larval stage, with Scer\GAL4²²¹

(Chen et al., 2012)

microtubule | larval stage | conditional, with Scer\GAL4⁴⁷⁷

(Chen et al., 2012)

mitochondrion | larval stage, with Scer\GAL4^Appl.G1a

(Swinter et al., 2023)

neuron, with Scer\GAL4^179Y

(Gunawardena et al., 2003)

neuron, with Scer\GAL4^Appl.G1a

(Gunawardena et al., 2003)

ommatidium, with Scer\GAL4^GMR.long

(Jia et al., 2013)

ommatidium, with Scer\GAL4^GMR.PF

(Vos et al., 2016, Tsou et al., 2013, Park et al., 2011, Kanuka et al., 2003)

ommatidium, with Scer\GAL4^GMR.PU

(Arya et al., 2010)

ommatidium | conditional, with Scer\GAL4^ninaE.PT

(Liu et al., 2012)

ommatidium | heat sensitive, with Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B

(Tonoki et al., 2011)

ommatidium | progressive, with Scer\GAL4^GMR.long

(Burr et al., 2014)

ommatidium | progressive, with Scer\GAL4^ninaE.PT

(Sowa et al., 2018)

photoreceptor, with Scer\GAL4^elav-C155

(Li et al., 2008)

photoreceptor, with Scer\GAL4^GMR.PU

(Hsu et al., 2014)

photoreceptor | conditional, with Scer\GAL4^ninaE.PD

(Lessing and Bonini, 2008)

photoreceptor | conditional, with Scer\GAL4^ninaE.PT

(Liu et al., 2012)

pigment cell, with Scer\GAL4^GMR.PF

(Martin-Lanneree et al., 2006, Bonini, 1999, Warrick et al., 1998)

pigment granule, with Scer\GAL4^GMR.PF

(Senoo-Matsuda et al., 2005)

retina, with Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009, Lessing and Bonini, 2008, Bilen et al., 2006, Senoo-Matsuda et al., 2005, Warrick et al., 2005, Ghosh and Feany, 2004, Bonini, 2002, Warrick et al., 1999, Warrick et al., 1998)

retina, with Scer\GAL4^GMR.PU

(Lin et al., 2015, Bilen and Bonini, 2007)

retina | progressive, with Scer\GAL4^GMR.PU

(Chan et al., 2000)

rhabdomere, with Scer\GAL4^elav-C155

(Warrick et al., 1999, Warrick et al., 1998)

rhabdomere | heat sensitive, with Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B

(Tonoki et al., 2011)

rhabdomere of eye photoreceptor cell, with Scer\GAL4^GMR.PF

(Tsoi et al., 2011)

rhabdomere of eye photoreceptor cell | heat sensitive, with Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B

(Lam et al., 2008)

rhabdomere of eye photoreceptor cell | progressive | heat sensitive, with Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B

(Wong et al., 2008)

sensory neuron | somatic clone, with Scer\GAL4^elav-C155

(Lessing and Bonini, 2008)

Detailed Description

Statement

Reference

Expression of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} under the control of Scer\GAL4^GMR.PF leads to progressive degeneration of photoreceptor cells, accompanied by eye depigmentation and roughness.

Expression of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} under the control of Scer\GAL4^RapGAP1-OK6 leads to an age-dependent reduction of locomotor capability, as shown by progressively reduced climbing score in negative geotaxis assay.

(Chakraborty et al., 2020)

Expression of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} under the control of Scer\GAL4^GMR.PU leads to retinal degeneration in adults.

(Tsuboyama et al., 2020)

Adults expressing Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} under the control of Scer\GAL4^GMR.PU display progressive eye defects, including loss of pigmentation.

(Chen et al., 2019)

The expression of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} under the control of Scer\GAL4^P2.4.Pdf severely impairs circadian behavior, as compared to controls.

(Xu et al., 2019)

The expression of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} under the control of Scer\GAL4^GMR.PF induces a rough eye phenotype, associated with depigmentation, necrotic spots, and disordered bristles; expression under the control of Scer\GAL4^ninaE.PT also leads to milder, later-onset (20 days old individuals) eye defects, namely disorganized ommatidia and tissue dissociation associated with the appearance of vacuoles, as compared to controls.

(Sowa et al., 2018)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU leads to age-progressive eye degeneration, manifested by loss of eye pigmentation in adult flies.

(Uechi et al., 2018)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU induces a rough eye phenotype in the adult eye.

(Alexopoulou et al., 2016)

Flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU exhibit glassy and depigmented eyes with abnormal lenses, as compared to controls.

(Fernandez-Funez et al., 2016)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^GMR.PF leads to degeneration of ommatidia in fly eyes (eyes are rough, speckled or collapsed).

(Vos et al., 2016)

Scer\GAL4^GMR.PF-mediated expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} results in a rough eye.

(Butzlaff et al., 2015)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF in larval eye imaginal discs causes a severe eye ablation phenotype.

(Kang et al., 2015)

Feeding flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav-C155 any of -(-)deprenyl (DEP), 2-amino-4,7-dimethylbenzothiazole (PGL) or hydroxynonenal (HNE) significantly decreases the number of aggregates seen in the brain.

(Lazarev et al., 2015)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the retina using Scer\GAL4^GMR.PU severely disrupts eye morphology,resulting in loss of pigmentation, neuron death, and retinal collapse.

Ubiquitous expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} using Scer\GAL4^da.PU shortens lifespan compared to wild-type.

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the nervous system using Scer\GAL4^nrv2.PS leads to decreased locomotion compared to wild-type.

Cystamine treatment enhances neurodegeneration in flies expressing Scer\GAL4^GMR.PU>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}.

(Lin et al., 2015)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^GMR.long results in depigmentation of the external retina and near complete loss (and detachment from the lamina) of the radial ommatidial array of the internal eye.

(Tsou et al., 2015)

The expression of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} under the control of Scer\GAL4^GMR.PU leads to strong toxicity in the eye, as judged by a progressive loss of eye pigmentation.

(Vinatier et al., 2015)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^repo.PU (along with Tub-Gal80ts) leads to neurodegeneration in 7 day old flies (presence of vacuoles).

(Wang et al., 2015)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the drosophila eye, under the control of Scer\GAL4^GMR.long results in robust degeneration of internal and external structures in the adylt eye.

(Burr et al., 2014)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in glia under the control of Scer\GAL4^repo.PU produces significant pathological changes in the adult brain, including large vacuoles, but no mitochondrial enlargement is seen.

(Hegde et al., 2014)

The eyes of 7-week old flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU exhibit total depigmentation with small, scattered necrotic spots. The hexagonal arrangement of photoreceptor clustering has completely disappeared, and numerous protein aggregates are observed.

(Hsu et al., 2014)

Eye-specific expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, under the control of Scer\GAL4^GMR.long results in eye degeneration.

(Liman et al., 2014)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the developing eye, under the control of Scer\GAL4^GMR.long, results in mild disruption of the regular, external lattice of the eye in adult flies. Stronger expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} results in a greater loss of cell integrity, and the pigmentation of the adult flies is completely faded with black point-like necrosis. The fly eyes undergo late-onset, progressive degeneration during adult life. Prolonged treatment with LiCl at a certain range (1-20mM) results in a dramatic improvement of eye depigmentation at 5 days after eclosion, with an obvious increase of pigmentation, decreased black point-like necrosis, and a nearly normal ommatidial pattern of the photoreceptor rhabdomeres. The most notable improvement is observed at the range of 15-20mM.

Neuronal expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, under the control of Scer\GAL4^nrv2.PS, causes decreased locomotor ability and a reduction in adult life span. The addition of 0-10mM LiCl to 1 day old Scer\GAL4^nrv2.PS>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} adult flies generates a dose-dependent increase in locomotor ability, compared to non-treated controls, but as the dose is gradually increased to 15mM, locomotor ability may be further impaired.

The median life span of flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^nrv2.PS increases from 41-47 days to 52-62 days (depending on the strength of expression), when these flies are treated with 5-15mM LiCl. However, a dose of 20mM LiCl has no effect on median life span.

(Jia et al., 2013)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the developing eye under the control of Scer\GAL4^GMR.PF causes massive degeneration of external and internal structures. Degeneration as a result of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} expression is marked by loss of pigmentation in the external eye, loss of ommatidia, a dramatic reduction in retinal depth, and the presence of aggregated structures/inclusions.

(Tsou et al., 2013)

Flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.long have a rough eye phenotype.

(Butler et al., 2012)

Larval ddaE neurons expressing Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} under the control of Scer\GAL4²²¹ show a significant increase in growing microtubules within dendrites, as compared to neurons in controls; these neurons show a severe increase in the proportion of dendrites persisting 18h after dendrite severance, as compared to similarly injured control neurons; these neurons also show a significant increase in growing microtubules within axons and significantly delayed axon beading 12h after axotomy, as compared to similarly injured control neurons.

Larval ddaC neurons expressing Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} under the control of Scer\GAL4⁴⁷⁷ show a moderately reduced dendritic arborization which does not seem to expand as the larval life progresses, as compared to controls. 12h after axotomy, these neurons show a significant increase in growing microtubules within axons, as compared to similarly injured control neurons.

Expression of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} under the control of Scer\GAL4^GMR.long induces eye defects, which range from discoloration to eye collapse and necrosis, as compared to controls.

(Chen et al., 2012)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ninaE.PT results in inclusion formation, a decrease in polyQ protein solubility and progressive neural loss. At 21 days the number of photoreceptors per ommatidium is reduced in male flies compared to controls.

(Liu et al., 2012)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ninaE.PT results in loss of photoreceptor cells in the ommatidia.

(McGurk and Bonini, 2012)

Flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.long display a rough eye phenotype characterized by pigment loss, a disturbed external surface and appearance of necrotic spots due to degeneration of photoreceptors and other retinal cells.

(Voßfeldt et al., 2012)

Larvae expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in class IV da neurons under the control of Scer\GAL4^ppk.PG exhibit striking dendritic abnormalities. Terminal dendritic branching and complexity is greatly reduced compared to controls, whereas the major dendrite branches are unaffected. At 96h after egg laying larvae almost completely blocked growth and branch initiation of terminal dendrites and the proportion of terminal dendrites showing branch retraction is similar to controls. Alterations are seen to the F-actin structures in distal dendrites, but stable microtubular structures are unaffected. The dendrite blebbing and breakages characteristic of dying da neurons is not observed.

Restricting expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} to the adult stages using an RU486-inducible Scer\GAL4^{ppk.Switch.PR} driver also causes a similar loss dendritic terminals in class IV da neurons. These dendritic defects are observed even when administration of RU486 is restricted to 3 days after eclosion, and do not appear to be reversed with aging.

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in class III da neurons under the control of Scer\GAL4^109(2)80 results in reduced filopodia (dendrite terminal structures) formation compared to controls. Major dendritic structures are unaffected.

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in class I da neurons under the control of Scer\GAL4²²¹ has no obvious effects on their dendrites.

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in dorsal cluster neurons under the control of Scer\GAL4^109(2)80 results in a reduction in F-actin structures in distal dendrites. Microtubular structures are not obviously altered.

(Lee et al., 2011)

Expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the developing eye under the control of Scer\GAL4^GMR.PF induces clear defects in the eye, with defective ommatidia seen in 18% of cases.

(Park et al., 2011)

When Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} expression is induced 'early', only for 4 days after eclosion (using the 'TARGET' system and Scer\GAL4^GMR.PF and Scer\GAL80^ts.αTub84B), rhabdomere loss is not observable until 40 days of age. However, when Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} expression os induced from 20 to 24 days of age (i.e. 'late'), neurodegeneration with rhabdomere loss of the ommatidia is observable at 40 days of age, suggesting that Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} expression in older flies causes more severe neurodegeneration than expression in younger flies.

(Tonoki et al., 2011)

Overexpression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU results in massive degeneration of retinal cells giving rise to rough and de-pigmented eyes in freshly eclosed flies. In 50 h old (mid pupal stage) eye discs expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} the integrity of photoreceptor cells is poor when compared with wild-type pupal retina. Small vacuoles are present in Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} expressing retinas and the characteristic arrangement of the seven photoreceptors and the actin filaments within them are also altered.

Unlike wild-type controls, flies overexpressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU do not show any significant phototaxis.

Pan-neuronal overexpression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} via Scer\GAL4^elav.PU results in 100% lethality at pupal stage.

(Arya et al., 2010)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF results in degeneration and depigmentation of the eye.

(Bohm et al., 2010)

Flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} using Scer\GAL4^GMR.PF show progressive eye degeneration, visualized by the presence of dark patches and collapsed eyes.

(Carra et al., 2010)

Pan-neural expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} (under the control of Scer\GAL4^elav-C155) causes age-dependent neurodegeneration, as quantified by decreased numbers of Kenyon cells in the mushroom body.

(Khurana et al., 2010)

Scer\GAL4^GMR.PF-mediated expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} causes eye degeneration.

(Mallik and Lakhotia, 2010)

Expression of the Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the adult eyes (under the control of an unknown Gal4 driver) show a rough eye phenotype.

(Rana et al., 2010)

Expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the eye under the control of Scer\GAL4^GMR.PU results in eye degeneration, and patched, speckled, and collapsed eye phenotypes are observed.

(Vos et al., 2010)

Flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF display a rough-eye phenotype.

(Jung et al., 2009)

Expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} using Scer\GAL4^GMR.PF induces substantial degeneration in eyes with loss of pigmentation and eye morphology.

2-day old flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} using Scer\GAL4^GMR.PF fail to detect light.

(Mallik and Lakhotia, 2009)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the developing eye, under the control of Scer\GAL4^GMR.PF causes only a slight disruption of the regular, external lattice of the eye in young flies; however, the eye morphology of these flies shows progressive degeneration over time, with significant loss of pigmentation by day 15.

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^da.G32 in adult flies (using the temperature sensitive Scer\GAL80^ts.αTub84B allele to limit expression) results in a shorter lifespan.

(Tonoki et al., 2009)

One day old flies expressing a strong insertion of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF show severe compound eye degeneration. This degeneration is strongly suppressed upon treatment with the HSF1-activating compound 17-AAG at concentrations of 500nM, 1.5µM and 5µM. Treatment at 50nM shows only a moderate therapeutic effect and treatment at 50µM has no effect. The suppression seen with 17-AAG is stronger than is seen with the histone deacetylase inhibitor SB, which shows only a weak effect. Treatment with GA at concentrations of 500nM and 5µM also results in modest suppression of compound eye degeneration, but no suppression is seen at concentrations of 500nM and 50µM. Treatment with RA at concentrations ranging from 50nM to 5µM also effectively suppresses neurodegeneration. No detectable changes are seen when the flies are treated with either CL (1 to 100 µM) or GGA (10µM to 40 mM).

Expression of a strong insertion of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the nervous system under the control of Scer\GAL4^elav.PLu significantly decreases the survival rate of flies during their development to adults. This lethality is significantly suppressed upon treatment with the HSF1-activating compound 17-AAG.

Eye discs from flies expressing a weak insertion of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF contain numerous inclusion bodies in the region posterior to the morphogenetic furrow. Significantly fewer inclusion bodies are seen when the flies are treated with the HSF1-activating compound 17-AAG and the size of the remaining inclusion bodies is significantly reduced. Treatment with 17-AAG also reduces the ratio of the anteroposterior width of the area with cells containing inclusion bodies to that of the area with cells containing diffusely distributed protein.

(Fujikake et al., 2008)

Expression of Scer\GAL4^GMR.PF>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} results in severe rhabdomere degeneration.

(Lam et al., 2008)

Flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the developing eye under the control of Scer\GAL4^GMR.PF have a normal external eye, although internally the retina is disorganised.

Flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in differentiated photoreceptor neurons under the control of Scer\GAL4^ninaE.PD are born with the normal complement of seven visible photoreceptors per ommatidium, but progressive degeneration occurs, reducing the number of photoreceptors to on average 6.4 per ommatidium by 12 days and 3.7 by 18 days.

Fewer neuron clones expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} (generated under the control of Scer\GAL4^elav-C155 using MARCM) are retained compared to wild type. Only 13% are still detectable at 3 days and none are recovered at 6 days. This compares to an 83% recovery rate in controls.

In retinal sections of animals expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in differentiated photoreceptor neurons under the control of Scer\GAL4^ninaE.PD inclusions are sparse at 24h but prominent by 4 days.

(Lessing and Bonini, 2008)

One day old flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav-C155 show mild loss of retinal integrity, with approximately 5.8 photoreceptors per ommatidium, rather than the usual seven seen in controls. The lifespan of these flies is reduced compared to controls. Photoreceptor loss is also seen in 25 day old flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in differentiated photoreceptors under the control of Scer\GAL4^ninaE.PD; these flies have on average 4.6 photoreceptors per ommatidium.

Flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} pan-neuronally under the control of Scer\GAL4^elav-C155 show normal climbing behaviour at one day old. Ability to climb becomes progressively worse with age, with approximately 42.1 percent of flies unable to climb by 12 days.

(Li et al., 2008)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of both Scer\GAL4^GMR.PF and Scer\GAL80^ts.αTub84B induced in adult flies results in microscopic aggregates and degeneration in the eye. Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} transgene expression causes progressive deterioration of rhabdomere integrity from day 12 post induction.

(Wong et al., 2008)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU results in external and internal degeneration of the eye, with pigment loss and severely reduced retinal thickness.

1 day old flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU are functionally blind in a phototaxis assay, distributing randomly between a light and dark chamber.

(Bilen and Bonini, 2007)

Expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^GMR.PF results in ablation of the adult eye.

(Ryoo et al., 2007)

50 day old flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PLu show almost no climbing activity.

(Umeda-Kameyama et al., 2007)

Expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the eye (under the control of Scer\GAL4^GMR.PF) induces degeneration, characterised by partial loss of pigmentation and retinal structure.

(Bilen et al., 2006)

Expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}, under the control of Scer\GAL4^GMR.PF, induces progressive degeneration of photoreceptors, coupled with the formation of protein aggregates in 2-day old flies.

(Boeddrich et al., 2006)

Flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^tim.PE have no gross morphological abnormalities but show a significant decrease in lifespan and a significant decrease in mating activity during 1 hour observation periods, despite of an unaffected fertility, as compared to controls; expression of a 'strong' expression line of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} disables circadian locomotor activity patterns, but not the overall locomotor levels, and results in a significant decrease in the number of Pdf-positive small ventral latero-neurons, but not of Pdf-positive large ventral latero-neurons, as compared to controls. Expression of a 'strong' expression line of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Ddc.PL causes no detectable circadian abnormality but does cause defects in female mating latency.

(Kadener et al., 2006)

Expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the brain under the control of Scer\GAL4^30Y induces apoptotic neurodegeneration in the absence of cell cycle activation. Cortical neuron loss and neuropil rarefaction is observed in these animals.

Expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the eye under the control of Scer\GAL4^GMR.PF results in a rough-eye phenotype.

(Khurana et al., 2006)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF results in roughened, depigmented eyes which contain black necrotic spots and are collapsed. Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^{elav.Switch.PO} in the presence of RU486 results in a reduction in adult life span compared to control flies (which have not been fed RU486).

(Martin-Lanneree et al., 2006)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU leads to progressive degeneration and pigment loss in the adult eye.

(Huen and Chan, 2005)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PU, Scer\GAL4^repo-M1B, or Scer\GAL4^Appl.G1a leads to an insertion-dependent lethal phenotype, with the most severely affected line showing pupal lethality, and the less severely affected lines showing reduced adult lifespan.

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^repo-M1B, but not Scer\GAL4^Appl.G1a, results in progressive neurodegeneration, with formation of vacuoles in the brain.

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^loco.PU leads to larval or pupal lethality.

Flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Appl.G1a or Scer\GAL4^repo-M1B exhibit a progressive deficit in phototaxis, when under the control of Scer\GAL4^repo-M1B (but not Scer\GAL4^Appl.G1a) show progressive defects in walking speed and activity, as compared to controls.

(Kretzschmar et al., 2005)

Targeted expression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} in neurons using the Scer\GAL4^elav-C155 driver results in early adult death.

Ectopic expression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1}, driven by Scer\GAL4^GMR.PF, leads to late-onset degeneration in adult eyes. Eyes show loss of retinal structure and lack of pigment one day after eclosion.

(Senoo-Matsuda et al., 2005)

Expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF results in severe degeneration of the retina that is associated with severe collapse of the eye.

Co-expression of Hsap\MJD^{fl.Q27.Scer\UAS.T:Hsap\MYC} restores the eye and retina phenotypes towards normal in flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

Co-expression of Hsap\MJD^{tr.Q27.Scer\UAS.T:Ivir\HA1} does not suppress the eye degeneration phenotype caused by Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

Co-expression of Hsap\MJD^{Δ.Scer\UAS.T:Hsap\MYC} suppresses the eye degeneration phenotype caused by Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

Co-expression of Hsap\MJD^{fl.Q27.UIMmut.Scer\UAS.T:Hsap\MYC} partially suppresses the eye degeneration phenotype caused by Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

Co-expression of Hsap\MJD^{fl.Q27.C14A.Scer\UAS.T:Hsap\MYC} does not suppress the eye degeneration phenotype caused by Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

Co-expression of Hsap\MJD^{fl.Q84.Scer\UAS.T:Hsap\MYC} partially suppresses the eye degeneration phenotype caused by Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

(Warrick et al., 2005)

Expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF results in a retinal degeneration phenotype.

Expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^30Y results in a brain degeneration phenotype; neurons are present in normal numbers in 1 day old flies, but approximately 50% of Kenyon cells degenerate by 20 days after eclosion.

(Ghosh and Feany, 2004)

When Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^elav-C155 nuclear aggregates are seen.

(Lee et al., 2004)

Animals expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^179Y or Scer\GAL4^Appl.G1a exhibit a severe sluggish larval movement phenotype. A large increase in neuronal apoptosis is seen. When Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} is overexpressed at 29^oC larvae do not survive to adulthood but die at second or third instar larval stage.

(Gunawardena et al., 2003)

When Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} us driven by Scer\GAL4^GMR.PF leads to severe, progressive eye degeneration contributing to abnormal ommatidium morphology.

(Kanuka et al., 2003)

Flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF have a severe eye degeneration phenotype, with loss of external and internal eye structure. The degeneration becomes more severe over the lifetime of the adult fly.

(Bonini, 2002)

Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1}; Scer\GAL4^GMR.PF flies have an eye neurodegeneration phenotype.

(Moreno et al., 2002)

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU results in severe degeneration of the eye, with loss of external pigmentation and severe loss of photoreceptor cells in the retina.

Weaker expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU results in a progressive degeneration of the retina as the adults age.

(Chan et al., 2000)

Strong expression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF results in a lack of eye pigmentation, indicating loss of pigment cells, and a collapsed eye, indicating loss of photoreceptor neurons. Weaker expression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF causes progressive degeneration of the eye during adult life.

(Bonini, 1999)

Flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF have degenerate eyes that lack pigment and show severe loss of retinal structure. Expression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav-C155 results in complete lethality or early adult death. Progressive degeneration of the eye, seen as disruption of the regular rhabdomere pattern, is seen.

(Warrick et al., 1999)

Flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF have rough eyes. The severity of the phenotype varies from mild roughness of the eye, through loss of pigment with severely disrupted eye morphology, to reduced eye size. The retina shows cell degeneration. The lamina and medulla show good structure and are normal in size, and the optic chiasm is present, even in flies with a severe phenotype. Large holes are visible in the most lateral part of the lamina, due to separation of the retinal basement membrane from the lamina in flies with moderate or severe phenotypes. The eye morphology progressively degenerates as the flies age. The retina does not deepen as much as normal in pupae expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF. Pigmentation initiates at the correct time, but only occurs round the periphery of the developing eye. Flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav-C155 emerge but show an early death phenotype in weak or moderate expressing P{UAS-Hsap\MJD.tr-Q78} lines. The brains of 4 day old flies appear shrunken compared to 1 day old flies, with the flies dying by 5 days. Gross degeneration of the brain is not seen. The eyes show some irregularity and loss of cell morphology of the rhabdomere lattice in 1 day old flies. A much greater loss of cell integrity is seen in 4 day old flies. Flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav-C155 in strong expressing P{UAS-Hsap\MJD.tr-Q78} lines do not survive to adulthood. Flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^how-24B die as embryos or larvae. Expression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^dpp.blk1 has no phenotypic effect.

(Warrick et al., 1998)

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Reference

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by CG17931^KK106162, Scer\GAL4^GMR.PU

(Tsuboyama et al., 2020)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by CG12384^KK112793, Scer\GAL4^GMR.PU

(Tsuboyama et al., 2020)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by CG11444^KK107891, Scer\GAL4^GMR.PU

(Tsuboyama et al., 2020)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by CG14818^KK110007, Scer\GAL4^GMR.PU

(Tsuboyama et al., 2020)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by vig2^KK102873, Scer\GAL4^GMR.PU

(Tsuboyama et al., 2020)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, enhanceable by Cul1^GD9650, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, enhanceable by Cul1^NIG.1877R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, enhanceable by FipoQ^NIG.2010R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, enhanceable by FipoQ^KK108266, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, enhanceable by slmb^NIG.3412R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has abnormal eye color phenotype, enhanceable by emb^JF01311, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has abnormal eye color phenotype, enhanceable by Kap-α3^UASp.cMa, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by emb^JF01311, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by Kap-α3^UASp.cMa, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has increased cell death | adult stage phenotype, enhanceable by emb^JF01311, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has increased cell death | adult stage phenotype, enhanceable by Kap-α3^UASp.cMa, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Hsap\HSPA1L^K71E.UAS.cFa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Hsap\HSPA1L^SBD-GG.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^da.PU has short lived phenotype, enhanceable by Tg^KK101591, Scer\GAL4^da.PU

(Lin et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Tg^GD10774, Scer\GAL4^GMR.PU

(Lin et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy phenotype, enhanceable by Tg^GD10774, Scer\GAL4^GMR.PU

(Lin et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Tg^KK101591, Scer\GAL4^GMR.PU

(Lin et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy phenotype, enhanceable by Tg^KK101591, Scer\GAL4^GMR.PU

(Lin et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^nrv2.PS has abnormal locomotor behavior phenotype, enhanceable by Scer\GAL4^da.PU/Tg^GD10774

(Lin et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^nrv2.PS has abnormal locomotor behavior phenotype, enhanceable by Scer\GAL4^da.PU/Tg^KK101591

(Lin et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^da.PU has short lived phenotype, enhanceable by Tg^GD10774, Scer\GAL4^da.PU

(Lin et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by CG7220^KK109208, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by STUB1^HMS00986, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by sip3^GD3145, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by Atg7^GD11671, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by Atg8a^HMS01328, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by Atg12^JF02704, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by ref(2)P^KK105338, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by DnaJ-1^HMS00688, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by CG5001^KK108978, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by CG7130^GD2776, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Tbp^UAS.cHa, Scer\GAL4^GMR.PU

(Hsu et al., 2014)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Tbp^sI10

(Hsu et al., 2014)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has abnormal neuroanatomy | progressive phenotype, enhanceable by sgg^UAS.cBa, Scer\GAL4^GMR.long

(Jia et al., 2013)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has melanotic necrosis | progressive phenotype, enhanceable by sgg^UAS.cBa, Scer\GAL4^GMR.long

(Jia et al., 2013)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has increased cell death phenotype, enhanceable by STUB1^HMS00889, Scer\GAL4^GMR.PF

(Tsou et al., 2013)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} has visible phenotype, enhanceable by Cul1^KK100827/Scer\GAL4^GMR.PU

(Bhutani et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} has visible phenotype, enhanceable by SkpA^GD16179/Scer\GAL4^GMR.PU

(Bhutani et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible | adult stage phenotype, enhanceable by γTub23C^GD8749, Scer\GAL4^GMR.long

(Chen et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by fh^RNAi.UAS.cAa, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by mAcon1^KK100999, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by UQCR-C1^KK108539, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by RhoGAP68F^KK102738, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by CG6873^GD12062, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by CG2887^GD9842, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by chm^GD1235, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by Ccs^GD9458, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by timeout^GD12305, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by PNKP^GD14266, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by DAAM^GD8382, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by CG33128^GD5069, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by Pkcδ^GD15429, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by CG43795^GD14309, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by Hsf^GD16368, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by AstA-R2^GD339, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by VGlut2^GD3675/Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by CG15399^GD9009, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by spg^GD10145, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by CG15534^GD3127, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by l(3)neo38^GD12076, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by Marf^GD11094, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by CG12935^GD3496, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, enhanceable by Ars2^GD12300, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ppk.PG has abnormal neuroanatomy | larval stage phenotype, enhanceable by Rac1^V12.UAS, Scer\GAL4^ppk.PG

(Lee et al., 2011)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by U2af50^VDRC.cUa, Scer\GAL4^GMR.PF

(Tsoi et al., 2011)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Prosβ6^1.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Diap1⁵/th[+]

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Diap1^RNAi.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Uba2^C175S.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has abnormal eye color phenotype, enhanceable by lncRNA:Hsrω^EP3037, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by Hsf^RNAi.UAS, Scer\GAL4^GMR.PF

(Fujikake et al., 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has abnormal neuroanatomy | adult stage phenotype, enhanceable by Hsf^RNAi.UAS, Scer\GAL4^GMR.PF

(Fujikake et al., 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PD has decreased cell number | conditional phenotype, enhanceable by Atx2^UAS.cSa, Scer\GAL4^ninaE.PD

(Lessing and Bonini, 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PD has decreased cell number | conditional phenotype, enhanceable by Df(2R)ED3610/+

(Lessing and Bonini, 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155 has short lived phenotype, enhanceable by mbl^UAS.cLa, Scer\GAL4^elav-C155

(Li et al., 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, enhanceable by Kdm2^EP3093, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy phenotype, enhanceable by Df(3L)CH20/+

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, enhanceable by Df(2L)r10/+

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, enhanceable by +/Df(2L)PM44

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has increased cell death phenotype, enhanceable by loqs^f00791

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has increased cell death phenotype, enhanceable by Dcr-1^Q1147X, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, enhanceable by Hsc70-4^K71S.UAS, Scer\GAL4^GMR.PU

(Huen and Chan, 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal eye color | progressive phenotype, enhanceable by Hsc70-4^K71S.UAS, Scer\GAL4^GMR.PU

(Huen and Chan, 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155 has short lived phenotype, enhanceable by Debcl^UAS.Tag:HA, Scer\GAL4^elav-C155

(Senoo-Matsuda et al., 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155 has short lived phenotype, enhanceable by Buffy^UAS.cQa, Scer\GAL4^elav-C155

(Senoo-Matsuda et al., 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy phenotype, enhanceable by DnaJ-1^{ΔJ.UAS.Tag:FLAG}, Scer\GAL4^GMR.PU

(Chan et al., 2000)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy phenotype, enhanceable by DnaJ-1^{G295D.UAS.Tag:FLAG}, Scer\GAL4^GMR.PU

(Chan et al., 2000)

NOT Enhanced by

Statement

Reference

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-enhanceable by ago^NIG.15010R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-enhanceable by Kdm2^GD7173, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-enhanceable by CG11658^NIG.11658R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-enhanceable by Fbxl4^GD5204, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-enhanceable by CG32085^GD10452, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-enhanceable by pall^NIG.3428R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-enhanceable by Fbxl7^GD11255, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-enhanceable by CG4911^NIG.4911R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-enhanceable by CG5961^NIG.5961R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-enhanceable by Fbxo42^GD12027, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-enhanceable by jet^GD14053, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-enhanceable by CG9003^GD13533, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-enhanceable by Fbw5^NIG.9144R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-enhanceable by FBXO11^GD14222, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-enhanceable by Skp2^GD5142, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-enhanceable by Ppa^GD14324, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-enhanceable by Rca1^NIG.10800R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-enhanceable by CG5445^NIG.5445R, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal eye color | progressive phenotype, non-enhanceable by CG5445^NIG.5445R, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, non-enhanceable by Rpn8^KK101319, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, non-enhanceable by Rpn11^GD8888, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, non-enhanceable by Prosβ6¹

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, non-enhanceable by mrj^GD15063, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^repo.PU has abnormal neuroanatomy | adult stage phenotype, non-enhanceable by Nos^UAS.cUa, Scer\GAL4^repo.PU

(Wang et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by Actn^GD1354, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by Rad23^KK107826, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by CG7083^KK101270, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by Drice^GD12284, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by Prosβ6^1.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by Uba2^C175S.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PD has decreased cell number | conditional phenotype, non-enhanceable by Atx2^ΔC1.UAS, Scer\GAL4^ninaE.PD

(Lessing and Bonini, 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, non-enhanceable by Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has increased cell death phenotype, non-enhanceable by Dcr-2^L811fsX, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Suppressed by

Statement

Reference

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155 has short lived phenotype, suppressible | partially by Hsap\ALKBH3^UAS.cSa, Scer\GAL4^elav-C155

(Sun et al., 2023)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^RapGAP1-OK6 has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible by PNKP^GS21535, Scer\GAL4^RapGAP1-OK6

(Chakraborty et al., 2020)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by PNKP^GS21535, Scer\GAL4^GMR.PF

(Chakraborty et al., 2020)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PS has visible | adult stage phenotype, suppressible | partially by Rubicon^GLC01466, Scer\GAL4^GMR.PS

(Nakamura et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PS has melanotic necrosis | adult stage phenotype, suppressible | partially by Rubicon^GLC01466, Scer\GAL4^GMR.PS

(Nakamura et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155 has abnormal adult locomotory behavior | progressive phenotype, suppressible | partially by Rubicon^GLC01466, Scer\GAL4^elav-C155

(Nakamura et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^P2.4.Pdf has abnormal circadian rhythm | adult stage phenotype, suppressible | partially by Atx2^HMS02726, Scer\GAL4^P2.4.Pdf

(Xu et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has abnormal eye color phenotype, suppressible by emb^EY08770, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has abnormal eye color phenotype, suppressible by cdm^GS17666, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has abnormal eye color phenotype, suppressible by Kap-α3^JF02686, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, suppressible by emb^EY08770, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, suppressible by cdm^GS17666, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, suppressible by Kap-α3^JF02686, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has increased cell death | adult stage phenotype, suppressible by emb^EY08770, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has increased cell death | adult stage phenotype, suppressible by cdm^GS17666, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has increased cell death | adult stage phenotype, suppressible by Kap-α3^JF02686, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Hsap\HSPA1L^UAS.cWa

(Fernandez-Funez et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.long has lethal phenotype, suppressible by Hsap\ATXN3^{UAS.Tag:polyHis}, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.long has lethal phenotype, suppressible by DnaJ-1^UAS.cKa, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by eff^HM05268, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Ube4B^JF02691, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by park^HMS01651, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Hsc70-4^JF03136, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Hsc70-3^HMS00397, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by DnaJ-1^UAS.cKa, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has abnormal neuroanatomy | progressive phenotype, suppressible by sgg^S9E.UAS, Scer\GAL4^GMR.long

(Jia et al., 2013)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has melanotic necrosis | progressive phenotype, suppressible by sgg^S9E.UAS, Scer\GAL4^GMR.long

(Jia et al., 2013)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.long

(Butler et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PT has abnormal neuroanatomy | conditional phenotype, suppressible by mir-34^UAS.cLa, Scer\GAL4^ninaE.PT

(Liu et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, suppressible by PICK1^KK109273, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, suppressible by PICK1^JF01199, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by EloA^GD1290, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by ppk14^GD947, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by bwa^GD3476, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by CG17048^GD3783, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Mal-A1^GD5459, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Polr2I^GD4234, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by aux^GD7187, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by trbd^GD14218, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by 5PtaseI^GD8685, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Hsc70-4^GD11264, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Hsc70-4^GD16584, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Gβ13F^GD7011, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by CG5687^GD2255, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Scer\GAL4^GMR.long/Trmt2a^GD11081

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Herc4^GD2240, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Usp2^GD5229, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by THADA^GD9074, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by CG16890^GD9226, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by MRG15^GD11902, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Prim1^GD4566, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Hsc70-1^GD13532, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by CG17919^GD17025, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Cad88C^GD2653, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Dab^GD4886, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Hrb27C^GD6964, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Doa^GD8588, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by LanB1^GD13179, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Droj2^GD14050, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by roq^GD9209, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Isha^GD11266, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Stip1^GD9818, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Fbxo42^GD12027, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ppk.PG has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by Rac1^UAS.cLa, Scer\GAL4^ppk.PG

(Lee et al., 2011)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ppk.PG has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by Pak^{UAS.Tag:Myr(Src64B)}, Scer\GAL4^ppk.PG

(Lee et al., 2011)

Diap1⁵/th[+], Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, suppressible | partially by Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, suppressible by Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal phototaxis phenotype, suppressible by Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav.PU has lethal | P-stage phenotype, suppressible by Hsp60D^RNAi.Sym.UAS, Scer\GAL4^elav.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, suppressible by Scer\GAL80^αTub84B.PB

(Bohm et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, suppressible by Scer\GAL80^αTub84B.PG

(Bohm et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF, nej^{F2161A.UAS.Tag:V5} has partially lethal - majority die | pupal stage phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF, nej^RNAi.UAS.cKa has lethal | pharate adult stage phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has abnormal eye color phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has abnormal phototaxis phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155 has lethal | pharate adult stage phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS/Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^da.G32 has short lived phenotype, suppressible | partially by Rpn11^UAS.cTa, Scer\GAL4^da.G32

(Tonoki et al., 2009)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B has abnormal neuroanatomy | heat sensitive phenotype, suppressible by Hsap\RACK1^UAS.cLa, Scer\GAL4^GMR.PF

(Lam et al., 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PD has decreased cell number | conditional phenotype, suppressible by Atx2^X1/Atx2[+]

(Lessing and Bonini, 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PD has decreased cell number | conditional phenotype, suppressible | partially by pAbp^UAS.cSa, Scer\GAL4^ninaE.PD

(Lessing and Bonini, 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155 has decreased cell number | somatic clone phenotype, suppressible by Atx2^X1/Atx2[+]

(Lessing and Bonini, 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155 has short lived phenotype, suppressible by mbl[+]/mbl^E27

(Li et al., 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B has abnormal neuroanatomy | progressive | heat sensitive phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B

(Wong et al., 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B has abnormal neuroanatomy | progressive | heat sensitive phenotype, suppressible by Hsc70-4^K71S.UAS, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B

(Wong et al., 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, suppressible by Hsp68^E407, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by Hsp68^E407, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, suppressible by mrj^E1050, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by mrj^E1050, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, suppressible by CG14207^EP1348, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by CG14207^EP1348, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by DnaJ-1^B345.2, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by DnaJ-1^EP411, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by Tpr2^EB7-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by Usp47^E213-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by wech^JM120, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by wech^JM265, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by wech^E546, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by wech^EP2594, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by Imp^EP1433, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by Acox1^B227.2, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by CG11700^EP1384, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by CG8209^B3-Sa, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by Faf2^E659, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by emb^E2-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by emb^E128-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by NFAT^EP1335, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by NFAT^EP1508, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by Sin3A^B9-E, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by dbr^EP456, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by dbr^EP9, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by orb2^B8-S, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal phototaxis | adult stage phenotype, suppressible by mrj^E1050, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal phototaxis | adult stage phenotype, suppressible by CG14207^EP1348

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by Prosβ6^1.B.UAS/DnaJ-1^B345.2, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by wech^JM265/Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} has abnormal locomotor behavior phenotype, suppressible by Scer\GAL4^elav.PLu/TrxT^UAS.cUa

(Umeda-Kameyama et al., 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} has abnormal locomotor behavior phenotype, suppressible by Trx2^UAS.cUa/Scer\GAL4^elav.PLu

(Umeda-Kameyama et al., 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} has abnormal locomotor behavior phenotype, suppressible by dhd^UAS.cUa/Scer\GAL4^elav.PLu

(Umeda-Kameyama et al., 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} has abnormal locomotor behavior phenotype, suppressible by TrxT^{D26A.K57I.UAS}/Scer\GAL4^elav.PLu

(Umeda-Kameyama et al., 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} has abnormal locomotor behavior phenotype, suppressible by TrxT^C35A.UAS/Scer\GAL4^elav.PLu

(Umeda-Kameyama et al., 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has increased cell death phenotype, suppressible by mir-ban^D.UAS.EGFP, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has increased cell death phenotype, suppressible by mir-ban^B90.1, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, suppressible | partially by Mlf^UAS.cFa, Scer\GAL4^{elav.Switch.PO}

(Martin-Lanneree et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, suppressible | partially by Mlf^UAS.cKa, Scer\GAL4^{elav.Switch.PO}

(Martin-Lanneree et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, suppressible by Mlf^UAS.cFa, Scer\GAL4^GMR.PF

(Martin-Lanneree et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, suppressible by Mlf^UAS.cKa, Scer\GAL4^GMR.PF

(Martin-Lanneree et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, suppressible by nej^EP1410, Scer\GAL4^GMR.PU

(Huen and Chan, 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal eye color | progressive phenotype, suppressible by nej^EP1410, Scer\GAL4^GMR.PU

(Huen and Chan, 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155 has short lived phenotype, suppressible by Debcl^GS2263, Scer\GAL4^elav-C155

(Senoo-Matsuda et al., 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^Appl.G1a has increased cell death phenotype, suppressible by Hsc70-4^UAS.cEa, Scer\GAL4^Appl.G1a

(Gunawardena et al., 2003)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, suppressible by DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^GMR.PF

(Bonini, 2002)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, suppressible by Hsap\HSPA1L^UAS.cWa/DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^GMR.PF

(Bonini, 2002)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF

(Bonini, 2002, Warrick et al., 1999)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155 has lethal phenotype, suppressible by DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^elav-C155

(Chan et al., 2000)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155 has lethal phenotype, suppressible by Hsap\HSPA1L^UAS.cWa/DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^elav-C155

(Chan et al., 2000)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, suppressible by DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^GMR.PU

(Chan et al., 2000)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy phenotype, suppressible by DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^GMR.PU

(Chan et al., 2000)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | progressive phenotype, suppressible by DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^GMR.PU

(Chan et al., 2000)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, suppressible by DnaJ-H^UAS.Tag:FLAG, Scer\GAL4^GMR.PU

(Chan et al., 2000)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy phenotype, suppressible by Hsap\HSPA1L^UAS.cWa/DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^GMR.PU

(Chan et al., 2000)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Warrick et al., 1998)

NOT suppressed by

Statement

Reference

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155 has short lived phenotype, non-suppressible by Hsap\ALKBH3^Mut.UAS, Scer\GAL4^elav-C155

(Sun et al., 2023)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-suppressible by Cul2^GD8913, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-suppressible by Cul3^GD7408, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-suppressible by Cul4^GD14006, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-suppressible by Cul5^GD8193, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has abnormal eye color phenotype, non-suppressible by cdm^JF01428, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by cdm^JF01428, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has increased cell death | adult stage phenotype, non-suppressible by cdm^JF01428, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-suppressible by CG5445^UAS.cUa, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal eye color | progressive phenotype, non-suppressible by CG5445^UAS.cUa, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by Usp8^HMS01898, Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by Hsc70-3^UAS.cEa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by Hsap\HSPA1L^SBD-GY.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by CG4461^UAS.Tag:V5, Scer\GAL4^GMR.PF

(Vos et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, non-suppressible by Rpn8^KK101319, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, non-suppressible by Rpn11^GD8888, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, non-suppressible by Prosβ6¹

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, non-suppressible by mrj^GD15063, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^repo.PU has abnormal neuroanatomy | adult stage phenotype, non-suppressible by Nos^JF03220, Scer\GAL4^repo.PU

(Wang et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^repo.PU has abnormal neuroanatomy | adult stage phenotype, non-suppressible by Nos^RNAi.UAS.cWa, Scer\GAL4^repo.PU

(Wang et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^repo.PU has abnormal neuroanatomy | adult stage phenotype, non-suppressible by p53^JF02513, Scer\GAL4^repo.PU

(Wang et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype, non-suppressible by Hsap\TRAP1^UAS.cBa, Scer\GAL4^GMR.long

(Butler et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PT has abnormal neuroanatomy | conditional phenotype, non-suppressible by Eip74EF[+]/Eip74EF^BG01805

(Liu et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by Actn^GD1354, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by Rad23^KK107826, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by CG7083^KK101270, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by Drice^GD12284, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ppk.PG has abnormal neuroanatomy | larval stage phenotype, non-suppressible by BacA\p35^UAS.cHa, Scer\GAL4^ppk.PG

(Lee et al., 2011)

Diap1^RNAi.UAS, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by Uba2^C175S.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Scer\GAL80^FRT.αTub84B

(Bohm et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, non-suppressible by CG11700^EP1384/Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage phenotype, non-suppressible by Usp47^E213-1A/Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has increased cell death phenotype, non-suppressible by mir-ban^Δ.as.B.UAS, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has increased cell death phenotype, non-suppressible by Dcr-2^L811fsX, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} has abnormal neuroanatomy phenotype, non-suppressible by Hsap\VCP^UAS.cBa/Scer\GAL4^GMR.PF

(Boeddrich et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, non-suppressible by Mlf[+]/Mlf^ΔC1

(Martin-Lanneree et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^{elav.Switch.PO} has short lived | RU486 conditional phenotype, non-suppressible by Mlf^Δ5-3/Mlf[+]

(Martin-Lanneree et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Dref^UAS.cSa, Scer\GAL4^GMR.PF

(Martin-Lanneree et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Dref^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Martin-Lanneree et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has visible | adult stage | progressive phenotype, non-suppressible by Hsp70Bc^+t14/Hsp70Bb^+t14

(Huen and Chan, 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has abnormal eye color | progressive phenotype, non-suppressible by Hsp70Bc^+t14/Hsp70Bb^+t14

(Huen and Chan, 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has increased cell death phenotype, non-suppressible by puc^UAS.cMa, Scer\GAL4^GMR.PF

(Moreno et al., 2002)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Hsc70-4^K71S.UAS, Scer\GAL4^GMR.PU has abnormal neuroanatomy phenotype, non-suppressible by DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^GMR.PU

(Chan et al., 2000)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by eya^UAS.cBa, Scer\GAL4^GMR.PF

(Warrick et al., 1999)

Enhancer of

Statement

Reference

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Atx2^UAS.cSa, Scer\GAL4^GMR.PF

(Lessing and Bonini, 2008)

NOT Enhancer of

Statement

Reference

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} is a non-enhancer of visible phenotype of Atx2^ΔC1.UAS, Scer\GAL4^GMR.PF

(Lessing and Bonini, 2008)

Other

Statement

Reference

FipoQ^NIG.2010R, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has increased cell death | adult stage phenotype

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU, slmb^NIG.3412R has increased cell death | adult stage phenotype

(Chen et al., 2019)

Cul1^GD9650, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has increased cell death | adult stage phenotype

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.long has lethal phenotype

(Tsou et al., 2015)

CG5001^KK108978, Hsap\ATXN3^{UAS.Tag:polyHis}, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype

(Tsou et al., 2015)

DnaJ-1^HMS00688, Hsap\ATXN3^{UAS.Tag:polyHis}, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has visible phenotype

(Tsou et al., 2015)

Hsap\ATXN3^{UAS.Tag:polyHis}, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Hsf^JF02415, Scer\GAL4^GMR.long has visible phenotype

(Tsou et al., 2015)

DnaJ-1^UAS.cKa, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Hsf^JF02415, Scer\GAL4^GMR.long has visible phenotype

(Tsou et al., 2015)

Hsap\ATXN3^{UAS.Tag:polyHis}, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Rad23^KK107826, Scer\GAL4^GMR.long has visible phenotype

(Tsou et al., 2015)

Cul1^KK100827, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has lethal phenotype

(Bhutani et al., 2012)

Cul1^GD9650, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has lethal phenotype

(Bhutani et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Nrx-IV^GD2436, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, RpS10a^GD7556, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long, brun^GD5423 has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, MED14^GD4081, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Prp8^GD6578, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long, Uck^GD229 has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long, vnc^GD7454 has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Nelf-E^GD9903, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long, bic^GD5037 has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Rab30^GD14116, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Ciz1^GD12382, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

CG8086^GD12374, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Rpn9^GD6909, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long, Sf3b5^GD12979 has lethal phenotype

(Voßfeldt et al., 2012)

CycJ^GD6936, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

HisRS^GD1599, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Prosβ2^GD10938, Scer\GAL4^GMR.long has lethal phenotype

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF, nej^{F2161A.UAS.Tag:V5} has partially lethal - majority die | pupal stage phenotype

(Mallik and Lakhotia, 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF, nej^RNAi.UAS.cKa has lethal | pharate adult stage phenotype

(Mallik and Lakhotia, 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF, lncRNA:Hsrω^RNAi.Sym.UAS has short lived phenotype

(Mallik and Lakhotia, 2009)

Df(3L)CH20/+, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has lethal phenotype

(Bilen and Bonini, 2007)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by CG17931^KK106162, Scer\GAL4^GMR.PU

(Tsuboyama et al., 2020)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by CG12384^KK112793, Scer\GAL4^GMR.PU

(Tsuboyama et al., 2020)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by CG11444^KK107891, Scer\GAL4^GMR.PU

(Tsuboyama et al., 2020)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by CG14818^KK110007, Scer\GAL4^GMR.PU

(Tsuboyama et al., 2020)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by vig2^KK102873, Scer\GAL4^GMR.PU

(Tsuboyama et al., 2020)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, enhanceable by Cul1^GD9650, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, enhanceable by Cul1^NIG.1877R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, enhanceable by FipoQ^NIG.2010R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, enhanceable by FipoQ^KK108266, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, enhanceable by slmb^NIG.3412R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by emb^JF01311, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Kap-α3^UASp.cMa, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Hsap\HSPA1L^K71E.UAS.cFa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has lens phenotype, enhanceable by Hsap\HSPA1L^K71E.UAS.cFa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Hsap\HSPA1L^SBD-GG.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has lens phenotype, enhanceable by Hsap\HSPA1L^SBD-GG.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by Tg^KK101591, Scer\GAL4^GMR.PU

(Lin et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Tg^GD10774, Scer\GAL4^GMR.PU

(Lin et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has retina phenotype, enhanceable by Tg^GD10774, Scer\GAL4^GMR.PU

(Lin et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Tg^KK101591, Scer\GAL4^GMR.PU

(Lin et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by CG7220^KK109208, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by STUB1^HMS00986, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by sip3^GD3145, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by Atg7^GD11671, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by Atg8a^HMS01328, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by Atg12^JF02704, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by ref(2)P^KK105338, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by DnaJ-1^HMS00688, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by CG5001^KK108978, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by CG7130^GD2776, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Tbp^UAS.cHa, Scer\GAL4^GMR.PU

(Hsu et al., 2014)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has photoreceptor phenotype, enhanceable by Tbp^UAS.cHa, Scer\GAL4^GMR.PU

(Hsu et al., 2014)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has photoreceptor phenotype, enhanceable by Tbp^sI10

(Hsu et al., 2014)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Tbp^sI10

(Hsu et al., 2014)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by sgg^UAS.cBa, Scer\GAL4^GMR.long

(Jia et al., 2013)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has ommatidium phenotype, enhanceable by sgg^UAS.cBa, Scer\GAL4^GMR.long

(Jia et al., 2013)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by STUB1^HMS00889, Scer\GAL4^GMR.PF

(Tsou et al., 2013)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by STUB1^HMS00889, Scer\GAL4^GMR.PF

(Tsou et al., 2013)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} has eye phenotype, enhanceable by Cul1^KK100827/Scer\GAL4^GMR.PU

(Bhutani et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} has eye phenotype, enhanceable by SkpA^GD16179/Scer\GAL4^GMR.PU

(Bhutani et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4⁴⁷⁷ has larval dorsal multidendritic neuron ddaC | larval stage phenotype, enhanceable by γTub23C^GD8749, Scer\GAL4⁴⁷⁷

(Chen et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4⁴⁷⁷ has dendritic tree | larval stage phenotype, enhanceable by γTub23C^GD8749, Scer\GAL4⁴⁷⁷

(Chen et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye | adult stage phenotype, enhanceable by γTub23C^GD8749, Scer\GAL4^GMR.long

(Chen et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by fh^RNAi.UAS.cAa, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by mAcon1^KK100999, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by UQCR-C1^KK108539, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by RhoGAP68F^KK102738, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by CG6873^GD12062, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by CG2887^GD9842, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by chm^GD1235, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by Ccs^GD9458, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by timeout^GD12305, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by PNKP^GD14266, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by DAAM^GD8382, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by CG33128^GD5069, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by Pkcδ^GD15429, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by CG43795^GD14309, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by Hsf^GD16368, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by AstA-R2^GD339, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by VGlut2^GD3675/Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by CG15399^GD9009, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by spg^GD10145, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by CG15534^GD3127, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by l(3)neo38^GD12076, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by Marf^GD11094, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by CG12935^GD3496, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, enhanceable by Ars2^GD12300, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ppk.PG has larval multidendritic class IV neuron | larval stage phenotype, enhanceable by Rac1^V12.UAS, Scer\GAL4^ppk.PG

(Lee et al., 2011)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by Mmus\Prnp^{P101L.UAS.Tag:3F4}, Scer\GAL4^GMR.PF

(Park et al., 2011)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Mmus\Prnp^{P101L.UAS.Tag:3F4}, Scer\GAL4^GMR.PF

(Park et al., 2011)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by U2af50^VDRC.cUa, Scer\GAL4^GMR.PF

(Tsoi et al., 2011)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has rhabdomere of eye photoreceptor cell phenotype, enhanceable by U2af50^VDRC.cUa, Scer\GAL4^GMR.PF

(Tsoi et al., 2011)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has ommatidium phenotype, enhanceable by Prosβ6^1.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has ommatidium phenotype, enhanceable by Diap1⁵/th[+]

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has ommatidium phenotype, enhanceable by Diap1^RNAi.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has ommatidium phenotype, enhanceable by Uba2^C175S.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by nej^{F2161A.UAS.Tag:V5}, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by nej^RNAi.UAS.cKa, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by lncRNA:Hsrω^EP3037, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by lncRNA:Hsrω^EP3037, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Hsf^RNAi.UAS, Scer\GAL4^GMR.PF

(Fujikake et al., 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PD has photoreceptor | conditional phenotype, enhanceable by Atx2^UAS.cSa, Scer\GAL4^ninaE.PD

(Lessing and Bonini, 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PD has photoreceptor | conditional phenotype, enhanceable by Df(2R)ED3610/+

(Lessing and Bonini, 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155 has photoreceptor phenotype, enhanceable by mbl^UAS.cLa, Scer\GAL4^elav-C155

(Li et al., 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Df(3L)CH20/+

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Df(2L)r10/+

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by +/Df(2L)PM44

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Kdm2^EP3093, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by loqs^f00791, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by loqs^f00791, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Dcr-1^Q1147X, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Dcr-1^Q1147X, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | adult stage | progressive phenotype, enhanceable by Hsc70-4^K71S.UAS, Scer\GAL4^GMR.PU

(Huen and Chan, 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Debcl^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Senoo-Matsuda et al., 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Debcl^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Senoo-Matsuda et al., 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has pigment granule phenotype, enhanceable by Debcl^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Senoo-Matsuda et al., 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Buffy^UAS.cQa, Scer\GAL4^GMR.PF

(Senoo-Matsuda et al., 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Buffy^UAS.cQa, Scer\GAL4^GMR.PF

(Senoo-Matsuda et al., 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has pigment granule phenotype, enhanceable by Buffy^UAS.cQa, Scer\GAL4^GMR.PF

(Senoo-Matsuda et al., 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y has adult brain phenotype, enhanceable by CG7231^EP2510, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Hsc70-4^K71S.UAS, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Atx2^EP3145, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by CG7231^EP2510, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by Prosβ6¹

(Kanuka et al., 2003)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Prosβ6¹

(Kanuka et al., 2003)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by DnaJ-1^{ΔJ.UAS.Tag:FLAG}, Scer\GAL4^GMR.PU

(Chan et al., 2000)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by DnaJ-1^{G295D.UAS.Tag:FLAG}, Scer\GAL4^GMR.PU

(Chan et al., 2000)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Hsc70-4^K71S.UAS, Scer\GAL4^GMR.PF

(Warrick et al., 1999)

NOT Enhanced by

Statement

Reference

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-enhanceable by ago^NIG.15010R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-enhanceable by Kdm2^GD7173, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-enhanceable by CG11658^NIG.11658R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-enhanceable by Fbxl4^GD5204, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-enhanceable by CG32085^GD10452, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-enhanceable by pall^NIG.3428R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-enhanceable by Fbxl7^GD11255, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-enhanceable by CG4911^NIG.4911R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-enhanceable by CG5961^NIG.5961R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-enhanceable by Fbxo42^GD12027, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-enhanceable by jet^GD14053, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-enhanceable by CG9003^GD13533, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-enhanceable by Fbw5^NIG.9144R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-enhanceable by FBXO11^GD14222, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-enhanceable by Skp2^GD5142, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-enhanceable by Ppa^GD14324, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-enhanceable by Rca1^NIG.10800R, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PT has eye | progressive phenotype, non-enhanceable by Kap-α3^UASp.cMa, Scer\GAL4^ninaE.PT

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PT has ommatidium | progressive phenotype, non-enhanceable by Kap-α3^UASp.cMa, Scer\GAL4^ninaE.PT

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-enhanceable by CG5445^NIG.5445R, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Lerp^GD306, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Dhc93AB^GD11054, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Cwc25^GD17298, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Cwc25^GD9830, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Scer\GAL4^GMR.PF/Trmt2a^GD11081

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by snRNP-U1-C^GD11660, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG5986^GD9900, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by fzy^GD11268, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Gdi^GD11312, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by par-6^GD4048, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Arv1^GD1675, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by DCTN1-p150^GD1455, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by DCTN2-p50^GD13758, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by αTub84B^GD9679, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by αTub84B^GD17779, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by αTub67C^GD13885, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Scamp^GD3371, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by g^GD7158, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by EloB^GD4863, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Spp^GD786, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Prosα7^GD3491, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Nedd8^GD12964, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Fer1^GD13372, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG10979^GD7154, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG17327^GD9348, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Hipk^GD9283, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Drak^GD9422, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG6330^GD11891, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Su(z)2^GD16388, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Su(z)2^GD4494, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Flo2^GD7328, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG7896^GD20, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG7896^GD14469, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG7896^GD2516, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG8664^GD3411, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Snp^GD11912, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Snp^GD10043, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Datp^GD15139, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Vha16-1^GD4523, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Vha16-1^GD17431, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Vha36-1^GD17846, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Lamtor1^GD12840, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by krz^GD8470, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Dab^GD4886, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by T3dh^GD10964, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by T3dh^GD16513, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG3500^GD2177, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by GstS1^GD16335, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Gabat^GD12238, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Cyp301a1^GD13977, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by ttv^GD1993, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG8785^GD1961, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Usp10^GD5121, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG42788^GD8865, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG18508^GD6805, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by nord^GD5955, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Mad1^GD9715, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Shrm^GD16363, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Shrm^GD13983, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG31259^GD2862, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG5500^GD4790, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by hep^GD1461, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG6418^GD11919, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by smash^GD10286, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by S-Lap2^GD10864, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by S-Lap2^GD16773, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG14621^GD3713, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Nuf2^GD14063, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Tet^GD9718, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Tet^GD14834, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Tet^GD14330, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG32809^GD11076, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG32809^GD11060, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG3511^GD11160, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG15629^GD890, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by CG15629^GD17179, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, non-enhanceable by Rpn8^KK101319, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, non-enhanceable by Rpn11^GD8888, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, non-enhanceable by Prosβ6¹

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, non-enhanceable by mrj^GD15063, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^repo.PU has adult brain phenotype, non-enhanceable by Nos^UAS.cUa, Scer\GAL4^repo.PU

(Wang et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, non-enhanceable by Cdk5^GD13840, Scer\GAL4^GMR.long

(Liman et al., 2014)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Actn^GD1354, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Rad23^KK107826, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by CG7083^KK101270, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Drice^GD12284, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, non-enhanceable by Prosβ6^1.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, non-enhanceable by Uba2^C175S.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155 has Kenyon cell phenotype, non-enhanceable by cathD¹

(Khurana et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Prosβ6^1.B.UAS/Prosβ2^1.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PD has photoreceptor | conditional phenotype, non-enhanceable by Atx2^ΔC1.UAS, Scer\GAL4^ninaE.PD

(Lessing and Bonini, 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Dcr-2^L811fsX, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, non-enhanceable by Dcr-2^L811fsX, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by gig^{ΔAkt-P.UAS.Tag:FLAG}, Scer\GAL4^GMR.PF

(Khurana et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y has adult brain phenotype, non-enhanceable by Hsc70-4^K71S.UAS, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y has adult brain phenotype, non-enhanceable by Sirt1^EP2300, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y has adult brain phenotype, non-enhanceable by tara^EP3463, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y has adult brain phenotype, non-enhanceable by pum^EP3461, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y has adult brain phenotype, non-enhanceable by Atx2^UAS.cSa, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y has adult brain phenotype, non-enhanceable by Atx2^EP3145, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, non-enhanceable by Sirt1^EP2300, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, non-enhanceable by tara^EP3463, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, non-enhanceable by pum^EP3461, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Suppressed by

Statement

Reference

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by PNKP^GS21535, Scer\GAL4^GMR.PF

(Chakraborty et al., 2020)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PS has eye phenotype, suppressible | partially by Rubicon^GLC01466, Scer\GAL4^GMR.PS

(Nakamura et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by emb^EY08770, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by cdm^GS17666, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Kap-α3^JF02686, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PT has eye | progressive phenotype, suppressible by Kap-α3^JF02686, Scer\GAL4^ninaE.PT

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PT has ommatidium | progressive phenotype, suppressible by Kap-α3^JF02686, Scer\GAL4^ninaE.PT

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by eff^HM05268, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Ube4B^JF02691, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by park^HMS01651, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Hsc70-4^JF03136, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Hsc70-3^HMS00397, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by DnaJ-1^UAS.cKa, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by sgg^S9E.UAS, Scer\GAL4^GMR.long

(Jia et al., 2013)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has ommatidium phenotype, suppressible by sgg^S9E.UAS, Scer\GAL4^GMR.long

(Jia et al., 2013)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.long

(Butler et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4²²¹ has microtubule | larval stage phenotype, suppressible by γTub23C^GD8749, Scer\GAL4²²¹

(Chen et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4²²¹ has larval dorsal multidendritic neuron ddaE | larval stage phenotype, suppressible by γTub23C^GD8749, Scer\GAL4²²¹

(Chen et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4²²¹ has dendrite | larval stage phenotype, suppressible by γTub23C^GD8749, Scer\GAL4²²¹

(Chen et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4²²¹ has microtubule | larval stage phenotype, suppressible by bsk^DN.UAS.cUa, Scer\GAL4²²¹

(Chen et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4²²¹ has larval dorsal multidendritic neuron ddaE | larval stage phenotype, suppressible by bsk^DN.UAS.cUa, Scer\GAL4²²¹

(Chen et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4²²¹ has dendrite | larval stage phenotype, suppressible by bsk^DN.UAS.cUa, Scer\GAL4²²¹

(Chen et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PT has adult brain | conditional phenotype, suppressible by mir-34^UAS.cLa, Scer\GAL4^ninaE.PT

(Liu et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PT has ommatidium | conditional phenotype, suppressible by mir-34^UAS.cLa, Scer\GAL4^ninaE.PT

(Liu et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PT has photoreceptor | conditional phenotype, suppressible by mir-34^UAS.cLa, Scer\GAL4^ninaE.PT

(Liu et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by PICK1^KK109273, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by PICK1^JF01199, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PT has eye photoreceptor cell phenotype, suppressible by PICK1^KK109273, Scer\GAL4^ninaE.PT

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PT has eye photoreceptor cell phenotype, suppressible by PICK1[+]/PICK1^ΔEP-147

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by EloA^GD1290, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by ppk14^GD947, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by bwa^GD3476, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by CG17048^GD3783, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Mal-A1^GD5459, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Polr2I^GD4234, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by aux^GD7187, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by trbd^GD14218, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by 5PtaseI^GD8685, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Hsc70-4^GD11264, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Hsc70-4^GD16584, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Gβ13F^GD7011, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by CG5687^GD2255, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Scer\GAL4^GMR.long/Trmt2a^GD11081

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Herc4^GD2240, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Usp2^GD5229, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by THADA^GD9074, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by CG16890^GD9226, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by MRG15^GD11902, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Prim1^GD4566, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Hsc70-1^GD13532, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by CG17919^GD17025, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Cad88C^GD2653, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Dab^GD4886, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Hrb27C^GD6964, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Doa^GD8588, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by LanB1^GD13179, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Droj2^GD14050, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by roq^GD9209, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Isha^GD11266, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Stip1^GD9818, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Fbxo42^GD12027, Scer\GAL4^GMR.long

(Voßfeldt et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ppk.PG has larval multidendritic class IV neuron | larval stage phenotype, suppressible | partially by Rac1^UAS.cLa, Scer\GAL4^ppk.PG

(Lee et al., 2011)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^109(2)80 has lobula columnar neuron LC14 | larval stage phenotype, suppressible | partially by Rac1^UAS.cLa, Scer\GAL4^109(2)80

(Lee et al., 2011)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ppk.PG has filamentous actin phenotype, suppressible | partially by Rac1^UAS.cLa, Scer\GAL4^ppk.PG

(Lee et al., 2011)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ppk.PG has larval multidendritic class IV neuron | larval stage phenotype, suppressible | partially by Pak^{UAS.Tag:Myr(Src64B)}, Scer\GAL4^ppk.PG

(Lee et al., 2011)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^109(2)80 has lobula columnar neuron LC14 | larval stage phenotype, suppressible | partially by Scer\GAL4^ppk.PG, Scer\GAL4^109(2)80

(Lee et al., 2011)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ppk.PG has filamentous actin phenotype, suppressible | partially by Scer\GAL4^ppk.PG/Scer\GAL4^ppk.PG

(Lee et al., 2011)

Diap1⁵/th[+], Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has ommatidium phenotype, suppressible | partially by Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has ommatidium phenotype, suppressible by Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Scer\GAL80^αTub84B.PB

(Bohm et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Scer\GAL80^αTub84B.PG

(Bohm et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Hsap\HSPB8^UAS.WT, Scer\GAL4^GMR.PF

(Carra et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Hsap\HSPB8^UAS.K141N, Scer\GAL4^GMR.PF

(Carra et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010, Mallik and Lakhotia, 2009)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF, nej^{F2161A.UAS.Tag:V5} has eye phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF, nej^RNAi.UAS.cKa has eye phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Prosβ2^1.UAS, Prosβ6^1.B.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible | partially by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Hsap\HSPB7^UAS.cVa, Scer\GAL4^GMR.PU

(Vos et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Hsap\ATXN3^{fl.Q27.UAS.Tag:MYC}, Scer\GAL4^GMR.PF

(Jung et al., 2009)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Hsap\ATXN3^{Q84.UAS.Tag:MYC.Tag:FLAG}, Scer\GAL4^GMR.PF

(Jung et al., 2009)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Hsap\ATXN3^{6M.Q83.UAS.Tag:MYC.Tag:FLAG}, Scer\GAL4^GMR.PF

(Jung et al., 2009)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, suppressible by lncRNA:Hsrω^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Mallik and Lakhotia, 2009)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye | progressive phenotype, suppressible by Rpn11^DANC, Scer\GAL4^GMR.PF

(Tonoki et al., 2009)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye | progressive phenotype, suppressible by Rpn11^GS13423, Scer\GAL4^GMR.PF

(Tonoki et al., 2009)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye | progressive phenotype, suppressible by Rpn11^UAS.cTa, Scer\GAL4^GMR.PF

(Tonoki et al., 2009)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B has rhabdomere of eye photoreceptor cell | heat sensitive phenotype, suppressible by Hsap\RACK1^UAS.cLa, Scer\GAL4^GMR.PF

(Lam et al., 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PD has photoreceptor | conditional phenotype, suppressible by Atx2^X1/Atx2[+]

(Lessing and Bonini, 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PD has photoreceptor | conditional phenotype, suppressible | partially by pAbp^UAS.cSa, Scer\GAL4^ninaE.PD

(Lessing and Bonini, 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155 has anterior wing margin | somatic clone phenotype, suppressible by Atx2^X1/Atx2[+]

(Lessing and Bonini, 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155 has sensory neuron | somatic clone phenotype, suppressible by Atx2^X1/Atx2[+]

(Lessing and Bonini, 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B has rhabdomere of eye photoreceptor cell | progressive | heat sensitive phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B

(Wong et al., 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B has rhabdomere of eye photoreceptor cell | progressive | heat sensitive phenotype, suppressible by Hsc70-4^K71S.UAS, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B

(Wong et al., 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B has eye | progressive | heat sensitive phenotype, suppressible by Hsc70-4^K71S.UAS, Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B

(Wong et al., 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Hsp68^E407, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has retina phenotype, suppressible by Hsp68^E407, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by mrj^E1050, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has retina phenotype, suppressible by mrj^E1050, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG14207^EP1348, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has retina phenotype, suppressible by CG14207^EP1348, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by DnaJ-1^B345.2, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by DnaJ-1^EP411, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Tpr2^EB7-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Usp47^E213-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by wech^JM120, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by wech^JM265, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by wech^E546, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by wech^EP2594, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Imp^EP1433, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Acox1^B227.2, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG11700^EP1384, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG8209^B3-Sa, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Faf2^E659, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by emb^E2-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by emb^E128-1A, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by NFAT^EP1335, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by NFAT^EP1508, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Sin3A^B9-E, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by dbr^EP456, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by dbr^EP9, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by orb2^B8-S, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Prosβ6^1.B.UAS/DnaJ-1^B345.2, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by wech^JM265/Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by mir-ban^D.UAS.EGFP, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, suppressible by mir-ban^D.UAS.EGFP, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by mir-ban^B90.1, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, suppressible by mir-ban^B90.1, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Mlf^UAS.cFa, Scer\GAL4^GMR.PF

(Martin-Lanneree et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Mlf^UAS.cKa, Scer\GAL4^GMR.PF

(Martin-Lanneree et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has pigment cell phenotype, suppressible by Mlf^UAS.cFa, Scer\GAL4^GMR.PF

(Martin-Lanneree et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has pigment cell phenotype, suppressible by Mlf^UAS.cKa, Scer\GAL4^GMR.PF

(Martin-Lanneree et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | adult stage | progressive phenotype, suppressible by nej^EP1410, Scer\GAL4^GMR.PU

(Huen and Chan, 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Debcl^GS2263, Scer\GAL4^GMR.PF

(Senoo-Matsuda et al., 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, suppressible by Debcl^GS2263, Scer\GAL4^GMR.PF

(Senoo-Matsuda et al., 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has pigment granule phenotype, suppressible by Debcl^GS2263, Scer\GAL4^GMR.PF

(Senoo-Matsuda et al., 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y has adult brain phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y has adult brain phenotype, suppressible by BacA\p35^UAS.cUa, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y has adult brain phenotype, suppressible by DnaJ-1^UAS.cKa, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y has adult brain phenotype, suppressible by Diap1^UAS.cLa, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, suppressible by BacA\p35^UAS.cUa, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, suppressible by DnaJ-1^UAS.cKa, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, suppressible by Diap1^UAS.cLa, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004, Bonini, 2002, Warrick et al., 1999)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^Appl.G1a has neuron phenotype, suppressible by Hsc70-4^UAS.cEa, Scer\GAL4^Appl.G1a

(Gunawardena et al., 2003)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Sec61α^k04917

(Kanuka et al., 2003)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has ommatidium phenotype, suppressible by Sec61α^k04917

(Kanuka et al., 2003)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^GMR.PF

(Bonini, 2002)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Hsap\HSPA1L^UAS.cWa/DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^GMR.PF

(Bonini, 2002)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^GMR.PF

(Bonini, 2002, Warrick et al., 1999)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^GMR.PU

(Chan et al., 2000)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye photoreceptor cell phenotype, suppressible by DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^GMR.PU

(Chan et al., 2000)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has retina | progressive phenotype, suppressible by DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^GMR.PU

(Chan et al., 2000)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by DnaJ-H^UAS.Tag:FLAG, Scer\GAL4^GMR.PU

(Chan et al., 2000)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has retina phenotype, suppressible by Hsap\HSPA1L^UAS.cWa/DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^GMR.PU

(Chan et al., 2000)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Warrick et al., 1998)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has pigment cell phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PF

(Warrick et al., 1998)

NOT suppressed by

Statement

Reference

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-suppressible by Cul2^GD8913, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-suppressible by Cul3^GD7408, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-suppressible by Cul4^GD14006, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-suppressible by Cul5^GD8193, Scer\GAL4^GMR.PU

(Chen et al., 2019)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by cdm^JF01428, Scer\GAL4^GMR.PF

(Sowa et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | progressive phenotype, non-suppressible by CG5445^UAS.cUa, Scer\GAL4^GMR.PU

(Uechi et al., 2018)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | adult stage phenotype, non-suppressible by Usp8^HMS01898, Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Hsc70-3^UAS.cEa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has lens phenotype, non-suppressible by Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has lens phenotype, non-suppressible by Hsc70-3^UAS.cEa, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Hsap\HSPA1L^SBD-GY.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has lens phenotype, non-suppressible by Hsap\HSPA1L^SBD-GY.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has ommatidium phenotype, non-suppressible by CG4461^UAS.Tag:V5, Scer\GAL4^GMR.PF

(Vos et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG4461^UAS.Tag:V5, Scer\GAL4^GMR.PF

(Vos et al., 2016)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by ttv^GD1993, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG8785^GD1961, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Usp10^GD5121, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG42788^GD8865, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG18508^GD6805, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by nord^GD5955, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Mad1^GD9715, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Shrm^GD16363, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Shrm^GD13983, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG31259^GD2862, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG5500^GD4790, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by hep^GD1461, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG6418^GD11919, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by smash^GD10286, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by S-Lap2^GD10864, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by S-Lap2^GD16773, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG14621^GD3713, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Nuf2^GD14063, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Tet^GD9718, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Tet^GD14834, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Tet^GD14330, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG32809^GD11076, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG32809^GD11060, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG3511^GD11160, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG15629^GD890, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG15629^GD17179, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Lerp^GD306, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Dhc93AB^GD11054, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Cwc25^GD17298, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Cwc25^GD9830, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Scer\GAL4^GMR.PF/Trmt2a^GD11081

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by snRNP-U1-C^GD11660, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG5986^GD9900, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by fzy^GD11268, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Gdi^GD11312, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by par-6^GD4048, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Arv1^GD1675, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by DCTN1-p150^GD1455, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by DCTN2-p50^GD13758, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by αTub84B^GD9679, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by αTub84B^GD17779, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by αTub67C^GD13885, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Scamp^GD3371, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by g^GD7158, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by EloB^GD4863, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Spp^GD786, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Prosα7^GD3491, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Nedd8^GD12964, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Fer1^GD13372, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG10979^GD7154, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG17327^GD9348, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Hipk^GD9283, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Drak^GD9422, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG6330^GD11891, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Su(z)2^GD16388, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Su(z)2^GD4494, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Flo2^GD7328, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG7896^GD20, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG7896^GD14469, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG7896^GD2516, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG8664^GD3411, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Snp^GD11912, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Snp^GD10043, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Datp^GD15139, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Vha16-1^GD4523, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Vha16-1^GD17431, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Vha36-1^GD17846, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Lamtor1^GD12840, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by krz^GD8470, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Dab^GD4886, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by T3dh^GD10964, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by T3dh^GD16513, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by CG3500^GD2177, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by GstS1^GD16335, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Gabat^GD12238, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Cyp301a1^GD13977, Scer\GAL4^GMR.PF

(Butzlaff et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Tg^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Lin et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, non-suppressible by Rpn8^KK101319, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, non-suppressible by Rpn11^GD8888, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, non-suppressible by Prosβ6¹

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, non-suppressible by mrj^GD15063, Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^repo.PU has adult brain phenotype, non-suppressible by Nos^JF03220, Scer\GAL4^repo.PU

(Wang et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^repo.PU has adult brain phenotype, non-suppressible by Nos^RNAi.UAS.cWa, Scer\GAL4^repo.PU

(Wang et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^repo.PU has adult brain phenotype, non-suppressible by p53^JF02513, Scer\GAL4^repo.PU

(Wang et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, non-suppressible by Cdk5^GD13840, Scer\GAL4^GMR.long

(Liman et al., 2014)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype, non-suppressible by Hsap\TRAP1^UAS.cBa, Scer\GAL4^GMR.long

(Butler et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PT has adult brain | conditional phenotype, non-suppressible by Eip74EF[+]/Eip74EF^BG01805

(Liu et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PT has ommatidium | conditional phenotype, non-suppressible by Eip74EF[+]/Eip74EF^BG01805

(Liu et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ninaE.PT has photoreceptor | conditional phenotype, non-suppressible by Eip74EF[+]/Eip74EF^BG01805

(Liu et al., 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Actn^GD1354, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Rad23^KK107826, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by CG7083^KK101270, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Drice^GD12284, Scer\GAL4^GMR.PU

(McGurk and Bonini, 2012)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^ppk.PG has larval multidendritic class IV neuron | larval stage phenotype, non-suppressible by BacA\p35^UAS.cHa, Scer\GAL4^ppk.PG

(Lee et al., 2011)

Diap1^RNAi.UAS, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has ommatidium phenotype, non-suppressible by Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Hsp60D^RNAi.Sym.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, non-suppressible by Uba2^C175S.UAS, Scer\GAL4^GMR.PU

(Arya et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Scer\GAL80^FRT.αTub84B

(Bohm et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Hsap\HSPB8^UAS.K141E, Scer\GAL4^GMR.PF

(Carra et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^elav-C155 has Kenyon cell phenotype, non-suppressible by cathD¹

(Khurana et al., 2010)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by CG11700^EP1384/Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Usp47^E213-1A/Prosβ6^1.B.UAS, Scer\GAL4^GMR.PU

(Bilen and Bonini, 2007)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by mir-ban^Δ.as.B.UAS, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by mir-ban^Δ.as.B.UAS, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Dcr-2^L811fsX, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by Dcr-2^L811fsX, Scer\GAL4^GMR.PF

(Bilen et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} has eye photoreceptor cell phenotype, non-suppressible by Hsap\VCP^UAS.cBa/Scer\GAL4^GMR.PF

(Boeddrich et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by dap^UAS.cdNa/Rbf^UAS.cDa, Scer\GAL4^GMR.PF

(Khurana et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by gig^{ΔAkt-P.UAS.Tag:FLAG}, Scer\GAL4^GMR.PF

(Khurana et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Dref^UAS.cSa, Scer\GAL4^GMR.PF

(Martin-Lanneree et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Dref^RNAi.UAS.cUa, Scer\GAL4^GMR.PF

(Martin-Lanneree et al., 2006)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU has eye | adult stage | progressive phenotype, non-suppressible by Hsp70Bc^+t14/Hsp70Bb^+t14

(Huen and Chan, 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Hsap\ATXN1L^UAS.Tag:FLAG, Scer\GAL4^GMR.PF

(Mizutani et al., 2005)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y has adult brain phenotype, non-suppressible by Atx2^UAS.cSa, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y has adult brain phenotype, non-suppressible by Atx2^EP3145, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by Sirt1^EP2300, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by tara^EP3463, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by pum^EP3461, Scer\GAL4^GMR.PF

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y has adult brain phenotype, non-suppressible by Hsc70-4^K71S.UAS, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y has adult brain phenotype, non-suppressible by Sirt1^EP2300, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y has adult brain phenotype, non-suppressible by tara^EP3463, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^30Y has adult brain phenotype, non-suppressible by pum^EP3461, Scer\GAL4^30Y

(Ghosh and Feany, 2004)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Sec61α^P560ex25

(Kanuka et al., 2003)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has ommatidium phenotype, non-suppressible by Sec61α^P560ex25

(Kanuka et al., 2003)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by puc^UAS.cMa, Scer\GAL4^GMR.PF

(Moreno et al., 2002)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Hsc70-4^K71S.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by DnaJ-1^UAS.Tag:FLAG, Scer\GAL4^GMR.PU

(Chan et al., 2000)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Hsap\MAPT^UAS.cAa, Scer\GAL4^GMR.PF

(Warrick et al., 1999)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by eya^UAS.cBa, Scer\GAL4^GMR.PF

(Warrick et al., 1999)

Enhancer of

Statement

Reference

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Atx2^UAS.cSa, Scer\GAL4^GMR.PF

(Lessing and Bonini, 2008)

NOT Enhancer of

Statement

Reference

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} is a non-enhancer of eye phenotype of Atx2^ΔC1.UAS, Scer\GAL4^GMR.PF

(Lessing and Bonini, 2008)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} is a non-enhancer of retina phenotype of Atx2^ΔC1.UAS, Scer\GAL4^GMR.PF

(Lessing and Bonini, 2008)

Other

Statement

Reference

CG5001^KK108978, Hsap\ATXN3^{UAS.Tag:polyHis}, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype

(Tsou et al., 2015)

DnaJ-1^HMS00688, Hsap\ATXN3^{UAS.Tag:polyHis}, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.long has eye phenotype

(Tsou et al., 2015)

Hsap\ATXN3^{UAS.Tag:polyHis}, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Hsf^JF02415, Scer\GAL4^GMR.long has eye phenotype

(Tsou et al., 2015)

DnaJ-1^UAS.cKa, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Hsf^JF02415, Scer\GAL4^GMR.long has eye phenotype

(Tsou et al., 2015)

Hsap\ATXN3^{UAS.Tag:polyHis}, Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Rad23^KK107826, Scer\GAL4^GMR.long has eye phenotype

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PF, lncRNA:Hsrω^RNAi.Sym.UAS has abdomen phenotype

(Mallik and Lakhotia, 2009)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Khc⁹, Scer\GAL4^179Y has axon | larval stage phenotype

(Gunawardena et al., 2003)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Khc⁹, Scer\GAL4^Appl.G1a has axon | larval stage phenotype

(Gunawardena et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The eye defects induced by the expression of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} under the control of Scer\GAL4^GMR.PU are aggravated by the co-expression of either Cul1^GD9650, slmb^NIG.3412R to the point of even leading to necrotic scars.

(Chen et al., 2019)

The rough eye phenotype and associated depigmentation and necrosis induced by the expression of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} under the control of Scer\GAL4^GMR.PF are severely exacerbated by the co-expression of emb^JF01311 or Kap-α3^UASp.cMa, are slightly improved by the co-expression of cdm^GS17666, emb^EY08770 or Kap-α3^JF02686, but do not seem to be affected by the co-expression of cdm^JF01428; the Kap-α3^UASp.cMa co-expression condition also leads to prominent degeneration of the ommatidia.

The late-onset eye defects (i.e. disorganized ommatidia and tissue dissociation associated with the appearance of vacuoles) induced by the expression of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} under the control of Scer\GAL4^ninaE.PT are mildly suppressed by the co-expression of Kap-α3^JF02686, but do not seem to be affected by the co-expression of Kap-α3^UASp.cMa.

(Sowa et al., 2018)

The age-progressive eye pigmentation loss characteristic for adult flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU is not significantly affected by co-expression of either CG5445^NIG.5445R or CG5445^Scer\UAS.cUa.

(Uechi et al., 2018)

The rough eye phenotype characteristic for adult flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU is not suppressed by expression of Usp8^HMS01898.

(Alexopoulou et al., 2016)

Co-expression of Hsap\HSPA1L^Scer\UAS.cWa (but not Hsap\HSPA1L^Scer\UAS.sec, Hsc70-3^Scer\UAS.cEa or Hsap\HSPA1L^{SBD-GY.Scer\UAS}) completely suppresses the eye phenotypes of flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

Co-expression of Hsap\HSPA1L^{K71E.Scer\UAS.cFa} or Hsap\HSPA1L^{SBD-GG.Scer\UAS} enhances the eye phenotypes of flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

(Fernandez-Funez et al., 2016)

Co-expression of Hsp67Bc^{Scer\UAS.T:SV5\V5} (but not CG4461^{Scer\UAS.T:SV5\V5}) significantly suppresses eye degeneration seen in flies with expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^GMR.PF. Co-expression of Hsp67Bc^GD11244 significantly enhances eye degeneration phenotypes seen in flies with expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^GMR.PF.

(Vos et al., 2016)

Co-expression of Tg^GD10774 exacerbates the Scer\GAL4^GMR.PU>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} eye phenotype. Tg^GD10774 increases neuron death as well as the area affected by retinal collapse and loss of pigmentation.

Co-expression of Tg^KK101591 exacerbates the Scer\GAL4^GMR.PU>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} eye phenotype. Tg^KK101591 increases neuron death as well as the area affected by retinal collapse and loss of pigmentation.

Co-expression of Tg^GD10774 with Scer\GAL4^da.PU>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} exhibit results in a mild reduction if the lifespan of Scer\GAL4^da.PU>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} flies.

Co-expression of Tg^KK101591 with Scer\GAL4^da.PU>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} exhibit results in a mild reduction if the lifespan of Scer\GAL4^da.PU>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} flies.

Co-expression of Tg^GD10774 with Scer\GAL4^da.PU>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} exacerbates the locomotor activity defects in Scer\GAL4^da.PU>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} flies.

Co-expression of Tg^KK101591 with Scer\GAL4^da.PU>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} exacerbates the locomotor activity defects in Scer\GAL4^da.PU>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} flies.

Overexpression of Tg^{Scer\UAS.T:Ivir\HA1} fails to mitigate the rough eye phenotype in Scer\GAL4^GMR.PU>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}.

(Lin et al., 2015)

Co-expression of Rad23^KK107826, DnaJ-1^HMS00688, CG5001^KK108978 or Hsf^JF02415 suppresses the protective role of expression of Hsap\ATXN3^{Scer\UAS.WT.T:Zzzz\His6} in suppressing eye degeneration in flies with Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^GMR.long.

Co-expression of eff^HM05268, CG9934^JF02691, park^HMS01651, CG7220^KK109208, STUB1^HMS00986, sip3^GD3145, Rpn8^KK101319, Rpn11^GD8888, Atg7^GD11671, Atg8a^HMS01328, Atg12^JF02704, ref(2)P^KK105338, mrj^GD15063, CG7130^GD2776, Hsc70-4^JF03136, Hsc70-3^HMS00397, CG10973^KK104957, Hsp27^HMS00807, Hsp60A^KK107896, Hsp83^HMS00796, simultaneous co-expression of Prosβ6^1.B.Scer\UAS and Prosβ2^1.Scer\UAS, or Prosβ6¹ does not suppress the protective role of expression of Hsap\ATXN3^{Scer\UAS.WT.T:Zzzz\His6} in suppression of eye degeneration in Scer\GAL4^GMR.long>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} flies.

Co-expression of eff^HM05268, CG9934^JF02691, park^HMS01651, Hsc70-4^JF03136 or Hsc70-3^HMS00397 partially suppresses eye degeneration in Scer\GAL4^GMR.long>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} flies.

Co-expression of CG7220^KK109208, STUB1^HMS00986, sip3^GD3145, Atg8a^HMS01328, Atg12^JF02704, ref(2)P^KK105338, Atg7^GD11671, DnaJ-1^HMS00688, CG5001^KK108978, CG7130^GD2776 enhances eye degeneration in Scer\GAL4^GMR.long>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} flies.

Co-expression of Rpn8^KK101319 or Rpn11^GD8888, mrj^GD15063 or Prosβ6¹ does not alter eye degeneration in Scer\GAL4^GMR.long>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} flies.

Simultaneous co-expression of Prosβ6^1.B.Scer\UAS and Prosβ2^1.Scer\UAS leads to lethality in Scer\GAL4^GMR.long>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} flies; extra co-expression of Hsap\ATXN3^{Scer\UAS.WT.T:Zzzz\His6} suppresses this lethality.

Co-expression of DnaJ-1^Scer\UAS.cKa suppresses eye degeneration (external and internal) in flies (both 1 day and 2 weeks old) with expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^GMR.long.

(Tsou et al., 2015)

Co-expression of Nos^{dsRNA.shRNA.Scer\UAS}, Nos^JF03220, Nos^Scer\UAS.cUa or p53^JF02513 does not significantly alter neurodegeneration in flies with expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^repo.PU.

(Wang et al., 2015)

Expression of Tbp^Scer\UAS.cHa enhances the rough eye phenotype seen in the eyes of flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU. The number of photoreceptors is also further reduced and there is an increase in aggregate formation.

Tbp^sI10 enhances the photoreceptor loss seen in the eyes of flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU. There is a reduction in the number of protein inclusions seen.

Tbp^sI10 enhances the eye phenotypes seen when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU. The eyes appear glassy with large necrotic patches.

(Hsu et al., 2014)

Reduction of Cdk5 transcript abundance, through the expression of Cdk5^GD13840 does not affect the eye degeneration seen in eyes expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} (all transgenes under the control of Scer\GAL4^GMR.long).

(Liman et al., 2014)

Expression of one copy of dominant-negative sgg^S9E.Scer\UAS in the developing eye, has no effect on toxicity due to expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}. However two copies of sgg^S9E.Scer\UAS partially suppresses Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}-induced eye depigmentation, with decreased black spots, more regular compound eye structure, and increased pigment cells.

Expression of sgg^Scer\UAS.cBa enhances the toxicity of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} flies (when both lines are expressed in the eye under the control of Scer\GAL4^GMR.long. Flies expressing one copy of both lines exhibit serious eye depigmentation, including a greater loss of pigment cells, rough eye collapse, and a highly disordered ommatidial array. These defects are exacerbated by an additional copy of the sgg^Scer\UAS.cBa transgene.

(Jia et al., 2013)

Expression of CHIP^HMS00889 in the developing eye under the control of Scer\GAL4^GMR.PF exacerbates the external eye degeneration caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, highlighted by the presence of necrotic spots. Co-expression of Hsap\ATXN3^{Scer\UAS.T:Zzzz\His6} dramatically suppresses eye degeneration, despite expression of CHIP^HMS00889.

(Tsou et al., 2013)

The rough eye phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.long is suppressed by co-expression of Hsap\HSPA1L^Scer\UAS.cWa, but is not suppressed by co-expression of Hsap\TRAP1^Scer\UAS.cBa.

(Butler et al., 2012)

Expression of mir-34^Scer\UAS.cLa partially suppresses the degeneration seen when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^ninaE.PT. Inclusion formation is slowed, the protein retains greater solubility and neural degeneration is suppressed. The reduced number of photoreceptors per ommatidium seen in 21 day old flies is also partially rescued.

One copy of Eip74EF^BG01805 has little effect on the degeneration seen when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^ninaE.PT.

(Liu et al., 2012)

Co-expression of Plip^GD4965 under the control of Scer\GAL4^ninaE.PT has no significant effect on Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}-induced photoreceptor cell degradation.

Co-expression of Plip^KK108325 under the control of Scer\GAL4^ninaE.PT has no significant effect on Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}-induced photoreceptor cell degradation.

(Chang et al., 2011)

Expression of BacA\p35^Scer\UAS.cHa fails to suppress the dendrite phenotypes seen when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed in class IV da neurons under the control of Scer\GAL4^ppk.PG.

Expression of Rac1^Scer\UAS.cLa partially suppresses the dendrite defects seen in class IV da neurons expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ppk.PG. The reduction in F-actin structures in the distal dendrites of dorsal cluster neurons when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^109(2)80 is also partially rescued.

Expression of Rac1^V12.Scer\UAS further enhances the dendrite defects seen in class IV da neurons expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ppk.PG.

Expression of Pak^{Scer\UAS.T:Myr-Src64B} partially suppresses the dendrite defects seen in class IV da neurons expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ppk.PG. The reduction in F-actin structures in the distal dendrites of dorsal cluster neurons when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^109(2)80 is also partially rescued.

(Lee et al., 2011)

Expression of Mmus\Prnp^{P101L.Scer\UAS.T:Hsap\PRNP-3F4} significantly enhances the pathogenic eye defects seen upon expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the eye (both lines under the control of Scer\GAL4^GMR.PF), with approximately 53% of ommatidia displaying aberrant structures.

(Park et al., 2011)

Co-expression of Hsp60D^{dsRNA.Sym.Scer\UAS} with Scer\GAL4^GMR.PU-driven Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} suppresses the eye degeneration phenotype resulting from Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} overexpression. The eyes show normal pigmentation and more or less regularly organised ommatidial arrays nearly comparable to those in wild-type eyes.

Co-expression of Hsp60D^{dsRNA.Sym.Scer\UAS} with Scer\GAL4^GMR.PU-driven Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} restores phototaxis.

Co-expression of Hsp60D^{dsRNA.Sym.Scer\UAS} via Scer\GAL4^elav.PU partially suppresses the lethality resulting from Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} overexpression. The escapers are short lived with a maximum life span of six days.

Co-expression of Pros26^1.Scer\UAS via Scer\GAL4^elav.PU does not significantly affect the Hsp60D^{dsRNA.Sym.Scer\UAS}-mediated partial suppression of the eye degeneration phenotype caused by Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} overexpression.

The Hsp60D^{dsRNA.Sym.Scer\UAS}-mediated suppression of the eye degeneration phenotype caused by Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} overexpression via Scer\GAL4^GMR.PU is not much affected by heterozygosity for th⁵.

Co-expression of Hsp60D^{dsRNA.Sym.Scer\UAS} via Scer\GAL4^GMR.PU fails to suppress the eye degeneration in Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} and th^{dsRNA.Scer\UAS} expressing flies.

The eye phenotype resulting from simultaneous expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} and Hsp60D^{dsRNA.Sym.Scer\UAS} via Scer\GAL4^GMR.PU does not appear to be affected by co-expression of Uba2^{C175S.Scer\UAS}.

The eye degeneration caused by Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} overexpression via Scer\GAL4^GMR.PU is enhanced by co-expression of Pros26^1.Scer\UAS.

Heterozygosity for th⁵ enhances the eye degeneration resulting from the overexpression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} via Scer\GAL4^GMR.PU.

Co-expression of th^{dsRNA.Scer\UAS} via Scer\GAL4^GMR.PU in Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}-expressing flies results in enhanced eye degeneration with reduction in eye size.

Simultaneous expression of Uba2^{C175S.Scer\UAS} and Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} via Scer\GAL4^GMR.PU enhances eye degradation, resulting in more glazed eyes with little pigmentation.

(Arya et al., 2010)

Scer\GAL80^{Scer\FRT.αTub84B} has no effect on the eye degeneration and depigmentation caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF. When FLPase is used to remove the Scer\FRT cassette in Scer\GAL80^{Scer\FRT.αTub84B}, generating Scer\GAL80^αTub84B.PB which expresses Scer\GAL80, the eye phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF is completely suppressed.

Flies carrying Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF and Scer\GAL80^αTub84B.PG have normal eyes, due to repression of Scer\GAL4^GMR.PF expression by Scer\GAL80^αTub84B.PG. This repression can be removed using FLPase (which removes the Scer\FRT cassette containing the Scer\GAL80 coding region from Scer\GAL80^αTub84B.PG).

(Bohm et al., 2010)

Co-expression of Hsap\HSPB8^Scer\UAS.WT or Hsp67Bc^{Scer\UAS.T:SV5\V5} significantly decreases the eye degeneration seen in Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF flies.

Co-expression of Hsp67Bc^GD11244 significantly worsens the eye degeneration seen in Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF flies.

Co-expression of Hsap\HSPB8^{Scer\UAS.K141E} has no significant effect on the eye degeneration phenotype seen in Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF flies.

Co-expression of Hsap\HSPB8^{Scer\UAS.K141N} significantly decreases the eye degeneration seen in Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF flies.

(Carra et al., 2010)

Removing cathD from mutant Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} overexpressing flies (under the control of Scer\GAL4^elav-C155 in a cathD¹ background) has no effect on Kenyon cell loss.

(Khurana et al., 2010)

Expression of nej^{F2161A.Scer\UAS.T:SV5\V5} in the Scer\GAL4^GMR.PF, Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} background results in 15% lethality at the pupal stage. Surviving flies show a reduction in eye size and a greater disruption in ommatidial arrays. Additional co-expression of one copy of P{Sym-UAS-Hsrω} improves the eye morphology and size and reduces pupal death.

Expression of nej^{dsRNA.Scer\UAS.cKa} in the Scer\GAL4^GMR.PF, Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} background results in >97% lethality at the pharate stage with eye degeneration being dramatically enhanced. Additional co-expression of P{Sym-UAS-Hsrω} robustly suppresses this enhanced eye damage, and also substantially reverses Scer\GAL4^GMR.PF, Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} eye degeneration in a dose-dependent manner. Co-expression of P{Sym-UAS-Hsrω} also improves emergence to adult stage in a dose-dependent manner.

The damaged eye phenotype that results from Scer\GAL4^GMR.PF-mediated expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} is suppressed by co-expression of P{Sym-UAS-Hsrω}, and is not further enhanced by co-expression of Pros26^1.B.Scer\UAS and Prosβ2^1.Scer\UAS. Co-expression of P{Sym-UAS-Hsrω} still suppresses the damage in Scer\GAL4^GMR.PF, Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Pros26^1.B.Scer\UAS, Prosβ2^1.Scer\UAS eyes, but the eyes are not rescued to the degree seen in Scer\GAL4^GMR.PF, Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} eyes.

(Mallik and Lakhotia, 2010)

Expression of Hsap\HSPB7^Scer\UAS.cVa in flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU suppresses the eye degeneration phenotype.

(Vos et al., 2010)

Expression of Hsap\MJD^{Q27.Scer\UAS.T:Hsap\MYC.T:Zzzz\FLAG} in flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF suppresses the eye phenotype.

Expression of Hsap\MJD^{Q84.Scer\UAS.T:Hsap\MYC.T:Zzzz\FLAG} in flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF partially suppresses the eye phenotype.

Expression of Hsap\MJD^{6M.Q83.Scer\UAS.T:Hsap\MYC.T:Zzzz\FLAG} in flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF partially suppresses the eye phenotype.

(Jung et al., 2009)

Co-expression of two copies of P{Sym-UAS-Hsrω} almost completely suppresses the Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF eye phenotype: the external appearance is wild type but rhabdomere arrays are still abnormal.

Co-expression of one or two copies of P{Sym-UAS-Hsrω} restores normal phototactic behaviour to Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF flies.

Co-expression of a single copy of P{Sym-UAS-Hsrω} rescues the pharate lethality seen in Scer\GAL4^elav-C155, Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} flies, allowing 94% of pupae to eclose. However, surviving female flies display abdominal swellings, and lifespan is reduced compared to controls.

(Mallik and Lakhotia, 2009)

The progressive degeneration of the eye caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF is suppressed by co-expression of either Rpn11^DANC, Rpn11^GS13423 or Rpn11^Scer\UAS.cTa.

Co-expression of Rpn11^Scer\UAS.cTa partially suppresses the reduced lifespan caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^da.G32 during adulthood.

Co-expression of Rpn11^{dsRNA.Scer\UAS} enhances the progressive eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

(Tonoki et al., 2009)

Expression of Hsf^{dsRNA.Scer\UAS} suppresses the ability of the HSF1-activating compound 17-AAG to rescue the degeneration seen in flies expressing a strong insertion of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF. The amount of degeneration seen is similar to that observed in untreated flies. However, expression of Hsf^{dsRNA.Scer\UAS} also slightly enhances the compound eye degeneration in the absence of 17-AAG.

(Fujikake et al., 2008)

A marked suppression of Scer\GAL4^GMR.PF>Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}-induced rhabdomere degeneration is observed when Hsap\GNB2L1^Scer\UAS.cLa is co-expressed.

(Lam et al., 2008)

Co-expression of Atx2^Scer\UAS.cSa and Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the developing eye under the control of Scer\GAL4^GMR.PF produces a more severe phenotype than in either mutant alone. The flies exhibit strong eye degeneration with loss of pigmentation and severe collapse of the retina.

Co-expression of Atx2^Scer\UAS.cSa and Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} in differentiated photoreceptor neurons under the control of Scer\GAL4^ninaE.PD enhances the photoreceptor loss seen when either construct is expressed alone. Flies are still born with the normal complement of seven visible photoreceptors, but whereas at six days the single mutants appear near normal, co-expression results in only 4.7 photoreceptors per ommatidium. At 18 days almost complete photoreceptor loss (1.3 photoreceptors per ommatidium) is seen.

One copy of Atx2^X1 suppresses the eye degeneration seen when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed in differentiated photoreceptor neurons under the control of Scer\GAL4^ninaE.PD. On average 6.9 visible photoreceptors are seen per ommatidium in 12 day old flies, similar to the 7 seen in controls. This compares to 6.4 when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed alone.

Homozygous Atx2^X1 suppresses the neuron loss seen in anterior wing margin clones induced in flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav-C155 (generated using MARCM). 77% of neurons are retained at 3 days, compared to only 13% when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed alone. 40% are recovered at 6 days, in contrast to the complete loss of neurons in Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} expressing flies.

Expression of Atx2^Scer\UAS.cSa enhances the rate of inclusion formation seen when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed in differentiated photoreceptor neurons under the control of Scer\GAL4^ninaE.PD. Inclusions are more prominent at 24 hours, but by four days appear similar to when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed alone.

Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} has no effect on the eye phenotype seen when Atx2^{ΔC1.Scer\UAS} is expressed in the developing eye under the control of Scer\GAL4^GMR.PF. The phenotype seen is identical to that seen when Atx2^{ΔC1.Scer\UAS} is expressed alone.

Co-expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} and Atx2^{ΔC1.Scer\UAS} in differentiated photoreceptor neurons under the control of Scer\GAL4^ninaE.PD causes mild photoreceptor loss at six days (an average of 6.7 visible photoreceptors per ommatidium, compared to seven in controls). This is similar to the phenotype seen when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed alone.

Expression of Atx2^{ΔC1.Scer\UAS} does not enhance the rate of inclusion formation seen when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed in differentiated photoreceptor neurons under the control of Scer\GAL4^ninaE.PD.

One copy of Df(2R)ED3610 enhances the photoreceptor loss seen when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed in differentiated photoreceptor neurons under the control of Scer\GAL4^ninaE.PD. On average 1.6 photoreceptors are seen per ommatidium in 18 day old flies, as opposed to the seven seen in wild type. This compares to 3.5 when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed alone.

Expression of pAbp^Scer\UAS.cSa partially suppresses the photoreceptor loss seen when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed in differentiated photoreceptor neurons under the control of Scer\GAL4^ninaE.PD. On average 6.0 visible photoreceptors are seen per ommatidium in 18 day old flies, as opposed to the seven seen in wild type. This compares to 4.2 when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed alone.

(Lessing and Bonini, 2008)

Expression of mbl^Scer\UAS.cLa enhances the reduction in lifespan and photoreceptor loss seen when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed pan-neuronally under the control of Scer\GAL4^elav-C155. Flies have on average 3.0 photoreceptors per ommatidium, compared to the usual seven. One copy of mbl^E27 partially suppresses the shortened lifespan seen when Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is expressed in the developing eye under the control of Scer\GAL4^elav-C155.

(Li et al., 2008)

Co-expression of BacA\p35^Scer\UAS.cHa restores the Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} induced loss of rhabdomeres at day 12 post induction. However, the suppressive effect of BacA\p35^Scer\UAS.cHa is lost at a later time point.

Co-expression of BacA\p35^Scer\UAS.cHa suppresses the Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} induced loss of rhabdomeres and significantly reduces the percentage of cells with aggregates.

Co-expression of Hsap\HSPA1L^Scer\UAS.cWa can suppress neurodegeneration induced by Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}.

(Wong et al., 2008)

Hsp68^E407, mrj^E1050 and CG14207^EP1348 are each strong suppressors of the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU. External eye pigmentation is restored, and the thickness of the retina is restored towards normal.

DnaJ-1^B345.2, DnaJ-1^EP411, Tpr2^EB7-1A, Ubp64E^E213-1A, wech^JM120, wech^JM265, wech^E546, wech^EP2594, Imp^EP1433 and CG5009^B227.2 are each strong suppressors of the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

CG11700^EP1384, CG8209^B3-Sa, Faf^E659, emb^E2-1A, emb^E128-1A, NFAT^EP1335 and NFAT^EP1508 are each moderate suppressors of the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

Sin3A^B9-E, dbr^EP456, dbr^EP9 and orb2^B8-S are each weak suppressors of the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

Kdm2^EP3093 is an enhancer of the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

Expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU in the presence of Df(3L)CH20/+ results in lethality and causes severe eye degeneration in pupae.

Df(2L)r10 and Df(2L)PM44 each dominantly enhance the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

Co-expression of mrj^E1050 completely restores normal visual behaviour, and co-expression of CG14207^EP1348 partially restores visual behaviour in 1 day old flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU and tested in a phototaxis assay.

Co-expression of Prosβ6^1.B.Scer\UAS does not enhance the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

In the presence of Prosβ6^1.B.Scer\UAS, CG11700^EP1384 cannot suppress the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

In the presence of Prosβ6^1.B.Scer\UAS, Ubp64E^E213-1A cannot suppress the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

DnaJ-1^B345.2 and wech^JM265 are each still able to suppress the eye degeneration phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU when the flies also carry Prosβ6^1.B.Scer\UAS.

(Bilen and Bonini, 2007)

The severe reduction in climbing ability seen in 50 day old flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PLu is partially suppressed by co-expression of one of TrxT^Scer\UAS.cUa, TrxT^{D26A.K57I.Scer\UAS}, TrxT^{C35A.Scer\UAS}, Trx-2^Scer\UAS.cUa or dhd^Scer\UAS.cUa.

(Umeda-Kameyama et al., 2007)

Eye degeneration due to expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the eye (under the control of Scer\GAL4^GMR.PF) is enhanced in a loqs^f00791 background, resulting in a severely degenerated eye with complete loss of pigmentation.

Expression of ban^{D.Scer\UAS.T:Avic\GFP-EGFP}, bearing only a 100bp region containing the ban miRNA suppresses degeneration in Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} Scer\GAL4^GMR.PF flies, restoring external and internal eye structures towards normal.

Expression of ban^{B.Scer\UAS.T:Avic\GFP-EGFP} does not suppress eye degeneration in Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} Scer\GAL4^GMR.PF flies.

Eye degeneration due to expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the eye (under the control of Scer\GAL4^GMR.PF) is enhanced in a Dcr-1^Q1147X background, resulting in a severely degenerated eye with complete loss of pigmentation.

Eye degeneration due to expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the eye (under the control of Scer\GAL4^GMR.PF) is unaffected by a Dcr-2^L811fsX background.

Co-expression of ban^B90.1 with Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} (under the control of Scer\GAL4^GMR.PF gives normal pigementation and improved retinal structure.

(Bilen et al., 2006)

Co-expression of Hsap\VCP^Scer\UAS.cBa with Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}, both under the control of Scer\GAL4^GMR.PF fails to suppress the Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} photoreceptor phenotype in 2-day old flies.

(Boeddrich et al., 2006)

The rough-eye phenotype observed in animals expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the eye under the control of Scer\GAL4^GMR.PF is not modified by co-expression of Rheb^AV4.

The rough-eye phenotype observed in animals expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} in the eye under the control of Scer\GAL4^GMR.PF is not modified by co-expression of gig^{ΔAkt-P.Scer\UAS.T:Zzzz\FLAG}.

(Khurana et al., 2006)

Co-expression of either Mlf^Scer\UAS.cFa or Mlf^Scer\UAS.cKa results in a strong suppression of the mutant eye phenotype caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF. The reduction in life span that is seen in flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^{elav.Switch.PO} in the presence of RU486 is partially rescued by co-expression of either Mlf^Scer\UAS.cFa or Mlf^Scer\UAS.cKa. The reduction in life span that is seen in flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^{elav.Switch.PO} in the presence of RU486 is not modified by the addition of Mlf^ΔC1/+ or Mlf^Δ5-3/+.

(Martin-Lanneree et al., 2006)

The progressive degeneration and pigmentation loss eye phenotype characteristic for flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU is suppressed by co-expression of Hsap\HSPA1L^Scer\UAS.cWa although signs of degeneration are eventually observed in aged (32 days post-eclosion) flies. The eye degeneration phenotype is partially suppressed by co-expression of nej^EP1410, is enhanced by co-expression of Hsc70-4^{K71S.Scer\UAS} but not modified by combination with Hsp70Bc^+t14 together with Hsp70Bb^+t14.

(Huen and Chan, 2005)

The eye phenotype caused by expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF, is not suppressed by coexpression of Hsap\Boat^{Scer\UAS.T:Zzzz\FLAG}.

(Mizutani et al., 2005)

Flies expressing both Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} and debcl^{Scer\UAS.T:Ivir\HA1} in their neurons, under the control of Scer\GAL4^elav-C155, show a significantly shorter lifespan than flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} alone.

Coexpression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} and debcl^{Scer\UAS.T:Ivir\HA1}, driven by Scer\GAL4^GMR.PF, accelerates the onset of eye neurodegeneration seen in adults expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1}. The loss of retinal structure and pigment defects are strongly enhanced by debcl^{Scer\UAS.T:Ivir\HA1} expression.

Overexpression of Buffy^Scer\UAS.cQa enhances the Scer\GAL4^GMR.PF;Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1}-induced eye neurodegeneration and lethality.

Eyes coexpressing debcl^{Scer\UAS.T:Ivir\HA1}, Buffy^Scer\UAS.cQa, and Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} (all driven by Scer\GAL4^GMR.PF) show a significantly weaker degenerative eye phenotype than eyes expressing Buffy^Scer\UAS.cQa and Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1}.

Ectopic expression of debcl^GS2263, under the control of Scer\GAL4^GMR.PF, suppresses the Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1}-induced neurodegeneration of the eye. In addition , debcl^GS2263 markedly rescues the early adult death of flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} in their neurons, driven by Scer\GAL4^elav-C155.

(Senoo-Matsuda et al., 2005)

Co-expression of Pros26^1.Scer\UAS suppresses the ability of Hsap\MJD^{fl.Q27.Scer\UAS.T:Hsap\MYC} to restore the eye and retina phenotypes towards normal in flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF, such that the triple mutant flies have a reduction in eye pigmentation, show collapse of the eye and loss of internal retinal tissue.

(Warrick et al., 2005)

When Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} is driven in neurons either by Scer\GAL4^Appl.G1a or Scer\GAL4^179Y, and combined with Khc⁹, mutant larval nerves contain axonal blockages. Mutant nerves also contain enlarged axons, some almost four or five times the diameter of those seen in wild-type. Sometimes "holes" lacking organelles are seen within the nerve.

(Gunawardena et al., 2003)

Co-expression of Hsap\HSPA1L^Scer\UAS.cWa partially suppresses the eye degeneration seen in flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

Co-expression of DnaJ-1^{Scer\UAS.T:Zzzz\FLAG} partially suppresses the eye degeneration seen in flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

Co-expression of both Hsap\HSPA1L^Scer\UAS.cWa and DnaJ-1^{Scer\UAS.T:Zzzz\FLAG} completely suppresses the eye degeneration seen in flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

(Bonini, 2002)

The eye neurodegeneration phenotype of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1}; Scer\GAL4^GMR.PF flies is not supressed by puc^Scer\UAS.cMa.

(Moreno et al., 2002)

Co-expression of DnaJ-1^{Scer\UAS.T:Zzzz\FLAG} restores external eye structure in animals expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU. Internal eye structure is partially rescued, with partial preservation of photoreceptor rhabdomere specialisations.

Co-expression of DnaJ-1^{Scer\UAS.T:Zzzz\FLAG} slow the progressive retinal degeneration seen in flies that weakly express Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

Co-expression of either DnaJ-1^{ΔJ.Scer\UAS.T:Zzzz\FLAG} or DnaJ-1^{G295D.Scer\UAS.T:Zzzz\FLAG} enhances the weak eye phenotype seen in flies that weakly express Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU, such that loss of pigmentation and collapse of the eye is seen.

Co-expression of DnaJ-H^{Scer\UAS.T:Zzzz\FLAG} only weakly suppresses the loss of eye pigmentation seen in flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

Expression of DnaJ-1^{Scer\UAS.T:Zzzz\FLAG} cannot suppress the severe eye degeneration seen in flies co-expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} and Hsc70-4^{K71S.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

Flies that co-express Hsap\HSPA1L^Scer\UAS.cWa, Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} and DnaJ-1^{ΔJ.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^GMR.PU have normal eyes.

Co-expression of Hsap\HSPA1L^Scer\UAS.cWa partially suppresses the retinal degeneration seen in flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

Simultaneous co-expression of both DnaJ-1^{Scer\UAS.T:Zzzz\FLAG} and Hsap\HSPA1L^Scer\UAS.cWa results in a stronger suppression of the retinal degeneration caused by expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU than expression of either construct alone.

(Chan et al., 2000)

The eye phenotype caused by expression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF is suppressed by coexpression of Hsap\HSPA1L^Scer\UAS.cWa; the eye appears normal externally, and internally eye structure is largely restored, although photoreceptor rhabdomere specialisations are not made. The eye degeneration phenotype caused by Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} expressed under the control of Scer\GAL4^GMR.PF is not suppressed by coexpression of Hsap\MAPT^Scer\UAS.cAa or eya^Scer\UAS.cBa. Adult viability in flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav-C155 is partially restored by coexpression of Hsap\HSPA1L^Scer\UAS.cWa and degeneration of the eye is slowed. Hsc70-4^{K71S.Scer\UAS} enhances the disruption of the eye caused by expression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF.

(Warrick et al., 1999)

Co-expression of BacA\p35^Scer\UAS.cHa in flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF partially restores eye pigmentation.

(Warrick et al., 1998)

Complementation and Rescue Data

Rescued by

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} is rescued by Hsap\ATXN3^{HNHH.UAS.Tag:polyHis}/Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} is rescued by Hsap\ATXN3^{UAS.Tag:polyHis}/Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} is rescued by Hsap\ATXN3^{UAS.Tag:polyHis}/Scer\GAL4^GMR.PF

(Tsou et al., 2013)

Partially rescued by

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} is partially rescued by Hsap\ATXN3^{W87A.UAS.Tag:polyHis}/Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} is partially rescued by Hsap\ATXN3^{fl.Q27.UAS.Tag:MYC}/Scer\GAL4^GMR.PU

(Vinatier et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} is partially rescued by Scer\GAL4^GMR.PF/Hsap\ATXN3^{K-null.UAS.Tag:polyHis}

(Tsou et al., 2013)

Not rescued by

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} is not rescued by Hsap\ATXN3^{C14A.UAS.Tag:polyHis}/Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} is not rescued by Hsap\ATXN3^{W87K.UAS.Tag:polyHis}/Scer\GAL4^GMR.long

(Tsou et al., 2015)

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA} is not rescued by Hsap\ATXN3^{C14A.UAS.Tag:polyHis}/Scer\GAL4^GMR.PF

(Tsou et al., 2013)

Comments

Co-expression of Hsap\ATXN3^{Scer\UAS.WT.T:Zzzz\His6} or Hsap\ATXN3^{HNHH.Scer\UAS.T:Zzzz\His6}, but not Hsap\ATXN3^{C14A.Scer\UAS.T:Zzzz\His6}, Hsap\ATXN3^{W87K.Scer\UAS.T:Zzzz\His6}, significantly suppresses the eye degeneration (internal and external) seen in flies with expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^GMR.long; co-expression of Hsap\ATXN3^{W87A.Scer\UAS.T:Zzzz\His6} partially suppresses the eye degeneration.

(Tsou et al., 2015)

Co-expression of Hsap\ATXN3^{Scer\UAS.T:Zzzz\His6} dramatically suppresses the eye degeneration seen upon expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} (with both transgenes under the control of Scer\GAL4^GMR.PF).

Co-expression of Hsap\ATXN3^{C14A.Scer\UAS.T:Zzzz\His6} does not suppress the eye degeneration seen upon expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} (with both transgenes under the control of Scer\GAL4^GMR.PF).

Co-expression of Hsap\ATXN3^{K117.Scer\UAS.T:Zzzz\His6} suppresses the eye degeneration seen upon expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} (with both transgenes under the control of Scer\GAL4^GMR.PF).

Co-expression of non-ubiquitinatable Hsap\ATXN3^{K-null.Scer\UAS.T:Zzzz\His6} partially suppresses the eye degeneration seen upon expression of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} (with both transgenes under the control of Scer\GAL4^GMR.PF). However, by 2 weeks of age the potency of Hsap\ATXN3^{K-null.Scer\UAS.T:Zzzz\His6} to suppress degeneration is markedly lower than that of Hsap\ATXN3^{Scer\UAS.T:Zzzz\His6} or Hsap\ATXN3^{K117.Scer\UAS.T:Zzzz\His6} transgenes. These flies still display severe eye degeneration and reduced retinal depth.

(Tsou et al., 2013)

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Mutant

Wild-type

Stocks (2)

Bloomington

8150

w^*; P{UAS-hATXN3.tr-Q78}c211.2

8141

w^*; P{UAS-hATXN3.tr-Q78}c37.3/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}

Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1}

Hsap\MJD^{Q78.UAS.T:HA1}

Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}

Name Synonyms

Secondary FlyBase IDs

References (121)

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