Allele Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}

General Information
Symbol	Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}	Species	H. sapiens
Name		FlyBase ID	FBal0090630
Feature type	allele	Associated gene	Hsap\ATXN3

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
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FB2013_03
FB2013_02	Controlled Vocabulary Terms decreased cell number somatic clone anterior wing margin sensory neuron
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Warrick et al., 1998) in vitro construct - regulatory fusion (Warrick et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: A truncated form of Hsap\MJD, consisting of an expanded length glutamine tract (78 repeats) flanked upstream by 12 amino acids and downstream by the carboxy terminal 43 amino acids of Hsap\MJD, is expressed under the control of Scer\UAS regulatory sequences. The Hsap\MJD protein is tagged at the N-terminal end with T:Ivir\HA1. (Warrick et al., 1998)
Carried in construct	P{UAS-Hsap\MJD.tr-Q78} (Martin-Lanneree et al., 2006, Warrick et al., 1999, Mizutani et al., 2005, Jung and Bonini, 2007, Moreno et al., 2002, Gunawardena et al., 2003, Lee et al., 2004, Bilen et al., 2006, Kanuka et al., 2003, Perez et al., 1998, Bonini, 1999, Warrick et al., 1998, Senoo-Matsuda et al., 2005, Kadener et al., 2006, Boeddrich et al., 2006, Umeda-Kameyama et al., 2007, Warrick et al., 2005, Bonini, 2002, Bohm et al., 2010, Ryoo et al., 2007, Mallik and Lakhotia, 2009, Arya et al., 2010, Khurana et al., 2006, Mallik and Lakhotia, 2010, Jung et al., 2009, Vos et al., 2010, Carra et al., 2010, Watson et al., 2008, Park et al., 2011, Ghosh and Feany, 2004, Khurana et al., 2010, Chang et al., 2011, Tonoki et al., 2011, Butler et al., 2012, Liu et al., 2012, Lessing and Bonini, 2008, Bhutani et al., 2012, Chan et al., 2000, Fujikake et al., 2008, Bilen and Bonini, 2007, Li et al., 2008)
Tagged with	T:Ivir\HA1 (Warrick et al., 1998, Perez et al., 1998, Bonini, 1999, Warrick et al., 1999, Moreno et al., 2002, Gunawardena et al., 2003, Kanuka et al., 2003, Lee et al., 2004, Mizutani et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class
	courtship behavior defective \| female, with Scer\GAL4^Ddc.PL (Kadener et al., 2006) decreased cell number \| conditional, with Scer\GAL4^ninaE.PD (Lessing and Bonini, 2008) decreased cell number \| somatic clone, with Scer\GAL4^elav-C155 (Lessing and Bonini, 2008) eye color defective, with Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2009) gravitaxis defective \| progressive, with Scer\GAL4^elav-C155 (Li et al., 2008) increased cell death, with Scer\GAL4^30Y (Khurana et al., 2006) increased cell death, with Scer\GAL4^179Y (Gunawardena et al., 2003) increased cell death, with Scer\GAL4^Appl.G1a (Gunawardena et al., 2003) increased cell death, with Scer\GAL4^GMR.PF (Moreno et al., 2002, Bilen et al., 2006) lethal, with Scer\GAL4^elav-C155 (Warrick et al., 1998, Warrick et al., 1999, Chan et al., 2000) lethal, with Scer\GAL4^how-24B (Warrick et al., 1998) lethal \| heat sensitive, with Scer\GAL4^179Y (Gunawardena et al., 2003) lethal \| heat sensitive, with Scer\GAL4^Appl.G1a (Gunawardena et al., 2003) lethal \| pharate adult stage, with Scer\GAL4^elav-C155 (Mallik and Lakhotia, 2009) lethal \| P-stage, with Scer\GAL4^elav.PU (Arya et al., 2010) locomotor behavior defective, with Scer\GAL4^elav.PLu (Umeda-Kameyama et al., 2007) locomotor behavior defective \| larval stage, with Scer\GAL4^179Y (Gunawardena et al., 2003) locomotor behavior defective \| larval stage, with Scer\GAL4^Appl.G1a (Gunawardena et al., 2003) locomotor rhythm defective, with Scer\GAL4^tim.PE (Kadener et al., 2006) mating defective, with Scer\GAL4^tim.PE (Kadener et al., 2006) neuroanatomy defective (Boeddrich et al., 2006) neuroanatomy defective, with Scer\GAL4^elav-C155 (Khurana et al., 2010) neuroanatomy defective, with Scer\GAL4^GMR.PU (Chan et al., 2000) neuroanatomy defective \| adult stage, with Scer\GAL4^GMR.PF (Fujikake et al., 2008) neuroanatomy defective \| adult stage, with Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) neuroanatomy defective \| conditional, with Scer\GAL4^ninaE.PT (Liu et al., 2012) neuroanatomy defective \| progressive, with Scer\GAL4^GMR.PU (Chan et al., 2000) partially lethal - majority die, with Scer\GAL4^elav.PLu (Fujikake et al., 2008) phototaxis defective, with Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2009) phototaxis defective, with Scer\GAL4^GMR.PU (Arya et al., 2010) phototaxis defective \| adult stage, with Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) short lived, with Scer\GAL4^elav-C155 (Senoo-Matsuda et al., 2005, Li et al., 2008) short lived, with Scer\GAL4^tim.PE (Kadener et al., 2006) short lived \| RU486 conditional, with Scer\GAL4^{elav.Switch.PO} (Martin-Lanneree et al., 2006) visible, with Scer\GAL4^elav-C155 (Warrick et al., 1998) visible, with Scer\GAL4^GMR.long (Butler et al., 2012) visible, with Scer\GAL4^GMR.PF (Warrick et al., 1998, Martin-Lanneree et al., 2006, Warrick et al., 1999, Bonini, 1999, Warrick et al., 2005, Bonini, 2002, Bohm et al., 2010) visible, with Scer\GAL4^GMR.PU (Arya et al., 2010, Chan et al., 2000, Bilen and Bonini, 2007) visible \| adult stage, with Scer\GAL4^GMR.PF (Fujikake et al., 2008)
Phenotype Manifest In
	adult brain, with Scer\GAL4^30Y (Khurana et al., 2006, Ghosh and Feany, 2004) adult brain, with Scer\GAL4^elav-C155 (Warrick et al., 1998) adult brain \| conditional, with Scer\GAL4^ninaE.PT (Liu et al., 2012) anterior wing margin \| somatic clone, with Scer\GAL4^elav-C155 (Lessing and Bonini, 2008) eye, with Scer\GAL4^elav-C155 (Warrick et al., 1998, Warrick et al., 1999) eye, with Scer\GAL4^GMR.long (Butler et al., 2012) eye, with Scer\GAL4^GMR.PF (Moreno et al., 2002, Warrick et al., 1998, Mizutani et al., 2005, Martin-Lanneree et al., 2006, Kanuka et al., 2003, Warrick et al., 1999, Bonini, 1999, Senoo-Matsuda et al., 2005, Warrick et al., 2005, Bonini, 2002, Ryoo et al., 2007, Bilen et al., 2006, Mallik and Lakhotia, 2009, Khurana et al., 2006, Mallik and Lakhotia, 2010, Jung et al., 2009, Carra et al., 2010, Park et al., 2011, Bohm et al., 2010, Fujikake et al., 2008) eye, with Scer\GAL4^GMR.PU (Vos et al., 2010, Chan et al., 2000, Bilen and Bonini, 2007) eye disc, with Scer\GAL4^GMR.PF (Fujikake et al., 2008) eye photoreceptor cell (Boeddrich et al., 2006) eye photoreceptor cell, with Scer\GAL4^GMR.PF (Bonini, 1999) eye photoreceptor cell, with Scer\GAL4^GMR.PU (Chan et al., 2000) Kenyon cell, with Scer\GAL4^30Y (Ghosh and Feany, 2004) Kenyon cell, with Scer\GAL4^elav-C155 (Khurana et al., 2010) LNv neuron, with Scer\GAL4^tim.PE (Kadener et al., 2006) neuron, with Scer\GAL4^179Y (Gunawardena et al., 2003) neuron, with Scer\GAL4^Appl.G1a (Gunawardena et al., 2003) ommatidium, with Scer\GAL4^GMR.PF (Kanuka et al., 2003, Park et al., 2011) ommatidium, with Scer\GAL4^GMR.PU (Arya et al., 2010) ommatidium \| conditional, with Scer\GAL4^ninaE.PT (Liu et al., 2012) ommatidium \| heat sensitive, with Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B (Tonoki et al., 2011) photoreceptor, with Scer\GAL4^elav-C155 (Li et al., 2008) photoreceptor \| conditional, with Scer\GAL4^ninaE.PD (Lessing and Bonini, 2008) photoreceptor \| conditional, with Scer\GAL4^ninaE.PT (Liu et al., 2012) pigment cell, with Scer\GAL4^GMR.PF (Warrick et al., 1998, Martin-Lanneree et al., 2006, Bonini, 1999) pigment granule, with Scer\GAL4^GMR.PF (Senoo-Matsuda et al., 2005) retina, with Scer\GAL4^GMR.PF (Warrick et al., 1998, Warrick et al., 1999, Senoo-Matsuda et al., 2005, Warrick et al., 2005, Bonini, 2002, Bilen et al., 2006, Mallik and Lakhotia, 2009, Ghosh and Feany, 2004, Lessing and Bonini, 2008) retina, with Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) retina \| progressive, with Scer\GAL4^GMR.PU (Chan et al., 2000) rhabdomere, with Scer\GAL4^elav-C155 (Warrick et al., 1998, Warrick et al., 1999) rhabdomere \| heat sensitive, with Scer\GAL4^GMR.PF, Scer\GAL80^ts.αTub84B (Tonoki et al., 2011) sensory neuron \| somatic clone, with Scer\GAL4^elav-C155 (Lessing and Bonini, 2008)
Detailed Description
	Statement Reference Flies expressing Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.long] have a rough eye phenotype. (Butler et al., 2012) Expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[ninaE.PT] results in inclusion formation, a decrease in polyQ protein solubility and progressive neural loss. At 21 days the number of photoreceptors per ommatidium is reduced in male flies compared to controls. (Liu et al., 2012) Expression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] in the developing eye under the control of Scer\GAL4[GMR.PF] induces clear defects in the eye, with defective ommatidia seen in 18% of cases. (Park et al., 2011) When Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] expression is induced 'early', only for 4 days after eclosion (using the 'TARGET' system and Scer\GAL4[GMR.PF] and Scer\GAL80[ts.αTub84B]), rhabdomere loss is not observable until 40 days of age. However, when Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] expression os induced from 20 to 24 days of age (i.e. 'late'), neurodegeneration with rhabdomere loss of the ommatidia is observable at 40 days of age, suggesting that Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] expression in older flies causes more severe neurodegeneration than expression in younger flies. (Tonoki et al., 2011) Overexpression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU] results in massive degeneration of retinal cells giving rise to rough and de-pigmented eyes in freshly eclosed flies. In 50 h old (mid pupal stage) eye discs expressing Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] the integrity of photoreceptor cells is poor when compared with wild-type pupal retina. Small vacuoles are present in Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] expressing retinas and the characteristic arrangement of the seven photoreceptors and the actin filaments within them are also altered. Unlike wild-type controls, flies overexpressing Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU] do not show any significant phototaxis. Pan-neuronal overexpression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] via Scer\GAL4[elav.PU] results in 100% lethality at pupal stage. (Arya et al., 2010) Expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PF] results in degeneration and depigmentation of the eye. (Bohm et al., 2010) Flies expressing Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] using Scer\GAL4[GMR.PF] show progressive eye degeneration, visualized by the presence of dark patches and collapsed eyes. (Carra et al., 2010) Pan-neural expression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] (under the control of Scer\GAL4[elav-C155]) causes age-dependent neurodegeneration, as quantified by decreased numbers of Kenyon cells in the mushroom body. (Khurana et al., 2010) Scer\GAL4[GMR.PF]-mediated expression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] causes eye degeneration. (Mallik and Lakhotia, 2010) Expression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] in the eye under the control of Scer\GAL4[GMR.PU] results in eye degeneration, and patched, speckled, and collapsed eye phenotypes are observed. (Vos et al., 2010) Flies expressing Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PF] display a rough-eye phenotype. (Jung et al., 2009) Expression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] using Scer\GAL4[GMR.PF] induces substantial degeneration in eyes with loss of pigmentation and eye morphology. 2-day old flies expressing Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] using Scer\GAL4[GMR.PF] fail to detect light. (Mallik and Lakhotia, 2009) One day old flies expressing a strong insertion of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PF] show severe compound eye degeneration. This degeneration is strongly suppressed upon treatment with the HSF1-activating compound 17-AAG at concentrations of 500nM, 1.5µM and 5µM. Treatment at 50nM shows only a moderate therapeutic effect and treatment at 50µM has no effect. The suppression seen with 17-AAG is stronger than is seen with the histone deacetylase inhibitor SB, which shows only a weak effect. Treatment with GA at concentrations of 500nM and 5µM also results in modest suppression of compound eye degeneration, but no suppression is seen at concentrations of 500nM and 50µM. Treatment with RA at concentrations ranging from 50nM to 5µM also effectively suppresses neurodegeneration. No detectable changes are seen when the flies are treated with either CL (1 to 100 µM) or GGA (10µM to 40 mM). Expression of a strong insertion of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] in the nervous system under the control of Scer\GAL4[elav.PLu] significantly decreases the survival rate of flies during their development to adults. This lethality is significantly suppressed upon treatment with the HSF1-activating compound 17-AAG. Eye discs from flies expressing a weak insertion of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PF] contain numerous inclusion bodies in the region posterior to the morphogenetic furrow. Significantly fewer inclusion bodies are seen when the flies are treated with the HSF1-activating compound 17-AAG and the size of the remaining inclusion bodies is significantly reduced. Treatment with 17-AAG also reduces the ratio of the anteroposterior width of the area with cells containing inclusion bodies to that of the area with cells containing diffusely distributed protein. (Fujikake et al., 2008) Flies expressing Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] in the developing eye under the control of Scer\GAL4[GMR.PF] have a normal external eye, although internally the retina is disorganised. Flies expressing Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] in differentiated photoreceptor neurons under the control of Scer\GAL4[ninaE.PD] are born with the normal complement of seven visible photoreceptors per ommatidium, but progressive degeneration occurs, reducing the number of photoreceptors to on average 6.4 per ommatidium by 12 days and 3.7 by 18 days. Fewer neuron clones expressing Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] (generated under the control of Scer\GAL4[elav-C155] using MARCM) are retained compared to wild type. Only 13% are still detectable at 3 days and none are recovered at 6 days. This compares to an 83% recovery rate in controls. In retinal sections of animals expressing Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] in differentiated photoreceptor neurons under the control of Scer\GAL4[ninaE.PD] inclusions are sparse at 24h but prominent by 4 days. (Lessing and Bonini, 2008) One day old flies expressing Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[elav-C155] show mild loss of retinal integrity, with approximately 5.8 photoreceptors per ommatidium, rather than the usual seven seen in controls. The lifespan of these flies is reduced compared to controls. Photoreceptor loss is also seen in 25 day old flies expressing Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] in differentiated photoreceptors under the control of Scer\GAL4[ninaE.PD]; these flies have on average 4.6 photoreceptors per ommatidium. Flies expressing Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] pan-neuronally under the control of Scer\GAL4[elav-C155] show normal climbing behaviour at one day old. Ability to climb becomes progressively worse with age, with approximately 42.1 percent of flies unable to climb by 12 days. (Li et al., 2008) Expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU] results in external and internal degeneration of the eye, with pigment loss and severely reduced retinal thickness. 1 day old flies expressing Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU] are functionally blind in a phototaxis assay, distributing randomly between a light and dark chamber. (Bilen and Bonini, 2007) Expression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] driven by Scer\GAL4[GMR.PF] results in ablation of the adult eye. (Ryoo et al., 2007) 50 day old flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PLu show almost no climbing activity. (Umeda-Kameyama et al., 2007) Expression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] in the eye (under the control of Scer\GAL4[GMR.PF]) induces degeneration, characterised by partial loss of pigmentation and retinal structure. (Bilen et al., 2006) Expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}, under the control of Scer\GAL4^GMR.PF, induces progressive degeneration of photoreceptors, coupled with the formation of protein aggregates in 2-day old flies. (Boeddrich et al., 2006) Expression of a 'strong' expression line of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^tim.PE disables circadian locomotor activity patterns. However, overall locomotor levels are not significantly different from wild type. Expression of a 'strong' expression line of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Ddc.PL causes no detectable circadian abnormality but does cause defects in female mating latency. Expression of a 'strong' expression line of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^tim.PE results in a significant decrease in the number of Pdf-positive small ventral latero-neurons, whereas the number of Pdf-positive large ventral latero-neurons is unaffected. Flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^tim.PE have no gross morphological abnormalities. Both male and female flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^tim.PE show a significant decrease in mating activity (during a 1 hour observation period); fertility of these flies is unaffected. (Kadener et al., 2006) Expression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] in the brain under the control of Scer\GAL4[30Y] induces apoptotic neurodegeneration in the absence of cell cycle activation. Cortical neuron loss and neuropil rarefaction is observed in these animals. Expression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] in the eye under the control of Scer\GAL4[GMR.PF] results in a rough-eye phenotype. (Khurana et al., 2006) Expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF results in roughened, depigmented eyes which contain black necrotic spots and are collapsed. Expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^{elav.Switch.PO} in the presence of RU486 results in a reduction in adult life span compared to control flies (which have not been fed RU486). (Martin-Lanneree et al., 2006) Targeted expression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} in neurons using the Scer\GAL4^elav-C155 driver results in early adult death. Ectopic expression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1}, driven by Scer\GAL4^GMR.PF, leads to late-onset degeneration in adult eyes. Eyes show loss of retinal structure and lack of pigment one day after eclosion. (Senoo-Matsuda et al., 2005) Expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF results in severe degeneration of the retina that is associated with severe collapse of the eye. Co-expression of Hsap\MJD^{fl.Q27.Scer\UAS.T:Hsap\MYC} restores the eye and retina phenotypes towards normal in flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF. Co-expression of Hsap\MJD^{tr.Q27.Scer\UAS.T:Ivir\HA1} does not suppress the eye degeneration phenotype caused by Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF. Co-expression of Hsap\MJD^{Δ.Scer\UAS.T:Hsap\MYC} suppresses the eye degeneration phenotype caused by Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF. Co-expression of Hsap\MJD^{fl.Q27.UIMmut.Scer\UAS.T:Hsap\MYC} partially suppresses the eye degeneration phenotype caused by Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF. Co-expression of Hsap\MJD^{fl.Q27.C14A.Scer\UAS.T:Hsap\MYC} does not suppress the eye degeneration phenotype caused by Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF. Co-expression of Hsap\MJD^{fl.Q84.Scer\UAS.T:Hsap\MYC} partially suppresses the eye degeneration phenotype caused by Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF. (Warrick et al., 2005) Expression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PF] results in a retinal degeneration phenotype. Expression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[30Y] results in a brain degeneration phenotype; neurons are present in normal numbers in 1 day old flies, but approximately 50% of Kenyon cells degenerate by 20 days after eclosion. (Ghosh and Feany, 2004) When Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^elav-C155 nuclear aggregates are seen. (Lee et al., 2004) Animals expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} driven by Scer\GAL4^179Y or Scer\GAL4^Appl.G1a exhibit a severe sluggish larval movement phenotype. A large increase in neuronal apoptosis is seen. When Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} is overexpressed at 29^oC larvae do not survive to adulthood but die at second or third instar larval stage. (Gunawardena et al., 2003) When Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} us driven by Scer\GAL4^GMR.PF leads to severe, progressive eye degeneration contributing to abnormal ommatidium morphology. (Kanuka et al., 2003) Flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF have a severe eye degeneration phenotype, with loss of external and internal eye structure. The degeneration becomes more severe over the lifetime of the adult fly. (Bonini, 2002) Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1}; Scer\GAL4^GMR.PF flies have an eye neurodegeneration phenotype. (Moreno et al., 2002) Expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU] results in severe degeneration of the eye, with loss of external pigmentation and severe loss of photoreceptor cells in the retina. Weaker expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU] results in a progressive degeneration of the retina as the adults age. (Chan et al., 2000) Strong expression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF results in a lack of eye pigmentation, indicating loss of pigment cells, and a collapsed eye, indicating loss of photoreceptor neurons. Weaker expression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF causes progressive degeneration of the eye during adult life. (Bonini, 1999) Flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF have degenerate eyes that lack pigment and show severe loss of retinal structure. Expression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav-C155 results in complete lethality or early adult death. Progressive degeneration of the eye, seen as disruption of the regular rhabdomere pattern, is seen. (Warrick et al., 1999) Flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF have rough eyes. The severity of the phenotype varies from mild roughness of the eye, through loss of pigment with severely disrupted eye morphology, to reduced eye size. The retina shows cell degeneration. The lamina and medulla show good structure and are normal in size, and the optic chiasm is present, even in flies with a severe phenotype. Large holes are visible in the most lateral part of the lamina, due to separation of the retinal basement membrane from the lamina in flies with moderate or severe phenotypes. The eye morphology progressively degenerates as the flies age. The retina does not deepen as much as normal in pupae expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF. Pigmentation initiates at the correct time, but only occurs round the periphery of the developing eye. Flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav-C155 emerge but show an early death phenotype in weak or moderate expressing P{UAS-Hsap\MJD.tr-Q78} lines. The brains of 4 day old flies appear shrunken compared to 1 day old flies, with the flies dying by 5 days. Gross degeneration of the brain is not seen. The eyes show some irregularity and loss of cell morphology of the rhabdomere lattice in 1 day old flies. A much greater loss of cell integrity is seen in 4 day old flies. Flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav-C155 in strong expressing P{UAS-Hsap\MJD.tr-Q78} lines do not survive to adulthood. Flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^how-24B die as embryos or larvae. Expression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^dpp.blk1 has no phenotypic effect. (Warrick et al., 1998)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav-C155 has short lived phenotype, enhanceable by Buffy^Scer\UAS.cQa, Scer\GAL4^elav-C155 (Senoo-Matsuda et al., 2005) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav-C155 has short lived phenotype, enhanceable by debcl^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav-C155 (Senoo-Matsuda et al., 2005) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav-C155 has short lived phenotype, enhanceable by mbl^Scer\UAS.cLa, Scer\GAL4^elav-C155 (Li et al., 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye color defective phenotype, enhanceable by Hsrω^EP3037, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2009) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has increased cell death phenotype, enhanceable by Dcr-1^Q1147X, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has increased cell death phenotype, enhanceable by loqs^f00791 (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF has neuroanatomy defective \| adult stage phenotype, enhanceable by Hsf^{dsRNA.Scer\UAS}, Scer\GAL4^GMR.PF (Fujikake et al., 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF has visible \| adult stage phenotype, enhanceable by Hsf^{dsRNA.Scer\UAS}, Scer\GAL4^GMR.PF (Fujikake et al., 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, enhanceable by +/Df(2L)PM44 (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, enhanceable by Df(2L)r10/+ (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, enhanceable by Kdm2^EP3093, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective phenotype, enhanceable by Df(3L)CH20/+ (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective phenotype, enhanceable by DnaJ-1^{G295D.Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PU (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective phenotype, enhanceable by DnaJ-1^{ΔJ.Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PU (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Prosβ6^1.Scer\UAS, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by th⁵/th[+] (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by th^{dsRNA.Scer\UAS}, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Uba2^{C175S.Scer\UAS}, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ninaE.PD has decreased cell number \| conditional phenotype, enhanceable by Atx2^Scer\UAS.cSa, Scer\GAL4^ninaE.PD (Lessing and Bonini, 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ninaE.PD has decreased cell number \| conditional phenotype, enhanceable by Df(2R)ED3610/+ (Lessing and Bonini, 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} has visible phenotype, enhanceable by lin19^GD9650/Scer\GAL4^GMR.PU (Bhutani et al., 2012) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} has visible phenotype, enhanceable by lin19^KK100827/Scer\GAL4^GMR.PU (Bhutani et al., 2012) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} has visible phenotype, enhanceable by skpA^GD16179/Scer\GAL4^GMR.PU (Bhutani et al., 2012)
NOT Enhanced by
Statement Reference Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Hsp60D^{dsRNA.Sym.Scer\UAS}/Hsp60D^{a.Sym.Scer\UAS}, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by Prosβ6^1.Scer\UAS, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Hsp60D^{dsRNA.Sym.Scer\UAS}/Hsp60D^{a.Sym.Scer\UAS}, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by Uba2^{C175S.Scer\UAS}, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has increased cell death phenotype, non-enhanceable by Dcr-2^L811fsX, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, non-enhanceable by Prosβ6^1.B.Scer\UAS, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ninaE.PD has decreased cell number \| conditional phenotype, non-enhanceable by Atx2^{ΔC1.Scer\UAS}, Scer\GAL4^ninaE.PD (Lessing and Bonini, 2008)
Suppressed by
Statement Reference Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^Appl.G1a has increased cell death phenotype, suppressible by Hsc70-4^Scer\UAS.cEa, Scer\GAL4^Appl.G1a (Gunawardena et al., 2003) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav.PU has lethal \| P-stage phenotype, suppressible \| partially by Hsp60D^{dsRNA.Sym.Scer\UAS}/Hsp60D^{a.Sym.Scer\UAS}, Scer\GAL4^elav.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^{elav.Switch.PO} has short lived \| RU486 conditional phenotype, suppressible \| partially by Mlf^Scer\UAS.cFa, Scer\GAL4^{elav.Switch.PO} (Martin-Lanneree et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^{elav.Switch.PO} has short lived \| RU486 conditional phenotype, suppressible \| partially by Mlf^Scer\UAS.cKa, Scer\GAL4^{elav.Switch.PO} (Martin-Lanneree et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav-C155 has decreased cell number \| somatic clone phenotype, suppressible by Atx2^X1/Atx2[+] (Lessing and Bonini, 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav-C155 has lethal \| pharate adult stage phenotype, suppressible by Scer\GAL4^GMR.PF/Hsrω^{a.Sym.Scer\UAS}/Hsrω^{dsRNA.Sym.Scer\UAS}/Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2009) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav-C155 has lethal phenotype, suppressible \| partially by DnaJ-1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^elav-C155 (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav-C155 has lethal phenotype, suppressible \| partially by Hsap\HSPA1L^Scer\UAS.cWa, Scer\GAL4^elav-C155 (Warrick et al., 1999, Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav-C155 has lethal phenotype, suppressible by Hsap\HSPA1L^Scer\UAS.cWa/DnaJ-1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^elav-C155 (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav-C155 has short lived phenotype, suppressible \| partially by mbl[+]/mbl^E27 (Li et al., 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav-C155 has short lived phenotype, suppressible by debcl^GS2263, Scer\GAL4^elav-C155 (Senoo-Matsuda et al., 2005) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.long has visible phenotype, suppressible by Hsap\HSPA1L^Scer\UAS.cWa, Scer\GAL4^GMR.long (Butler et al., 2012) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF, nej^{dsRNA.Scer\UAS.cKa} has lethal \| pharate adult stage phenotype, suppressible by Hsrω^{a.Sym.Scer\UAS}/Hsrω^{dsRNA.Sym.Scer\UAS}, Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF, nej^{F2161A.Scer\UAS.T:SV5\V5} has partially lethal - majority die \| pupal stage phenotype, suppressible by Hsrω^{a.Sym.Scer\UAS}/Hsrω^{dsRNA.Sym.Scer\UAS}, Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye color defective phenotype, suppressible by Hsrω^{a.Sym.Scer\UAS}/Hsrω^{dsRNA.Sym.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2009) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has increased cell death phenotype, suppressible by ban^B90.1, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has increased cell death phenotype, suppressible by ban^{D.Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has phototaxis defective phenotype, suppressible by Hsrω^{a.Sym.Scer\UAS}/Hsrω^{dsRNA.Sym.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2009) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, suppressible \| partially by DnaJ-1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bonini, 2002) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, suppressible \| partially by Hsap\HSPA1L^Scer\UAS.cWa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bonini, 2002) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, suppressible \| partially by Mlf^Scer\UAS.cFa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Martin-Lanneree et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, suppressible \| partially by Mlf^Scer\UAS.cKa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Martin-Lanneree et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, suppressible by BacA\p35^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Warrick et al., 1998) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, suppressible by Hsap\HSPA1L^Scer\UAS.cWa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Warrick et al., 1999) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, suppressible by Hsap\HSPA1L^Scer\UAS.cWa/DnaJ-1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bonini, 2002) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, suppressible by Scer\GAL80^αTub84B.PB (Bohm et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, suppressible by Scer\GAL80^αTub84B.PG (Bohm et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU, th⁵/th[+] has visible phenotype, suppressible \| partially by Hsp60D^{dsRNA.Sym.Scer\UAS}/Hsp60D^{a.Sym.Scer\UAS}, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible \| partially by CG8209^B3-Sa, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible \| partially by CG11700^EP1384, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible \| partially by CG14207^EP1348, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible \| partially by dbr^EP9, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible \| partially by dbr^EP456, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible \| partially by emb^E2-1A, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible \| partially by emb^E128-1A, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible \| partially by Faf^E659, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible \| partially by Hsp68^E407, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible \| partially by NFAT^EP1335, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible \| partially by NFAT^EP1508, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible \| partially by orb2^B8-S, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible \| partially by Sin3A^B9-E, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible by CG5009^B227.2, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible by DnaJ-1^B345.2, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible by DnaJ-1^EP411, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible by Imp^EP1433, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible by mrj^E1050, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible by Prosβ6^1.B.Scer\UAS/DnaJ-1^B345.2, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible by Tpr2^EB7-1A, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible by Ubp64E^E213-1A, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible by wech^E546, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible by wech^EP2594, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible by wech^JM120, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible by wech^JM265, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, suppressible by wech^JM265/Prosβ6^1.B.Scer\UAS, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| progressive phenotype, suppressible by DnaJ-1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PU (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective phenotype, suppressible \| partially by DnaJ-1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PU (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective phenotype, suppressible \| partially by Hsap\HSPA1L^Scer\UAS.cWa, Scer\GAL4^GMR.PU (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective phenotype, suppressible by Hsap\HSPA1L^Scer\UAS.cWa/DnaJ-1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PU (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has phototaxis defective \| adult stage phenotype, suppressible \| partially by CG14207^EP1348 (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has phototaxis defective \| adult stage phenotype, suppressible by mrj^E1050, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has phototaxis defective phenotype, suppressible by Hsp60D^{dsRNA.Sym.Scer\UAS}/Hsp60D^{a.Sym.Scer\UAS}, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has visible phenotype, suppressible \| partially by CG14207^EP1348, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has visible phenotype, suppressible \| partially by DnaJ-H^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PU (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has visible phenotype, suppressible \| partially by Hsp68^E407, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has visible phenotype, suppressible by DnaJ-1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PU (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has visible phenotype, suppressible by Hsp60D^{dsRNA.Sym.Scer\UAS}/Hsp60D^{a.Sym.Scer\UAS}, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has visible phenotype, suppressible by mrj^E1050, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ninaE.PD has decreased cell number \| conditional phenotype, suppressible \| partially by pAbp^Scer\UAS.cSa, Scer\GAL4^ninaE.PD (Lessing and Bonini, 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ninaE.PD has decreased cell number \| conditional phenotype, suppressible by Atx2^X1/Atx2[+] (Lessing and Bonini, 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ninaE.PT has neuroanatomy defective \| conditional phenotype, suppressible \| partially by mir-34^Scer\UAS.cLa, Scer\GAL4^ninaE.PT (Liu et al., 2012) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} has locomotor behavior defective phenotype, suppressible \| partially by dhd^Scer\UAS.cUa/Scer\GAL4^elav.PLu (Umeda-Kameyama et al., 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} has locomotor behavior defective phenotype, suppressible \| partially by Scer\GAL4^elav.PLu/TrxT^Scer\UAS.cUa (Umeda-Kameyama et al., 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} has locomotor behavior defective phenotype, suppressible \| partially by Trx-2^Scer\UAS.cUa/Scer\GAL4^elav.PLu (Umeda-Kameyama et al., 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} has locomotor behavior defective phenotype, suppressible \| partially by TrxT^{C35A.Scer\UAS}/Scer\GAL4^elav.PLu (Umeda-Kameyama et al., 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} has locomotor behavior defective phenotype, suppressible \| partially by TrxT^{D26A.K57I.Scer\UAS}/Scer\GAL4^elav.PLu (Umeda-Kameyama et al., 2007)
NOT suppressed by
Statement Reference Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Hsc70-4^{K71S.Scer\UAS}, Scer\GAL4^GMR.PU has neuroanatomy defective phenotype, non-suppressible by DnaJ-1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PU (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Hsp60D^{dsRNA.Sym.Scer\UAS}/Hsp60D^{a.Sym.Scer\UAS}, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by Uba2^{C175S.Scer\UAS}, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^{elav.Switch.PO} has short lived \| RU486 conditional phenotype, non-suppressible by Mlf[+]/Mlf^ΔC1 (Martin-Lanneree et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^{elav.Switch.PO} has short lived \| RU486 conditional phenotype, non-suppressible by Mlf^Δ5-3/Mlf[+] (Martin-Lanneree et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.long has visible phenotype, non-suppressible by Hsap\TRAP1^Scer\UAS.cBa, Scer\GAL4^GMR.long (Butler et al., 2012) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has increased cell death phenotype, non-suppressible by ban^{B.Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has increased cell death phenotype, non-suppressible by Dcr-2^L811fsX, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has increased cell death phenotype, non-suppressible by puc^Scer\UAS.cMa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Moreno et al., 2002) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Dref^{dsRNA.Scer\UAS.cUa}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Martin-Lanneree et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Dref^Scer\UAS.cSa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Martin-Lanneree et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by eya^Scer\UAS.cBa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Warrick et al., 1999) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by Scer\GAL80^{Scer\FRT.αTub84B} (Bohm et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU, th^{dsRNA.Scer\UAS} has visible phenotype, non-suppressible by Hsp60D^{dsRNA.Sym.Scer\UAS}/Hsp60D^{a.Sym.Scer\UAS}, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, non-suppressible by CG11700^EP1384/Prosβ6^1.B.Scer\UAS, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has neuroanatomy defective \| adult stage phenotype, non-suppressible by Ubp64E^E213-1A/Prosβ6^1.B.Scer\UAS, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ninaE.PT has neuroanatomy defective \| conditional phenotype, non-suppressible by Eip74EF[+]/Eip74EF^BG01805 (Liu et al., 2012) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} has neuroanatomy defective phenotype, non-suppressible by Hsap\VCP^Scer\UAS.cBa/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Boeddrich et al., 2006)
Enhancer of
Statement Reference Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Atx2^Scer\UAS.cSa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Lessing and Bonini, 2008)
NOT Enhancer of
Statement Reference Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is a non-enhancer of visible phenotype of Atx2^{ΔC1.Scer\UAS}, Scer\GAL4^GMR.PF (Lessing and Bonini, 2008)
Other
Statement Reference Df(3L)CH20/+, Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has lethal phenotype (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Hsrω^{dsRNA.Sym.Scer\UAS}, Hsrω^{a.Sym.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has short lived phenotype (Mallik and Lakhotia, 2009) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF, nej^{dsRNA.Scer\UAS.cKa} has lethal \| pharate adult stage phenotype (Mallik and Lakhotia, 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF, nej^{F2161A.Scer\UAS.T:SV5\V5} has partially lethal - majority die \| pupal stage phenotype (Mallik and Lakhotia, 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU, lin19^GD9650 has lethal phenotype (Bhutani et al., 2012) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU, lin19^KK100827 has lethal phenotype (Bhutani et al., 2012)
Phenotype Manifest In
Enhanced by
Statement Reference Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^30Y has adult brain phenotype, enhanceable by CG7231^EP2510, Scer\GAL4^30Y (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav-C155 has photoreceptor phenotype, enhanceable by mbl^Scer\UAS.cLa, Scer\GAL4^elav-C155 (Li et al., 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Buffy^Scer\UAS.cQa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Senoo-Matsuda et al., 2005) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Dcr-1^Q1147X, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, enhanceable by debcl^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Senoo-Matsuda et al., 2005) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Hsc70-4^{K71S.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Warrick et al., 1999) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Hsp67Bc^GD11244, Scer\GAL4^GMR.PF (Carra et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Hsrω^EP3037, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2009) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, enhanceable by loqs^f00791, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Mmus\Prnp^{P101L.Scer\UAS.T:Hsap\PRNP-3F4}, Scer\GAL4^GMR.PF (Park et al., 2011) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, enhanceable by nej^{dsRNA.Scer\UAS.cKa}, Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, enhanceable by nej^{F2161A.Scer\UAS.T:SV5\V5}, Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Prosβ6¹ (Kanuka et al., 2003) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by Mmus\Prnp^{P101L.Scer\UAS.T:Hsap\PRNP-3F4}, Scer\GAL4^GMR.PF (Park et al., 2011) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by Prosβ6¹ (Kanuka et al., 2003) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has pigment granule phenotype, enhanceable by Buffy^Scer\UAS.cQa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Senoo-Matsuda et al., 2005) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has pigment granule phenotype, enhanceable by debcl^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Senoo-Matsuda et al., 2005) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Atx2^EP3145, Scer\GAL4^GMR.PF (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Atx2^Scer\UAS.cSa, Scer\GAL4^GMR.PF (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Buffy^Scer\UAS.cQa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Senoo-Matsuda et al., 2005) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, enhanceable by CG7231^EP2510, Scer\GAL4^GMR.PF (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Dcr-1^Q1147X, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, enhanceable by debcl^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Senoo-Matsuda et al., 2005) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Hsc70-4^{K71S.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Hsrω^EP3037, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2009) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, enhanceable by loqs^f00791, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Hsf^{dsRNA.Scer\UAS}, Scer\GAL4^GMR.PF (Fujikake et al., 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF has retina phenotype, enhanceable by Atx2^Scer\UAS.cSa, Scer\GAL4^GMR.PF (Lessing and Bonini, 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by +/Df(2L)PM44 (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Df(2L)r10/+ (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Df(3L)CH20/+ (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by DnaJ-1^{G295D.Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PU (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by DnaJ-1^{ΔJ.Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PU (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Kdm2^EP3093, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has ommatidium phenotype, enhanceable by Prosβ6^1.Scer\UAS, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has ommatidium phenotype, enhanceable by th⁵/th[+] (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has ommatidium phenotype, enhanceable by th^{dsRNA.Scer\UAS}, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has ommatidium phenotype, enhanceable by Uba2^{C175S.Scer\UAS}, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ninaE.PD has photoreceptor \| conditional phenotype, enhanceable by Atx2^Scer\UAS.cSa, Scer\GAL4^ninaE.PD (Lessing and Bonini, 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ninaE.PD has photoreceptor \| conditional phenotype, enhanceable by Df(2R)ED3610/+ (Lessing and Bonini, 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} has eye phenotype, enhanceable by lin19^GD9650/Scer\GAL4^GMR.PU (Bhutani et al., 2012) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} has eye phenotype, enhanceable by lin19^KK100827/Scer\GAL4^GMR.PU (Bhutani et al., 2012) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} has eye phenotype, enhanceable by skpA^GD16179/Scer\GAL4^GMR.PU (Bhutani et al., 2012)
NOT Enhanced by
Statement Reference Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Hsp60D^{dsRNA.Sym.Scer\UAS}/Hsp60D^{a.Sym.Scer\UAS}, Scer\GAL4^GMR.PU has ommatidium phenotype, non-enhanceable by Prosβ6^1.Scer\UAS, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Hsp60D^{dsRNA.Sym.Scer\UAS}/Hsp60D^{a.Sym.Scer\UAS}, Scer\GAL4^GMR.PU has ommatidium phenotype, non-enhanceable by Uba2^{C175S.Scer\UAS}, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^30Y has adult brain phenotype, non-enhanceable by Atx2^EP3145, Scer\GAL4^30Y (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^30Y has adult brain phenotype, non-enhanceable by Atx2^Scer\UAS.cSa, Scer\GAL4^30Y (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^30Y has adult brain phenotype, non-enhanceable by Hsc70-4^{K71S.Scer\UAS}, Scer\GAL4^30Y (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^30Y has adult brain phenotype, non-enhanceable by pum^EP3461, Scer\GAL4^30Y (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^30Y has adult brain phenotype, non-enhanceable by Sir2^EP2300, Scer\GAL4^30Y (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^30Y has adult brain phenotype, non-enhanceable by tara^EP3463, Scer\GAL4^30Y (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav-C155 has Kenyon cell phenotype, non-enhanceable by cathD¹ (Khurana et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Dcr-2^L811fsX, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by gig^{ΔAkt-P.Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF (Khurana et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Prosβ6^1.B.Scer\UAS/Prosβ2^1.Scer\UAS, Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, non-enhanceable by Dcr-2^L811fsX, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, non-enhanceable by pum^EP3461, Scer\GAL4^GMR.PF (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, non-enhanceable by Sir2^EP2300, Scer\GAL4^GMR.PF (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, non-enhanceable by tara^EP3463, Scer\GAL4^GMR.PF (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Prosβ6^1.B.Scer\UAS, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ninaE.PD has photoreceptor \| conditional phenotype, non-enhanceable by Atx2^{ΔC1.Scer\UAS}, Scer\GAL4^ninaE.PD (Lessing and Bonini, 2008)
Suppressed by
Statement Reference Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Prosβ2^1.Scer\UAS, Prosβ6^1.B.Scer\UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible \| partially by Hsrω^{a.Sym.Scer\UAS}/Hsrω^{dsRNA.Sym.Scer\UAS}, Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^30Y has adult brain phenotype, suppressible by BacA\p35^Scer\UAS.cUa, Scer\GAL4^30Y (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^30Y has adult brain phenotype, suppressible by DnaJ-1^Scer\UAS.cKa, Scer\GAL4^30Y (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^30Y has adult brain phenotype, suppressible by Hsap\HSPA1L^Scer\UAS.cWa, Scer\GAL4^30Y (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^30Y has adult brain phenotype, suppressible by th^Scer\UAS.cLa, Scer\GAL4^30Y (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^Appl.G1a has neuron phenotype, suppressible by Hsc70-4^Scer\UAS.cEa, Scer\GAL4^Appl.G1a (Gunawardena et al., 2003) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav-C155 has anterior wing margin \| somatic clone phenotype, suppressible by Atx2^X1/Atx2[+] (Lessing and Bonini, 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav-C155 has eye phenotype, suppressible \| partially by Hsap\HSPA1L^Scer\UAS.cWa, Scer\GAL4^elav-C155 (Warrick et al., 1999) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav-C155 has rhabdomere phenotype, suppressible \| partially by Hsap\HSPA1L^Scer\UAS.cWa, Scer\GAL4^elav-C155 (Warrick et al., 1999) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav-C155 has sensory neuron \| somatic clone phenotype, suppressible by Atx2^X1/Atx2[+] (Lessing and Bonini, 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.long has eye phenotype, suppressible by Hsap\HSPA1L^Scer\UAS.cWa, Scer\GAL4^GMR.long (Butler et al., 2012) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF, nej^{dsRNA.Scer\UAS.cKa} has eye phenotype, suppressible by Hsrω^{a.Sym.Scer\UAS}/Hsrω^{dsRNA.Sym.Scer\UAS}, Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF, nej^{F2161A.Scer\UAS.T:SV5\V5} has eye phenotype, suppressible by Hsrω^{a.Sym.Scer\UAS}/Hsrω^{dsRNA.Sym.Scer\UAS}, Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible \| partially by DnaJ-1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bonini, 2002) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible \| partially by Hsap\ATXN3^{6M.Q83.Scer\UAS.T:Hsap\MYC.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF (Jung et al., 2009) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible \| partially by Hsap\ATXN3^{Q84.Scer\UAS.T:Hsap\MYC.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF (Jung et al., 2009) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible \| partially by Hsap\HSPA1L^Scer\UAS.cWa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bonini, 2002) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible \| partially by Hsap\HSPB8^{Scer\UAS.K141N}, Scer\GAL4^GMR.PF (Carra et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible \| partially by Hsap\HSPB8^Scer\UAS.WT, Scer\GAL4^GMR.PF (Carra et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible \| partially by Hsp67Bc^{Scer\UAS.T:SV5\V5}, Scer\GAL4^GMR.PF (Carra et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible \| partially by Mlf^Scer\UAS.cFa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Martin-Lanneree et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible \| partially by Mlf^Scer\UAS.cKa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Martin-Lanneree et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible \| partially by Sec61α^k04917 (Kanuka et al., 2003) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible by BacA\p35^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Warrick et al., 1998) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible by ban^B90.1, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible by ban^{D.Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible by debcl^GS2263, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Senoo-Matsuda et al., 2005) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible by Hsap\ATXN3^{fl.Q27.Scer\UAS.T:Hsap\MYC}, Scer\GAL4^GMR.PF (Jung et al., 2009) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible by Hsap\HSPA1L^Scer\UAS.cWa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Warrick et al., 1999) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible by Hsap\HSPA1L^Scer\UAS.cWa/DnaJ-1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bonini, 2002) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible by Hsrω^{a.Sym.Scer\UAS}/Hsrω^{dsRNA.Sym.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2009, Mallik and Lakhotia, 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible by Scer\GAL80^αTub84B.PB (Bohm et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, suppressible by Scer\GAL80^αTub84B.PG (Bohm et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has ommatidium phenotype, suppressible \| partially by Sec61α^k04917 (Kanuka et al., 2003) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has pigment cell phenotype, suppressible \| partially by Mlf^Scer\UAS.cFa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Martin-Lanneree et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has pigment cell phenotype, suppressible \| partially by Mlf^Scer\UAS.cKa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Martin-Lanneree et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has pigment cell phenotype, suppressible by BacA\p35^Scer\UAS.cHa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Warrick et al., 1998) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has pigment granule phenotype, suppressible by debcl^GS2263, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Senoo-Matsuda et al., 2005) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, suppressible \| partially by Hsap\HSPA1L^Scer\UAS.cWa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bonini, 2002) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, suppressible \| partially by Hsrω^{a.Sym.Scer\UAS}/Hsrω^{dsRNA.Sym.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mallik and Lakhotia, 2009) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, suppressible by BacA\p35^Scer\UAS.cUa, Scer\GAL4^GMR.PF (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, suppressible by ban^B90.1, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, suppressible by ban^{D.Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, suppressible by debcl^GS2263, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Senoo-Matsuda et al., 2005) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, suppressible by DnaJ-1^Scer\UAS.cKa, Scer\GAL4^GMR.PF (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, suppressible by Hsap\HSPA1L^Scer\UAS.cWa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Warrick et al., 1999, Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, suppressible by th^Scer\UAS.cLa, Scer\GAL4^GMR.PF (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU, th⁵/th[+] has ommatidium phenotype, suppressible \| partially by Hsp60D^{dsRNA.Sym.Scer\UAS}/Hsp60D^{a.Sym.Scer\UAS}, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible \| partially by CG8209^B3-Sa, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible \| partially by CG11700^EP1384, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible \| partially by CG14207^EP1348, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible \| partially by dbr^EP9, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible \| partially by dbr^EP456, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible \| partially by DnaJ-H^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PU (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible \| partially by emb^E2-1A, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible \| partially by emb^E128-1A, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible \| partially by Faf^E659, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible \| partially by Hsp68^E407, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible \| partially by NFAT^EP1335, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible \| partially by NFAT^EP1508, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible \| partially by orb2^B8-S, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible \| partially by Sin3A^B9-E, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by CG5009^B227.2, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by DnaJ-1^B345.2, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by DnaJ-1^EP411, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by DnaJ-1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PU (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Hsap\HSPB7^Scer\UAS.cVa, Scer\GAL4^GMR.PU (Vos et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Imp^EP1433, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by mrj^E1050, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Prosβ6^1.B.Scer\UAS/DnaJ-1^B345.2, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Tpr2^EB7-1A, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Ubp64E^E213-1A, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by wech^E546, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by wech^EP2594, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by wech^JM120, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by wech^JM265, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, suppressible by wech^JM265/Prosβ6^1.B.Scer\UAS, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye photoreceptor cell phenotype, suppressible \| partially by DnaJ-1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PU (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has ommatidium phenotype, suppressible by Hsp60D^{dsRNA.Sym.Scer\UAS}/Hsp60D^{a.Sym.Scer\UAS}, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has retina \| progressive phenotype, suppressible by DnaJ-1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PU (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has retina phenotype, suppressible \| partially by CG14207^EP1348, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has retina phenotype, suppressible \| partially by Hsap\HSPA1L^Scer\UAS.cWa, Scer\GAL4^GMR.PU (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has retina phenotype, suppressible \| partially by Hsp68^E407, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has retina phenotype, suppressible by Hsap\HSPA1L^Scer\UAS.cWa/DnaJ-1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PU (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has retina phenotype, suppressible by mrj^E1050, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ninaE.PD has photoreceptor \| conditional phenotype, suppressible \| partially by pAbp^Scer\UAS.cSa, Scer\GAL4^ninaE.PD (Lessing and Bonini, 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ninaE.PD has photoreceptor \| conditional phenotype, suppressible by Atx2^X1/Atx2[+] (Lessing and Bonini, 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ninaE.PT has adult brain \| conditional phenotype, suppressible \| partially by mir-34^Scer\UAS.cLa, Scer\GAL4^ninaE.PT (Liu et al., 2012) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ninaE.PT has ommatidium \| conditional phenotype, suppressible \| partially by mir-34^Scer\UAS.cLa, Scer\GAL4^ninaE.PT (Liu et al., 2012) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ninaE.PT has photoreceptor \| conditional phenotype, suppressible \| partially by mir-34^Scer\UAS.cLa, Scer\GAL4^ninaE.PT (Liu et al., 2012)
NOT suppressed by
Statement Reference Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Hsc70-4^{K71S.Scer\UAS}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by DnaJ-1^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PU (Chan et al., 2000) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Hsp60D^{dsRNA.Sym.Scer\UAS}/Hsp60D^{a.Sym.Scer\UAS}, Scer\GAL4^GMR.PU has ommatidium phenotype, non-suppressible by Uba2^{C175S.Scer\UAS}, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^30Y has adult brain phenotype, non-suppressible by Atx2^EP3145, Scer\GAL4^30Y (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^30Y has adult brain phenotype, non-suppressible by Atx2^Scer\UAS.cSa, Scer\GAL4^30Y (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^30Y has adult brain phenotype, non-suppressible by Hsc70-4^{K71S.Scer\UAS}, Scer\GAL4^30Y (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^30Y has adult brain phenotype, non-suppressible by pum^EP3461, Scer\GAL4^30Y (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^30Y has adult brain phenotype, non-suppressible by Sir2^EP2300, Scer\GAL4^30Y (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^30Y has adult brain phenotype, non-suppressible by tara^EP3463, Scer\GAL4^30Y (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^elav-C155 has Kenyon cell phenotype, non-suppressible by cathD¹ (Khurana et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.long has eye phenotype, non-suppressible by Hsap\TRAP1^Scer\UAS.cBa, Scer\GAL4^GMR.long (Butler et al., 2012) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by ban^{B.Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by dap^{Scer\UAS.cdNa}/Rbf^Scer\UAS.cDa, Scer\GAL4^GMR.PF (Khurana et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Dcr-2^L811fsX, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Dref^{dsRNA.Scer\UAS.cUa}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Martin-Lanneree et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Dref^Scer\UAS.cSa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Martin-Lanneree et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by eya^Scer\UAS.cBa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Warrick et al., 1999) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by gig^{ΔAkt-P.Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF (Khurana et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Hsap\ATXN1L^{Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Mizutani et al., 2005) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Hsap\HSPB8^{Scer\UAS.K141E}, Scer\GAL4^GMR.PF (Carra et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Hsap\MAPT^Scer\UAS.cAa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Warrick et al., 1999) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by puc^Scer\UAS.cMa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Moreno et al., 2002) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Scer\GAL80^{Scer\FRT.αTub84B} (Bohm et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by Sec61α^P560ex25 (Kanuka et al., 2003) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has ommatidium phenotype, non-suppressible by Sec61α^P560ex25 (Kanuka et al., 2003) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by ban^{B.Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by Dcr-2^L811fsX, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by pum^EP3461, Scer\GAL4^GMR.PF (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by Sir2^EP2300, Scer\GAL4^GMR.PF (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has retina phenotype, non-suppressible by tara^EP3463, Scer\GAL4^GMR.PF (Ghosh and Feany, 2004) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU, th^{dsRNA.Scer\UAS} has ommatidium phenotype, non-suppressible by Hsp60D^{dsRNA.Sym.Scer\UAS}/Hsp60D^{a.Sym.Scer\UAS}, Scer\GAL4^GMR.PU (Arya et al., 2010) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by CG11700^EP1384/Prosβ6^1.B.Scer\UAS, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Ubp64E^E213-1A/Prosβ6^1.B.Scer\UAS, Scer\GAL4^GMR.PU (Bilen and Bonini, 2007) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ninaE.PT has adult brain \| conditional phenotype, non-suppressible by Eip74EF[+]/Eip74EF^BG01805 (Liu et al., 2012) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ninaE.PT has ommatidium \| conditional phenotype, non-suppressible by Eip74EF[+]/Eip74EF^BG01805 (Liu et al., 2012) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ninaE.PT has photoreceptor \| conditional phenotype, non-suppressible by Eip74EF[+]/Eip74EF^BG01805 (Liu et al., 2012) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} has eye photoreceptor cell phenotype, non-suppressible by Hsap\VCP^Scer\UAS.cBa/Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Boeddrich et al., 2006)
Enhancer of
Statement Reference Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Atx2^Scer\UAS.cSa, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Lessing and Bonini, 2008)
NOT Enhancer of
Statement Reference Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is a non-enhancer of eye phenotype of Atx2^{ΔC1.Scer\UAS}, Scer\GAL4^GMR.PF (Lessing and Bonini, 2008) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} is a non-enhancer of retina phenotype of Atx2^{ΔC1.Scer\UAS}, Scer\GAL4^GMR.PF (Lessing and Bonini, 2008)
Other
Statement Reference Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Hsrω^{dsRNA.Sym.Scer\UAS}, Hsrω^{a.Sym.Scer\UAS}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abdomen phenotype (Mallik and Lakhotia, 2009) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Khc⁹, Scer\GAL4^179Y has axon \| larval stage phenotype (Gunawardena et al., 2003, Gunawardena et al., 2003) Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Khc⁹, Scer\GAL4^Appl.G1a has axon \| larval stage phenotype (Gunawardena et al., 2003, Gunawardena et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference The rough eye phenotype caused by expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.long] is suppressed by co-expression of Hsap\HSPA1L[Scer\UAS.cWa], but is not suppressed by co-expression of Hsap\TRAP1[Scer\UAS.cBa]. (Butler et al., 2012) Expression of mir-34[Scer\UAS.cLa] partially suppresses the degeneration seen when Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] is expressed under the control of Scer\GAL4[ninaE.PT]. Inclusion formation is slowed, the protein retains greater solubility and neural degeneration is suppressed. The reduced number of photoreceptors per ommatidium seen in 21 day old flies is also partially rescued. One copy of Eip74EF[BG01805] has little effect on the degeneration seen when Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] is expressed under the control of Scer\GAL4[ninaE.PT]. (Liu et al., 2012) Co-expression of Plip[GD4965] under the control of Scer\GAL4[ninaE.PT] has no significant effect on Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1]-induced photoreceptor cell degradation. Co-expression of Plip[KK108325] under the control of Scer\GAL4[ninaE.PT] has no significant effect on Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1]-induced photoreceptor cell degradation. (Chang et al., 2011) Expression of Mmus\Prnp[P101L.Scer\UAS.T:Hsap\PRNP-3F4] significantly enhances the pathogenic eye defects seen upon expression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] in the eye (both lines under the control of Scer\GAL4[GMR.PF]), with approximately 53% of ommatidia displaying aberrant structures. (Park et al., 2011) Co-expression of Hsp60D[dsRNA.Sym.Scer\UAS] with Scer\GAL4[GMR.PU]-driven Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] suppresses the eye degeneration phenotype resulting from Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] overexpression. The eyes show normal pigmentation and more or less regularly organised ommatidial arrays nearly comparable to those in wild-type eyes. Co-expression of Hsp60D[dsRNA.Sym.Scer\UAS] with Scer\GAL4[GMR.PU]-driven Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] restores phototaxis. Co-expression of Hsp60D[dsRNA.Sym.Scer\UAS] via Scer\GAL4[elav.PU] partially suppresses the lethality resulting from Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] overexpression. The escapers are short lived with a maximum life span of six days. Co-expression of Pros26[1.Scer\UAS] via Scer\GAL4[elav.PU] does not significantly affect the Hsp60D[dsRNA.Sym.Scer\UAS]-mediated partial suppression of the eye degeneration phenotype caused by Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] overexpression. The Hsp60D[dsRNA.Sym.Scer\UAS]-mediated suppression of the eye degeneration phenotype caused by Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] overexpression via Scer\GAL4[GMR.PU] is not much affected by heterozygosity for th[5]. Co-expression of Hsp60D[dsRNA.Sym.Scer\UAS] via Scer\GAL4[GMR.PU] fails to suppress the eye degeneration in Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] and th[dsRNA.Scer\UAS] expressing flies. The eye phenotype resulting from simultaneous expression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] and Hsp60D[dsRNA.Sym.Scer\UAS] via Scer\GAL4[GMR.PU] does not appear to be affected by co-expression of Uba2[C175S.Scer\UAS]. The eye degeneration caused by Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] overexpression via Scer\GAL4[GMR.PU] is enhanced by co-expression of Pros26[1.Scer\UAS]. Heterozygosity for th[5] enhances the eye degeneration resulting from the overexpression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] via Scer\GAL4[GMR.PU]. Co-expression of th[dsRNA.Scer\UAS] via Scer\GAL4[GMR.PU] in Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1]-expressing flies results in enhanced eye degeneration with reduction in eye size. Simultaneous expression of Uba2[C175S.Scer\UAS] and Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] via Scer\GAL4[GMR.PU] enhances eye degradation, resulting in more glazed eyes with little pigmentation. (Arya et al., 2010) Scer\GAL80[Scer\FRT.αTub84B] has no effect on the eye degeneration and depigmentation caused by expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PF]. When FLPase is used to remove the Scer\FRT cassette in Scer\GAL80[Scer\FRT.αTub84B], generating Scer\GAL80[αTub84B.PB] which expresses Scer\GAL80, the eye phenotype caused by expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PF] is completely suppressed. Flies carrying Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1], Scer\GAL4[GMR.PF] and Scer\GAL80[αTub84B.PG] have normal eyes, due to repression of Scer\GAL4[GMR.PF] expression by Scer\GAL80[αTub84B.PG]. This repression can be removed using FLPase (which removes the Scer\FRT cassette containing the Scer\GAL80 coding region from Scer\GAL80[αTub84B.PG]). (Bohm et al., 2010) Co-expression of Hsap\HSPB8[Scer\UAS.WT] or Hsp67Bc[Scer\UAS.T:SV5\V5] significantly decreases the eye degeneration seen in Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1], Scer\GAL4[GMR.PF] flies. Co-expression of Hsp67Bc[GD11244] significantly worsens the eye degeneration seen in Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1], Scer\GAL4[GMR.PF] flies. Co-expression of Hsap\HSPB8[Scer\UAS.K141E] has no significant effect on the eye degeneration phenotype seen in Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1], Scer\GAL4[GMR.PF] flies. Co-expression of Hsap\HSPB8[Scer\UAS.K141N] significantly decreases the eye degeneration seen in Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1], Scer\GAL4[GMR.PF] flies. (Carra et al., 2010) Removing cathD from mutant Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] overexpressing flies (under the control of Scer\GAL4[elav-C155] in a cathD[1] background) has no effect on Kenyon cell loss. (Khurana et al., 2010) Expression of nej[F2161A.Scer\UAS.T:SV5\V5] in the Scer\GAL4[GMR.PF], Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] background results in 15% lethality at the pupal stage. Surviving flies show a reduction in eye size and a greater disruption in ommatidial arrays. Additional co-expression of one copy of P{Sym-UAS-Hsrω} improves the eye morphology and size and reduces pupal death. Expression of nej[dsRNA.Scer\UAS.cKa] in the Scer\GAL4[GMR.PF], Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] background results in >97% lethality at the pharate stage with eye degeneration being dramatically enhanced. Additional co-expression of P{Sym-UAS-Hsrω} robustly suppresses this enhanced eye damage, and also substantially reverses Scer\GAL4[GMR.PF], Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] eye degeneration in a dose-dependent manner. Co-expression of P{Sym-UAS-Hsrω} also improves emergence to adult stage in a dose-dependent manner. The damaged eye phenotype that results from Scer\GAL4[GMR.PF]-mediated expression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] is suppressed by co-expression of P{Sym-UAS-Hsrω}, and is not further enhanced by co-expression of Pros26[1.B.Scer\UAS] and Prosβ2[1.Scer\UAS]. Co-expression of P{Sym-UAS-Hsrω} still suppresses the damage in Scer\GAL4[GMR.PF], Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1], Pros26[1.B.Scer\UAS], Prosβ2[1.Scer\UAS] eyes, but the eyes are not rescued to the degree seen in Scer\GAL4[GMR.PF], Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] eyes. (Mallik and Lakhotia, 2010) Expression of Hsap\HSPB7[Scer\UAS.cVa] in flies expressing Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU] suppresses the eye degeneration phenotype. (Vos et al., 2010) Expression of Hsap\MJD[Q27.Scer\UAS.T:Hsap\MYC.T:Zzzz\FLAG] in flies expressing Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PF] suppresses the eye phenotype. Expression of Hsap\MJD[Q84.Scer\UAS.T:Hsap\MYC.T:Zzzz\FLAG] in flies expressing Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PF] partially suppresses the eye phenotype. Expression of Hsap\MJD[6M.Q83.Scer\UAS.T:Hsap\MYC.T:Zzzz\FLAG] in flies expressing Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PF] partially suppresses the eye phenotype. (Jung et al., 2009) Co-expression of two copies of P{Sym-UAS-Hsrω} almost completely suppresses the Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1], Scer\GAL4[GMR.PF] eye phenotype: the external appearance is wild type but rhabdomere arrays are still abnormal. Co-expression of one or two copies of P{Sym-UAS-Hsrω} restores normal phototactic behaviour to Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1], Scer\GAL4[GMR.PF] flies. Co-expression of a single copy of P{Sym-UAS-Hsrω} rescues the pharate lethality seen in Scer\GAL4[elav-C155], Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] flies, allowing 94% of pupae to eclose. However, surviving female flies display abdominal swellings, and lifespan is reduced compared to controls. (Mallik and Lakhotia, 2009) Expression of Hsf[dsRNA.Scer\UAS] suppresses the ability of the HSF1-activating compound 17-AAG to rescue the degeneration seen in flies expressing a strong insertion of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PF]. The amount of degeneration seen is similar to that observed in untreated flies. However, expression of Hsf[dsRNA.Scer\UAS] also slightly enhances the compound eye degeneration in the absence of 17-AAG. (Fujikake et al., 2008) Co-expression of Atx2[Scer\UAS.cSa] and Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] in the developing eye under the control of Scer\GAL4[GMR.PF] produces a more severe phenotype than in either mutant alone. The flies exhibit strong eye degeneration with loss of pigmentation and severe collapse of the retina. Co-expression of Atx2[Scer\UAS.cSa] and Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] in differentiated photoreceptor neurons under the control of Scer\GAL4[ninaE.PD] enhances the photoreceptor loss seen when either construct is expressed alone. Flies are still born with the normal complement of seven visible photoreceptors, but whereas at six days the single mutants appear near normal, co-expression results in only 4.7 photoreceptors per ommatidium. At 18 days almost complete photoreceptor loss (1.3 photoreceptors per ommatidium) is seen. One copy of Atx2[X1] suppresses the eye degeneration seen when Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] is expressed in differentiated photoreceptor neurons under the control of Scer\GAL4[ninaE.PD]. On average 6.9 visible photoreceptors are seen per ommatidium in 12 day old flies, similar to the 7 seen in controls. This compares to 6.4 when Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] is expressed alone. Homozygous Atx2[X1] suppresses the neuron loss seen in anterior wing margin clones induced in flies expressing Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[elav-C155] (generated using MARCM). 77% of neurons are retained at 3 days, compared to only 13% when Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] is expressed alone. 40% are recovered at 6 days, in contrast to the complete loss of neurons in Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] expressing flies. Expression of Atx2[Scer\UAS.cSa] enhances the rate of inclusion formation seen when Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] is expressed in differentiated photoreceptor neurons under the control of Scer\GAL4[ninaE.PD]. Inclusions are more prominent at 24 hours, but by four days appear similar to when Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] is expressed alone. Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] has no effect on the eye phenotype seen when Atx2[ΔC1.Scer\UAS] is expressed in the developing eye under the control of Scer\GAL4[GMR.PF]. The phenotype seen is identical to that seen when Atx2[ΔC1.Scer\UAS] is expressed alone. Co-expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] and Atx2[ΔC1.Scer\UAS] in differentiated photoreceptor neurons under the control of Scer\GAL4[ninaE.PD] causes mild photoreceptor loss at six days (an average of 6.7 visible photoreceptors per ommatidium, compared to seven in controls). This is similar to the phenotype seen when Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] is expressed alone. Expression of Atx2[ΔC1.Scer\UAS] does not enhance the rate of inclusion formation seen when Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] is expressed in differentiated photoreceptor neurons under the control of Scer\GAL4[ninaE.PD]. One copy of Df(2R)ED3610 enhances the photoreceptor loss seen when Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] is expressed in differentiated photoreceptor neurons under the control of Scer\GAL4[ninaE.PD]. On average 1.6 photoreceptors are seen per ommatidium in 18 day old flies, as opposed to the seven seen in wild type. This compares to 3.5 when Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] is expressed alone. Expression of pAbp[Scer\UAS.cSa] partially suppresses the photoreceptor loss seen when Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] is expressed in differentiated photoreceptor neurons under the control of Scer\GAL4[ninaE.PD]. On average 6.0 visible photoreceptors are seen per ommatidium in 18 day old flies, as opposed to the seven seen in wild type. This compares to 4.2 when Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] is expressed alone. (Lessing and Bonini, 2008) Expression of mbl[Scer\UAS.cLa] enhances the reduction in lifespan and photoreceptor loss seen when Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] is expressed pan-neuronally under the control of Scer\GAL4[elav-C155]. Flies have on average 3.0 photoreceptors per ommatidium, compared to the usual seven. One copy of mbl[E27] partially suppresses the shortened lifespan seen when Hsap\ATXN3[tr.Q61.Scer\UAS.T:Ivir\HA1] is expressed in the developing eye under the control of Scer\GAL4[GMR.PF]. (Li et al., 2008) Hsp68[E407], mrj[E1050] and CG14207[EP1348] are each strong suppressors of the eye degeneration phenotype caused by expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU]. External eye pigmentation is restored, and the thickness of the retina is restored towards normal. DnaJ-1[B345.2], DnaJ-1[EP411], Tpr2[EB7-1A], Ubp64E[E213-1A], wech[JM120], wech[JM265], wech[E546], wech[EP2594], Imp[EP1433] and CG5009[B227.2] are each strong suppressors of the eye degeneration phenotype caused by expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU]. CG11700[EP1384], CG8209[B3-Sa], Faf[E659], emb[E2-1A], emb[E128-1A], NFAT[EP1335] and NFAT[EP1508] are each moderate suppressors of the eye degeneration phenotype caused by expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU]. Sin3A[B9-E], dbr[EP456], dbr[EP9] and orb2[B8-S] are each weak suppressors of the eye degeneration phenotype caused by expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU]. Kdm2[EP3093] is an enhancer of the eye degeneration phenotype caused by expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU]. Expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU] in the presence of Df(3L)CH20/+ results in lethality and causes severe eye degeneration in pupae. Df(2L)r10 and Df(2L)PM44 each dominantly enhance the eye degeneration phenotype caused by expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU]. Co-expression of mrj[E1050] completely restores normal visual behaviour, and co-expression of CG14207[EP1348] partially restores visual behaviour in 1 day old flies expressing Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU] and tested in a phototaxis assay. Co-expression of Prosβ6[1.B.Scer\UAS] does not enhance the eye degeneration phenotype caused by expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU]. In the presence of Prosβ6[1.B.Scer\UAS], CG11700[EP1384] cannot suppress the eye degeneration phenotype caused by expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU]. In the presence of Prosβ6[1.B.Scer\UAS], Ubp64E[E213-1A] cannot suppress the eye degeneration phenotype caused by expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU]. DnaJ-1[B345.2] and wech[JM265] are each still able to suppress the eye degeneration phenotype caused by expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU] when the flies also carry Prosβ6[1.B.Scer\UAS]. (Bilen and Bonini, 2007) The severe reduction in climbing ability seen in 50 day old flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PLu is partially suppressed by co-expression of one of TrxT^Scer\UAS.cUa, TrxT^{D26A.K57I.Scer\UAS}, TrxT^{C35A.Scer\UAS}, Trx-2^Scer\UAS.cUa or dhd^Scer\UAS.cUa. (Umeda-Kameyama et al., 2007) Eye degeneration due to expression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] in the eye (under the control of Scer\GAL4[GMR.PF]) is enhanced in a loqs[f00791] background, resulting in a severely degenerated eye with complete loss of pigmentation. Expression of ban[D.Scer\UAS.T:Avic\GFP-EGFP], bearing only a 100bp region containing the ban miRNA suppresses degeneration in Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] Scer\GAL4[GMR.PF] flies, restoring external and internal eye structures towards normal. Expression of ban[B.Scer\UAS.T:Avic\GFP-EGFP] does not suppress eye degeneration in Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] Scer\GAL4[GMR.PF] flies. Eye degeneration due to expression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] in the eye (under the control of Scer\GAL4[GMR.PF]) is enhanced in a Dcr-1[Q1147X] background, resulting in a severely degenerated eye with complete loss of pigmentation. Eye degeneration due to expression of Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] in the eye (under the control of Scer\GAL4[GMR.PF]) is unaffected by a Dcr-2[L811fsX] background. Co-expression of ban[B90.1] with Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] (under the control of Scer\GAL4[GMR.PF] gives normal pigementation and improved retinal structure. (Bilen et al., 2006) Co-expression of Hsap\VCP^Scer\UAS.cBa with Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}, both under the control of Scer\GAL4^GMR.PF fails to suppress the Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} photoreceptor phenotype in 2-day old flies. (Boeddrich et al., 2006) The rough-eye phenotype observed in animals expressing Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] in the eye under the control of Scer\GAL4[GMR.PF] is not modified by co-expression of Rheb[AV4]. The rough-eye phenotype observed in animals expressing Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] in the eye under the control of Scer\GAL4[GMR.PF] is not modified by co-expression of gig[ΔAkt-P.Scer\UAS.T:Zzzz\FLAG]. The rough-eye phenotype observed in animals expressing Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] in the eye under the control of Scer\GAL4[GMR.PF] is not modified by co-expression of dap[Scer\UAS.cdNa] and Rbf[Scer\UAS.cDa]. (Khurana et al., 2006) Co-expression of either Mlf^Scer\UAS.cFa or Mlf^Scer\UAS.cKa results in a strong suppression of the mutant eye phenotype caused by expression of Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF. The reduction in life span that is seen in flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^{elav.Switch.PO} in the presence of RU486 is partially rescued by co-expression of either Mlf^Scer\UAS.cFa or Mlf^Scer\UAS.cKa. The reduction in life span that is seen in flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^{elav.Switch.PO} in the presence of RU486 is not modified by the addition of Mlf^ΔC1/+ or Mlf^Δ5-3/+. (Martin-Lanneree et al., 2006) The eye phenotype caused by expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF, is not suppressed by coexpression of Hsap\Boat^{Scer\UAS.T:Zzzz\FLAG}. (Mizutani et al., 2005) Flies expressing both Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} and debcl^{Scer\UAS.T:Ivir\HA1} in their neurons, under the control of Scer\GAL4^elav-C155, show a significantly shorter lifespan than flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} alone. Coexpression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} and debcl^{Scer\UAS.T:Ivir\HA1}, driven by Scer\GAL4^GMR.PF, accelerates the onset of eye neurodegeneration seen in adults expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1}. The loss of retinal structure and pigment defects are strongly enhanced by debcl^{Scer\UAS.T:Ivir\HA1} expression. Overexpression of Buffy^Scer\UAS.cQa enhances the Scer\GAL4^GMR.PF;Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1}-induced eye neurodegeneration and lethality. Eyes coexpressing debcl^{Scer\UAS.T:Ivir\HA1}, Buffy^Scer\UAS.cQa, and Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} (all driven by Scer\GAL4^GMR.PF) show a significantly weaker degenerative eye phenotype than eyes expressing Buffy^Scer\UAS.cQa and Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1}. Ectopic expression of debcl^GS2263, under the control of Scer\GAL4^GMR.PF, suppresses the Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1}-induced neurodegeneration of the eye. In addition , debcl^GS2263 markedly rescues the early adult death of flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} in their neurons, driven by Scer\GAL4^elav-C155. (Senoo-Matsuda et al., 2005) Co-expression of Pros26^1.Scer\UAS suppresses the ability of Hsap\MJD^{fl.Q27.Scer\UAS.T:Hsap\MYC} to restore the eye and retina phenotypes towards normal in flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF, such that the triple mutant flies have a reduction in eye pigmentation, show collapse of the eye and loss of internal retinal tissue. (Warrick et al., 2005) When Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} is driven in neurons either by Scer\GAL4^Appl.G1a or Scer\GAL4^179Y, and combined with Khc⁹, mutant larval nerves contain axonal blockages. Mutant nerves also contain enlarged axons, some almost four or five times the diameter of those seen in wild-type. Sometimes "holes" lacking organelles are seen within the nerve. (Gunawardena et al., 2003) Co-expression of Hsap\HSPA1L^Scer\UAS.cWa partially suppresses the eye degeneration seen in flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF. Co-expression of DnaJ-1^{Scer\UAS.T:Zzzz\FLAG} partially suppresses the eye degeneration seen in flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF. Co-expression of both Hsap\HSPA1L^Scer\UAS.cWa and DnaJ-1^{Scer\UAS.T:Zzzz\FLAG} completely suppresses the eye degeneration seen in flies expressing Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF. (Bonini, 2002) The eye neurodegeneration phenotype of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1}; Scer\GAL4^GMR.PF flies is not supressed by puc^Scer\UAS.cMa. (Moreno et al., 2002) Co-expression of DnaJ-1[Scer\UAS.T:Zzzz\FLAG] restores external eye structure in animals expressing Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU]. Internal eye structure is partially rescued, with partial preservation of photoreceptor rhabdomere specialisations. Co-expression of DnaJ-1[Scer\UAS.T:Zzzz\FLAG] slow the progressive retinal degeneration seen in flies that weakly express Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU]. Co-expression of either DnaJ-1[ΔJ.Scer\UAS.T:Zzzz\FLAG] or DnaJ-1[G295D.Scer\UAS.T:Zzzz\FLAG] enhances the weak eye phenotype seen in flies that weakly express Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU], such that loss of pigmentation and collapse of the eye is seen. Co-expression of DnaJ-H[Scer\UAS.T:Zzzz\FLAG] only weakly suppresses the loss of eye pigmentation seen in flies expressing Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU]. Expression of DnaJ-1[Scer\UAS.T:Zzzz\FLAG] cannot suppress the severe eye degeneration seen in flies co-expressing Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] and Hsc70-4[K71S.Scer\UAS] under the control of Scer\GAL4[GMR.PU]. Flies that co-express Hsap\HSPA1L[Scer\UAS.cWa], Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] and DnaJ-1[ΔJ.Scer\UAS.T:Zzzz\FLAG] under the control of Scer\GAL4[GMR.PU] have normal eyes. Co-expression of Hsap\HSPA1L[Scer\UAS.cWa] partially suppresses the retinal degeneration seen in flies expressing Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU]. Simultaneous co-expression of both DnaJ-1[Scer\UAS.T:Zzzz\FLAG] and Hsap\HSPA1L[Scer\UAS.cWa] results in a stronger suppression of the retinal degeneration caused by expression of Hsap\ATXN3[tr.Q78.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[GMR.PU] than expression of either construct alone. (Chan et al., 2000) The eye phenotype caused by expression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF is suppressed by coexpression of Hsap\HSPA1L^Scer\UAS.cWa; the eye appears normal externally, and internally eye structure is largely restored, although photoreceptor rhabdomere specialisations are not made. The eye degeneration phenotype caused by Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} expressed under the control of Scer\GAL4^GMR.PF is not suppressed by coexpression of Hsap\MAPT^Scer\UAS.cAa or eya^Scer\UAS.cBa. Adult viability in flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav-C155 is partially restored by coexpression of Hsap\HSPA1L^Scer\UAS.cWa and degeneration of the eye is slowed. Hsc70-4^{K71S.Scer\UAS} enhances the disruption of the eye caused by expression of Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF. (Warrick et al., 1999) Co-expression of BacA\p35^Scer\UAS.cHa in flies expressing Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF partially restores eye pigmentation. (Warrick et al., 1998)
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	8141 w^; P{UAS-Hsap\MJD.tr-Q78}c37.3 8150 w^; P{UAS-Hsap\MJD.tr-Q78}c211.2
Notes on Origin
Discoverer

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Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} Hsap\MJD^{Q78.Scer\UAS.T:Ivir\HA1} Hsap\MJD^{Q78.UAS.T:HA1} Hsap\MJD^{tr.Q78.Scer\UAS.T:Ivir\HA1}
Name Synonym
Secondary FlyBase IDs

References ( 42 )

Generate a list of	All references relating to this allele ( 42 )

List References by type	Research paper ( 40 ) Review ( 1 ) Abstract ( 1 )
Recent research papers ( 6 )
	Bhutani et al., 2012, Cell Death Dis. 3: e428 Dysregulation of core components of SCF complex in poly-glutamine disorders. [FBrf0219951] Butler et al., 2012, PLoS Genet. 8(2): e1002488 The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity. [FBrf0217423] Liu et al., 2012, Nature 482(7386): 519--523 The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila. [FBrf0217556] Chang et al., 2011, PLoS Genet. 7(2): e1001288 Pathogenic VCP/TER94 Alleles Are Dominant Actives and Contribute to Neurodegeneration by Altering Cellular ATP Level in a Drosophila IBMPFD Model. [FBrf0213008] Park et al., 2011, Biochem. Biophys. Res. Commun. 404(2): 638--645 Normal prion protein in Drosophila enhances the toxicity of pathogenic polyglutamine proteins and alters susceptibility to oxidative and autophagy signaling modulators. [FBrf0212784] Tonoki et al., 2011, Genes Cells 16(5): 557--564 Aging causes distinct characteristics of polyglutamine amyloids in vivo. [FBrf0213535] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...

Allele Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1

Allele Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}