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General Information
Symbol
Dmel\Hr783
Species
D. melanogaster
Name
FlyBase ID
FBal0090633
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Dhr783
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C21495049T

Reported nucleotide change:

C?T

Amino acid change:

R353term | Hr78-PA; R355term | Hr78-PB; R355term | Hr78-PC; R355term | Hr78-PD; R355term | Hr78-PE; R355term | Hr78-PF

Reported amino acid change:

R355term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The premature stop codon is predicted to result in a truncated protein that lacks the C-terminal 354 amino acids of the wild-type protein.

Amino acid replacement: R355term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Embryos derived from females carrying Hr783 homozygous germline clones (which lack maternal but not zygotic Hr78 function) have an increase in the instance of unhatched eggs and a decrease in the amount of fertilized embryos compared to controls. Hr783/Df(3L)79-2 mutants lacking zygotic Hr78 function die during the second and third larval instar, while Hr783/+ mutants without maternal Hr78 function display very low levels of lethality. During the molt between first and second instar larvae, the tracheae of Hr783/Df(3L)79-2 mutants begin to fill with gas, as occurs in wild type, but stop before this process is complete. This results in second instar larvae that have tracheal branches filled with fluid, either partially or almost completely. Such fluid filling is also seen in 7-9% of first instar larvae.

Mutants die as third instar larvae. Mutant larvae exhibit asynchronous development at the second to third instar moult, reduced size during the third instar, tracheal defect and failure to pupariate.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

Hr78Scer\UAS.Fa driven by Scer\GAL4dimm-929, expressed in the tracheae and many other body parts, rescues the larval lethal phenotype of ~7% of Hr78 null mutants. Hr78Scer\UAS.Fa driven by Scer\GAL41407, expressed in the tracheae and CNS, rescues the larval lethal phenotype of ~29% of Hr78 null mutants.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Selected as: F2 lethal that fails to complement Df(3L)10-2 and Df(3L)79-2.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (4)