Amino acid replacement: N69I.
The amino acid replacement, caused by a point mutation, is found in the kinase domain of ik2.
A20676582T
N69I | IKKepsilon-PB; N69I | IKKepsilon-PC
N69I
Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
At low temperature and in uncrowded culture conditions, rare escaper ik22 adults (<1%) are observed, but they die shortly after eclosion. These escapers often exhibit abnormal bristles, both the interommatidial and the humeral bristles are affected. At high magnification, the actin footprints along the length of the bristle shaft in ik22 escaper adult eyes appears less organised than those in wild-type bristles. In wild-type, interommatidial bristles are found at alternating vertices, whereas in ik22 mutants these bristles are often duplicated at a single vertex and are misshapen and kinked.