FB2025_01 , released February 20, 2025
Allele: Dmel\Polr2BSM
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General Information
Symbol
Dmel\Polr2BSM
Species
D. melanogaster
Name
FlyBase ID
FBal0091643
Feature type
allele
Associated gene
Dmel\Polr2B
Associated Insertion(s)
Carried in Construct
P{Polr2BSM.K}
Key Links
Transgenic product class
missense_variant
(Krasnoselskaya et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Krasnoselskaya et al., 1998)
Mutagen
in vitro construct
(Krasnoselskaya et al., 1998)
Progenitor genotype
Carried in construct
P{Polr2BSM.K}
Cytology
Description

Construct: Nucleotide substitution: A2966T. This substitution is shared by in vivo-generated strong suppressors. Nucleotide substitution: G3065A. This substitution is shared by in vivo-generated mild suppressors.

(Krasnoselskaya et al., 1998)
Allele components
Component
Use(s)
Encoded product / tool
Polr2B
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Polr2BSM has phenotype, suppressible by Polr2AK1

      (Krasnoselskaya et al., 1998)
      Suppressor of
      Statement
      Reference

      Polr2BSM is a suppressor of phenotype of Polr2A120

      (Krasnoselskaya et al., 1998)

      Polr2BSM is a suppressor of phenotype of Polr2AK1

      (Krasnoselskaya et al., 1998)
      NOT Suppressor of
      Statement
      Reference

      Polr2BSM is a non-suppressor of phenotype of Polr2A12

      (Krasnoselskaya et al., 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Behaves as a strong suppressor but not a mild suppressor. Flies carrying RpII215K1, RpII140A5 and RpII140SM are viable: i.e. RpII215K1 and RpII140SM show reciprocal suppression.

      (Krasnoselskaya et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Polr2BSM fails to rescue Polr2BA5

      (Krasnoselskaya et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Polr2BSM
      RpII140SM
      Name Synonyms
      Secondary FlyBase IDs
        References (1)