Allele Dmel\RpII140^S8

General Information
Symbol	Dmel\RpII140^S8	Species	D. melanogaster
Name		FlyBase ID	FBal0091645
Feature type	allele	Associated gene	Dmel\RpII140

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Mortin, 1990, Krasnoselskaya et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3R:9,953,977..9,953,977 reported_na_change=A2966T\|FBrf0103162 reported_pr_change=S728C\|FBrf0103162 pr_change=S728C evidence=experimental na_change=A9953977T (Kim et al., 1994)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Mutant lesions in RpII140^S1, RpII140^S2, RpII140^S5, RpII140^S6 and RpII140^S8 are identical. Nucleotide substitution: A2966T. (Krasnoselskaya et al., 1998) Amino acid replacement: S728C. Nucleotide substitution: A2966T. (Kim et al., 1994)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Mortin, 1990)
Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference RpII140^S8 is a suppressor of lethal phenotype of RpII215^K1 (Kim et al., 1994)
NOT Suppressor of
Statement Reference RpII140^S8 is a non-suppressor of lethal phenotype of RpII215¹ (Kim et al., 1994) RpII140^S8 is a non-suppressor of lethal phenotype of RpII215¹² (Kim et al., 1994) RpII140^S8 is a non-suppressor of lethal phenotype of RpII215⁶⁶ (Kim et al., 1994) RpII140^S8 is a non-suppressor of lethal phenotype of RpII215¹⁰⁶ (Kim et al., 1994) RpII140^S8 is a non-suppressor of lethal phenotype of RpII215¹⁰⁸ (Kim et al., 1994) RpII140^S8 is a non-suppressor of lethal phenotype of RpII215¹⁰⁹ (Kim et al., 1994) RpII140^S8 is a non-suppressor of lethal phenotype of RpII215^ts (Kim et al., 1994) RpII140^S8 is a non-suppressor of lethal phenotype of RpII215^Ubl (Kim et al., 1994)
Phenotype Manifest In
Enhancer of
Statement Reference RpII140^S8 is an enhancer of phenotype of RpII215²⁷ (Krasnoselskaya et al., 1998)
Suppressor of
Statement Reference RpII140^S8 is a suppressor of \| heat sensitive phenotype of RpII215^K1 (Mortin, 1990) RpII140^S8 is a suppressor of phenotype of RpII215¹²⁰ (Krasnoselskaya et al., 1998) RpII140^S8 is a suppressor of phenotype of RpII215^K1 (Krasnoselskaya et al., 1998)
Additional Comments
Genetic Interactions
Statement Reference The recessive lethality of RpII215¹, RpII215^Ubl, RpII215^ts, RpII215⁶⁶, RpII215¹⁰⁶, RpII215¹⁰⁸, RpII215¹² or RpII215¹⁰⁹ is not rescued by one copy of RpII140^S8. The recessive lethality of RpII215^K1 is rescued to more than 50% viability by one copy of RpII140^S8. (Kim et al., 1994)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Induced with: pros^S8. (Krasnoselskaya et al., 1998) Isolated as: Suppressor of the conditional lethality of RpII215^K1. (Mortin, 1990)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	anon-S8^S8 RpII140^S8 S8 (Mortin, 1990)
Name Synonym
Secondary FlyBase IDs
	FBal0051793
References ( 3 )
Research paper	Krasnoselskaya et al., 1998, Mol. Gen. Genet. 258(5): 457--465 Selection and analysis of rare second-site suppressors of Drosophila RNA polymerase II mutations. [FBrf0103303] Kim et al., 1994, J. Mol. Biol. 244(7): 13--22 Molecular modeling of RNA polymerase II mutations onto DNA polymerase I. [FBrf0103162] Mortin, 1990, Proc. Natl. Acad. Sci. U.S.A. 87: 4864--4868 Use of second-site suppressor mutations in Drosophila to identify components of the transcriptional machinery. [FBrf0052847]

Allele Dmel\RpII140S8

Allele Dmel\RpII140^S8