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General Information
Symbol
Dmel\MerΔBB.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0091728
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

The Mer coding region lacking amino acids 171 to 177 in the conserved N-terminal region and tagged at the N-terminal end with Tag:MYC, is expressed under the control of UASt regulatory sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of MerΔBB.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4ap.PU in cells of the wing disc proper has no significant effect on the morphology or proliferation of the overlying peripodial membrane cells in third instar larvae. The wings of the adult flies however curl downwards due to the overgrowth of the dorsal surface.

Flies carrying one copy of MerΔBB.Scer\UAS.T:Hsap\MYC expressed under the control of one copy of Scer\GAL4en-e16E have a moderately overgrown posterior wing compartment with no disruption in venation. Flies carrying two copies of MerΔBB.Scer\UAS.T:Hsap\MYC expressed under the control of two copies of Scer\GAL4en-e16E show an enlargement of the posterior wing compartment with disruptions in venation, particularly along vein 5 and the posterior crossvein. Disruptions include formation of ectopic vein material. The wings are also held out from the body axis.

Flies expressing MerΔBB.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4en-e16E show expansion of the wing blade. This phenotype is enhanced if the flies are also heterozygous for Mer4, and is suppressed if the flies are also carrying Mer+t36. Flies expressing MerΔBB.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4ap-md52 have wings heldout at an average of 45o from the body axis. This phenotype is greatly suppressed by Mer1-600.Scer\UAS.T:Hsap\MYC and slightly suppressed by MerScer\UAS.T:Hsap\MYC.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
Enhancer of
Other
Additional Comments
Genetic Interactions
Statement
Reference

Flies carrying one copy of MerΔBB.Scer\UAS.T:Hsap\MYC expressed under the control of one copy of Scer\GAL4en-e16E and also carrying one copy of Df(2R)Px2 or bs364 show wing blistering. The overgrowth of the posterior compartment seen in flies carrying one copy of MerΔBB.Scer\UAS.T:Hsap\MYC expressed under the control of one copy of Scer\GAL4en-e16E is enhanced by sbb94, sbb256, sbb270, E(Mer)IIb187, E(Mer)IIb209, bs242, net383 or E(Mer)IIIa320. The wing phenotype seen in flies carrying one copy of MerΔBB.Scer\UAS.T:Hsap\MYC expressed under the control of one copy of Scer\GAL4ap-md52 is modified by bs242, sbb256, net383, E(Mer)IIb187 or E(Mer)IIIa239. Expression of MerΔBB.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4ap-md52 in combination with either sbbunspecified or bsunspecified results in a significant blistered wing phenotype.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Fails to rescue the lethality of Mer4 hemizygous males when expressed under the control of Scer\GAL4T80.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
MerΔBB.Scer\UAS.T:Hsap\MYC
MerΔBB.UAS.T:Myc
MerΔBB.UAS.Tag:MYC
Name Synonyms
Secondary FlyBase IDs
    References (4)