FlyBase Allele Report: Dmel\Dp[UAS.cDa]

General Information

Symbol

Dmel\Dp^UAS.cDa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Dyson

FlyBase ID

FBal0091839

Feature type

allele

Associated gene

Dmel\Dp

Associated Insertion(s)

Carried in Construct

P{UAS-Dp.D}

Also Known As

UAS-Dp, UAS-dDp

Key Links

Transgenic product class

wild_type

(Neufeld et al., 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Neufeld et al., 1998)

Mutagen

in vitro construct

(Britton and Edgar, 1998, Neufeld et al., 1998)

Progenitor genotype

Carried in construct

P{UAS-Dp.D}

Cytology

Description

UAS regulatory sequences drive Dp expression.

(Neufeld et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of prostate cancer

CEA with E2f1^UAS.cNa

(Sekar et al., 2023)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^GMR.PF

(Morris et al., 2006)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Morris et al., 2006)

Detailed Description

Statement

Reference

Expressing Dp^UAS.cDa under the control of Scer\GAL4^GMR.long does not have a major effect on retinal morphology, as compared to controls.

(Bervoets et al., 2019)

Scer\GAL4^GMR.PF driven expression of Dp^Scer\UAS.cDa causes a blackened and rough eye phenotype.

(Morris et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^esg.PU has increased cell growth rate | adult stage | male phenotype, enhanceable by shd^HMC06461, Scer\GAL4^esg.PU

(Sekar et al., 2023)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.long has visible | adult stage phenotype, enhanceable by Hsap\YARS1^E196K.UAS, Scer\GAL4^GMR.long

(Bervoets et al., 2019)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by His2Av[+]/His2Av⁸¹⁰

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by His2Av[+]/His2Av⁰⁵¹⁴⁶

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Pc³/Pc[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Pc[+]/Pc^f01890

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Su(z)2¹/Su(z)2[+]

(Ji et al., 2012)

Dp^UAS.cDa, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by cass^RNAi.UAS, Scer\GAL4^GMR.PF

(Morris et al., 2006)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^ptc-559.1 has increased occurrence of cell division | larval stage phenotype, enhanceable by mir-ban^EP3622

(Brennecke et al., 2003)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^ptc-559.1 has decreased cell death | larval stage phenotype, enhanceable by mir-ban^EP3622

(Brennecke et al., 2003)

NOT Enhanced by

Statement

Reference

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.long has visible | adult stage phenotype, non-enhanceable by Hsap\YARS1^WT.UAS, Scer\GAL4^GMR.long

(Bervoets et al., 2019)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by Asx[+]/Asx¹

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by eff[+]/eff^mer4

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by e(Pc)84DE^T66.1/e(Pc)84DE[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by kis^BG01657/kis[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by pho[+]/pho¹

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by Su(z)2^1.a1/Su(z)2[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by Su(z)2^1.b7/Su(z)2[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by Su(z)2^k06344/Su(z)2[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by Su(z)12³/Su(z)12[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by tara¹/tara[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by tou²/tou[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by brm[+]/brm²

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by trx[+]/trx^KG08639

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-enhanceable by Mi-2[+]/Mi-2^j3D4

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has visible phenotype, non-enhanceable by p53^259H.GUS, Scer\GAL4^GMR.PF

(Moon et al., 2008)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has increased cell death phenotype, non-enhanceable by p53^5A-1-4

(Moon et al., 2008)

Suppressed by

Statement

Reference

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^esg.PU has abnormal cell cycle | male | adult stage phenotype, suppressible by EcR^JF02538, Scer\GAL4^esg.PU

(Sekar et al., 2023)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^esg.PU has increased cell growth rate | male | adult stage phenotype, suppressible by E2f1^JF02718, Scer\GAL4^esg.PU

(Sekar et al., 2023)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has increased cell death phenotype, suppressible by mir-11^UAS.DsRed2, Scer\GAL4^GMR.PU

(Truscott et al., 2014)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has increased cell death phenotype, suppressible by mir-11^UAS.DsRed2, Scer\GAL4^GMR.PF

(Truscott et al., 2011)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has increased cell death phenotype, suppressible by BacA\p35^UAS.cUa, Scer\GAL4^GMR.PF

(Truscott et al., 2011)

BacA\p35^UAS.cHa, Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^vg.int2.1 has visible phenotype, suppressible | partially by vg[+]/vg^null

(Legent et al., 2006)

NOT suppressed by

Statement

Reference

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^esg.PU has abnormal cell cycle | male | adult stage phenotype, non-suppressible by Dad^UAS.cTa, Scer\GAL4^esg.PU

(Sekar et al., 2023)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^esg.PU has increased cell growth rate | male | adult stage phenotype, non-suppressible by Dad^UAS.cTa, Scer\GAL4^esg.PU

(Sekar et al., 2023)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^esg.PU has abnormal cell cycle | male | adult stage phenotype, non-suppressible by shd^HMC06461, Scer\GAL4^esg.PU

(Sekar et al., 2023)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.long has visible | adult stage phenotype, non-suppressible by Hsap\YARS1^WT.UAS, Scer\GAL4^GMR.long

(Bervoets et al., 2019)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has increased cell death phenotype, non-suppressible by mir-998^UAS.cTa, Scer\GAL4^GMR.PU

(Truscott et al., 2014)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by Asx[+]/Asx¹

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by eff[+]/eff^mer4

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by e(Pc)84DE^T66.1/e(Pc)84DE[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by kis^BG01657/kis[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by pho[+]/pho¹

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by Su(z)2^1.a1/Su(z)2[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by Su(z)2^1.b7/Su(z)2[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by Su(z)2^k06344/Su(z)2[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by Su(z)12³/Su(z)12[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by tara¹/tara[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by tou²/tou[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by brm[+]/brm²

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by trx[+]/trx^KG08639

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has visible phenotype, non-suppressible by Mi-2[+]/Mi-2^j3D4

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has abnormal cell cycle phenotype, non-suppressible by mir-11^UAS.DsRed2, Scer\GAL4^GMR.PF

(Truscott et al., 2011)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^ptc-559.1 has increased cell death phenotype, non-suppressible by pico^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^ptc-559.1

(Lyulcheva et al., 2008)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has visible phenotype, non-suppressible by p53^259H.GUS, Scer\GAL4^GMR.PF

(Moon et al., 2008)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has increased cell death phenotype, non-suppressible by p53^5A-1-4

(Moon et al., 2008)

Enhancer of

Statement

Reference

Dp^UAS.cDa, Scer\GAL4^Act88F.PD is an enhancer of visible phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Morris et al., 2006)

Dp^UAS.cDa, Scer\GAL4^Act5C.PP is an enhancer of abnormal mitotic cell cycle phenotype of E2f1^UAS.cNa, Scer\GAL4^Act5C.PP

(Neufeld et al., 1998)

Suppressor of

Statement

Reference

E2f1^UAS.cNa, Dp^UAS.cDa, Scer\GAL4^GMR.PU is a suppressor | partially of visible phenotype of arm^S44Y.GMR

(Morris et al., 2008)

E2f1^UAS.cNa, Dp^UAS.cDa, Scer\GAL4^vg.int2.1, BacA\p35^UAS.cHa is a suppressor of visible phenotype of vg^83b27

(Legent et al., 2006)

NOT Suppressor of

Statement

Reference

Dp^UAS.cDa, Scer\GAL4^Tub.PU is a non-suppressor of increased occurrence of cell division | somatic clone | pupal stage P6 phenotype of Scer\GAL4^Tub.PU, cbt^UAS.cMa

(Zhang et al., 2021)

E2f1^UAS.cNa, Dp^UAS.cDa, CycA^UAS.cWa, Scer\GAL4^GMR.PF is a non-suppressor of abnormal mitotic cell cycle | somatic clone phenotype of Delta^RevF10

(Baonza and Freeman, 2005)

Other

Statement

Reference

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^esg.PU has increased cell growth rate | male | adult stage phenotype

(Sekar et al., 2023)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^esg.PU has abnormal cell cycle | male | adult stage phenotype

(Sekar et al., 2023)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^NP1624 has increased occurrence of cell division | spermatogenesis phenotype

(Sainz de la Maza et al., 2022)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^en.PU has increased occurrence of cell division | third instar larval stage phenotype

(Zhang et al., 2021)

Dp^UAS.cDa, E2f1⁰⁷¹⁷², E2f1^UAS.cNa, Scer\GAL4^Tub.PU has increased cell number | somatic clone | third instar larval stage phenotype

(Zhang et al., 2021)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.long has visible | adult stage phenotype

(Bervoets et al., 2019)

Dp^UAS.cDa, E2f1^UAS.cNa, Hsap\YARS1^E196K.UAS, Scer\GAL4^GMR.long has abnormal size | adult stage phenotype

(Bervoets et al., 2019)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^Su(H).GBE has increased occurrence of cell division | adult stage phenotype

(Kohlmaier et al., 2015)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^{Delta-05151-G} has increased occurrence of cell division | adult stage phenotype

(Kohlmaier et al., 2015)

Cdk2^UAS.Tag:MYC, CycE^UAS.cLa, Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^{Delta-05151-G} has increased occurrence of cell division | adult stage phenotype

(Kohlmaier et al., 2015)

Cdk2^UAS.Tag:MYC, CycE^UAS.cLa, Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^Su(H).GBE has increased occurrence of cell division | adult stage phenotype

(Kohlmaier et al., 2015)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU, tara[+]/tara^BG01673 has lethal phenotype

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has increased cell death phenotype

(Truscott et al., 2011)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has increased occurrence of cell division phenotype

(Truscott et al., 2011)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^ptc-559.1 has increased cell death phenotype

(Lyulcheva et al., 2008)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^{elav.Switch.PO} has increased cell death phenotype

(Khurana et al., 2006)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^elav.PLu has lethal phenotype

(Khurana et al., 2006)

BacA\p35^UAS.cHa, Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^vg.int2.1 has visible phenotype

(Legent et al., 2006)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has increased occurrence of cell division | larval stage phenotype

(Baonza and Freeman, 2005)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^ptc-559.1 has decreased cell death | larval stage phenotype

(Brennecke et al., 2003)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^ptc-559.1 has increased occurrence of cell division | larval stage phenotype

(Brennecke et al., 2003)

BacA\p35^UAS.cHa, Dp^UAS.cDa, Scer\GAL4^αTub84B.PL, scrib¹ has lethal | somatic clone | pupal stage phenotype

(Brumby and Richardson, 2003)

BacA\p35^UAS.cHa, Dp^UAS.cDa, Scer\GAL4^αTub84B.PL, scrib¹ has hyperplasia | somatic clone | larval stage phenotype

(Brumby and Richardson, 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^esg.PU has male accessory gland secondary cell phenotype, enhanceable by shd^HMC06461, Scer\GAL4^esg.PU

(Sekar et al., 2023)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.long has eye phenotype, enhanceable by Hsap\YARS1^E196K.UAS, Scer\GAL4^GMR.long

(Bervoets et al., 2019)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by His2Av[+]/His2Av⁰⁵¹⁴⁶

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Pc³/Pc[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Pc[+]/Pc^f01890

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Su(z)2¹/Su(z)2[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by His2Av[+]/His2Av⁸¹⁰

(Ji et al., 2012)

Dp^UAS.cDa, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by cass^RNAi.UAS, Scer\GAL4^GMR.PF

(Morris et al., 2006)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^ptc-559.1 has wing disc phenotype, enhanceable by mir-ban^EP3622, Scer\GAL4^ptc-559.1

(Brennecke et al., 2003)

NOT Enhanced by

Statement

Reference

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.long has eye phenotype, non-enhanceable by Hsap\YARS1^WT.UAS, Scer\GAL4^GMR.long

(Bervoets et al., 2019)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Asx[+]/Asx¹

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by eff[+]/eff^mer4

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by e(Pc)84DE^T66.1/e(Pc)84DE[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by kis^BG01657/kis[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by pho[+]/pho¹

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Su(z)2^1.a1/Su(z)2[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Su(z)2^1.b7/Su(z)2[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Su(z)2^k06344/Su(z)2[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Su(z)12³/Su(z)12[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by tara¹/tara[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by tou²/tou[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by brm[+]/brm²

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by trx[+]/trx^KG08639

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-enhanceable by Mi-2[+]/Mi-2^j3D4

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by p53^259H.GUS, Scer\GAL4^GMR.PF

(Moon et al., 2008)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has eye disc posterior to the morphogenetic furrow phenotype, non-enhanceable by p53^5A-1-4

(Moon et al., 2008)

Suppressed by

Statement

Reference

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^esg.PU has male accessory gland secondary cell phenotype, suppressible by EcR^JF02538, Scer\GAL4^esg.PU

(Sekar et al., 2023)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye disc phenotype, suppressible by mir-11^UAS.DsRed2, Scer\GAL4^GMR.PU

(Truscott et al., 2014)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has eye disc phenotype, suppressible by mir-11^UAS.DsRed2, Scer\GAL4^GMR.PF

(Truscott et al., 2011)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has eye disc phenotype, suppressible by BacA\p35^UAS.cUa, Scer\GAL4^GMR.PF

(Truscott et al., 2011)

BacA\p35^UAS.cHa, Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^vg.int2.1 has wing phenotype, suppressible | partially by vg[+]/vg^null

(Legent et al., 2006)

NOT suppressed by

Statement

Reference

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^esg.PU has male accessory gland secondary cell phenotype, non-suppressible by Dad^UAS.cTa, Scer\GAL4^esg.PU

(Sekar et al., 2023)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.long has eye phenotype, non-suppressible by Hsap\YARS1^WT.UAS, Scer\GAL4^GMR.long

(Bervoets et al., 2019)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye disc phenotype, non-suppressible by mir-998^UAS.cTa, Scer\GAL4^GMR.PU

(Truscott et al., 2014)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Asx[+]/Asx¹

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by eff[+]/eff^mer4

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by e(Pc)84DE^T66.1/e(Pc)84DE[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by kis^BG01657/kis[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by pho[+]/pho¹

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Su(z)2^1.a1/Su(z)2[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Su(z)2^1.b7/Su(z)2[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Su(z)2^k06344/Su(z)2[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Su(z)12³/Su(z)12[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by tara¹/tara[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by tou²/tou[+]

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by brm[+]/brm²

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by trx[+]/trx^KG08639

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by Mi-2[+]/Mi-2^j3D4

(Ji et al., 2012)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has eye disc phenotype, non-suppressible by mir-11^UAS.DsRed2, Scer\GAL4^GMR.PF

(Truscott et al., 2011)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^ptc-559.1 has wing disc phenotype, non-suppressible by pico^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^ptc-559.1

(Lyulcheva et al., 2008)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has eye phenotype, non-suppressible by p53^259H.GUS, Scer\GAL4^GMR.PF

(Moon et al., 2008)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has eye disc posterior to the morphogenetic furrow phenotype, non-suppressible by p53^5A-1-4

(Moon et al., 2008)

Enhancer of

Statement

Reference

Dp^UAS.cDa, Scer\GAL4^Act88F.PD is an enhancer of wing blade phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Morris et al., 2006)

Dp^UAS.cDa, Scer\GAL4^en-e16E is an enhancer of wing disc phenotype of E2f1^UAS.cNa, Scer\GAL4^en-e16E

(Neufeld et al., 1998)

Suppressor of

Statement

Reference

E2f1^UAS.cNa, Dp^UAS.cDa, Scer\GAL4^Tub.PU is a suppressor of follicle stem cell | somatic clone phenotype of CycE^WX

(Wang and Kalderon, 2009)

Scer\GAL4^Tub.PU, Scer\GAL4^Act5C.PI, E2f1^UAS.cNa/Dp^UAS.cDa is a suppressor of follicle stem cell | somatic clone phenotype of CycE^AR95/CycE^WX.UAS.cWa, Scer\GAL4^Act5C.PI, Scer\GAL4^Tub.PU

(Wang and Kalderon, 2009)

E2f1^UAS.cNa, Dp^UAS.cDa, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of arm^S44Y.GMR

(Morris et al., 2008)

E2f1^UAS.cNa, Dp^UAS.cDa, Scer\GAL4^vg.int2.1, BacA\p35^UAS.cHa is a suppressor of wing blade phenotype of vg^83b27

(Legent et al., 2006)

NOT Suppressor of

Statement

Reference

Dp^UAS.cDa, Scer\GAL4^Tub.PU is a non-suppressor of wing disc | somatic clone | pupal stage P6 phenotype of Scer\GAL4^Tub.PU, cbt^UAS.cMa

(Zhang et al., 2021)

E2f1^UAS.cNa, Dp^UAS.cDa, CycA^UAS.cWa, Scer\GAL4^GMR.PF is a non-suppressor of eye disc | somatic clone phenotype of Delta^RevF10

(Baonza and Freeman, 2005)

Other

Statement

Reference

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^esg.PU has male accessory gland secondary cell phenotype

(Sekar et al., 2023)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^NP1624 has somatic cell of testis phenotype

(Sainz de la Maza et al., 2022)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^en.PU has wing disc posterior compartment | third instar larval stage phenotype

(Zhang et al., 2021)

Dp^UAS.cDa, E2f1⁰⁷¹⁷², E2f1^UAS.cNa, Scer\GAL4^Tub.PU has wing disc | somatic clone | third instar larval stage phenotype

(Zhang et al., 2021)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.long has eye phenotype

(Bervoets et al., 2019)

Dp^UAS.cDa, E2f1^UAS.cNa, Hsap\YARS1^E196K.UAS, Scer\GAL4^GMR.long has eye phenotype

(Bervoets et al., 2019)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^Su(H).GBE has adult midgut phenotype

(Kohlmaier et al., 2015)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^{Delta-05151-G} has adult midgut phenotype

(Kohlmaier et al., 2015)

Cdk2^UAS.Tag:MYC, CycE^UAS.cLa, Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^{Delta-05151-G} has adult midgut phenotype

(Kohlmaier et al., 2015)

Cdk2^UAS.Tag:MYC, CycE^UAS.cLa, Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^Su(H).GBE has adult midgut phenotype

(Kohlmaier et al., 2015)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has eye disc phenotype

(Truscott et al., 2011, Baonza and Freeman, 2005)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^ptc-559.1 has wing disc phenotype

(Lyulcheva et al., 2008, Brennecke et al., 2003)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PF has eye disc posterior to the morphogenetic furrow phenotype

(Moon et al., 2008)

Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^{elav.Switch.PO} has adult brain phenotype

(Khurana et al., 2006)

BacA\p35^UAS.cHa, Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^vg.int2.1 has wing phenotype

(Legent et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of E2f1^UAS.cNa and Dp^UAS.cDa under the control of Scer\GAL4^en.PU induces increased mitosis in the third instar larval wing disc posterior compartment.

Third instar larval wing disc clones homozygous for E2f1⁰⁷¹⁷² and that also co-express E2f1^UAS.cNa and Dp^UAS.cDa under the control of Scer\GAL4^Tub.PU have more cells than controls.

(Zhang et al., 2021)

Co-expressing E2f1^UAS.cNa and Dp^UAS.cDa under the control of Scer\GAL4^GMR.long results in a rough eye phenotype.

(Bervoets et al., 2019)

Simultaneous expression of E2f1^Scer\UAS.cUa and Dp^Scer\UAS.cDa under the control of Scer\GAL4^ptc.PU in cells of the wing disc proper has no significant effect on the morphology or proliferation of the overlying peripodial membrane cells in third instar larvae.

(Panneton et al., 2015)

Expression of mir-998^Scer\UAS.cTa does not suppress the apoptosis seen in the eye disc in flies expressing expressing E2f1^Scer\UAS.cNa and Dp^Scer\UAS.cDa under the control of Scer\GAL4^GMR.PU.

Expression of mir-11^{Scer\UAS.T:Disc\RFP-DsRed2} suppresses the apoptosis seen in the eye disc in flies expressing E2f1^Scer\UAS.cNa and Dp^Scer\UAS.cDa under the control of Scer\GAL4^GMR.PU.

(Truscott et al., 2014)

Cells posterior to the second mitotic wave in the eye disc which are co-expressing E2f^Scer\UAS.cNa and Dp^Scer\UAS.cDa under the control of Scer\GAL4^GMR.PF undergo ectopic S phases. In addition, independently of the ectopic S phases, co-expression of E2f^Scer\UAS.cNa and Dp^Scer\UAS.cDa under the control of Scer\GAL4^GMR.PF results in the induction of apoptosis in the eye disc.

The addition of mir-11^{Scer\UAS.T:Disc\RFP-DsRed2} does not prevent the ectopic S phases which are induced posterior to the morphogenetic furrow by co-expression of E2f^Scer\UAS.cNa and Dp^Scer\UAS.cDa under the control of Scer\GAL4^GMR.PF. However, co-expression of mir-11^{Scer\UAS.T:Disc\RFP-DsRed2} does suppress the ability of co-expression of E2f^Scer\UAS.cNa and Dp^Scer\UAS.cDa under the control of Scer\GAL4^GMR.PF to induce apoptosis in the eye disc.

(Truscott et al., 2011)

Scer\GAL4^tub-driven co-expression of E2f^Scer\UAS.cNa and Dp^Scer\UAS.cDa in follicle stem cell (FSC) clones suppresses the CycE^WX-associated defective FSC-maintenance phenotype.

Scer\GAL4^tub- and Scer\GAL4^Act5C.PI-driven co-expression of E2f^Scer\UAS.cNa and Dp^Scer\UAS.cDa in CycE^AR95 follicle stem cell (FSC) clones also expressing CycE^{WX.Scer\UAS.cWa} suppresses the CycE^WX-associated defective FSC-maintenance phenotype.

(Wang and Kalderon, 2009)

Overexpression of E2f^Scer\UAS.cNa and Dp^Scer\UAS.cDa in a stripe of cells in the wing using Scer\GAL4^ptc-559.1 results in high levels of cell death.

Co-expression of pico^{Scer\UAS.T:Zzzz\His6,T:Hsap\MYC} with E2f^Scer\UAS.cNa and Dp^Scer\UAS.cDa in a stripe of cells in the wing using Scer\GAL4^ptc-559.1 fails to suppress cell death.

(Lyulcheva et al., 2008)

The rough eye phenotype of Scer\GAL4^GMR.PF, E2f^Scer\UAS.cNa, Dp^Scer\UAS.cDa flies is unaffected by co-expression of p53^259H.GUS.

Scer\GAL4^GMR.PF drives the expression of E2f^Scer\UAS.cNa and Dp^Scer\UAS.cDa in the posterior region of the eye disc inducing a pattern of apoptosis.

The apoptosis in the eye disc induced by the co-expression of E2f^Scer\UAS.cNa and Dp^Scer\UAS.cDa under the control of Scer\GAL4^GMR.PF is unaffected by homozygous p53^5A-1-4.

(Moon et al., 2008)

Simultaneous expression of E2f^Scer\UAS.cNa and Dp^Scer\UAS.cDa under the control of Scer\GAL4^GMR.PU partially suppresses the rough eye phenotype caused by arm^S44Y.GMR.

(Morris et al., 2008)

Expression of Dp^Scer\UAS.cDa and E2f^Scer\UAS.cNa in the brain under the control of Scer\GAL4^elav.PLu results in lethality.

10 day old brains from animals expressing Dp^Scer\UAS.cDa and E2f^Scer\UAS.cNa under the control of the selective driver Scer\GAL4^{elav.Switch.PO} display marked loss of cortical neurons and rarefaction of the underlying neuropil compared to controls.

(Khurana et al., 2006)

The blackened and rough eye phenotype resulting from the expression of Scer\GAL4^GMR.PF-driven Dp^Scer\UAS.cDa is enhanced by co-expression of Aac11^{dsRNA.Scer\UAS}.

(Morris et al., 2006)

Co-expression of E2f^Scer\UAS.cNa and Dp^Scer\UAS.cDa under the control of Scer\GAL4^GMR.PF produces significant excess mitoses in the eye disc.

Co-expression of Dl^Scer\UAS.cJa results in a moderate but reproducible and statistically significant increase in the number of mitoses seen in eye discs expressing E2f^Scer\UAS.cNa and Dp^Scer\UAS.cDa under the control of Scer\GAL4^GMR.PF.

Co-overexpression of CycA^Scer\UAS.cWa, E2f^Scer\UAS.cNa and Dp^Scer\UAS.cDa (using Scer\GAL4^GMR.PF) does not significantly rescue the S phase phenotype seen in Dl^RevF10 clones in a Minute/+ background.

(Baonza and Freeman, 2005)

When E2f^Scer\UAS.cNa and Dp^Scer\UAS.cDa are driven by Scer\GAL4^ptc-559.1 cells in the wing disc overproliferate. Many of these cells drop out of the epithelial layer and have pycnotic nuclei. The addition of ban^EP3622 enhances the overproliferation phenotype seen in E2f^Scer\UAS.cNa, Dp^Scer\UAS.cDa, Scer\GAL4^ptc-559.1 animals. Fewer cells show pyknotic nuclei, though many cells still drop out of the epithelial layer.

(Brennecke et al., 2003)

Marked clones in the eye disc which are homozygous for scrib¹ and are co-expressing Dp^Scer\UAS.cDa, E2f^Scer\UAS.cNa and BacA\p35^Scer\UAS.cHa under the control of Scer\GAL4^Act5C.PI do not show metastatic behaviour.

(Pagliarini and Xu, 2003)

Co-expression of both E2f1^Scer\UAS.cNa and Dp^Scer\UAS.cDa in starved larvae under the control of Scer\GAL4^Act5C.PP is sufficient to drive most endoreplicating cells into S phase, as assayed by BrdU incorporation.

(Britton and Edgar, 1998)

Co-expression of Dp^Scer\UAS.cDa enhances the effects of E2f^Scer\UAS.cNa expressed under the control of either Scer\GAL4^Act5C.PP or Scer\GAL4^en-e16E.

(Neufeld et al., 1998)

Xenogenetic Interactions

Statement

Reference

Additional expression of Hsap\YARS1^E196K.UAS enhances the rough eye phenotype induced by the co-expression of E2f1^UAS.cNa and Dp^UAS.cDa under the control of Scer\GAL4^GMR.long, leading to a decrease in eye size.

(Bervoets et al., 2019)

Co-expression of BacA\p35^Scer\UAS.cUa suppresses the induction of apoptosis in the eye disc caused by co-expression of E2f^Scer\UAS.cNa and Dp^Scer\UAS.cDa under the control of Scer\GAL4^GMR.PF.

(Truscott et al., 2011)

Co-expression of E2f^Scer\UAS.cNa, Dp^Scer\UAS.cDa and BacA\p35^Scer\UAS.cHa under the control of Scer\GAL4^vg.int2.1 results in a wing nicking phenotype, which is partially suppressed by vg^null/+.

Co-expression of E2f^Scer\UAS.cNa, Dp^Scer\UAS.cDa and BacA\p35^Scer\UAS.cHa under the control of Scer\GAL4^vg.int2.1 rescues wing appendage growth in vg^83b27 flies; wing blade features such as bristles, wing veins and margin are often seen in the rescued appendages.

Co-expression of E2f^Scer\UAS.cNa, Dp^Scer\UAS.cDa and BacA\p35^Scer\UAS.cHa under the control of Scer\GAL4^vg.int2.1 does not wing blade growth in vg^null flies and only a slight increase in wing hinge growth is seen.

(Legent et al., 2006)

Complementation and Rescue Data

Partially rescues

Dp^UAS.cDa/Scer\GAL4^NP1624 partially rescues Dp^GD4444

(Herrera et al., 2021)

Scer\GAL80^{hh-MI10526-T3XG80.0}, Dp^UAS.cDa, Scer\GAL4^NP1624 partially rescues Dp^GD4444

(Herrera et al., 2021)

Dp^UAS.cDa/Scer\GAL4^Mef2.PR partially rescues Dp^a3/Df(2R)Exel7124

(Zappia et al., 2021)

Dp^UAS.cDa/Scer\GAL4^Cg.PA partially rescues Dp^a3/Df(2R)Exel7124

(Zappia et al., 2021)

Comments