A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\ApcQ8

General Information
SymbolDmel\ApcQ8SpeciesD. melanogaster
NameFlyBase IDFBal0091898
Feature typealleleAssociated geneDmel\Apc
Also Known Asapc1Q8, D-APCQ8, dAPCQ8
Map ( GBrowse ) GBrowse View Helpdetailed view FBal0091896 FBal0091897 FBal0091898
Allele class
Mutagen
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Description
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FB2013_03
FB2013_02
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hide Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
point mutation
3R:24,665,205..24,665,205
evidence=experimental
na_change=C24665205T
(Ahmed et al., 1998)
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
Nucleotide substitution: C1486T. Amino acid replacement: Q426@.
(Ahmed et al., 1998)
Cytology
hide Phenotypic Data
hide Phenotypic Class
cell lethal | adult stage
(Xin et al., 2011)
increased cell death
(Mendes et al., 2009)
increased cell death | pupal stage (with ApcS76)
(Lin et al., 2004)
lethal | recessive | heat sensitive
(Ahmed et al., 1998)
viable
(Ahmed et al., 2002)
hide Phenotype Manifest In
eye photoreceptor cell
(Ahmed et al., 1998, Takacs et al., 2008, Takacs et al., 2008, Benchabane et al., 2011)
eye photoreceptor cell | P-stage (with ApcS76)
(Lin et al., 2004)
male germline stem cell & centrosome (with Df(3R)3450)
(Yamashita et al., 2003)
male germline stem cell & spindle (with Df(3R)3450)
(Yamashita et al., 2003)
neuron & retina & pupa
(Ahmed et al., 2002)
photoreceptor | adult stage
(Xin et al., 2011)
photoreceptor cell
(Mendes et al., 2009)
photoreceptor cell R1
(Ahmed et al., 1998)
photoreceptor cell R2
(Ahmed et al., 1998)
photoreceptor cell R3
(Ahmed et al., 1998)
photoreceptor cell R4
(Ahmed et al., 1998)
photoreceptor cell R5
(Ahmed et al., 1998)
photoreceptor cell R6
(Ahmed et al., 1998)
photoreceptor cell R7
(Ahmed et al., 1998)
photoreceptor cell R8
(Ahmed et al., 1998)
hide Detailed Description
Statement
Reference
Photoreceptor cells undergo apoptosis in homozygous flies.
(Benchabane et al., 2011)
All photoreceptors undergo apoptosis in homozygous Apc[Q8] mutants. The pigment cell lattice remains intact. Prior to photoreceptor cell death the photoreceptors appear shorter and aberrant specification of all inner photoreceptors in the dorsal half of the retina to a dorsal rim area fate, as evidenced by enlarged rhabdomeres.
(Xin et al., 2011)
Apc[Q8] adult retina exhibit complete photoreceptor cell loss.
(Mendes et al., 2009)
All photoreceptors in homozygous mutants undergo apoptosis.
(Takacs et al., 2008)
Mutants show photoreceptor apoptosis.
(Takacs et al., 2008)
Ectopic photoreceptor apoptosis is seen in the developing eyes of ApcS76/ApcQ8 pupae, beginning at around 35 hours after puparium formation (APF) and peaking at 42 hours APF. This timing is identical to that of photoreceptor apoptosis occurring at the periphery of the developing eye in wild-type pupae.
(Lin et al., 2004)
Spindle orientation and centrosome position are perturbed in the germline stem cells of ApcQ8/Df(3R)3450 males.
(Yamashita et al., 2003)
Homozygotes survive to adulthood. They show apoptotic death of all retinal neurons in all ommatidia during pupal development. The pigment cell lattice remains intact.
(Ahmed et al., 2002)
Asymmetric divisions of neuroblasts appear to be unaffected in the brains of mutant larvae.
(Akong et al., 2002)
Homozygous adults raised at the permissive temperature are morphologically normal, although they lack pseudopupils. All photoreceptor cells within all ommatidia are missing, although the pigment cell lattice remains intact in newly eclosed flies. The pigment cells enlarge to the point of confluence several days after eclosion. Heterozygous adults have wild-type ommatidia. Retinal axonal projections to the optic lobe are intact in homozygous third instar larvae. At 45-50% pupal development, many apoptotic nuclei are seen in homozygous eye discs. Apoptosis is restricted to the retinal neurons; no apoptotic nuclei are seen in non-neuronal cells in the eye disc. Apoptosis is not seen in wild-type eye discs at this stage. The actin cytoskeleton of the mutant photoreceptor cells is disorganised, in contrast to wild-type.
(Ahmed et al., 1998)
hide External Data
Linkouts
hide Interactions
hide Phenotypic Class
hideSuppressed by
Statement
Reference
Apc2g10, ApcQ8 has lethal | embryonic stage | germline clone | rescuable maternal effect phenotype, suppressible | partially by Apc2FL.T:Avic\GFP-EGFP
(Zhou et al., 2011, Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has lethal | embryonic stage | germline clone | rescuable maternal effect phenotype, suppressible | partially by Apc2R1-R5SA.T:Avic\GFP-EGFP
(Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has lethal | embryonic stage | germline clone | rescuable maternal effect phenotype, suppressible | partially by Apc2R1-R5SD.T:Avic\GFP-EGFP
(Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has lethal | embryonic stage | germline clone | rescuable maternal effect phenotype, suppressible | partially by Apc2R3-R5ExR.T:Avic\GFP-EGFP
(Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has lethal | embryonic stage | germline clone | rescuable maternal effect phenotype, suppressible | partially by Apc2R3-R5SA.T:Avic\GFP-EGFP
(Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has lethal | embryonic stage | germline clone | rescuable maternal effect phenotype, suppressible | partially by Apc2R3-R5SD.T:Avic\GFP-EGFP
(Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has lethal | embryonic stage | germline clone | rescuable maternal effect phenotype, suppressible | partially by Apc2ΔC30.T:Avic\GFP-EGFP
(Zhou et al., 2011)
ApcQ8/ApcS76 has increased cell death | pupal stage phenotype, suppressible | partially by Df(3L)H99/+
(Lin et al., 2004)
ApcQ8 has cell lethal | adult stage phenotype, suppressible by ewg1/ewg2
(Xin et al., 2011)
ApcQ8 has cell lethal | adult stage phenotype, suppressible by ewgP1
(Xin et al., 2011)
ApcQ8 has cell lethal | adult stage phenotype, suppressible by ewgP1/ewg2
(Xin et al., 2011)
ApcQ8 has increased cell death phenotype, suppressible | partially by ninaA[+]/ninaAE110V
(Mendes et al., 2009)
ApcQ8 has increased cell death phenotype, suppressible | partially by ninaAE110V
(Mendes et al., 2009)
ApcQ8 has size defective | adult stage phenotype, suppressible | partially by ewgP1/ewg2
(Xin et al., 2011)
ApcQ8 has size defective | adult stage phenotype, suppressible by ewg1/ewg2
(Xin et al., 2011)
hideNOT suppressed by
Statement
Reference
Apc2g10, ApcQ8 has lethal | embryonic stage | germline clone | rescuable maternal effect phenotype, non-suppressible | partially by Apc2ΔC30.T:Avic\GFP-EGFP
(Zhou et al., 2011)
Apc2g10, ApcQ8 has lethal | embryonic stage | germline clone | rescuable maternal effect phenotype, non-suppressible by Apc2R1-R5ExR.T:Avic\GFP-EGFP
(Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has lethal | embryonic stage | germline clone | rescuable maternal effect phenotype, non-suppressible by Apc2Δ15RΔ20RΔB.T:Avic\GFP-EGFP
(Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has lethal | embryonic stage | germline clone | rescuable maternal effect phenotype, non-suppressible by Apc2Δ20RΔB.T:Avic\GFP-EGFP
(Kunttas-Tatli et al., 2012)
hideOther
Statement
Reference
Apc25-3, ApcQ8 has visible phenotype
(Takacs et al., 2008)
Apc219-3, ApcQ8, AxnS044230 has neuroanatomy defective | somatic clone | third instar larval stage phenotype
(Roberts et al., 2012)
Apc219-3, ApcQ8 has neuroanatomy defective | somatic clone | third instar larval stage phenotype
(Roberts et al., 2012)
Apc219-3/Apc25-3, ApcQ8 has visible phenotype
(Takacs et al., 2008)
Apc233, ApcQ8, AxnS044230 has neuroanatomy defective | somatic clone | third instar larval stage phenotype
(Roberts et al., 2012)
Apc233, ApcQ8 has neuroanatomy defective | somatic clone | third instar larval stage phenotype
(Roberts et al., 2012)
Apc233/Apc25-3, ApcQ8 has visible phenotype
(Takacs et al., 2008)
Apc2d40, ApcQ8 has lethal | germline clone | rescuable maternal effect phenotype
(Akong et al., 2002, Akong et al., 2002, Akong et al., 2002)
Apc2d40, ApcQ8 has lethal | larval stage phenotype
(Ahmed et al., 2002, Akong et al., 2002, Akong et al., 2002, Ahmed et al., 2002, Akong et al., 2002, Akong et al., 2002, Akong et al., 2002, Akong et al., 2002)
Apc2d40, ApcQ8 has visible | somatic clone phenotype
(Ahmed et al., 2002, Ahmed et al., 2002)
Apc2g10, ApcQ8 has cell shape defective | somatic clone | third instar larval stage phenotype
(Roberts et al., 2012)
Apc2g10, ApcQ8 has lethal | embryonic stage | germline clone | rescuable maternal effect phenotype
(Zhou et al., 2011, Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has lethal | embryonic stage phenotype
(Roberts et al., 2011, Roberts et al., 2012)
Apc2g10, ApcQ8 has lethal | larval stage phenotype
(Akong et al., 2002, Akong et al., 2002, Akong et al., 2002, Akong et al., 2002, Akong et al., 2002, Akong et al., 2002)
Apc2g10, ApcQ8 has neuroanatomy defective | somatic clone | third instar larval stage phenotype
(Roberts et al., 2012)
Apc2G5028/Apc25-3, ApcQ8 has visible phenotype
(Takacs et al., 2008)
Apc2G5028/Apc233, ApcQ8 has visible phenotype
(Takacs et al., 2008)
Apc2ΔS, ApcQ8 has lethal | larval stage phenotype
(Akong et al., 2002, Akong et al., 2002, Akong et al., 2002)
Apc2ΔS, ApcQ8 has lethal | recessive | larval stage phenotype
(Akong et al., 2002, Akong et al., 2002, Akong et al., 2002)
ApcQ8, ewgP1, ewgelav.NS has cell lethal | adult stage phenotype
(Xin et al., 2011)
hide Phenotype Manifest In
hideNOT Enhanced by
Statement
Reference
Apc2d40, ApcQ8, AxnS044230 has denticle belt | germline clone phenotype, non-enhanceable by Apc2Scer\UAS.T:Avic\GFP/Scer\GAL4da.G32
(Tolwinski, 2009)
Apc2d40, ApcQ8, AxnS044230 has denticle belt | germline clone phenotype, non-enhanceable by Apc2Scer\UAS.T:Myr-Src64B,T:Zzzz\FLAG/Scer\GAL4da.G32
(Tolwinski, 2009)
Apc2d40, ApcQ8, AxnS044230 has denticle belt | germline clone phenotype, non-enhanceable by AxnScer\UAS.T:Myr-Src64B,T:Zzzz\FLAG/Scer\GAL4da.G32
(Tolwinski, 2009)
Apc2d40, ApcQ8 has denticle belt | germline clone phenotype, non-enhanceable by AxnScer\UAS.T:Myr-Src64B,T:Zzzz\FLAG/Scer\GAL4da.G32
(Tolwinski, 2009)
hideSuppressed by
Statement
Reference
Apc233, ApcQ8 has intestinal stem cell | somatic clone phenotype, suppressible by panΔN.Scer\UAS/Scer\GAL4tub.PU
(Lee et al., 2009)
Apc2d40, ApcQ8, AxnS044230 has denticle belt | germline clone phenotype, suppressible by AxnScer\UAS.cHa/Scer\GAL4da.G32
(Tolwinski, 2009)
Apc2d40, ApcQ8 has denticle belt | germline clone phenotype, suppressible by Apc2Scer\UAS.T:Avic\GFP/Scer\GAL4da.G32
(Tolwinski, 2009)
Apc2d40, ApcQ8 has denticle belt | germline clone phenotype, suppressible by AxnScer\UAS.cHa/Scer\GAL4da.G32
(Tolwinski, 2009)
Apc2g10, ApcQ8 has embryonic/larval cuticle | embryonic stage phenotype, suppressible | partially by Apc2ΔArmRepeats.T:Avic\GFP-EGFP
(Roberts et al., 2012)
Apc2g10, ApcQ8 has embryonic/larval cuticle | embryonic stage phenotype, suppressible by Apc2WT.T:Avic\GFP-EGFP
(Roberts et al., 2012)
Apc2g10, ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype, suppressible | partially by Apc2FL.T:Avic\GFP-EGFP
(Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype, suppressible | partially by Apc2R1-R5SA.T:Avic\GFP-EGFP
(Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype, suppressible | partially by Apc2R1-R5SD.T:Avic\GFP-EGFP
(Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype, suppressible | partially by Apc2R3-R5ExR.T:Avic\GFP-EGFP
(Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype, suppressible | partially by Apc2R3-R5SA.T:Avic\GFP-EGFP
(Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype, suppressible | partially by Apc2R3-R5SD.T:Avic\GFP-EGFP
(Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype, suppressible by Apc2FL.T:Avic\GFP-EGFP
(Zhou et al., 2011)
Apc2g10, ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype, suppressible by Apc2ΔC30.T:Avic\GFP-EGFP
(Zhou et al., 2011)
Apc2g10, ApcQ8 has intestinal stem cell | somatic clone phenotype, suppressible | partially by panΔN.Scer\UAS/Scer\GAL4tub.PU
(Lee et al., 2009)
Apc2N175K, ApcQ8 has embryonic/first instar larval cuticle phenotype, suppressible by AxnScer\UAS.T:Avic\GFP/Scer\GAL4arm.PS
(Cliffe et al., 2003)
Apc2N175K, ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype, suppressible by AxnScer\UAS.T:Avic\GFP/Scer\GAL4arm.PS
(Mendoza-Topaz et al., 2011)
ApcQ8/ApcS76 has eye photoreceptor cell | P-stage phenotype, suppressible | partially by Df(3L)H99/+
(Lin et al., 2004)
ApcQ8 has eye photoreceptor cell phenotype, suppressible | partially by Apc2123/Apc2[+]
(Takacs et al., 2008)
ApcQ8 has eye photoreceptor cell phenotype, suppressible | partially by BacA\p35GMR.PH
(Ahmed et al., 1998)
ApcQ8 has eye photoreceptor cell phenotype, suppressible by Apc2[+]/Apc233
(Takacs et al., 2008)
ApcQ8 has eye photoreceptor cell phenotype, suppressible by Apc233
(Takacs et al., 2008)
ApcQ8 has eye photoreceptor cell phenotype, suppressible by Apc245
(Takacs et al., 2008)
ApcQ8 has eye photoreceptor cell phenotype, suppressible by arm4
(Ahmed et al., 1998)
ApcQ8 has eye photoreceptor cell phenotype, suppressible by Df(3L)27-3/Df(3L)ED4136
(Benchabane et al., 2011)
ApcQ8 has eye photoreceptor cell phenotype, suppressible by Df(3R)Apc2-79/+
(Takacs et al., 2008)
ApcQ8 has eye photoreceptor cell phenotype, suppressible by Df(3R)crb87-4/+
(Takacs et al., 2008)
ApcQ8 has eye photoreceptor cell phenotype, suppressible by Df(3R)crb-F89-4/+
(Takacs et al., 2008)
ApcQ8 has eye photoreceptor cell phenotype, suppressible by Df(3R)w6/+
(Takacs et al., 2008)
ApcQ8 has eye photoreceptor cell phenotype, suppressible by ebd1QF1
(Benchabane et al., 2011)
ApcQ8 has eye photoreceptor cell phenotype, suppressible by pan13
(Ahmed et al., 1998)
ApcQ8 has eye photoreceptor cell phenotype, suppressible by panciD
(Ahmed et al., 1998)
ApcQ8 has eye photoreceptor cell phenotype, suppressible by sggScer\UAS.cSa/Scer\GAL4elav-C155
(Ahmed et al., 1998)
ApcQ8 has neuron & retina & pupa phenotype, suppressible | partially by Apc2+t7
(Ahmed et al., 2002)
ApcQ8 has photoreceptor | adult stage phenotype, suppressible by ewg1/ewg2
(Xin et al., 2011)
ApcQ8 has photoreceptor | adult stage phenotype, suppressible by ewgP1
(Xin et al., 2011)
ApcQ8 has photoreceptor | adult stage phenotype, suppressible by ewgP1/ewg2
(Xin et al., 2011)
ApcQ8 has photoreceptor cell phenotype, suppressible | partially by ninaA[+]/ninaAE110V
(Mendes et al., 2009)
ApcQ8 has photoreceptor cell phenotype, suppressible | partially by ninaAE110V
(Mendes et al., 2009)
ApcQ8 has retina phenotype, suppressible | partially by +/Df(3L)ED4136
(Benchabane et al., 2011)
ApcQ8 has retina phenotype, suppressible | partially by BacA\p35GMR.PH
(Benchabane et al., 2011)
ApcQ8 has retina phenotype, suppressible | partially by CG13895190
(Benchabane et al., 2011)
ApcQ8 has retina phenotype, suppressible by Df(3L)27-3
(Benchabane et al., 2011)
ApcQ8 has retina phenotype, suppressible by Df(3L)ED4157
(Benchabane et al., 2011)
ApcQ8 has retina phenotype, suppressible by Df(3L)ED4196
(Benchabane et al., 2011)
ApcQ8 has retina phenotype, suppressible by Df(3L)ED9698
(Benchabane et al., 2011)
ApcQ8 has retina phenotype, suppressible by ebd1Df5/ebd1240
(Benchabane et al., 2011)
ApcQ8 has retina phenotype, suppressible by ebd1EY01876/CG3371[+]
(Benchabane et al., 2011)
ApcQ8 has retina phenotype, suppressible by ebd1EY01876/Df(3L)ED4136
(Benchabane et al., 2011)
ApcQ8 has rhabdomere | adult stage phenotype, suppressible | partially by ewgP1/ewg2
(Xin et al., 2011)
ApcQ8 has rhabdomere | adult stage phenotype, suppressible by ewg1/ewg2
(Xin et al., 2011)
hideNOT suppressed by
Statement
Reference
Apc2d40, ApcQ8, AxnS044230 has denticle belt | germline clone phenotype, non-suppressible by Apc2Scer\UAS.T:Avic\GFP/Scer\GAL4da.G32
(Tolwinski, 2009)
Apc2d40, ApcQ8, AxnS044230 has denticle belt | germline clone phenotype, non-suppressible by Apc2Scer\UAS.T:Myr-Src64B,T:Zzzz\FLAG/Scer\GAL4da.G32
(Tolwinski, 2009)
Apc2d40, ApcQ8, AxnS044230 has denticle belt | germline clone phenotype, non-suppressible by AxnScer\UAS.T:Myr-Src64B,T:Zzzz\FLAG/Scer\GAL4da.G32
(Tolwinski, 2009)
Apc2d40, ApcQ8 has denticle belt | germline clone phenotype, non-suppressible by Apc2Scer\UAS.T:Myr-Src64B,T:Zzzz\FLAG/Scer\GAL4da.G32
(Tolwinski, 2009)
Apc2d40, ApcQ8 has denticle belt | germline clone phenotype, non-suppressible by AxnScer\UAS.T:Myr-Src64B,T:Zzzz\FLAG/Scer\GAL4da.G32
(Tolwinski, 2009)
Apc2f90, ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype, non-suppressible by AxnScer\UAS.T:Avic\GFP/Scer\GAL4arm.PS
(Mendoza-Topaz et al., 2011)
Apc2g10, ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype, non-suppressible by Apc2R1-R5ExR.T:Avic\GFP-EGFP
(Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype, non-suppressible by Apc2Δ15RΔ20RΔB.T:Avic\GFP-EGFP
(Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype, non-suppressible by Apc2Δ20RΔB.T:Avic\GFP-EGFP
(Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype, non-suppressible by Apc2ΔC30.T:Avic\GFP-EGFP
(Zhou et al., 2011)
ApcQ8 has eye photoreceptor cell phenotype, non-suppressible by +/Df(3R)357
(Takacs et al., 2008)
ApcQ8 has eye photoreceptor cell phenotype, non-suppressible by Apc2g10/Apc2[+]
(Takacs et al., 2008)
ApcQ8 has phenotype, non-suppressible by arm8
(Ahmed et al., 1998)
ApcQ8 has retina phenotype, non-suppressible by Df(3L)ED4125
(Benchabane et al., 2011)
ApcQ8 has retina phenotype, non-suppressible by Df(3L)ED4238
(Benchabane et al., 2011)
hideEnhancer of
Statement
Reference
ApcQ8 is an enhancer of embryonic/first instar larval cuticle phenotype of Apc2d40
(Ahmed et al., 2002)
ApcQ8 is an enhancer of embryonic/larval cuticle | embryonic stage phenotype of Apc2g10
(Roberts et al., 2012)
ApcQ8 is an enhancer of oocyte phenotype of Apc2N175K
(Hamada and Bienz, 2002)
hideNOT Enhancer of
Statement
Reference
ApcQ8/Apc2d40 is a non-enhancer of denticle belt | germline clone phenotype of AxnS044230
(Tolwinski, 2009)
ApcQ8 is a non-enhancer of nucleus | germline clone | embryonic stage 4 phenotype of Apc2g10
(McCartney et al., 2006)
hideNOT Suppressor of
Statement
Reference
ApcQ8/Apc2d40 is a non-suppressor of denticle belt | germline clone phenotype of AxnS044230
(Tolwinski, 2009)
hideOther
Statement
Reference
Apc25-3, ApcQ8 has abdominal sternite bristle phenotype
(Takacs et al., 2008)
Apc25-3, ApcQ8 has pleural membrane phenotype
(Takacs et al., 2008)
Apc25-3, ApcQ8 has sternite phenotype
(Takacs et al., 2008)
Apc219-3, ApcQ8, AxnS044230 has medulla | somatic clone | third instar larval stage phenotype
(Roberts et al., 2012)
Apc219-3, ApcQ8 has medulla | somatic clone | third instar larval stage phenotype
(Roberts et al., 2012)
Apc219-3/Apc25-3, ApcQ8 has wing phenotype
(Takacs et al., 2008)
Apc233, ApcQ8, AxnS044230 has medulla | somatic clone | third instar larval stage phenotype
(Roberts et al., 2012)
Apc233, ApcQ8 has intestinal stem cell | somatic clone phenotype
(Lee et al., 2009)
Apc233, ApcQ8 has medulla | somatic clone | third instar larval stage phenotype
(Roberts et al., 2012)
Apc233/Apc25-3, ApcQ8 has abdominal sternite bristle | ectopic phenotype
(Takacs et al., 2008)
Apc233/Apc25-3, ApcQ8 has pleural membrane phenotype
(Takacs et al., 2008)
Apc233/Apc25-3, ApcQ8 has sternite phenotype
(Takacs et al., 2008)
Apc2c9/Apc2g10, ApcQ8 has adult midgut | heat sensitive phenotype
(Lee et al., 2009)
Apc2d40, ApcQ8 has adult head & cuticle | ectopic | somatic clone phenotype
(Ahmed et al., 2002, Ahmed et al., 2002)
Apc2d40, ApcQ8 has adult head & cuticle | somatic clone phenotype
(Ahmed et al., 2002, Ahmed et al., 2002)
Apc2d40, ApcQ8 has antenna | somatic clone phenotype
(Ahmed et al., 2002, Ahmed et al., 2002)
Apc2d40, ApcQ8 has denticle belt | germline clone | maternal effect phenotype
(Akong et al., 2002, Akong et al., 2002, Akong et al., 2002)
Apc2d40, ApcQ8 has denticle belt | germline clone phenotype
(Tolwinski, 2009)
Apc2d40, ApcQ8 has dorsal closure embryo | germline clone | maternal effect phenotype
(Akong et al., 2002, Akong et al., 2002, Akong et al., 2002)
Apc2d40, ApcQ8 has embryonic/first instar larval cuticle | germline clone | maternal effect phenotype
(Akong et al., 2002, Akong et al., 2002, Akong et al., 2002)
Apc2d40, ApcQ8 has eye | somatic clone phenotype
(Ahmed et al., 2002, Ahmed et al., 2002)
Apc2d40, ApcQ8 has genitalia | somatic clone phenotype
(Ahmed et al., 2002, Ahmed et al., 2002)
Apc2d40, ApcQ8 has leg | somatic clone phenotype
(Ahmed et al., 2002, Ahmed et al., 2002)
Apc2d40, ApcQ8 has macrochaeta | ectopic | somatic clone phenotype
(Akong et al., 2002, Akong et al., 2002, Akong et al., 2002)
Apc2d40, ApcQ8 has mesothoracic tergum | somatic clone phenotype
(Ahmed et al., 2002, Akong et al., 2002, Ahmed et al., 2002, Akong et al., 2002, Akong et al., 2002)
Apc2d40, ApcQ8 has stage 14 embryo | germline clone | maternal effect phenotype
(Akong et al., 2002, Akong et al., 2002, Akong et al., 2002)
Apc2d40, ApcQ8 has tergite | somatic clone phenotype
(Ahmed et al., 2002, Ahmed et al., 2002)
Apc2d40, ApcQ8 has wing | somatic clone phenotype
(Ahmed et al., 2002, Akong et al., 2002, Ahmed et al., 2002, Akong et al., 2002, Akong et al., 2002)
Apc2d40, ApcQ8 has wing margin bristle | ectopic | somatic clone phenotype
(Ahmed et al., 2002, Akong et al., 2002, Ahmed et al., 2002, Akong et al., 2002, Akong et al., 2002)
Apc2f90, ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype
(Mendoza-Topaz et al., 2011)
Apc2f90/Apc2[+], ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype
(Mendoza-Topaz et al., 2011)
Apc2g10, ApcQ8, NdsRNA.P.Scer\UAS, Scer\GAL4tub.PU has intestinal stem cell | somatic clone phenotype
(Lee et al., 2009)
Apc2g10, ApcQ8 has adult midgut | somatic clone phenotype
(Lee et al., 2009)
Apc2g10, ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype
(Zhou et al., 2011, Kunttas-Tatli et al., 2012)
Apc2g10, ApcQ8 has embryonic/larval cuticle phenotype
(Roberts et al., 2011, Roberts et al., 2012)
Apc2g10, ApcQ8 has medulla | somatic clone | third instar larval stage phenotype
(Roberts et al., 2012)
Apc2g10, ApcQ8 has spindle | embryonic stage 4 phenotype
(McCartney et al., 2006)
Apc2g10, ApcQ8 has wing disc | somatic clone | third instar larval stage phenotype
(Roberts et al., 2012)
Apc2G5028/Apc25-3, ApcQ8 has abdominal sternite bristle phenotype
(Takacs et al., 2008)
Apc2G5028/Apc25-3, ApcQ8 has pleural membrane phenotype
(Takacs et al., 2008)
Apc2G5028/Apc25-3, ApcQ8 has sternite phenotype
(Takacs et al., 2008)
Apc2G5028/Apc233, ApcQ8 has abdominal sternite bristle | ectopic phenotype
(Takacs et al., 2008)
Apc2G5028/Apc233, ApcQ8 has pleural membrane phenotype
(Takacs et al., 2008)
Apc2G5028/Apc233, ApcQ8 has sternite phenotype
(Takacs et al., 2008)
Apc2N175K, ApcQ8 has embryonic/first instar larval cuticle phenotype
(Cliffe et al., 2003, Cliffe et al., 2003)
Apc2N175K, ApcQ8 has embryonic/larval cuticle | germline clone | rescuable maternal effect | embryonic stage phenotype
(Mendoza-Topaz et al., 2011)
Apc2ΔS, ApcQ8 has neuroblast | larval stage phenotype
(Akong et al., 2002, Akong et al., 2002, Akong et al., 2002)
ApcQ8, ewgP1, ewgelav.NS has photoreceptor | adult stage phenotype
(Xin et al., 2011)
ApcQ8/Apc[+], Khc8 has phenotype
(Henthorn et al., 2011)
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hide Genetic Interactions
Statement
Reference
23% of embryos derived from females carrying homozygous Apc2[g10] Apc[Q8] germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique) are able to hatch. All of the surviving embryos are maternally double null and zygotically heterozygous for the double-null chromosome. A further 25% of embryos display weak cuticle defects and these are also zygotically heterozygous for Apc2[g10] and Apc[Q8]. All of the maternally and zygotically double mutant embryos die showing severe cuticle defects. Expression of Apc2[FL.T:Avic\GFP-EGFP] partially suppresses the lethality seen in embryos derived from females carrying homozygous Apc2[g10] Apc[Q8] germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique). 46% of embryos are able to hatch. The remaining progeny exhibit a very weak cuticle phenotype. Expression of Apc2[Δ20RΔB.T:Avic\GFP-EGFP] fails to suppresses the lethality seen in embryos derived from females carrying homozygous Apc2[g10] Apc[Q8] germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique). 24% of embryos are able to hatch and the severity of the cuticle defects in the remaining progeny is similar to the double mutant alone. Expression of Apc2[Δ15RΔ20RΔB.T:Avic\GFP-EGFP] fails to suppress the lethality seen in embryos derived from females carrying homozygous Apc2[g10] Apc[Q8] germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique). Between 18% and 24% of embryos are able to hatch, depending on the expression level of the transgenes. The severity of the cuticle defects in the remaining progeny is similar to the double mutant alone. Expression of Apc2[R3-R5SA.T:Avic\GFP-EGFP] partially suppresses the lethality seen in embryos derived from females carrying homozygous Apc2[g10] Apc[Q8] germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique). 68% of embryos are able to hatch. Expression of Apc2[R3-R5SD.T:Avic\GFP-EGFP] partially suppresses the lethality seen in embryos derived from females carrying homozygous Apc2[g10] Apc[Q8] germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique). 40% of embryos are able to hatch. Expression of Apc2[R1-R5SA.T:Avic\GFP-EGFP] partially suppresses the lethality seen in embryos derived from females carrying homozygous Apc2[g10] Apc[Q8] germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique). 51% of embryos are able to hatch. The remaining progeny exhibit a more severe cuticle phenotype than in the double mutant alone. Expression of Apc2[R1-R5SD.T:Avic\GFP-EGFP] partially suppresses the lethality seen in embryos derived from females carrying homozygous Apc2[g10] Apc[Q8] germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique). 49% of embryos are able to hatch. The remaining progeny exhibit a more severe cuticle phenotype than in the double mutant alone. Expression of Apc2[R1-R5ExR.T:Avic\GFP-EGFP] fails to suppress the lethality seen in embryos derived from females carrying homozygous Apc2[g10] Apc[Q8] germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique). 21% of embryos are able to hatch. The severity of the cuticle defects in the remaining progeny is similar to the double mutant alone. Expression of Apc2[R3-R5ExR.T:Avic\GFP-EGFP] partially suppresses the lethality seen in embryos derived from females carrying homozygous Apc2[g10] Apc[Q8] germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique). 50% of embryos are able to hatch. The remaining progeny exhibit a very weak cuticle phenotype.
(Kunttas-Tatli et al., 2012)
The cells around the wing pouch in Apc2[g10] Apc[Q8] double mutant third instar larval wing disc clones are apically constricted and invaginated. No apical constriction is seen in the cells surrounding the wing pouch in Apc[Q8] Apc2[33] double mutant third instar larval clones. Apc2[g10] Apc[Q8] double mutant clone cells generated in the medullar region of third instar larval brains segregate from their neighbours to form cysts. When clones are induced in the medullar neurons the axons do not extend to the medullar neuropil, forming knots in the center of the clones rather than the normal finely fasciculated projections seen in wild type. Apc2[19-3] Apc[Q8] double mutant clone cells generated in the medullar region of third instar larval brains segregate from their neighbours to form cysts. When clones are induced in the medullar neurons the axons do not extend to the medullar neuropil, forming knots in the center of the clones rather than the normal finely fasciculated projections seen in wild type. Apc2[19-3] Apc[Q8] double mutant clone cells generated in the medullar region of third instar larval brains sometimes segregate from their neighbours to form cysts. When clones are induced in the medullar neurons the axons extend correctly to the medullar neuropil. Apc[Q8] enhances the embryonic cuticle phenotype seen in Apc2[g10] mutants. In Apc2[g10] Apc[Q8] double mutant embryos all cells are converted to posterior fates. No cells are seen that secrete the denticles normally seen in the anterior cuticle. Expression of Apc2[ΔArmRepeats.T:Avic\GFP-EGFP] provides a very weak rescue of the anterior fate loss seen in Apc2[g10] Apc[Q8] maternal/zygotic mutant embryos. Expression of Apc2[T:Avic\GFP-EGFP] rescues the anterior fate loss seen in Apc2[g10] Apc[Q8] maternal/zygotic mutant embryos. Apc2[19-3] Apc[Q8] Axn[S044230] triple mutant clone cells generated in the medullar region of third instar larval brains sometimes segregate from their neighbours to form cysts. When clones are induced in the medullar neurons the axons extend correctly to the medullar neuropil.
(Roberts et al., 2012)
Embryos derived from Apc2[g10] Apc[Q8] males crossed to females containing double homozygous germline clones generate naked cuticle. These embryos show approximately 50% lethality (as half the embryos are paternally rescued). The cuticle defects of embryos derived from Apc2[g10] Apc[Q8] males crossed to females containing double homozygous germline clones are rescued by expression of Apc2[T:Avic\GFP-EGFP,T:Zzzz\Mito-actA]. The embryonic lethality is partially rescued (19% lethality is seen). The cuticle defects of embryos derived from Apc2[g10] Apc[Q8] males crossed to females containing double homozygous germline clones are strongly rescued by expression of Apc2[T:Avic\GFP-EGFP,T:Mmmm\c-Ha-Ras]. The embryonic lethality is partially rescued (41% lethality is seen). The cuticle defects of embryos derived from Apc2[g10] Apc[Q8] males crossed to females containing double homozygous germline clones are strongly rescued by expression of Apc2[T:Myr-Src64B,T:Avic\GFP-EGFP]. The embryonic lethality is partially rescued (33% lethality is seen). The cuticle defects of embryos derived from Apc2[g10] Apc[Q8] males crossed to females containing double homozygous germline clones are partially rescued by expression of Apc2[T:Avic\GFP-EGFP,T:Hsap\CAAX]. The embryonic lethality is not rescued.
(Roberts et al., 2012)
ebd1[240]/ebd1[Df5] suppresses the apoptosis of photoreceptor cells which is seen in Apc[Q8] homozygotes, such that the rescued photoreceptors are wild type in length. Homozygosity for CG13895[190] partially suppresses the apoptosis of photoreceptor cells which is seen in Apc[Q8] homozygotes; photoreceptors are seen only in a subset of ommatidia, and these ommatidia have less than seven photoreceptors. ebd2[136] weakly suppresses the apoptosis of photoreceptor cells which is seen in Apc[Q8] homozygotes.
(Benchabane et al., 2011)
ebd1[QF1] suppresses the photoreceptor apoptosis phenotype seen in Apc[Q8] flies. The photoreceptor apoptosis phenotype seen in Apc[Q8] flies is suppressed by Df(3L)27-3/Df(3L)ED4136.
(Benchabane et al., 2011)
Scer\GAL4[elav.PU]-driven Hsap\TFRC[Scer\UAS.T:Avic\GFP] is mis-localized in Khc[8]/+, Apc[Q8]/+ animals.
(Henthorn et al., 2011)
Embryos maternally and zygotically double mutant for Apc[Q8] and Apc2[N175K] display a naked cuticle phenotype. Embryos maternally and zygotically double mutant for Apc[Q8] and Apc2[f90] display a naked cuticle phenotype. Expression of Axn[Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[arm.PS] restores normal-looking denticle belts in embryos maternally and zygotically mutant for Apc[Q8] and Apc2[N175K]. Expression of Axn[Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[arm.PS] is unable to restore normal-looking denticle belts in embryos that are maternally and zygotically mutant for Apc[Q8] and Apc2[f90]. Every single embryo exhibits a completely naked cuticle, without any sign of denticle restoration. Expression of Axn[Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[arm.PS] restores normal-looking denticle belts in embryos derived from females containing Apc[Q8] Apc2[f90] double mutant germline clones crossed with wild type males. Expressing Axn[FGmut.Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[arm.PS] does not suppress the naked cuticle phenotype seen in Apc[Q8] Apc2[f90] double mutant embryos. Only occasional individual denticles are seen.
(Mendoza-Topaz et al., 2011)
Embryos derived from Apc2[g10] Apc[Q8] males crossed to females containing double homozygous germline clones generate naked cuticle. These embryos show approximately 50% lethality (as half the embryos are paternally rescued). The cuticle defects and lethality of embryos derived from Apc2[g10] Apc[Q8] males crossed to females containing double homozygous germline clones are rescued by expression of Apc2[WT.T:Avic\GFP-EGFP], Apc2[ΔR3.T:Avic\GFP-EGFP] or Apc2[Δ15.T:Avic\GFP-EGFP]. The cuticle defects and lethality of embryos derived from Apc2[g10] Apc[Q8] males crossed to females containing double homozygous germline clones are not rescued by Apc2[KeepR3.T:Avic\GFP-EGFP], Apc2[Δ20.T:Avic\GFP-EGFP], Apc2[ΔR2.T:Avic\GFP-EGFP], Apc2[ΔB.T:Avic\GFP-EGFP] or Apc2[d40.T:Avic\GFP-EGFP]. Apc2[Δ15Δ20.T:Avic\GFP-EGFP] does not rescue the cuticle defects of embryos derived from Apc2[g10] Apc[Q8] males crossed to females containing double homozygous germline clones. Apc2[Δ15Δ20.T:Avic\GFP-EGFP] may show some dominant negative activity, as 82% embryonic lethality is seen, suggesting that the ability of paternally supplied Apc[+] and Apc2[+] to rescue embryonic lethality is compromised. Apc2[ΔSAMP.T:Avic\GFP-EGFP] does not rescue the cuticle defects of embryos derived from Apc2[g10] Apc[Q8] males crossed to females containing double homozygous germline clones. Apc2[ΔSAMP.T:Avic\GFP-EGFP] may show some dominant negative activity, as 71% embryonic lethality is seen, suggesting that the ability of paternally supplied Apc[+] and Apc2[+] to rescue embryonic lethality is compromised.
(Roberts et al., 2011)
Hemizygous ewg[P1] suppresses the apoptosis seen in Apc[Q8] mutant photoreceptors. This apoptosis can be restored by expressing ewg[elav.NS]. Hemizygous ewg[1]/ewg[2] suppresses the apoptosis seen in Apc[Q8] mutant photoreceptors. The shortening of photoreceptor length seen prior to apoptosis is also suppressed, as is the rhabdomere enlargement seen as a result of misspecification of all of the photoreceptors in the dorsal half of the retina to a dorsal rim area fate. Hemizygous ewg[P1]/ewg[2] suppresses the apoptosis seen in Apc[Q8] mutant photoreceptors. The shortening of photoreceptor length seen prior to apoptosis is also suppressed, and the rhabdomere enlargement seen as a result of misspecification of all of the photoreceptors in the dorsal half of the retina to a dorsal rim area fate is also partially suppressed. This is most evident near the dorsal-ventral equator.
(Xin et al., 2011)
23% of embryos derived from females carrying homozygous Apc2[g10] Apc[Q8] germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique) are able to hatch. All of the surviving embryos are maternally double null and zygotically heterozygous for the double-null chromosome, whilst all of the maternally and zygotically mutant embryos died. The embryos display a range of cuticle defects including a reduction in cuticle size due to excess cell death, a hole in the anterior cuticle due to a failure in head involution and the production of excess smooth cuticle at the expense of denticles. Expression of Apc2[FL.T:Avic\GFP-EGFP] suppresses the lethality seen in embryos derived from females carrying homozygous Apc2[g10] Apc[Q8] germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique). 46% of embryos are able to hatch. The cuticle defects are also significantly rescued. Expression of Apc2[ΔC30.T:Avic\GFP-EGFP] suppresses the lethality seen in embryos derived from females carrying homozygous Apc2[g10] Apc[Q8] germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique). 46% of embryos are able to hatch. The cuticle defects are also significantly rescued. Expression of Apc2[N-SAMP.T:Avic\GFP-EGFP] is unable to suppress the lethality seen in embryos derived from females carrying homozygous Apc2[g10] Apc[Q8] germline clones and heterozygous double mutant males (generated using the FRT-FLP-DFS technique). 17% of embryos are able to hatch and the severity of the cuticle defects is similar to in the double mutant alone.
(Zhou et al., 2011)
Apc2[g10], Apc[Q8]/Apc2[c9] adults shifted to the non-permissive temperature show an increase in BrdU incorporation in the midgut compared to controls maintained at the permissive temperature. 5 days after clone induction in adults, Apc2[g10], Apc[Q8] double mutant clones in the midgut have a significantly increased number of cells per clone compared to controls. There is a significant increase in cell size both in the anterior and posterior midgut, with the average size being greater in the posterior midgut. Intestinal stem cell self-renewal is unaffected at 5 and 10 days after clone induction in the adult. 20 days after clone induction in adults, midguts containing Apc2[g10], Apc[Q8] double mutant clones are associated with gross anatomical changes, including hyperplasia and multilayered cellular masses that distort the luminal surface of the midgut. Apc2[g10], Apc[Q8] double mutant clones in the adult midgut that are also expressing N[dsRNA.P.Scer\UAS] under the control of Scer\GAL4[tub] often show extensive proliferation and multilayering 10 days after induction in the adult. The number of intestinal stem cells present and the mitotic index of the intestinal stem cells 5 days after induction is significantly higher in Apc2[g10], Apc[Q8] double mutant clones in the adult midgut that are also expressing N[dsRNA.P.Scer\UAS] under the control of Scer\GAL4[tub] compared to clones expressing N[dsRNA.P.Scer\UAS] under the control of Scer\GAL4[tub] in an otherwise wild-type background. Apc2[33] Apc[Q8] double mutant intestinal stem cell clones in the adult midgut show hyperplasia. The hyperplasia seen in Apc2[33] Apc[Q8] double mutant intestinal stem cell clones in the adult midgut is completely suppressed if they are also expressing pan[ΔN.Scer\UAS] under the control of Scer\GAL4[tub]. The hyperplasia seen in Apc2[g10] Apc[Q8] double mutant intestinal stem cell clones in the adult midgut is partially suppressed if they are also expressing pan[ΔN.Scer\UAS] under the control of Scer\GAL4[tub].
(Lee et al., 2009)
A heterozygous or homozygous ninaA[E110V] background is sufficient to induce a partial rescue of photoreceptor cells from Apc[Q8]-induced loss.
(Mendes et al., 2009)
The ventral cuticle of Apc[Q8], Apc2[d40] double mutant embryos is naked. Expression of Axn[Scer\UAS.cHa] under the control of Scer\GAL4[da.G32] blocks the naked-cuticle phenotype of Apc[Q8], Apc2[d40] double mutant embryos. Expression of Axn[Scer\UAS.T:Src64B,T:Zzzz\FLAG] under the control of Scer\GAL4[da.G32] has no effect on the naked-cuticle phenotype of Apc[Q8], Apc2[d40] double mutant embryos. Expression of Apc2[Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[da.G32] restores wild-type patterning of the ventral cuticle in Apc[Q8], Apc2[d40] double mutant embryos. Expression of Apc2[Scer\UAS.T:Src64B,T:Zzzz\FLAG] under the control of Scer\GAL4[da.G32] fails to restore wild-type patterning of the ventral cuticle in Apc[Q8], Apc2[d40] double mutant embryos. Triple mutants for Axn[S044230], Apc[Q8] and Apc2[d40] have naked ventral embryonic epidermis. The ventral denticle belt phenotype of Axn[S044230], Apc[Q8], Apc2[d40] triple mutants is suppressed by expression of Axn[Scer\UAS.cHa] under the control of Scer\GAL4[da.G32]. Expression of Axn[Scer\UAS.T:Src64B,T:Zzzz\FLAG] under the control of Scer\GAL4[da.G32] has no effect on the ventral denticle belt phenotype of Axn[S044230], Apc[Q8], Apc2[d40] triple mutants. Expression of Apc2[Scer\UAS.T:Avic\GFP] under the control of Scer\GAL4[da.G32] has no effect on the ventral denticle belt phenotype of Axn[S044230], Apc[Q8], Apc2[d40] triple mutants. Expression of Apc2[Scer\UAS.T:Src64B,T:Zzzz\FLAG] under the control of Scer\GAL4[da.G32] has no effect on the ventral denticle belt phenotype of Axn[S044230], Apc[Q8], Apc2[d40] triple mutants.
(Tolwinski, 2009)
ApcQ8 Apc25-3 double homozygotes show loss of sternites and sternal bristles and expansion of the pleura in the abdomen. ApcQ8 Apc25-3/ApcQ8 Apc2G5028 double mutants show loss of sternites and sternal bristles and expansion of the pleura in the abdomen. ApcQ8 Apc25-3/ApcQ8 Apc219-3 double mutants show a wing to notum transformation. The photoreceptor cell apoptosis phenotype seen in ApcQ8 homozygotes is suppressed by Apc233/+ but not by Apc2g10/+.
(Takacs et al., 2008)
ApcQ8 Apc25-3/ApcQ8 Apc233 double mutants show expansion of sternal territory in the abdomen and ectopic sternal bristles, at the expense of the pleura. ApcQ8 Apc2G5028/ApcQ8 Apc233 double mutants show expansion of sternal territory in the abdomen and ectopic sternal bristles, at the expense of the pleura.
(Takacs et al., 2008)
There is no difference in the frequency of mispositioned oocytes between wild type and Apc2g10, ApcQ8 double mutant mutant germlines. Apc2g10, ApcQ8 maternal/zygotic double mutant embryos show no defects in epithelial structure and do not show a total disruption of the cuticle. Apc2g10, ApcQ8 maternally mutant syncytial embryos show similar levels (35 vs 37%) of cortical nuclei movement to the anterior to Apc2g10 syncytial embryos. Apc2g10, ApcQ8 maternally mutant syncytial embryos do not have significant defects in overall spindle morphology or orientation but do show a slight but significant lengthening of the pole-to-pole distance. These double mutants show normal symmetric cell division.
(McCartney et al., 2006)
Ectopic photoreceptor apoptosis in the developing eyes of ApcS76/ApcQ8 pupae is greatly reduced by Df(3L)H99/+.
(Lin et al., 2004)
ApcQ8, Apc2N175K double mutant embryos have a naked cuticle phenotype.
(Cliffe et al., 2003)
ApcQ8 Apc2d40 double mutant homozygotes derived from heterozygous parents differentiate a normal larval cuticle but die during the larval stage. ApcQ8 Apc2d40 double mutant clones in the wing autonomously form marginal structures, adopting the fate of those marginal cells that are closest to the clone; they form bristles in the anterior and thin tapered hairs in the posterior. The clones can occupy up to 1/3 of the wing surface. ApcQ8 Apc2d40 double mutant clones result in outgrowths in the proximal leg and duplications in the distal leg. The duplications arise from the dorsal side of the leg and contain both homozygous clone cells and neighbouring heterozygous cells. Double mutant clones are rarely found in parts of the leg that have differentiated into dorsal structures. Double mutant clones are frequently found in ventral structures and ventral bristles in these clones are often morphologically normal. ApcQ8 Apc2d40 double mutant clones in the eye show transformation into ectopic head cuticle. These clones can occupy up to half the eye. ApcQ8 Apc2d40 double mutant clones also produce mutant phenotypes in the head cuticle, antennae, labial disc derivatives, notum, tergites and genitalia. The expansion of naked cuticle seen in embryos derived from Apc2d40 females mated to Apc2d40 males is enhanced if the maternal or zygotic dose of Apc is reduced by half (using ApcQ8); in these double mutant embryos most denticles are eliminated. Embryos derived from ApcQ8 Apc2d40 double mutant germline clones (lacking maternal but not zygotic Apc and Apc2) have some cuticle defects but often hatch and survive to adulthood. Animals derived from ApcQ8 Apc2d40 double mutant germline clones and also lacking zygotic Apc (animal is homozygous for ApcQ8) die either during embryonic or larval stages and differentiate partially naked cuticles. The cuticle defects of embryos derived from ApcQ8 Apc2d40 double mutant germline clones are also enhanced if the embryos lack zygotic Apc2 (embryo is homozygous for Apc2d40). One copy of Apc2+t7 is able to partially prevent the apoptosis of retinal neurons seen in ApcQ8 homozygotes.
(Ahmed et al., 2002)
Apc2d40, ApcQ8 double homozygotes die a first instar larvae. Apc2g10, ApcQ8 double homozygotes die as second instar larvae. Apc2ΔS, ApcQ8 double homozygotes die as second instar larvae. Double mutant second larval instar brains are essentially normal in size and the optic anlage has become epithelial. Second instar larval mushroom body neuroblasts proliferate as normal, but the number of other mitotic neuroblasts is drastically reduced relative to wild type. BrdU incorporation in the brain is drastically reduced in second instar larvae, with most labelled cells appearing to be mushroom body neuroblasts. The remaining larval neuroblasts retain the ability to divide asymetrically. The axonal scaffold is unaltered in Apc2ΔS, ApcQ8 double mutant embryos.
(Akong et al., 2002)
Apc2d40 ApcQ8, Apc2ΔS ApcQ8, and Apc2g10 ApcQ8 double zygotic mutants are embryonic viable and exhibit a wild-type cuticle pattern, but die as larvae. In the embryonic progeny of Apc2ΔS ApcQ8/Apc2ΔS males and females crossed to each other ventral cells secrete only naked cuticle. This is a more severe cuticle phenotype than that seen in Apc2ΔS maternal and zygotic mutant embryos. Apc2d40 ApcQ8 maternal and zygotic double mutants exhibit a much stronger embryonic cuticle phenotype than Apc2d40 maternal and zygotic single mutants. Maternal and zygotic double mutant cuticles are shorter, and, unlike Apc2d40 maternal and zygotic single mutants, most embryos completely lack denticles. Maternal and zygotic double mutants also exhibit a complete failure of head involution. Dorsally, all cells are transformed to the fate normally adopted by posterior cells, and thus all secrete fine dorsal hairs. These embryos also exhibit slight abnormalities in dorsal closure not seen in the single mutant. Embryos receiving paternal wild-type copies of Apc2 and Apc are rescued to viability. Patches of ectopic wing margin bristles are seen in the wing blades of animals in which Apc2d40 ApcQ8 double mutant clones have been induced. Ectopic bristles are also seen in the nota of these animals.
(Akong et al., 2002)
The penetrance of the oocyte mislocalisation phenotype see in Apc2N175K mutant females is increased to 32% if they are also mutant for ApcQ8.
(Hamada and Bienz, 2002)
Overexpression of BacA\p35GMR.PH in ApcQ8 homozygotes rescues the retinal neurons from death. The rescued photoreceptors appear normal at the apical surface of the eye, but at more basal levels they have dramatically shrunken diameters and lose contacts with their neighbours. Many photoreceptors are rescued from death in homozygotes carrying one copy of arm4. The rescued photoreceptors appear completely normal from apex to base. Many photoreceptors are rescued from death in ApcQ8 homozygotes carrying one copy of armS5.T:Hsap\MYC, armS12.T:Hsap\MYC or armS15.T:Hsap\MYC in an arm4/+ background. Many photoreceptors are rescued from death in ApcQ8 homozygotes carrying one copy of sggScer\UAS.cSa expressed under the control of Scer\GAL4elav-C155. The rescued cells are only seen at the apical surface of the eye, there is no rescue more basally. Some photoreceptors are rescued from death in ApcQ8 homozygotes carrying one copy of panciD or pan13. The rescued cells are only seen at the apical surface of the eye, there is no rescue more basally. Photoreceptors are not rescued from death in ApcQ8 homozygotes carrying one copy of armS14.T:Hsap\MYC in an arm4/+ background. Photoreceptors are not rescued from death in homozygotes carrying one copy of arm8.
(Ahmed et al., 1998)
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Statement
Reference
BacA\p35[GMR.PH] Apc[Q8] flies have shortened photoreceptors, which are visible in apical cross sections of the retina, but do not extend to its base.
(Benchabane et al., 2011)
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Comments
hide Stocks ( 1 )
Bloomington
7211
w*; P{neoFRT}82B sr1 e1 Apc2N175K ApcQ8/TM3, P{ActGFP}JMR2, Ser1
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hide Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym
apc1Q8
(Tolwinski and Wieschaus, 2004, Yamashita et al., 2003, Tolwinski, 2009, Henthorn et al., 2011)
APC1Q8
(Akong et al., 2002, Akong et al., 2002, Zimmerman et al., 2007, McCartney et al., 2006, Roberts et al., 2012, Kunttas-Tatli et al., 2012)
Apc1Q8
(Ahmed et al., 2002, Takacs et al., 2008, Benchabane et al., 2011, Benchabane et al., 2011, Takacs et al., 2008, Lee et al., 2009, Henthorn et al., 2011)
APCQ8
(Roberts et al., 2012, Brumby et al., 2004, Zhou et al., 2011, Roberts et al., 2011)
ApcQ8
(Xin et al., 2011, Christensen et al., 2009.5.6, Mattie et al., 2010)
apcQ8
(Mendes et al., 2009)
D-APCQ8
(Cliffe et al., 2003, Ahmed et al., 1998)
dAPCQ8
(Hamada and Bienz, 2002)
dApcQ8
(Mendoza-Topaz et al., 2011)
Name Synonym
Secondary FlyBase IDs
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Kunttas-Tatli et al., 2012, Genetics 190(3): 1059--1075
Destruction complex function in the wnt signaling pathway of Drosophila requires multiple interactions between adenomatous polyposis coli 2 and armadillo. [FBrf0217816]
Roberts et al., 2012, Mol. Biol. Cell 23(11): 2041--2056
Regulation of Wnt signaling by the tumor suppressor adenomatous polyposis coli does not require the ability to enter the nucleus or a particular cytoplasmic localization. [FBrf0218500]
Roberts et al., 2012, PLoS ONE 7(2): e31284
Defining Components of the ßcatenin Destruction Complex and Exploring Its Regulation and Mechanisms of Action during Development. [FBrf0217546]
Benchabane et al., 2011, EMBO J. 30(8): 1444--1458
Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity. [FBrf0213544]
Henthorn et al., 2011, Mol. Biol. Cell 22(21): 4038--4046
A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila. [FBrf0216511]
Mendoza-Topaz et al., 2011, Open Biol. 1(3): 110013
The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled. [FBrf0218486]
Roberts et al., 2011, Mol. Biol. Cell 22(11): 1845--1863
Deconstructing the sscatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling. [FBrf0213765]
Xin et al., 2011, Development 138(22): 4955--4967
Erect Wing facilitates context-dependent Wnt/Wingless signaling by recruiting the cell-specific Armadillo-TCF adaptor Earthbound to chromatin. [FBrf0216486]
Zhou et al., 2011, J. Cell Sci. 124(9): 1589--1600
Cortical localization of APC2 plays a role in actin organization but not in Wnt signaling in Drosophila. [FBrf0213457]
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