Allele Dmel\tkv^{Scer\UAS.T:Ivir\HA1}

General Information
Symbol	Dmel\tkv^{Scer\UAS.T:Ivir\HA1}	Species	D. melanogaster
Name		FlyBase ID	FBal0092479
Feature type	allele	Associated gene	Dmel\tkv

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Haerry et al., 1998) in vitro construct - regulatory fusion (Haerry et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Full length wild-type tkv, tagged with T:Ivir\HA1 is expressed under the control of Scer\UAS regulatory sequences. (Haerry et al., 1998)
Carried in construct	P{UAS-tkv.T:HA1} (McCabe et al., 2004, Haerry et al., 1998, Bennett et al., 2003, Bangi and Wharton, 2006, Wang et al., 2007)
Tagged with	T:Ivir\HA1 (Haerry et al., 1998, Bennett et al., 2003, McCabe et al., 2004)
Cytology
Phenotypic Data
Phenotypic Class
	visible, with Scer\GAL4^A9 (Haerry et al., 1998) visible, with Scer\GAL4^en-e16E (Haerry et al., 1998)
Phenotype Manifest In
	wing disc, with Scer\GAL4^A9 (Haerry et al., 1998) wing vein L4, with Scer\GAL4^A9 (Haerry et al., 1998) wing vein L4, with Scer\GAL4^en-e16E (Haerry et al., 1998) wing vein L5, with Scer\GAL4^en-e16E (Haerry et al., 1998)
Detailed Description
	Statement Reference Flies expressing tkv^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^vg.PM have essentially wild-type wings. (Bennett et al., 2003) Larvae expressing tkv^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^A9 have small wing discs. Adult wings show loss of wing vein L4. Flies expressing tkv^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^en-e16E show truncation of the distal part of wing vein L4 and lack most of vein L5. (Haerry et al., 1998)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference Scer\GAL4^A9/tkv^{Scer\UAS.T:Ivir\HA1} is an enhancer of visible phenotype of Scer\GAL4^A9, gbb^Scer\UAS.cKa (Bangi and Wharton, 2006) Scer\GAL4^vg.PM/tkv^{Scer\UAS.T:Ivir\HA1} is an enhancer of visible phenotype of Scer\GAL4^vg.PM, put^Scer\UAS.cMa (Bennett et al., 2003)
NOT Suppressor of
Statement Reference Pp1-87B^{Scer\UAS.T:Ivir\HA1}/tkv^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^vg.PM is a non-suppressor of visible phenotype of I-2^{Scer\UAS.T:Zzzz\His6,T:Hsap\MYC}, Scer\GAL4^vg.PM, put^Scer\UAS.cMa (Bennett et al., 2003)
Phenotype Manifest In
Enhancer of
Statement Reference Scer\GAL4^A9/tkv^{Scer\UAS.T:Ivir\HA1} is an enhancer of wing vein phenotype of Scer\GAL4^A9, gbb^Scer\UAS.cKa (Bangi and Wharton, 2006) Scer\GAL4^vg.PM/tkv^{Scer\UAS.T:Ivir\HA1} is an enhancer of wing phenotype of Scer\GAL4^vg.PM, put^Scer\UAS.cMa (Bennett et al., 2003)
NOT Suppressor of
Statement Reference Pp1-87B^{Scer\UAS.T:Ivir\HA1}/tkv^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^vg.PM is a non-suppressor of wing phenotype of I-2^{Scer\UAS.T:Zzzz\His6,T:Hsap\MYC}, Scer\GAL4^vg.PM, put^Scer\UAS.cMa (Bennett et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference Coexpression of tkv^{Scer\UAS.T:Ivir\HA1} and gbb^Scer\UAS.cKa enhances the Scer\GAL4^A9>gbb^Scer\UAS.cKa wing vein phenotype so that a higher percentage of wings have extensive amounts of wing vein tissue. (Bangi and Wharton, 2006) The modest wing overgrowth phenotype caused by expression of put^Scer\UAS.cMa under the control of Scer\GAL4^vg.PM is enhanced by co-expression of tkv^{Scer\UAS.T:Ivir\HA1}. (Bennett et al., 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Scer\GAL4^elav.PLu/tkv^{Scer\UAS.T:Ivir\HA1} rescues tkv¹/tkv⁸ (McCabe et al., 2004)
Comments	Expression of tkv^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav.PLu in the neurons rescues neuromuscular junction size in tkv¹/tkv⁸ mutants. (McCabe et al., 2004)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	tkv^{Scer\UAS.T:Ivir\HA1} tkv^{UAS.T:Ivir\HA1}
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Wang et al., 2007, Nat. Neurosci. 10(2): 177--185 Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules. [FBrf0194450] Bangi and Wharton, 2006, Development 133(17): 3295--3303 Dual function of the Drosophila Alk1/Alk2 ortholog Saxophone shapes the Bmp activity gradient in the wing imaginal disc. [FBrf0194511] McCabe et al., 2004, Neuron 41(6): 891--905 Highwire regulates presynaptic BMP signaling essential for synaptic growth. [FBrf0175022] Bennett et al., 2003, Genetics 164(1): 235--245 Ectopic expression of inhibitors of Protein phosphatase type 1 (PP1) can be used to analyze roles of PP1 in Drosophila development. [FBrf0158995] Haerry et al., 1998, Development 125(20): 3977--3987 Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila. [FBrf0104902]

Allele Dmel\tkvScer\UAS.T:Ivir\HA1

Allele Dmel\tkv^{Scer\UAS.T:Ivir\HA1}